Lipoxin A4-Induced Heme Oxygenase-1 Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury via p38 MAPK Activation and Nrf2/ARE Complex

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Chen, Xiao Qing ^a   Wu, Sheng Hua ^a   Zhou, Yu ^a   Tang, Yan Rong ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; HEME OXYGENASE 1; HEME OXYGENASE INHIBITOR; LACTATE DEHYDROGENASE; LIPOXIN A; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; TRANSCRIPTION FACTOR NRF2; CARDIOTONIC AGENT; LIPOXIN; OXYGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL DAMAGE; CELL HYPOXIA; CELL NUCLEUS; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; ENHANCER REGION; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME SYNTHESIS; GENE ACTIVITY; GENE EXPRESSION; HEART MUSCLE CELL; HEART PROTECTION; INTRACELLULAR TRANSPORT; MALE; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; REOXYGENATION; ANIMAL; ANOXIA; BIOSYNTHESIS; CELL SHAPE; CELL SURVIVAL; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PATHOLOGY; UPREGULATION; WISTAR RAT; DRUG EFFECTS;

RATTUS;

ANIMALS; ANOXIA; ANTIOXIDANT RESPONSE ELEMENTS; CARDIOTONIC AGENTS; CELL SHAPE; CELL SURVIVAL; CREATINE KINASE; ENZYME INDUCTION; HEME OXYGENASE-1; L-LACTATE DEHYDROGENASE; LIPOXINS; MALE; MYOCYTES, CARDIAC; NF-E2-RELATED FACTOR 2; OXYGEN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84879475972     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067120     Document Type: Article

References (34)

1. Yellon DM, Hausenloy DJ, (2007) Myocardial reperfusion injury. N Eng J Med 357: 1121-1135.
2. Eltzschig HK, Eckle T, (2011) Ischemia and reperfusion-from mechanism to translation. Nat Med 17: 1391-401.
3. Hangaishi M, Ishizaka N, Aizawa T, Kurihara Y, Taguchi J, et al. (2000) Induction of heme oxygenase-1 can act protectively against cardiac ischemia/reperfusion in vivo. Biochem Biophys Res Commun 279: 582-588.
4. Vulapalli SR, Chen Z, Chua BHL, Wang T, Liang CS, (2002) Cardioselective overexpression of HO-1 prevents I/R-induced cardiac dysfunction and apoptosis. Am J Physiol Heart Circ Physiol 283: H688-H694.
5. Lee YS, Kang YJ, Kim HJ, Park MK, Seo HG, et al. (2006) Higenamine reduces apoptotic cell death by induction of heme oxygenase-1 in rat myocardial ischemia-reperfusion injury. Apoptosis 11: 1091-100.
6. Kim YM, Ha YM, Jin YC, Shi LY, Lee YS, et al. (2009) Palmatine from Coptidis rhizoma reduces ischemia-reperfusion-mediated acute myocardial injury in the rat. Food Chem Toxicol 47: 2097-2102.
7. Hwa JS, Jin YC, Lee YS, Ko YS, Kim YM, et al. (2012) 2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction. J Ethnopharmacol 139: 605-615.
8. Serhan CN, Chiang N, (2008) Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. Br J Pharmacol 153: S200-S215.
9. Nascimento-Silva V, Arruda MA, Barja-Fidalgo C, Fierro IM, (2007) Aspirin-triggered lipoxin A4 blocks reactive oxygen species generation in endothelial cells: a novel antioxidative mechanism. Thromb Haemost 97: 88-98.
10. Hecht I, Rong J, Sampaio AL, Hermesh C, Rutledge C, et al. (2009) A novel peptide agonist of formyl-peptide receptor-like 1 (ALX) displays anti-inflammatory and cardioprotective effects. J Pharmacol Exp Ther 328: 426-434.
11. Chen Z, Wu Z, Huang C, Zhao Y, Zhou Y, et al. (2013) Effect of lipoxin A4 on myocardial ischemia reperfusion injury following cardiac arrest in a rabbit model. Inflammation 36: 468-475.
12. Nascimento-Silva V, Arruda MA, Barja-Fidalgo C, Villela CG, Fierro IM, (2005) Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells. Am J Physiol Cell Physiol 289: C557-C563.
13. Biteman B, Hassan IR, Walker E, Leedom AJ, Dunn M, et al. (2007) Interdependence of lipoxin A4 and heme-oxygenase in counter-regulating inflammation during corneal wound healing. FASEB J 21: 2257-2266.
14. Jin SW, Zhang L, Lian QQ, Liu D, Wu P, et al. (2007) Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in mice: the role of heme oxygenase-1. Anesth Analg 104: 369-377.
15. Alam J, Cook JL, (2003) Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway. Curr Pharm 9: 2499-2511.
16. Masuya Y, Hioki K, Tokunaga R, Taketani S, (1998) Involvement of the tyrosine phosphorylation pathway in induction of human heme oxygenase-1 by hemin, sodium arsenite, and cadmium chloride. J Biochem 124: 628-633.
17. Chen JC, Huang KC, Lin WW, (2006) HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways. Cell Signal 18: 32-39.
18. Liu XM, Peyton KJ, Ensenat D, Wang H, Hannink M, et al. (2007) Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival. Cardiovasc Res 75: 381-389.
19. McMahon B, Stenson C, McPhillips F, Fanning A, Brady HR, et al. (2000) Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. J Biol Chem 275: 27566-27575.
20. Wu SH, Wu XH, Lu C, Dong L, Zhou GP, et al. (2006) Lipoxin A4 inhibits connective tissue growth factor-induced production of chemokines in rat mesangial cells. Kidney Int 69: 248-256.
21. Wu SH, Wu XH, Lu C, Dong L, Chen ZQ, (2006) Lipoxin A4 inhibits proliferation of human lung fibroblasts induced by connective tissue growth factor. Am J Respir Cell Mol Biol 34: 65-72.
22. Wu SH, Liao PY, Dong L, Chen ZQ, (2008) Signal pathway involved in inhibition by lipoxin A4 of production of interleukins in endothelial cells by lipopolysaccharide. Inflamm Res 57: 430-437.
23. Wu SH, Zhang YM, Tao HX, Dong L, (2010) Lipoxin A4 inhibits transition of epithelial to mesenchymal cells in proximal tubules. Am J Nephrol 32: 122-136.
24. Pang H, Yi P, Wu P, Liu Z, Liu Z, et al. (2011) Effect of lipoxin A4 on lipopolysaccharide-induced endothelial hyperpermeability. Sci World J 11: 1056-1067.
25. Hu CP, Dandapat A, Liu Y, Hermonat PL, Mehta JL, (2007) Blockade of hypoxia-reoxygenation-mediated collagen type I expression and MMP activity by overexpression of TGF-β1 delivered by AAV in mouse cardiomyocytes. Am J Physiol Heart Circ Physiol 293: H1833-H1838.
26. Komuro I, Kaida T, Shibazaki Y, Kurabayashi M, Katoh Y, (1990) Stretching cardiac myocytes stimulates protooncogene expression. J Biol Chem 265: 3595-3598.
27. Kacimi R, Chentoufi J, Honbo N, Long CS, Karliner JS, (2000) Hypoxia differentially regulates stress proteins in cultured cardiomyocytes: role of the p38 stress-activated kinase signaling cascade, and relation to cytoprotection. Cardiovasc Res 46: 139-150.
28. Schulz R, Belosjorow S, Gres P, Jansen J, Michel MC, et al. (2002) p38 MAP kinase is a mediator of ischemic preconditioning in pigs. Cardiovasc Res 55: 690-700.
29. Bassi R, Heads R, Marber MS, Clark JE, (2008) Targeting p38-MAPK in the ischemic heart: kill or cure? Curr Opin Pharmacol 8: 141-146.
30. Mann GE, Niehueser-Saran J, Watson A, Gao L, Ishii T, et al. (2007) Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia. Acta Physiol Sin 59: 117-127.
31. Kensler TW, Wakabayashi N, Biswal S, (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47: 89-116.
32. Zhang L, Zhang X, Wu P, Li H, Jin S, et al. (2008) BML-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis. Inflamm Res 57: 157-162.
33. Levy BD, Lukacs NW, Berlin AA, Schmidt B, Guilford WJ, et al. (2007) Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism. FASEB J 21: 3877-3884.
34. Wu SH, Wu XH, Liao PY, Dong L, (2007) Signal transduction involved in protective effects of 15(R/S)- methyl-lipoxin A4 on mesangioproliferative nephritis in rats. Prostaglandins Leukot Essent Fatty Acids 76: 173-180.