메뉴 건너뛰기




Volumn 188, Issue 11, 2012, Pages 5723-5733

Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; CERAMIDE SYNTHASE 6; CYCLOSERINE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PALMITIC ACID; SPHINGOSINE ACYLTRANSFERASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84862102041     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1103109     Document Type: Article
Times cited : (46)

References (44)
  • 1
    • 34548133584 scopus 로고    scopus 로고
    • Multiple sclerosis: A complicated picture of autoimmunity
    • DOI 10.1038/ni1507, PII NI1507
    • McFarland, H. F., and R. Martin. 2007. Multiple sclerosis: a complicated picture of autoimmunity. Nat. Immunol. 8: 913-919. (Pubitemid 47300005)
    • (2007) Nature Immunology , vol.8 , Issue.9 , pp. 913-919
    • McFarland, H.F.1    Martin, R.2
  • 2
    • 35848956116 scopus 로고    scopus 로고
    • The contribution of nitric oxide and interferon gamma to the regulation of the neuro-inflammation in experimental autoimmune encephalomyelitis
    • DOI 10.1016/j.jneuroim.2007.09.007, PII S0165572807003116, Regulation of Neuroinflammation
    • Willenborg, D. O., M. Staykova, S. Fordham, N. O'Brien, and D. Linares. 2007. The contribution of nitric oxide and interferon gamma to the regulation of the neuro-inflammation in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 191: 16-25. (Pubitemid 350060995)
    • (2007) Journal of Neuroimmunology , vol.191 , Issue.1-2 , pp. 16-25
    • Willenborg, D.O.1    Staykova, M.2    Fordham, S.3    O'Brien, N.4    Linares, D.5
  • 3
    • 80053307800 scopus 로고    scopus 로고
    • TNF-a: A paradigm of paradox and complexity in multiple sclerosis and its animal models
    • Lim, S.-Y., and C. Constantinescu. 2010. TNF-a: a paradigm of paradox and complexity in multiple sclerosis and its animal models. Open Autoimmun. J. 2: 160-170.
    • (2010) Open Autoimmun. J. , vol.2 , pp. 160-170
    • Lim, S.-Y.1    Constantinescu, C.2
  • 5
    • 0028855346 scopus 로고
    • Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I
    • Selmaj, K., W. Papierz, A. Glabiński, and T. Kohno. 1995. Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I. J. Neuroimmunol. 56: 135-141.
    • (1995) J. Neuroimmunol. , vol.56 , pp. 135-141
    • Selmaj, K.1    Papierz, W.2    Glabiński, A.3    Kohno, T.4
  • 7
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • DOI 10.1038/nrm2329, PII NRM2329
    • Hannun, Y. A., and L. M. Obeid. 2008. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 9: 139-150. (Pubitemid 351158911)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.2 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 8
    • 78649761056 scopus 로고    scopus 로고
    • Sphingolipids in multiple sclerosis
    • Jana, A., and K. Pahan. 2010. Sphingolipids in multiple sclerosis. Neuromolecular Med. 12: 351-361.
    • (2010) Neuromolecular Med. , vol.12 , pp. 351-361
    • Jana, A.1    Pahan, K.2
  • 9
    • 78649790713 scopus 로고    scopus 로고
    • The role of the ceramide acyl chain length in neurodegeneration: Involvement of ceramide synthases
    • Ben-David, O., and A. H. Futerman. 2010. The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases. Neuromolecular Med. 12: 341-350.
    • (2010) Neuromolecular Med. , vol.12 , pp. 341-350
    • Ben-David, O.1    Futerman, A.H.2
  • 10
    • 77954709548 scopus 로고    scopus 로고
    • The acid sphingomyelinase/ceramide pathway: Biomedical significance and mechanisms of regulation
    • Zeidan, Y. H., and Y. A. Hannun. 2010. The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation. Curr. Mol. Med. 10: 454-466.
    • (2010) Curr. Mol. Med. , vol.10 , pp. 454-466
    • Zeidan, Y.H.1    Hannun, Y.A.2
  • 11
    • 77953461364 scopus 로고    scopus 로고
    • The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis
    • Becker, K. A., J. Riethmüller, Y. Zhang, and E. Gulbins. 2010. The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis. Open Respir. Med. J. 4: 39-47.
    • (2010) Open Respir. Med. J. , vol.4 , pp. 39-47
    • Becker, K.A.1    Riethmüller, J.2    Zhang, Y.3    Gulbins, E.4
  • 12
    • 0035217962 scopus 로고    scopus 로고
    • Modes of action of Freund's adjuvants in experimental models of autoimmune diseases
    • Billiau, A., and P. Matthys. 2001. Modes of action of Freund's adjuvants in experimental models of autoimmune diseases. J. Leukoc. Biol. 70: 849-860. (Pubitemid 33151123)
    • (2001) Journal of Leukocyte Biology , vol.70 , Issue.6 , pp. 849-860
    • Billiau, A.1    Matthys, P.2
  • 13
    • 0024518801 scopus 로고
    • The long-term administration of L-cycloserine to mice: Specific reduction of cerebroside level
    • DOI 10.1007/BF00971318
    • Sundaram, K. S., and M. Lev. 1989. The long-term administration of L-cycloserine to mice: specific reduction of cerebroside level. Neurochem. Res. 14: 245-248. (Pubitemid 19132454)
    • (1989) Neurochemical Research , vol.14 , Issue.3 , pp. 245-248
    • Sundaram, K.S.1    Lev, M.2
  • 16
    • 41949140023 scopus 로고    scopus 로고
    • Characterization of ceramide synthase 2: Tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
    • Laviad, E. L., L. Albee, I. Pankova-Kholmyansky, S. Epstein, H. Park, A. H. Merrill, Jr., and A. H. Futerman. 2008. Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. J. Biol. Chem. 283: 5677-5684.
    • (2008) J. Biol. Chem. , vol.283 , pp. 5677-5684
    • Laviad, E.L.1    Albee, L.2    Pankova-Kholmyansky, I.3    Epstein, S.4    Park, H.5    Merrill Jr., A.H.6    Futerman, A.H.7
  • 18
    • 67649196932 scopus 로고    scopus 로고
    • Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis
    • Nath, N., M. Khan, M. K. Paintlia, I. Singh, M. N. Hoda, and S. Giri. 2009. Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis. J. Immunol. 182: 8005-8014.
    • (2009) J. Immunol. , vol.182 , pp. 8005-8014
    • Nath, N.1    Khan, M.2    Paintlia, M.K.3    Singh, I.4    Hoda, M.N.5    Giri, S.6
  • 21
    • 0020448709 scopus 로고
    • 15N]nitrate in biological fluids
    • DOI 10.1016/0003-2697(82)90118-X
    • Green, L. C., D. A. Wagner, J. Glogowski, P. L. Skipper, J. S. Wishnok, and S. R. Tannenbaum. 1982. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 126: 131-138. (Pubitemid 13203451)
    • (1982) Analytical Biochemistry , vol.126 , Issue.1 , pp. 131-138
    • Green, L.C.1    Wagner, D.A.2    Glogowski, J.3
  • 22
    • 80052246111 scopus 로고    scopus 로고
    • Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
    • Ajami, B., J. L. Bennett, C. Krieger, K. M. McNagny, and F. M. Rossi. 2011. Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat. Neurosci. 14: 1142-1149.
    • (2011) Nat. Neurosci. , vol.14 , pp. 1142-1149
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    McNagny, K.M.4    Rossi, F.M.5
  • 23
    • 78649752513 scopus 로고    scopus 로고
    • Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis
    • Domingues, H. S., M. Mues, H. Lassmann, H. Wekerle, and G. Krishnamoorthy. 2010. Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS ONE 5: e15531.
    • (2010) PLoS ONE , vol.5
    • Domingues, H.S.1    Mues, M.2    Lassmann, H.3    Wekerle, H.4    Krishnamoorthy, G.5
  • 24
    • 0028061167 scopus 로고
    • Nitric oxide as a potential pathological mechanism in demyelination: Its differential effects on primary glial cells in vitro
    • DOI 10.1016/0306-4522(94)90435-9
    • Mitrovic, B., L. J. Ignarro, S. Montestruque, A. Smoll, and J. E. Merrill. 1994. Nitric oxide as a potential pathological mechanism in demyelination: its differential effects on primary glial cells in vitro. Neuroscience 61: 575-585. (Pubitemid 24240305)
    • (1994) Neuroscience , vol.61 , Issue.3 , pp. 575-585
    • Mitrovic, B.1
  • 25
    • 0027161216 scopus 로고
    • Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide
    • Merrill, J. E., L. J. Ignarro, M. P. Sherman, J. Melinek, and T. E. Lane. 1993. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J. Immunol. 151: 2132-2141. (Pubitemid 23235686)
    • (1993) Journal of Immunology , vol.151 , Issue.4 , pp. 2132-2141
    • Merrill, J.E.1    Ignarro, L.J.2    Sherman, M.P.3    Melinek, J.4    Lane, T.E.5
  • 26
    • 0029410743 scopus 로고
    • Interferon-gamma-induced oligodendrocyte cell death: Implications for the pathogenesis of multiple sclerosis
    • Vartanian, T., Y. Li, M. Zhao, and K. Stefansson. 1995. Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis. Mol. Med. 1: 732-743. (Pubitemid 3013083)
    • (1995) Molecular Medicine , vol.1 , Issue.7 , pp. 732-743
    • Vartanian, T.1    Li, Y.2    Zhao, M.3    Stefansson, K.4
  • 27
    • 0035159618 scopus 로고    scopus 로고
    • Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of Valpha14 NK T cells
    • Pál, E., T. Tabira, T. Kawano, M. Taniguchi, S. Miyake, and T. Yamamura. 2001. Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of Valpha 14 NK T cells. J. Immunol. 166: 662-668. (Pubitemid 32038491)
    • (2001) Journal of Immunology , vol.166 , Issue.1 , pp. 662-668
    • Pal, E.1    Tabira, T.2    Kawano, T.3    Taniguchi, M.4    Miyake, S.5    Yamamura, T.6
  • 28
    • 70350133784 scopus 로고    scopus 로고
    • Sphingolipids in inflammation: Pathological implications and potential therapeutic targets
    • Nixon, G. F. 2009. Sphingolipids in inflammation: pathological implications and potential therapeutic targets. Br. J. Pharmacol. 158: 982-993.
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 982-993
    • Nixon, G.F.1
  • 30
    • 3042841602 scopus 로고    scopus 로고
    • A novel role of lactosylceramide in the regulation of lipopolysaccharide/ interferon-gamma-mediated inducible nitric oxide synthase gene expression: Implications for neuroinflammatory diseases
    • DOI 10.1523/JNEUROSCI.1271-04.2004
    • Pannu, R., J. S. Won, M. Khan, A. K. Singh, and I. Singh. 2004. A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon- gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases. J. Neurosci. 24: 5942-5954. (Pubitemid 38859392)
    • (2004) Journal of Neuroscience , vol.24 , Issue.26 , pp. 5942-5954
    • Pannu, R.1    Won, J.-S.2    Khan, M.3    Singh, A.K.4    Singh, I.5
  • 31
    • 0035964774 scopus 로고    scopus 로고
    • Sphingomyelinase but not ceramide induces nitric oxide synthase expression in rat brain microglia
    • DOI 10.1016/S0304-3940(01)02162-0, PII S0304394001021620
    • Yang, M. S., I. Jou, H. Inn-Oc, and E. Joe. 2001. Sphingomyelinase but not ceramide induces nitric oxide synthase expression in rat brain microglia. Neurosci. Lett. 311: 133-136. (Pubitemid 32900623)
    • (2001) Neuroscience Letters , vol.311 , Issue.2 , pp. 133-136
    • Yang, M.-S.1    Jou, I.2    Inn-Oc, H.3    Joe, E.-H.4
  • 32
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • DOI 10.1038/nri1733
    • Gordon, S., and P. R. Taylor. 2005. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5: 953-964. (Pubitemid 41746764)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.12 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 34
    • 83555164961 scopus 로고    scopus 로고
    • Aberrant upregulation of astroglial ceramide potentiates oligodendrocyte injury
    • Kim, S., A. J. Steelman, Y. Zhang, H. C. Kinney, and J. Li. 2012. Aberrant upregulation of astroglial ceramide potentiates oligodendrocyte injury. Brain Pathol. 22: 41-57.
    • (2012) Brain Pathol. , vol.22 , pp. 41-57
    • Kim, S.1    Steelman, A.J.2    Zhang, Y.3    Kinney, H.C.4    Li, J.5
  • 35
    • 2942594278 scopus 로고    scopus 로고
    • Multiple sclerosis: Glatiramer acetate inhibits monocyte reactivity in vitro and in vivo
    • DOI 10.1093/brain/awh163
    • Weber, M. S., M. Starck, S. Wagenpfeil, E. Meinl, R. Hohlfeld, and C. Farina. 2004. Multiple sclerosis: glatiramer acetate inhibits monocyte reactivity in vitro and in vivo. Brain 127: 1370-1378. (Pubitemid 38745515)
    • (2004) Brain , vol.127 , Issue.6 , pp. 1370-1378
    • Weber, M.S.1    Starck, M.2    Wagenpfeil, S.3    Meinl, E.4    Hohlfeld, R.5    Farina, C.6
  • 36
    • 0033015085 scopus 로고    scopus 로고
    • Interferon beta-1b treatment modulates TNFalpha and IFNgamma spontaneous gene expression in MS
    • Gayo, A., L. Mozo, A. Suárez, A. Tuñón, C. Lahoz, and C. Gutiérrez. 1999. Interferon beta-1b treatment modulates TNFalpha and IFNgamma spontaneous gene expression in MS. Neurology 52: 1764-1770. (Pubitemid 29260887)
    • (1999) Neurology , vol.52 , Issue.9 , pp. 1764-1770
    • Gayo, A.1    Mozo, L.2    Suarez, A.3    Tunon, A.4    Lahoz, C.5    Gutierrez, G.6
  • 38
    • 33845338764 scopus 로고    scopus 로고
    • Sphingolipid metabolism in neural cells
    • DOI 10.1016/j.bbamem.2006.06.009, PII S0005273606002203, Sphingolipids, Apoptosis and Disease
    • van Echten-Deckert, G., and T. Herget. 2006. Sphingolipid metabolism in neural cells. Biochim. Biophys. Acta 1758: 1978-1994. (Pubitemid 44879360)
    • (2006) Biochimica et Biophysica Acta - Biomembranes , vol.1758 , Issue.12 , pp. 1978-1994
    • Van Echten-Deckert, G.1    Herget, T.2
  • 39
    • 84855918312 scopus 로고    scopus 로고
    • Ceramide synthases at the centre of sphingolipid metabolism and biology
    • Mullen, T. D., Y. A. Hannun, and L. M. Obeid. 2012. Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem. J. 441: 789-802.
    • (2012) Biochem. J. , vol.441 , pp. 789-802
    • Mullen, T.D.1    Hannun, Y.A.2    Obeid, L.M.3
  • 40
    • 0036694787 scopus 로고    scopus 로고
    • Identification of ceramide binding proteins in neuronal cells: A critical point of view
    • Elsen, L., R. Betz, G. Schwarzmann, K. Sandhoff, and G. van Echten-Deckert. 2002. Identification of ceramide binding proteins in neuronal cells: a critical point of view. Neurochem. Res. 27: 717-727.
    • (2002) Neurochem. Res. , vol.27 , pp. 717-727
    • Elsen, L.1    Betz, R.2    Schwarzmann, G.3    Sandhoff, K.4    Van Echten-Deckert, G.5
  • 41
    • 55749104704 scopus 로고    scopus 로고
    • A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis
    • Wheeler, D., V. V. Bandaru, P. A. Calabresi, A. Nath, and N. J. Haughey. 2008. A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis. Brain 131: 3092-3102.
    • (2008) Brain , vol.131 , pp. 3092-3102
    • Wheeler, D.1    Bandaru, V.V.2    Calabresi, P.A.3    Nath, A.4    Haughey, N.J.5
  • 43
    • 0035554898 scopus 로고    scopus 로고
    • Multiple sclerosis: A two-stage disease
    • Steinman, L. 2001. Multiple sclerosis: a two-stage disease. Nat. Immunol. 2: 762-764.
    • (2001) Nat. Immunol. , vol.2 , pp. 762-764
    • Steinman, L.1
  • 44
    • 17844381010 scopus 로고    scopus 로고
    • Macrophages and neurodegeneration
    • DOI 10.1016/j.brainresrev.2004.12.008, Glial-Neuron Crosstalk in Neuroinflamation, Neurodegeneration and Neuroprotection
    • Hendriks, J. J., C. E. Teunissen, H. E. de Vries, and C. D. Dijkstra. 2005. Macrophages and neurodegeneration. Brain Res. Brain Res. Rev. 48: 185-195. (Pubitemid 40585749)
    • (2005) Brain Research Reviews , vol.48 , Issue.2 , pp. 185-195
    • Hendriks, J.J.A.1    Teunissen, C.E.2    De Vries, H.E.3    Dijkstra, C.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.