Global DNA methylation analysis of human atherosclerotic plaques reveals extensive genomic hypomethylation and reactivation at imprinted locus 14q32 involving induction of a miRNA cluster

European Heart Journal

Volumn 36, Issue 16, 2015, Pages 993-1000

  Aavik, Einari ^a   Lumivuori, Henri ^a   Leppänen, Olli ^b   Wirth, Thomas ^a   Häkkinen, Sanna Kaisa ^a   Bräsen, Jan Hinrich ^c   Beschorner, Ulrich ^d   Zeller, Thomas ^d   Braspenning, Maarten ^e   Van Criekinge, Wim ^f   Mäkinen, Kimmo ^g   Ylä Herttuala, Seppo ^a,g  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UPPSALA UNIVERSITY   (Sweden)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY HEART CENTER FREIBURG BAD KROZINGEN   (Germany)

^e NXT Dx ^*  (Belgium)

^f GHENT UNIVERSITY   (Belgium)

^g KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Atherosclerosis; DNA methylation; Epigenetics; Peripheral vascular disease

Indexed keywords

MICRORNA; MICRORNA 127; MICRORNA 136; MICRORNA 410; MICRORNA 431; MICRORNA 432; MICRORNA 433; UNCLASSIFIED DRUG; MESSENGER RNA; PLACENTA PROTEIN; RTL1 PROTEIN, HUMAN;

AGED; ARTICLE; ATHEROSCLEROTIC PLAQUE; CHROMATIN; CHROMOSOME; CHROMOSOME 14Q32; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; GENE ONTOLOGY; GENETIC ASSOCIATION; GENOME IMPRINTING; HUMAN; HUMAN CELL; MAMMARY ARTERY; PRIORITY JOURNAL; CASE CONTROL STUDY; CHROMOSOME 14; DOWN REGULATION; EXON; GENETICS; MALE; METABOLISM; PROMOTER REGION; UPREGULATION;

AGED; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 14; DNA METHYLATION; DOWN-REGULATION; EXONS; FEMALE; GENE ONTOLOGY; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MICRORNAS; PLAQUE, ATHEROSCLEROTIC; PREGNANCY PROTEINS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; UP-REGULATION;

EID: 84928406659     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehu437     Document Type: Article

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