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Volumn 5, Issue NOV, 2014, Pages

MicroRNA-146a: A dominant, negative regulator of the innate immune response

Author keywords

Innate immunity; microRNAs; Neurodegeneration; Toll like receptors

Indexed keywords

CYCLOOXYGENASE 2; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MICRORNA; MICRORNA 145; MICRORNA 146A; MICRORNA 150; MICRORNA 155; MICRORNA 21; MICRORNA 223; MITOGEN ACTIVATED PROTEIN KINASE; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 11; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84919674993     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00578     Document Type: Review
Times cited : (310)

References (91)
  • 1
    • 0036212849 scopus 로고    scopus 로고
    • Innate immune recognition
    • Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol (2002) 20:197-216. doi: 10.1146/annurev.immunol.20.083001.084359
    • (2002) Annu Rev Immunol , vol.20 , pp. 197-216
    • Janeway Jr., C.A.1    Medzhitov, R.2
  • 2
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol (2004) 4(7):499-511. doi:10.1038/nri1391
    • (2004) Nat Rev Immunol , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 3
    • 0027751663 scopus 로고
    • elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell (1993) 75(5):843-54. doi:10.1016/0092-8674(93)90529-Y
    • (1993) Cell , vol.75 , Issue.5 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3    The, C.4
  • 4
    • 0034597777 scopus 로고    scopus 로고
    • Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
    • Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature (2000) 408(6808):86-9. doi:10.1038/35040556
    • (2000) Nature , vol.408 , Issue.6808 , pp. 86-89
    • Pasquinelli, A.1
  • 5
    • 56549129538 scopus 로고    scopus 로고
    • Chromatin structure analyses identify miRNA promoters
    • Ozsolak F, Poling LL, Wang Z, Liu H, Liu XS, Roeder RG, et al. Chromatin structure analyses identify miRNA promoters. Genes Dev (2008) 22(22):3172-83. doi:10.1101/gad.1706508
    • (2008) Genes Dev , vol.22 , Issue.22 , pp. 3172-3183
    • Ozsolak, F.1
  • 6
    • 60149088848 scopus 로고    scopus 로고
    • Origins and mechanisms of miRNAs and siRNAs
    • Carthew RW, Sontheimer EJ. Origins and mechanisms of miRNAs and siRNAs. Cell (2009) 136(4):642-55. doi:10.1016/j.cell.2009.01.035
    • (2009) Cell , vol.136 , Issue.4 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 7
    • 34548537573 scopus 로고    scopus 로고
    • A MicroRNA feedback circuit in midbrain dopamine neurons
    • Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, et al. A MicroRNA feedback circuit in midbrain dopamine neurons. Science (2007) 317(5842):1220-4. doi:10.1126/science.1140481
    • (2007) Science , vol.317 , Issue.5842 , pp. 1220-1224
    • Kim, J.1
  • 8
    • 33747608638 scopus 로고    scopus 로고
    • NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    • Taganov KD, Boldin MP, Chang KJ, Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 103(33):12481-6. doi:10.1073/pnas.0605298103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.33 , pp. 124816
    • Taganov, K.D.1    Boldin, M.P.2    Chang, K.J.3    Baltimore, D.4
  • 9
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell (2009) 136(2):215-33. doi:10.1016/j.cell.2009.01.002
    • (2009) Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 10
    • 18044377963 scopus 로고    scopus 로고
    • Principles of microRNA-target recognition
    • Brennecke J, Stark A, Russell RB, Cohen SM. Principles of microRNA-target recognition. PLoS Biol (2005) 3(3):e85. doi:10.1371/journal.pbio.0030085
    • (2005) PLoS Biol , vol.3 , Issue.3
    • Brennecke, J.1    Stark, A.2    Russell, R.B.3    Cohen, S.M.4
  • 11
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature (2005) 433(7027):769-73. doi:10.1038/nature03315
    • (2005) Nature , vol.433 , Issue.7027 , pp. 769-773
    • Lim, L.1
  • 12
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res (2009) 19(1):92-105. doi:10.1101/gr.082701.108
    • (2009) Genome Res , vol.19 , Issue.1 , pp. 92-105
    • Friedman, R.C.1    Farh, K.K.2    Burge, C.B.3    Bartel, D.P.4
  • 13
    • 1942435249 scopus 로고    scopus 로고
    • Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
    • Bartel DP, Chen CZ. Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet (2004) 5(5):396-400. doi:10.1038/nrg1328
    • (2004) Nat Rev Genet , vol.5 , Issue.5 , pp. 396-400
    • Bartel, D.P.1    Chen, C.Z.2
  • 14
    • 67651034231 scopus 로고    scopus 로고
    • Fine-tuning neural gene expression with microRNAs
    • Schratt G. Fine-tuning neural gene expression with microRNAs. Curr Opin Neurobiol (2009) 19(2):213-9. doi:10.1016/j.conb.2009.05.015
    • (2009) Curr Opin Neurobiol , vol.19 , Issue.2 , pp. 213-219
    • Schratt, G.1
  • 15
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science (2004) 303(5654):83-6. doi:10.1126/science.1091903
    • (2004) Science , vol.303 , Issue.5654 , pp. 83-86
    • Chen, C.Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 16
    • 79958257077 scopus 로고    scopus 로고
    • miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
    • Boldin MP, Taganov KD, Rao DS, Yang L, Zhao JL, Kalwani M, et al. miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med (2011) 208(6):1189-201. doi:10.1084/jem.20101823
    • (2011) J Exp Med , vol.208 , Issue.6 , pp. 1189-1201
    • Boldin, M.1
  • 17
    • 79959362128 scopus 로고    scopus 로고
    • NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies
    • Zhao JL, Rao DS, Boldin MP, Taganov KD, O'Connell RM, Baltimore D. NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies. Proc Natl Acad Sci U S A (2011) 108(22):9184-9. doi:10.1073/pnas.1105398108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.22 , pp. 9184-9189
    • Zhao, J.L.1    Rao, D.S.2    Boldin, M.P.3    Taganov, K.D.4    O'Connell, R.M.5    Baltimore, D.6
  • 18
    • 73849121794 scopus 로고    scopus 로고
    • Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype
    • Starczynowski DT, Kuchenbauer F, Argiropoulos B, Sung S, Morin R, Muranyi A, et al. Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype. Nat Med (2010) 16(1):49-58. doi:10.1038/nm.2054
    • (2010) Nat Med , vol.16 , Issue.1 , pp. 49-58
    • Starczynowski, D.1
  • 19
    • 77956632634 scopus 로고    scopus 로고
    • Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses
    • Lu LF, Boldin MP, Chaudhry A, Lin LL, Taganov KD, Hanada T, et al. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell (2010) 142(6):914-29. doi:10.1016/j.cell.2010.08.012
    • (2010) Cell , vol.142 , Issue.6 , pp. 914-929
    • Lu, L.1
  • 20
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell (2006) 124(4):783-801. doi:10.1016/j.cell.2006.02.015
    • (2006) Cell , vol.124 , Issue.4 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 21
    • 0034681434 scopus 로고    scopus 로고
    • Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inlammatory signaling pathways
    • Slack JL, Schooley K, Bonnert TP, Mitcham JL, Qwarnstrom EE, Sims JE, et al. Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inlammatory signaling pathways. J Biol Chem (2000) 275(7):4670-8. doi:10.1074/jbc.275.7.4670
    • (2000) J Biol Chem , vol.275 , Issue.7 , pp. 4670-4678
    • Slack, J.1
  • 22
    • 79952186298 scopus 로고    scopus 로고
    • MicroRNAs: the fine-tuners of toll-like receptor signalling
    • O'Neill LA, Sheedy FJ, McCoy CE. MicroRNAs: the fine-tuners of toll-like receptor signalling. Nat Rev Immunol (2011) 11(3):163-75. doi:10.1038/nri2957
    • (2011) Nat Rev Immunol , vol.11 , Issue.3 , pp. 163-175
    • O'Neill, L.A.1    Sheedy, F.J.2    McCoy, C.E.3
  • 23
    • 0033968625 scopus 로고    scopus 로고
    • Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
    • Takeuchi O, Takeda K, Hoshino K, Adachi O, Ogawa T, Akira S. Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int Immunol (2000) 12(1):113-7. doi:10.1093/intimm/12.1.113
    • (2000) Int Immunol , vol.12 , Issue.1 , pp. 113-117
    • Takeuchi, O.1    Takeda, K.2    Hoshino, K.3    Adachi, O.4    Ogawa, T.5    Akira, S.6
  • 24
    • 0043176281 scopus 로고    scopus 로고
    • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    • Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 301(5633):640-3. doi:10.1126/science.1087262
    • (2003) Science , vol.301 , Issue.5633 , pp. 640-643
    • Yamamoto, M.1
  • 25
    • 52249094653 scopus 로고    scopus 로고
    • Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
    • Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH, Chan EK. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther (2008) 10(4):R101. doi:10.1186/ar2493
    • (2008) Arthritis Res Ther , vol.10 , Issue.4
    • Pauley, K.M.1    Satoh, M.2    Chan, A.L.3    Bubb, M.R.4    Reeves, W.H.5    Chan, E.K.6
  • 26
    • 71749096218 scopus 로고    scopus 로고
    • Chan EK. miR-146a is critical for endotoxin-induced tolerance: implication in innate immunity
    • Nahid MA, Pauley KM, Satoh M, Chan EK. miR-146a is critical for endotoxin-induced tolerance: implication in innate immunity. J Biol Chem (2009) 284(50):34590-9. doi:10.1074/jbc. M109.056317
    • (2009) J Biol Chem , vol.284 , Issue.50 , pp. 34590-34599
    • Nahid, M.A.1    Pauley, K.M.2    Satoh, M.3
  • 27
    • 68149165370 scopus 로고    scopus 로고
    • MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2
    • Hou J, Wang P, Lin L, Liu X, Ma F, An H, et al. MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol (2009) 183(3):2150-8. doi:10.4049/jimmunol.0900707
    • (2009) J Immunol , vol.183 , Issue.3 , pp. 2150-2158
    • Hou, J.1
  • 28
    • 65249138193 scopus 로고    scopus 로고
    • MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins
    • Tang Y, Luo X, Cui H, Ni X, Yuan M, Guo Y, et al. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum (2009) 60(4):1065-75. doi:10.1002/art.24436
    • (2009) Arthritis Rheum , vol.60 , Issue.4 , pp. 1065-1075
    • Tang, Y.1
  • 29
    • 79251592866 scopus 로고    scopus 로고
    • Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling
    • Nahid MA, Satoh M, Chan EK. Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling. J Immunol (2011) 186(3):1723-34. doi:10.4049/jimmunol.1002311
    • (2011) J Immunol , vol.186 , Issue.3 , pp. 1723-1734
    • Nahid, M.A.1    Satoh, M.2    Chan, E.K.3
  • 31
    • 80052364758 scopus 로고    scopus 로고
    • MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-alpha during TLR4-induced gene reprogramming
    • El Gazzar M, Church A, Liu T, McCall CE. MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-alpha during TLR4-induced gene reprogramming. J Leukoc Biol (2011) 90(3):509-19. doi:10.1189/jlb.0211074
    • (2011) J Leukoc Biol , vol.90 , Issue.3 , pp. 509-519
    • El Gazzar, M.1    Church, A.2    Liu, T.3    McCall, C.E.4
  • 32
    • 45549101837 scopus 로고    scopus 로고
    • Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells
    • Perry MM, Moschos SA, Williams AE, Shepherd NJ, Larner-Svensson HM, Lindsay MA. Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells. J Immunol (2008) 180(8):5689-98. doi:10.4049/jimmunol.180.8.5689
    • (2008) J Immunol , vol.180 , Issue.8 , pp. 5689-5698
    • Perry, M.M.1    Moschos, S.A.2    Williams, A.E.3    Shepherd, N.J.4    Larner-Svensson, H.M.5    Lindsay, M.A.6
  • 33
    • 70349884016 scopus 로고    scopus 로고
    • Divergent intracellular pathways regulate interleukin-1beta-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells
    • Perry MM, Williams AE, Tsitsiou E, Larner-Svensson HM, Lindsay MA. Divergent intracellular pathways regulate interleukin-1beta-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells. FEBS Lett (2009) 583(20):3349-55. doi:10.1016/j.febslet.2009.09.038
    • (2009) FEBS Lett , vol.583 , Issue.20 , pp. 3349-3355
    • Perry, M.M.1    Williams, A.E.2    Tsitsiou, E.3    Larner-Svensson, H.M.4    Lindsay, M.A.5
  • 34
    • 77956697558 scopus 로고    scopus 로고
    • Pharmacological studies of the mechanism and function of interleukin-1beta-induced miRNA-146a expression in primary human airway smooth muscle
    • 68-9921-11-68
    • Larner-Svensson HM, Williams AE, Tsitsiou E, Perry MM, Jiang X, Chung KF, et al. Pharmacological studies of the mechanism and function of interleukin-1beta-induced miRNA-146a expression in primary human airway smooth muscle. Respir Res (2010) 11:68-9921-11-68. doi:10.1186/1465-9921-11-68
    • (2010) Respir Res , vol.11
    • Larner-Svensson, H.1
  • 35
    • 77954488963 scopus 로고    scopus 로고
    • miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation
    • Jurkin J, Schichl YM, Koeffel R, Bauer T, Richter S, Konradi S, et al. miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation. J Immunol (2010) 184(9):4955-65. doi:10.4049/jimmunol.0903021
    • (2010) J Immunol , vol.184 , Issue.9 , pp. 4955-4965
    • Jurkin, J.1
  • 36
    • 84890925835 scopus 로고    scopus 로고
    • MicroRNA-146a regulates survival and maturation of human plasmacytoid dendritic cells
    • Karrich JJ, Jachimowski LC, Libouban M, Iyer A, Brandwijk K, Taanman-Kueter EW, et al. MicroRNA-146a regulates survival and maturation of human plasmacytoid dendritic cells. Blood (2013) 122(17):3001-9. doi:10.1182/blood-2012-12-475087
    • (2013) Blood , vol.122 , Issue.17 , pp. 3001-3009
    • Karrich, J.1
  • 37
    • 84879973586 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor 4 signaling by IL-10-dependent microRNA-146b
    • Curtale G, Mirolo M, Renzi TA, Rossato M, Bazzoni F, Locati M. Negative regulation of toll-like receptor 4 signaling by IL-10-dependent microRNA-146b. Proc Natl Acad Sci U S A (2012) 110(28):11499-504. doi:10.1073/pnas.1219852110
    • (2012) Proc Natl Acad Sci U S A , vol.110 , Issue.28 , pp. 11499-11504
    • Curtale, G.1    Mirolo, M.2    Renzi, T.A.3    Rossato, M.4    Bazzoni, F.5    Locati, M.6
  • 38
    • 84894495362 scopus 로고    scopus 로고
    • STAT3-regulated miR-146b forms a feedback circuit to counteract the NF-?B/IL-6 axis and STAT3-driven cancer phenotypes
    • Xiang M, Birkbak NJ, Vafaizadeh V, Walker SR, Yeh JE, Liu S, et al. STAT3-regulated miR-146b forms a feedback circuit to counteract the NF-κB/IL-6 axis and STAT3-driven cancer phenotypes. Sci Signal (2014) 7(310):ra11. doi:10.1126/scisignal.2004497
    • (2014) Sci Signal , vol.7 , Issue.310
    • Xiang, M.1
  • 39
    • 84872196963 scopus 로고    scopus 로고
    • MicroRNAs in the regulation of TLR and RIG-I pathways
    • Li Y, Shi X. MicroRNAs in the regulation of TLR and RIG-I pathways. Cell Mol Immunol (2013) 10(1):65-71. doi:10.1038/cmi.2012.55
    • (2013) Cell Mol Immunol , vol.10 , Issue.1 , pp. 65-71
    • Li, Y.1    Shi, X.2
  • 40
    • 68649091506 scopus 로고    scopus 로고
    • The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs
    • Androulidaki A, Iliopoulos D, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, et al. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity (2009) 31(2):220-31. doi:10.1016/j.immuni.2009.06.024
    • (2009) Immunity , vol.31 , Issue.2 , pp. 220-231
    • Androulidaki, A.1
  • 41
    • 35348929402 scopus 로고    scopus 로고
    • A cellular micro-RNA, let-7i, regulates toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection
    • Chen XM, Splinter PL, O'Hara SP, LaRusso NF. A cellular micro-RNA, let-7i, regulates toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J Biol Chem (2007) 282(39):28929-38. doi:10.1074/jbc. M702633200
    • (2007) J Biol Chem , vol.282 , Issue.39 , pp. 28929-28938
    • Chen, X.M.1    Splinter, P.L.2    O'Hara, S.P.3    LaRusso, N.F.4
  • 42
    • 77951704878 scopus 로고    scopus 로고
    • Flanking region sequence information to refine microRNA target predictions
    • Heikham R, Shankar R. Flanking region sequence information to refine microRNA target predictions. J Biosci (2010) 35(1):105-18. doi:10.1007/s12038-010-0013-7
    • (2010) J Biosci , vol.35 , Issue.1 , pp. 105-118
    • Heikham, R.1    Shankar, R.2
  • 43
    • 79952575527 scopus 로고    scopus 로고
    • MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-lie receptor 4
    • Yang K, He YS, Wang XQ, Lu L, Chen QJ, Liu J, et al. MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-lie receptor 4. FEBS Lett (2011) 585(6):854-60. doi:10.1016/j.febslet.2011.02.009
    • (2011) FEBS Lett , vol.585 , Issue.6 , pp. 854-860
    • Yang, K.1
  • 44
    • 84900090390 scopus 로고    scopus 로고
    • MiR-146a regulates IL-6 production in lipopolysaccharide-induced RAW264 7 macrophage cells by inhibiting Notch1
    • He Y, Sun X, Huang C, Long XR, Lin X, Zhang L, et al. MiR-146a regulates IL-6 production in lipopolysaccharide-induced RAW264.7 macrophage cells by inhibiting Notch1. Inflammation (2014) 37(1):71-82. doi:10.1007/s10753-013-9713-0
    • (2014) Inflammation , vol.37 , Issue.1 , pp. 71-82
    • He, Y.1
  • 45
    • 84859382730 scopus 로고    scopus 로고
    • microRNA regulation of inflammatory responses
    • O'Connell RM, Rao DS, Baltimore D. microRNA regulation of inflammatory responses. Annu Rev Immunol (2012) 30:295-312. doi:10.1146/annurev-immunol-020711-075013
    • (2012) Annu Rev Immunol , vol.30 , pp. 295-312
    • O'Connell, R.M.1    Rao, D.S.2    Baltimore, D.3
  • 46
    • 67649318940 scopus 로고    scopus 로고
    • MicroRNAs miR146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
    • Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, et al. MicroRNAs miR146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (2009) 1(4):402-11.
    • (2009) Aging , vol.1 , Issue.4 , pp. 402-411
    • Bhaumik, D.1
  • 47
    • 61849173539 scopus 로고    scopus 로고
    • The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13
    • Jones SW, Watkins G, Le Good N, Roberts S, Murphy CL, Brockbank SM, et al. The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13. Osteoarthritis Cartilage (2009) 17(4):464-72. doi:10.1016/j.joca.2008.09.012
    • (2009) Osteoarthritis Cartilage , vol.17 , Issue.4 , pp. 464-472
    • Jones, S.1
  • 48
    • 38849160013 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways
    • Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X, et al. Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J Virol (2008) 82(4):1946-58.
    • (2008) J Virol , vol.82 , Issue.4 , pp. 1946-1958
    • Cameron, J.1
  • 49
    • 39049139743 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a
    • Motsch N, Pfuhl T, Mrazek J, Barth S, Grasser FA. Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a. RNA Biol (2007) 4(3):131-7. doi:10.4161/rna.4.3.5206
    • (2007) RNA Biol , vol.4 , Issue.3 , pp. 131-137
    • Motsch, N.1    Pfuhl, T.2    Mrazek, J.3    Barth, S.4    Grasser, F.A.5
  • 50
    • 84872334678 scopus 로고    scopus 로고
    • Regulation of innate receptor pathways by microRNAs
    • Zhang Y, Li Y. Regulation of innate receptor pathways by microRNAs. Sci China Life Sci (2013) 56(1):13-8. doi:10.1007/s11427-012-4428-2
    • (2013) Sci China Life Sci , vol.56 , Issue.1 , pp. 13-18
    • Zhang, Y.1    Li, Y.2
  • 51
    • 42149148610 scopus 로고    scopus 로고
    • Signal transduction pathways used by NLR-type innate immune receptors
    • Kufer TA. Signal transduction pathways used by NLR-type innate immune receptors. Mol Biosyst (2008) 4(5):380-6. doi:10.1039/b718948f
    • (2008) Mol Biosyst , vol.4 , Issue.5 , pp. 380-386
    • Kufer, T.A.1
  • 52
    • 44349171085 scopus 로고    scopus 로고
    • The nod-like receptor (NLR) family: a tale of similarities and differences
    • Proell M, Riedl SJ, Fritz JH, Rojas AM, Schwarzenbacher R. The nod-like receptor (NLR) family: a tale of similarities and differences. PLoS One (2008) 3(4):e2119. doi:10.1371/journal.pone.0002119
    • (2008) PLoS One , vol.3 , Issue.4
    • Proell, M.1    Riedl, S.J.2    Fritz, J.H.3    Rojas, A.M.4    Schwarzenbacher, R.5
  • 53
    • 84887833141 scopus 로고    scopus 로고
    • 2-nitric oxide-responsive microRNA-146a activates Sonic hedgehog signaling to orchestrate inflammatory responses in murine model of inflammatory bowel disease
    • 2-nitric oxide-responsive microRNA-146a activates Sonic hedgehog signaling to orchestrate inflammatory responses in murine model of inflammatory bowel disease. J Biol Chem (2013) 288(46):33037-48. doi:10.1074/jbc. M113.492496
    • (2013) J Biol Chem , vol.288 , Issue.46 , pp. 33037-33048
    • Ghorpade, D.S.1    Sinha, A.Y.2    Holla, S.3    Singh, V.4    Balaji, K.N.5
  • 54
    • 0030444204 scopus 로고    scopus 로고
    • Genetic basis of systemic lupus erythematosus
    • Vyse TJ, Kotzin BL. Genetic basis of systemic lupus erythematosus. Curr Opin Immunol (1996) 8(6):843-51. doi:10.1016/S0952-7915(96)80014-8
    • (1996) Curr Opin Immunol , vol.8 , Issue.6 , pp. 843-851
    • Vyse, T.J.1    Kotzin, B.L.2
  • 55
    • 34447099218 scopus 로고    scopus 로고
    • Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease
    • Fairhurst AM, Wandstrat AE, Wakeland EK. Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease. Adv Immunol (2006) 92:1-69. doi:10.1016/S0065-2776(06)92001-X
    • (2006) Adv Immunol , vol.92 , pp. 1-69
    • Fairhurst, A.M.1    Wandstrat, A.E.2    Wakeland, E.K.3
  • 56
    • 0344492212 scopus 로고    scopus 로고
    • Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
    • Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci U S A (2003) 100(5):2610-5. doi:10.1073/pnas.0337679100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.5 , pp. 2610-2615
    • Baechler, E.1
  • 57
    • 0037451167 scopus 로고    scopus 로고
    • Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
    • Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J, Banchereau J, et al. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med (2003) 197(6):711-23. doi:10.1084/jem.20021553
    • (2003) J Exp Med , vol.197 , Issue.6 , pp. 711-723
    • Bennett, L.1
  • 58
    • 10444248118 scopus 로고    scopus 로고
    • Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus
    • Kirou KA, Lee C, George S, Louca K, Papagiannis IG, Peterson MG, et al. Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus. Arthritis Rheum (2004) 50(12):3958-67. doi:10.1002/art.20798
    • (2004) Arthritis Rheum , vol.50 , Issue.12 , pp. 3958-3967
    • Kirou, K.1
  • 59
    • 0141986842 scopus 로고    scopus 로고
    • Analysis of gene expression profiles in human systemic lupus erythematosus using oligonucleotide microarray
    • Han GM, Chen SL, Shen N, Ye S, Bao CD, Gu YY. Analysis of gene expression profiles in human systemic lupus erythematosus using oligonucleotide microarray. Genes Immun (2003) 4(3):177-86. doi:10.1038/sj.gene.6363966
    • (2003) Genes Immun , vol.4 , Issue.3 , pp. 177-186
    • Han, G.M.1    Chen, S.L.2    Shen, N.3    Ye, S.4    Bao, C.D.5    Gu, Y.Y.6
  • 60
    • 79959836816 scopus 로고    scopus 로고
    • A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus
    • Luo X, Yang W, Ye DQ, Cui H, Zhang Y, Hirankarn N, et al. A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. PLoS Genet (2011) 7(6):e1002128. doi:10.1371/journal.pgen.1002128
    • (2011) PLoS Genet , vol.7 , Issue.6
    • Luo, X.1
  • 61
    • 84859910035 scopus 로고    scopus 로고
    • Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene
    • Lofgren SE, Frostegard J, Truedsson L, Pons-Estel BA, D'Alfonso S, Witte T, et al. Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene. Genes Immun (2012) 13(3):268-74. doi:10.1038/gene.2011.84
    • (2012) Genes Immun , vol.13 , Issue.3 , pp. 268-274
    • Lofgren, S.1
  • 62
    • 79951578001 scopus 로고    scopus 로고
    • Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus
    • Zhang J, Yang B, Ying B, Li D, Shi Y, Song X, et al. Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus. Mol Biol Rep (2011) 38(3):1463-8. doi:10.1007/s11033-010-0252-6
    • (2011) Mol Biol Rep , vol.38 , Issue.3 , pp. 1463-1468
    • Zhang, J.1
  • 63
    • 77950456388 scopus 로고    scopus 로고
    • Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3 STAT4 and TRAF1/C5 in an inception cohort
    • Morgan AW, Robinson JI, Conaghan PG, Martin SG, Hensor EM, Morgan MD, et al. Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort. Arthritis Res Ther (2010) 12(2):R57. doi:10.1186/ar2969
    • (2010) Arthritis Res Ther , vol.12 , Issue.2
    • Morgan, A.1
  • 64
    • 43949136123 scopus 로고    scopus 로고
    • Expression of microRNA-146 in rheumatoid arthritis synovial tissue
    • Nakasa T, Miyaki S, Okubo A, Hashimoto M, Nishida K, Ochi M, et al. Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum (2008) 58(5):1284-92. doi:10.1002/art.23429
    • (2008) Arthritis Rheum , vol.58 , Issue.5 , pp. 1284-1292
    • Nakasa, T.1
  • 65
    • 42449156220 scopus 로고    scopus 로고
    • Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
    • Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, et al. Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum (2008) 58(4):1001-9. doi:10.1002/art.23386
    • (2008) Arthritis Rheum , vol.58 , Issue.4 , pp. 1001-1009
    • Stanczyk, J.1
  • 66
    • 15444357762 scopus 로고    scopus 로고
    • Requirement for NF-kappaB in osteoclast and B-cell development
    • Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, et al. Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev (1997) 11(24):3482-96. doi:10.1101/gad.11.24.3482
    • (1997) Genes Dev , vol.11 , Issue.24 , pp. 3482-3496
    • Franzoso, G.1
  • 67
    • 0242662616 scopus 로고    scopus 로고
    • Direct inhibition of NF-kappa B blocks bone erosion associated with inflammatory arthritis
    • Clohisy JC, Roy BC, Biondo C, Frazier E, Willis D, Teitelbaum SL, et al. Direct inhibition of NF-kappa B blocks bone erosion associated with inflammatory arthritis. J Immunol (2003) 171(10):5547-53. doi:10.4049/jimmunol.171.10.5547
    • (2003) J Immunol , vol.171 , Issue.10 , pp. 5547-5553
    • Clohisy, J.1
  • 68
    • 84855234703 scopus 로고    scopus 로고
    • Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population
    • Yang B, Zhang JL, Shi YY, Li DD, Chen J, Huang ZC, et al. Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population. Mol Biol Rep (2011) 38(8):4913-9. doi:10.1007/s11033-010-0633-x
    • (2011) Mol Biol Rep , vol.38 , Issue.8 , pp. 4913-4919
    • Yang, B.1
  • 69
    • 77957873680 scopus 로고    scopus 로고
    • A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility
    • Chatzikyriakidou A, Voulgari PV, Georgiou I, Drosos AA. A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility. Joint Bone Spine (2010) 77(5):411-3. doi:10.1016/j.jbspin.2010.05.013
    • (2010) Joint Bone Spine , vol.77 , Issue.5 , pp. 411-413
    • Chatzikyriakidou, A.1    Voulgari, P.V.2    Georgiou, I.3    Drosos, A.A.4
  • 70
    • 77951058306 scopus 로고    scopus 로고
    • The role of microRNA-146a (miR-146a) and its target IL-1R-associated kinase (IRAK1) in psoriatic arthritis susceptibility
    • Chatzikyriakidou A, Voulgari PV, Georgiou I, Drosos AA. The role of microRNA-146a (miR-146a) and its target IL-1R-associated kinase (IRAK1) in psoriatic arthritis susceptibility. Scand J Immunol (2010) 71(5):382-5. doi:10.1111/j.1365-3083.2010.02381.x
    • (2010) Scand J Immunol , vol.71 , Issue.5 , pp. 382-385
    • Chatzikyriakidou, A.1    Voulgari, P.V.2    Georgiou, I.3    Drosos, A.A.4
  • 71
    • 79959720798 scopus 로고    scopus 로고
    • Altered miR-146a expression in Sjogren's syndrome and its functional role in innate immunity
    • Pauley KM, Stewart CM, Gauna AE, Dupre LC, Kuklani R, Chan AL, et al. Altered miR-146a expression in Sjogren's syndrome and its functional role in innate immunity. Eur J Immunol (2011) 41(7):2029-39. doi:10.1002/eji.201040757
    • (2011) Eur J Immunol , vol.41 , Issue.7 , pp. 2029-2039
    • Pauley, K.1
  • 72
    • 84855934791 scopus 로고    scopus 로고
    • Increased microRNA-146a/b TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjogren's syndrome
    • Zilahi E, Tarr T, Papp G, Griger Z, Sipka S, Zeher M. Increased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjogren's syndrome. Immunol Lett (2012) 141(2):165-8. doi:10.1016/j.imlet.2011.09.006
    • (2012) Immunol Lett , vol.141 , Issue.2 , pp. 165-168
    • Zilahi, E.1    Tarr, T.2    Papp, G.3    Griger, Z.4    Sipka, S.5    Zeher, M.6
  • 73
    • 13444262768 scopus 로고    scopus 로고
    • Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjogren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate
    • Bombardieri M, Barone F, Pittoni V, Alessandri C, Conigliaro P, Blades MC, et al. Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjogren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate. Arthritis Res Ther (2004) 6(5):R447-56. doi:10.1186/ar1209
    • (2004) Arthritis Res Ther , vol.6 , Issue.5 , pp. R447-R456
    • Bombardieri, M.1
  • 74
    • 4344652308 scopus 로고    scopus 로고
    • Relationship between serum levels of IL-18 and IgG1 in patients with primary Sjogren's syndrome, rheumatoid arthritis and healthy controls
    • Eriksson P, Andersson C, Ekerfelt C, Ernerudh J, Skogh T. Relationship between serum levels of IL-18 and IgG1 in patients with primary Sjogren's syndrome, rheumatoid arthritis and healthy controls. Clin Exp Immunol (2004) 137(3):617-20. doi:10.1111/j.1365-2249.2004.02562.x
    • (2004) Clin Exp Immunol , vol.137 , Issue.3 , pp. 617-620
    • Eriksson, P.1    Andersson, C.2    Ekerfelt, C.3    Ernerudh, J.4    Skogh, T.5
  • 75
    • 2942748333 scopus 로고    scopus 로고
    • Circulating cytokines in primary Sjogren's syndrome determined by a multiplex cytokine array system
    • Szodoray P, Alex P, Brun JG, Centola M, Jonsson R. Circulating cytokines in primary Sjogren's syndrome determined by a multiplex cytokine array system. Scand J Immunol (2004) 59(6):592-9. doi:10.1111/j.0300-9475.2004.01432.x
    • (2004) Scand J Immunol , vol.59 , Issue.6 , pp. 592-599
    • Szodoray, P.1    Alex, P.2    Brun, J.G.3    Centola, M.4    Jonsson, R.5
  • 76
    • 0032842855 scopus 로고    scopus 로고
    • Salivary gland cytokine expression in NOD and normal BALB/c mice
    • Yamano S, Atkinson JC, Baum BJ, Fox PC. Salivary gland cytokine expression in NOD and normal BALB/c mice. Clin Immunol (1999) 92(3):265-75. doi:10.1006/clim.1999.4759
    • (1999) Clin Immunol , vol.92 , Issue.3 , pp. 265-275
    • Yamano, S.1    Atkinson, J.C.2    Baum, B.J.3    Fox, P.C.4
  • 77
    • 84893946623 scopus 로고    scopus 로고
    • MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease
    • Kiko T, Nakagawa K, Tsuduki T, Furukawa K, Arai H, Miyazawa T. MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease. J Alzheimers Dis (2014) 39(2):253-9. doi:10.3233/JAD-130932
    • (2014) J Alzheimers Dis , vol.39 , Issue.2 , pp. 253-259
    • Kiko, T.1    Nakagawa, K.2    Tsuduki, T.3    Furukawa, K.4    Arai, H.5    Miyazawa, T.6
  • 78
    • 84885178226 scopus 로고    scopus 로고
    • MicroRNAs in Alzheimers disease: differential expression in hippocampus and cell-free cerebrospinal fluid
    • Muller M, Kuiperji HB, Claassen JA, Kusters B, Verbeek MM. MicroRNAs in Alzheimers disease: differential expression in hippocampus and cell-free cerebrospinal fluid. Neurobiol Aging (2014) 35(1):152-8. doi:10.1016/j.neurobiolaging.2013.07.005
    • (2014) Neurobiol Aging , vol.35 , Issue.1 , pp. 152-158
    • Muller, M.1    Kuiperji, H.B.2    Claassen, J.A.3    Kusters, B.4    Verbeek, M.M.5
  • 79
    • 81255152428 scopus 로고    scopus 로고
    • Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome
    • Lukiw WJ, Dua P, Pogue AI, Eicken C, Hill JM. Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome. J Toxicol Environ Health A (2011) 74(22-24):1460-8. doi:10.1080/15287394.2011.618973
    • (2011) J Toxicol Environ Health A , vol.74 , Issue.22-24 , pp. 1460-1468
    • Lukiw, W.J.1    Dua, P.2    Pogue, A.I.3    Eicken, C.4    Hill, J.M.5
  • 80
    • 84901844552 scopus 로고    scopus 로고
    • Expression, regulation and function of microRNAs in multiple sclerosis
    • Ma X, Zhou J, Zhong Y, Jiang L, Mu P, Li Y, et al. Expression, regulation and function of microRNAs in multiple sclerosis. Int J Med Sci (2014) 11(8):810-8. doi:10.7150/ijms.8647
    • (2014) Int J Med Sci , vol.11 , Issue.8 , pp. 810-818
    • Ma, X.1
  • 81
    • 57649119790 scopus 로고    scopus 로고
    • An NF-kappaB-sensitive micro RNA- 146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells
    • Lukiw WJ, Zhao Y, Cui JG. An NF-kappaB-sensitive micro RNA- 146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem (2008) 283(46):31315-22. doi:10.1074/jbc. M805371200
    • (2008) J Biol Chem , vol.283 , Issue.46 , pp. 31315-31322
    • Lukiw, W.J.1    Zhao, Y.2    Cui, J.G.3
  • 82
    • 84868089393 scopus 로고    scopus 로고
    • Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimers disease (AD) brain
    • Lukiw WJ, Alexandrov PN. Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimers disease (AD) brain. Mol Neurobiol (2012) 46(1):11-9. doi:10.1007/s12035-012-8234-4
    • (2012) Mol Neurobiol , vol.46 , Issue.1 , pp. 11-19
    • Lukiw, W.J.1    Alexandrov, P.N.2
  • 83
    • 79959379335 scopus 로고    scopus 로고
    • Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells
    • Li YY, Cui JG, Dua P, Pogue AI, Bhattacharjee S, Lukiw WJ. Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells. Neurosci Lett (2011) 499(2):109-13. doi:10.1016/j.neulet.2011.05.044
    • (2011) Neurosci Lett , vol.499 , Issue.2 , pp. 109-113
    • Li, Y.Y.1    Cui, J.G.2    Dua, P.3    Pogue, A.I.4    Bhattacharjee, S.5    Lukiw, W.J.6
  • 85
    • 84870847550 scopus 로고    scopus 로고
    • Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected mice
    • Majer A, Medina SJ, Niu Y, Abrenica B, Manguiat KJ, Frost KL, et al. Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected mice. PLoS Pathog (2012) 8(11):e1003002. doi:10.1371/journal.ppat.1003002
    • (2012) PLoS Pathog , vol.8 , Issue.11
    • Majer, A.1
  • 86
    • 84857154347 scopus 로고    scopus 로고
    • MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state
    • Saba R, Gushue S, Huzarewich RL, Manguiat K, Medina S, Robertson C, et al. MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state. PLoS One (2012) 7(2):e30832. doi:10.1371/journal.pone.0030832
    • (2012) PLoS One , vol.7 , Issue.2
    • Saba, R.1
  • 87
    • 0031127379 scopus 로고    scopus 로고
    • PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie
    • Williams A, Lucassen PJ, Ritchie D, Bruce M. PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie. Exp Neurol (1997) 144:433-8. doi:10.1006/exnr.1997.6424
    • (1997) Exp Neurol , vol.144 , pp. 433-438
    • Williams, A.1    Lucassen, P.J.2    Ritchie, D.3    Bruce, M.4
  • 88
    • 84855859453 scopus 로고    scopus 로고
    • Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages
    • Jiang M, Xiang Y, Wang D, Gao J, Liu D, Liu Y, et al. Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages. Aging Cell (2012) 11(1):29-40. doi:10.1111/j.1474-9726.2011.00757.x
    • (2012) Aging Cell , vol.11 , Issue.1 , pp. 29-40
    • Jiang, M.1
  • 89
    • 84901848126 scopus 로고    scopus 로고
    • Microglia change from a reactive to an age-like phenotype with the time in culture
    • Caldeira C, Oliveria AF, Cunha C, Vaz AR, Falcao AS, Fernandes A, et al. Microglia change from a reactive to an age-like phenotype with the time in culture. Front Cell Neurosci (2014) 8:152. doi:10.3389/fncel.2014.00152
    • (2014) Front Cell Neurosci , vol.8 , pp. 152
    • Caldeira, C.1
  • 90
    • 84891715379 scopus 로고    scopus 로고
    • Rheumatoid arthritis and Alzheimers disease: genetic and epigenetic links in inflammatory regulation
    • Ferraccioli G, Carbonella A, Gremese E, Alivernini S. Rheumatoid arthritis and Alzheimers disease: genetic and epigenetic links in inflammatory regulation. Discov Med (2012) 14(79):379-88.
    • (2012) Discov Med , vol.14 , Issue.79 , pp. 379-388
    • Ferraccioli, G.1    Carbonella, A.2    Gremese, E.3    Alivernini, S.4
  • 91
    • 0036850023 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease and prion disease
    • Eikelenboom P, Bate C, Van Gool WA, Hoozemans JJ, Rozemuller JM, Veerhuis R, et al. Neuroinflammation in Alzheimer's disease and prion disease. Glia (2002) 40(2):232-9. doi:10.1002/glia.10146
    • (2002) Glia , vol.40 , Issue.2 , pp. 232-239
    • Eikelenboom, P.1


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