GE-180: A novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO)

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 3, 2012, Pages 1308-1313

  Wadsworth, Harry ^a   Jones, Paul A ^a   Chau, Wai Fung ^a   Durrant, Clare ^a   Fouladi, Naghmeh ^a   Passmore, Joanna ^a   O'Shea, Dennis ^a   Wynn, Duncan ^a   Morisson Iveson, Veronique ^a   Ewan, Amanda ^a   Thaning, Mikkel ^b   Mantzilas, Dimitrios ^b   Gausemel, Ingvil ^b   Khan, Imtiaz ^a   Black, Andrew ^a   Avory, Michelle ^a   Trigg, William ^a  

^a GE HEALTHCARE   (United Kingdom)

^b GE HEALTHCARE   (Norway)

Author keywords

Neuroinflammation; PBR; PET; Radiosynthesis; TSPO

Indexed keywords

FLUORINE 18; GE 180; PROTEIN; TRACER; TSPO PROTEIN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; CARBAZOLE DERIVATIVE; DIAGNOSTIC AGENT; FLUORINE; GE-180; LIGAND; TSPO PROTEIN, HUMAN;

ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG SPECIFICITY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; NEUROGENIC INFLAMMATION; POSITRON EMISSION TOMOGRAPHY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; HEART MUSCLE; METABOLISM; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; CARBAZOLES; FLUORINE RADIOISOTOPES; LIGANDS; MOLECULAR STRUCTURE; MYOCARDIUM; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA;

EID: 84856212426     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.084     Document Type: Article

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