Effect of simulated gastro-duodenal digestion on the allergenic reactivity of beta-lactoglobulin

Clinical and Translational Allergy

Volumn 1, Issue 1, 2011, Pages 1-11

  Bossios, Apostolos ^a,d   Theodoropoulou, Maria ^a,f   Mondoulet, Lucie ^b,e   Rigby, Neil M ^c   Papadopoulos, Nikolaos G ^a   Bernard, Hervé ^b   Adel Patient, Karine ^b   Wal, Jean Michel ^b   Mills, Clare EN ^c   Papageorgiou, Photini ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b CEA SACLAY   (France)

^c NORWICH RESEARCH PARK   (United Kingdom)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e DBV TECHNOLOGIES   (France)

^f UNIVERSITY OF THESSALY   (Greece)

Author keywords

Basophil activation; cow's milk allergy; flow cytometry; in vitro digestion; skin prick test; lactoglobulin

Indexed keywords

BETA LACTOGLOBULIN; IMMUNOGLOBULIN E; PHOSPHATIDYLCHOLINE;

ALLERGIC REACTION; ANTIGEN EXPRESSION; ARTICLE; BASOPHIL; BINDING AFFINITY; BLOOD SAMPLING; CELL ACTIVATION; CHILD; CLINICAL ARTICLE; DIGESTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GASTROINTESTINAL TRANSIT; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INFANT; LYMPHOCYTE PROLIFERATION; MALE; MILK ALLERGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRICK TEST; PRIORITY JOURNAL;

EID: 85006297747     PISSN: None     EISSN: 20457022     Source Type: Journal    
DOI: 10.1186/2045-7022-1-6     Document Type: Article

References (46)

1. Sampson HA: Food allergy. Part 1: immunopathogenesis and clinical disorders. J Allergy Clin Immunol. 1999, 103 (5 Pt 1): 717-28.
2. Sampson HA: Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol. 2001, 107 (5): 891-6.
3. Hill DJ, Hoskin CS: Cow's milk allergy in infancy and early childhood. Clin Exp Allergy. 1996, 26 (3): 243-6.
4. Hill DJ, Hosking CS, Heine RG: Clinical spectrum of food allergy in children in Australia and South-East Asia: identification and targets for treatment. Ann Med. 1999, 31 (4): 272-81.
5. Fiocchi A, Schünemann HJ, Brozek J, Restani P, Beyer K, Troncone R, Martelli A, Terracciano L, Bahna SL, Rancé F, Ebisawa M, Heine RG, Assa'ad A, Sampson H, Verduci E, Bouygue GR, Baena-Cagnani C, Canonica W, Lockey RF: Diagnosis and Rationale for Action Against Cow's Milk Allergy (DRACMA): a summary report. J Allergy Clin Immunol. 2010, 126 (6): 1119-28 e12.
6. Vieira MC, Morais MB, Spolidoro JV, Toporovski MS, Cardoso AL, Araujo GT, Nudelman V, Fonseca MC: A survey on clinical presentation and nutritional status of infants with suspected cow' milk allergy. BMC Pediatrics. 2010, 10 (1): 25-
7. García-Ara C, Boyano-Martínez T, Díaz-Pena JM, Martín-Muñoz F, Reche-Frutos M, Martín-Esteban M: Specific IgE levels in the diagnosis of immediate hypersensitivity to cows' milk protein in the infant. J Allergy Clin Immunol. 2001, 107 (1): 185-90.
8. Schouten B, van Esch BC, van Thuijl AO, Blokhuis BR, Groot Kormelink T, Hofman GA, Moro GE, Boehm G, Arslanoglu S, Sprikkelman AB, Willemsen LE, Knippels LM, Redegeld FA, Garssen J: Contribution of IgE and immunoglobulin free light chain in the allergic reaction to cow's milk proteins. J Allergy Clin Immunol. 2010, 125 (6): 1308-14.
9. Papiz MZ, Sawyer L, Eliopoulos EE, North AC, Findlay JB, Sivaprasadarao R, Jones TA, Newcomer ME, Kraulis PJ: The structure of beta-lactoglobulin and its similarity to plasma retinol-binding protein. Nature. 1986, 324 (6095): 383-5.
10. Breiteneder H, Mills EN: Molecular properties of food allergens. J Allergy Clin Immunol. 2005, 115 (1): 14-23; quiz 24.
11. Taylor SL, Lemanske RF, Bush RK, Busse WW: Food allergens: structure and immunologic properties. Ann Allergy. 1987, 59 (5 Pt 2): 93-9.
12. Untersmayr E, Bakos N, Schöll I, Kundi M, Roth-Walter F, Szalai K, Riemer AB, Ankersmit HJ, Scheiner O, Boltz-Nitulescu G, Jensen-Jarolim E: Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients. FASEB J. 2005, 19 (6): 656-8.
13. Sélo I, Clément G, Bernard H, Chatel J, Créminon C, Peltre G, Wal J: Allergy to bovine beta-lactoglobulin: specificity of human IgE to tryptic peptides. Clin Exp Allergy. 1999, 29 (8): 1055-63.
14. Van Hoeyveld EM, Escalona-Monge M, de Swert LF, Stevens EA: Allergenic and antigenic activity of peptide fragments in a whey hydrolysate formula. Clin Exp Allergy. 1998, 28 (9): 1131-7.
15. Gortler I, Urbanek R, Forster J: Characterization of antigens and allergens in hypo-allergenic infant formulae. Eur J Pediatr. 1995, 154 (4): 289-94.
16. Szépfalusi Z, Nentwich I, Jost E, Gerstmayr M, Ebner C, Frischer T, Urbanek R: Cord blood mononuclear cells and milk-specific T-cell clones are tools to evaluate the residual immunogenicity of hydrolyzed milk formulas. J Allergy Clin Immunol. 1998, 101 (4 Pt 1): 514-20.
17. Privalle LS: Phosphomannose Isomerase, a Novel Plant Selection System. Annals of the New York Academy of Sciences. 2002, 964 (1): 129-138.
18. Astwood JD, Leach JN, Fuchs RL: Stability of food allergens to digestion in vitro. Nat Biotech. 1996, 14 (10): 1269-1273.
19. Pali-Schöll I, Jensen-Jarolim E: Anti-acid medication as a risk factor for food allergy. Allergy. 2011, 66 (4): 469-477.
20. Burks AW, Williams LW, Thresher W, Connaughton C, Cockrell G, Helm RM: Allergenicity of peanut and soybean extracts altered by chemical or thermal denaturation in patients with atopic dermatitis and positive food challenges. J Allergy Clin Immunol. 1992, 90 (6 Pt 1): 889-97.
21. Vassilopoulou E, Rigby N, Moreno FJ, Zuidmeer L, Akkerdaas J, Tassios I, Papadopoulos NG, Saxoni-Papageorgiou P, van Ree R, Mills C: Effect of in vitro gastric and duodenal digestion on the allergenicity of grape lipid transfer protein. J Allergy Clin Immunol. 2006, 118 (2): 473-80.
22. Mandalari G, Adel-Patient K, Barkholt V, Baro C, Bennett L, Bublin M, Gaier S, Graser G, Ladics GS, Mierzejewska D, Vassilopoulou E, Vissers YM, Zuidmeer L, Rigby NM, Salt LJ, Defernez M, Mulholland F, Mackie AR, Wickham MS, Mills EN: In vitro digestibility of beta-casein and beta-lactoglobulin under simulated human gastric and duodenal conditions: a multi-laboratory evaluation. Regul Toxicol Pharmacol. 2009, 55 (3): 372-81.
23. Becker WM: Characterization of Ara h 1 by two-dimensional electrophoresis immunoblot and recombinant techniques: new digestion experiments with peanuts imitating the gastrointestinal tract. Int Arch Allergy Immunol. 1997, 113 (1-3): 118-21.
24. Fu TJ, Abbott UR, Hatzos C: Digestibility of food allergens and nonallergenic proteins in simulated gastric fluid and simulated intestinal fluid-a comparative study. J Agric Food Chem. 2002, 50 (24): 7154-60.
25. Kenna JG, Evans RM: Digestibility of proteins in simulated gastric fluid[abstract]. Toxicologist. 2000, 54: 141-
26. Yagami T, Haishima Y, Nakamura A, Osuna H, Ikezawa Z: Digestibility of allergens extracted from natural rubber latex and vegetable foods. J Allergy Clin Immunol. 2000, 106 (4): 752-62.
27. Fu TJ, Abbott UR, Hatzos C: Digestion stability as a criterion for protein allergenicity assessment. Ann N Y Acad Sci. 2002, 964: 99-110.
28. Kimber I, Lumley CE, Metcalfe DD: Allergenicity of proteins. Hum Exp Toxicol. 1997, 16 (9): 516-8.
29. Kimber I, Dearman RJ: Food allergy: what are the issues?. Toxicol Lett. 2001, 120 (1-3): 165-70.
30. Taylor SL, Hefle SL: Will genetically modified foods be allergenic?. J Allergy Clin Immunol. 2001, 107 (5): 765-71.
31. Moreno FJ, Mackie AR, Mills EN: Phospholipid interactions protect the milk allergen alpha-lactalbumin from proteolysis during in vitro digestion. J Agric Food Chem. 2005, 53 (25): 9810-6.
32. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970, 227 (5259): 680-5.
33. Negroni L, Bernard H, Clement G, Chatel JM, Brune P, Frobert Y, Wal JM, Grassi J: Two-site enzyme immunometric assays for determination of native and denatured beta-lactoglobulin. J Immunol Methods. 1998, 220 (1-2): 25-37.
34. Position paper: Allergen standardization and skin tests. The European Academy of Allergology and Clinical Immunology. Allergy. 1993, 48 (14 Suppl): 48-82.
35. Caruelle D, Grassi J, Courty J, Groux-Muscatelli B, Pradelles P, Barritault D, Caruelle JP: Development and testing of radio and enzyme immunoassays for acidic fibroblast growth factor (aFGF). Anal Biochem. 1988, 173 (2): 328-39.
36. Rodríguez-Trabado A, Cámara-Hijón C, Ramos-Cantariño A, Porcel-Carreño SL, Jiménez-Timón S, Pereira-Navarro G, Hernández-Arbeiza FJ, Fernández-Pereira L: Basophil activation test for the in vitro diagnosis of nonsteroidal anti-inflammatory drug hypersensitivity. Allergy Asthma Proc. 2008, 29 (3): 241-249.
37. Hemery ML, Arnoux B, Dhivert-Donnadieu H, Rongier M, Barbotte E, Verdier R, Demoly P: Confirmation of the diagnosis of natural rubber latex allergy by the Basotest method. Int Arch Allergy Immunol. 2005, 136 (1): 53-7.
38. Papadopoulos NG, Syrigou EI, Bossios A, Manou O, Gourgiotis D, Saxoni-Papageorgiou P: Correlation of lymphocyte proliferating cell nuclear antigen expression with dietary cow's milk antigen load in infants with allergy to cow's milk. Int Arch Allergy Immunol. 1999, 119 (1): 64-8.
39. Marquez UM, Lajolo FM: Composition and digestibility of albumin, globulins, and glutelins from Phaseolus vulgaris. J Agric Food Chem. 1981, 29 (5): 1068-74.
40. Dupont D, Mandalari G, Molle D, Jardin J, Léonil J, Faulks RM, Wickham MS, Mills EN, Mackie AR: Comparative resistance of food proteins to adult and infant in vitro digestion models. Mol Nutr Food Res. 2010, 54 (6): 767-80.
41. Lucas JS, Cochrane SA, Warner JO, Hourihane JO: The effect of digestion and pH on the allergenicity of kiwifruit proteins. Pediatr Allergy Immunol. 2008, 19 (5): 392-8.
42. Schmidt DG, Meijer RJ, Slangen CJ, van Beresteijn EC: Raising the pH of the pepsin-catalysed hydrolysis of bovine whey proteins increases the antigenicity of the hydrolysates. Clin Exp Allergy. 1995, 25 (10): 1007-17.
43. Bindslev-Jensen C, Briggs D, Osterballe M: Can we determine a threshold level for allergenic foods by statistical analysis of published data in the literature?. Allergy. 2002, 57 (8): 741-6.
44. Taylor SL, Hefle SL, Bindslev-Jensen C, Atkins FM, Andre C, Bruijnzeel-Koomen C, Burks AW, Bush RK, Ebisawa M, Eigenmann PA, Host A, Hourihane JO, Isolauri E, Hill DJ, Knulst A, Lack G, Sampson HA, Moneret-Vautrin DA, Rance F, Vadas PA, Yunginger JW, Zeiger RS, Salminen JW, Madsen C, Abbott P: A consensus protocol for the determination of the threshold doses for allergenic foods: how much is too much?. Clin Exp Allergy. 2004, 34 (5): 689-95.
45. Untersmayr E, Poulsen LK, Platzer MH, Pedersen MH, Boltz-Nitulescu G, Skov PS, Jensen-Jarolim E: The effects of gastric digestion on codfish allergenicity. J Allergy Clin Immunol. 2005, 115 (2): 377-82.
46. Vickery BP, Chin S, Burks AW: Pathophysiology of food allergy. Pediatr Clin North Am. 2011, 58 (2): 363-76. ix-x