Cord blood mononuclear cells and milk-specific T-cell clones are tools to evaluate the residual immunogenicity of hydrolyzed milk formulas

Journal of Allergy and Clinical Immunology

Volumn 101, Issue 4 I, 1998, Pages 514-520

  Szépfalusi, Zsolt ^a,b   Nentwich, Ivo ^a   Jost, Eva ^a   Gerstmayr, Marianne ^a   Ebner, Christof ^a   Frischer, Thomas ^a   Urbanek, Radvan ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cord blood cells; Cytokines; Hydrolyzed milk formulas; Milk proteins; Proliferative response; T cell clones

Indexed keywords

CASEIN;

ANTIBODY RESPONSE; ANTIGEN PRESENTING CELL; ARTICLE; ARTIFICIAL MILK; ATOPY; BREAST FEEDING; CELL CLONE; CELL PROLIFERATION; CELL TRANSFORMATION; ENERGY EXPENDITURE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPSTEIN BARR VIRUS; HELPER CELL; HUMAN; HUMAN CELL; HYDROLYSIS; IMMUNOGENICITY; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0031959222     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(98)70359-8     Document Type: Article

References (28)

1. Laver WG, Air GM, Webster RG, Smith-Gill SJ. Epitopes on protein antigens: misconceptions and realities. Cell 1990;61:553-6.
2. Snyder SL, Sobocinski PZ. An improved 2,4,6-trinitrobenzenesulfonic acid method for the determination of amines. Anal Biochem 1975;64:284-8.
3. Davis NC, Smith EL. Assay of proteolytic enzymes. In: Methods of biochemical analysis. New York: INTERSCIENCE; 1955. p. 215-57.
4. Oldaeus G, Björksten B, Einarsson R, Kjellman NIM. Antigenicity and allergenicity of cow milk hydrolysates intended for infant feeding. Pediatr Allergy Immunol 1991;4:156-64.
5. Restani P, Velona T, Plebani A, Ugazio AG, Poiesi C, Muraro A, et al. Evaluation by SDS-PAGE and immunoblotting of residual anti-genicity in hydrolysed protein formula. Clin Exp Allergy 1995;25:651-8.
6. Oldaeus G, Björksten B, Einarsson R, Kjellman NIM. Antigenicity and allergenicity of cow milk hydrolysates intended for infant feeding. Pediatr Allergy Immunol 1991;4:156-64.
7. Wahn U, Wahl R, Rugo E. Comparison of the residual allergenic activity of six different hydrolyzed protein formulas. J Pediatr 1992;121:S80-4.
8. Dean TP, Adler BR, Ruge F, Warner JO. In vitro allergenicity of cow's milk substitutes. Clin Exp Allergy 1993;23:205-10.
9. Van Neerven J, Ebner C, Yssel H, Kapsenberg M, Lamb J. T-cell responses to allergens: epitope-specificity and clinical relevance. Immunol today 1996;17:526-32.
10. Vaarala O, Saukkonen T, Savilahti E, Klemola T, Akerblom HK. Development of immune response to cow's milk proteins in infants receiving cow's milk or hydrolyzed formula. J Allergy Clin Immunol 1995;96:917-23.
11. Eigenmann PA, Belli DC, Ludi F, Kahn JM, Polla BS. In vitro lymphocyte proliferation with milk and a casein-whey protein hydrolyzed formula in children with cow's milk allergy. J Allergy Clin Immunol 1995;96:549-57.
12. Holt P, McMenamin, Nelson D. Primary sensitization to inhalant allergens during infancy. Pediatr Allergy Immunol 1990;1:3-13.
13. Holt P. Immunoprophylaxis of atopy: Light at the end of the tunnel? Immunol Today 1994;15:484-9.
14. Szépfalusi Z, Nentwich I, Gerstmayr M, Jost E, Todoran L, Gratzl R, et al. Prenatal allergen contact with milk proteins. Clin Exp Allergy 1997;27:28-35.
15. Tang MLK, Kemp AS, Thorbum J, Hill DJ. Reduced interferongamma secretion in neonates and subsequent atopy. Lancet 1994;344:983-5.
16. Ebner C, Szépfalusi Z, Ferreira F, Jilek A, Valenta R, Parronchi P, et al. Identification of multiple T cell epitopes on Bet v 1, the major birch pollen allergen, using specific T cell clones and overlapping peptides. J Immunol 1993;150:1047-54.
17. Ferreira F, Hirtenlehner K, Jilek A, Godnick-Cvar J, Breiteneder H, Grimm R, et al. Dissection of Immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: potential use of hypoallergenic isoforms for immunotherapy. J Exp Med 1996;183:599-609.
18. Ellis M, Short J, Heiner D. Anaphylaxis after ingestion of a recently introduced hydrolyzed whey protein formula. J Pediatr 1991;118:74-7.
19. Saylor J, Bahna S. Anaphylaxis to casein hydrolysate formula. J Pediatr 1991;118:71-4.
20. Sütas Y, Soppi E, Korhonen H, Syvvioja E-L, Saxelin M, Rokka T, et al. Suppression of lymphocyte proliferation in vitro by bovine caseins hydrolyzed with Lactobacillus casein GG-derived enzymes. J Allergy Clin Immunol 1996;98:216-24.
21. Brown MA, Halonen MJ, Martinez FD. Cutting the cord: Is birth already too late for primary prevention of allergy? Clin Exp Allergy 1997;27:4-6.
22. Schwartz RH. T lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu Rev Immunol 1985;3:237-55.
23. Rothbart JB, Busch R, Howland K, Bal V, Fenton C, Taylor WR, et al. Structural analysis of a peptide-HLA class II complex: identification of critical interactions for its formation and recognition by T cell receptor. Int Immunol 1989;1:479-86.
24. Gauchat J-F, Lebman DA, Coffman RL, Gascan H, de Vries JE. Structure and expression of germline transcripts in human B cells induced by interleukin-4 to switch to IgE production. J Exp Med 1990;172:463-71.
25. Ebner C, Schenk S, Najafian N, Siemann U, Steiner R, Fischer G, et al. Nonallergic individuals recognize the same T cell epitopes of Bet v 1, the major birch pollen allergen, as atopic patients. J Immunol 1995;154:1932-40.
26. Mosmann T, Coffman RL. TH1 and TH2 cells: different patterns of lymphokines secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-63.
27. Schwartz RH. A cell culture model for T lymphocyte clonal anergy. Science 1990;248:1349-56.
28. Lewis DB, Yu CC, Meyer J, English BK, Kahn SJ, Wilson CB. Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells. J Clin Invest 1991;87:194-202.