-
1
-
-
67349143998
-
Classification and basic pathology of Alzheimer disease
-
Duyckaerts C, Delatour B, Potier MC: Classification and basic pathology of Alzheimer disease. Acta Neuropathol 2009, 118: 5-36. 10.1007/s00401-009-0532-1
-
(2009)
Acta Neuropathol
, vol.118
, pp. 5-36
-
-
Duyckaerts, C.1
Delatour, B.2
Potier, M.C.3
-
2
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J, Allsop D: Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 1991, 12: 383-388.
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
3
-
-
0025753852
-
The molecular pathology of Alzheimer's disease
-
Selkoe DJ: The molecular pathology of Alzheimer's disease. Neuron 1991, 6: 487-498. 10.1016/0896-6273(91)90052-2
-
(1991)
Neuron
, vol.6
, pp. 487-498
-
-
Selkoe, D.J.1
-
4
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Mueller-Hill B: The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987, 325: 733-736. 10.1038/325733a0
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Mueller-Hill, B.9
-
5
-
-
0021256895
-
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner GG, Wong CW: Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984, 120: 885-890. 10.1016/S0006-291X(84)80190-4
-
(1984)
Biochem Biophys Res Commun
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
6
-
-
0022156464
-
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels
-
Masters CL, Multhaup G, Simms G, Pottgiesser J, Martins RN, Beyreuther K: Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. The EMBO journal 1985, 4: 2757-2763.
-
(1985)
The EMBO journal
, vol.4
, pp. 2757-2763
-
-
Masters, C.L.1
Multhaup, G.2
Simms, G.3
Pottgiesser, J.4
Martins, R.N.5
Beyreuther, K.6
-
7
-
-
0026597063
-
Alzheimer's disease: the amyloid cascade hypothesis
-
Hardy JA, Higgins GA: Alzheimer's disease: the amyloid cascade hypothesis. Science 1992, 256: 184-185. 10.1126/science.1566067
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
8
-
-
0032989712
-
Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease
-
Price JL, Morris JC: Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann Neurol 1999, 45: 358-368. 10.1002/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X
-
(1999)
Ann Neurol
, vol.45
, pp. 358-368
-
-
Price, J.L.1
Morris, J.C.2
-
9
-
-
0033525520
-
Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
-
Moechars D, Dewachter I, Lorent K, Reverse D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, Haute CV, Checler F, Godaux E, Cordell B, Van Leuven F: Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem 1999, 274: 6483-6492. 10.1074/jbc.274.10.6483
-
(1999)
J Biol Chem
, vol.274
, pp. 6483-6492
-
-
Moechars, D.1
Dewachter, I.2
Lorent, K.3
Reverse, D.4
Baekelandt, V.5
Naidu, A.6
Tesseur, I.7
Spittaels, K.8
Haute, C.V.9
Checler, F.10
Godaux, E.11
Cordell, B.12
Van Leuven, F.13
-
10
-
-
12144288683
-
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
-
Schmitz C, Rutten BP, Pielen A, Schafer S, Wirths O, Tremp G, Czech C, Blanchard V, Multhaup G, Rezaie P, Korr H, Steinbusch HW, Pradier L, Bayer TA: Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am J Pathol 2004, 164: 1495-1502. 10.1016/S0002-9440(10)63235-X
-
(2004)
Am J Pathol
, vol.164
, pp. 1495-1502
-
-
Schmitz, C.1
Rutten, B.P.2
Pielen, A.3
Schafer, S.4
Wirths, O.5
Tremp, G.6
Czech, C.7
Blanchard, V.8
Multhaup, G.9
Rezaie, P.10
Korr, H.11
Steinbusch, H.W.12
Pradier, L.13
Bayer, T.A.14
-
11
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
-
Haass C, Selkoe DJ: Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 2007, 8: 101-112. 10.1038/nrm2101
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
12
-
-
7244236841
-
A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide - the first step of a fatal cascade
-
Wirths O, Multhaup G, Bayer TA: A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide - the first step of a fatal cascade. J Neurochem 2004, 91: 513-520. 10.1111/j.1471-4159.2004.02737.x
-
(2004)
J Neurochem
, vol.91
, pp. 513-520
-
-
Wirths, O.1
Multhaup, G.2
Bayer, T.A.3
-
13
-
-
38049056730
-
Lipids revert inert A[beta] amyloid fibrils to neurotoxic protofibrils that affect learning in mice
-
Martins IC, Kuperstein I, Wilkinson H, Maes E, Vanbrabant M, Jonckheere W, Van Gelder P, Hartmann D, D'Hooge R, De Strooper B, Schymkowitz J, Rousseau F: Lipids revert inert A[beta] amyloid fibrils to neurotoxic protofibrils that affect learning in mice. The EMBO journal 2008, 27: 224-233. 10.1038/sj.emboj.7601953
-
(2008)
The EMBO journal
, vol.27
, pp. 224-233
-
-
Martins, I.C.1
Kuperstein, I.2
Wilkinson, H.3
Maes, E.4
Vanbrabant, M.5
Jonckheere, W.6
Van Gelder, P.7
Hartmann, D.8
D'Hooge, R.9
De Strooper, B.10
Schymkowitz, J.11
Rousseau, F.12
-
14
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K: Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci 1985, 82: 4245-4249. 10.1073/pnas.82.12.4245
-
(1985)
Proc Natl Acad Sci
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
15
-
-
0028106152
-
Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging
-
Näslund J, Schierhorn A, Hellman U, Lannfelt L, Roses AD, Tjernberg LO, Silberring J, Gandy SE, Winblad B, Greengard P: Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging. Proc Natl Acad Sci 1994, 91: 8378-8382. 10.1073/pnas.91.18.8378
-
(1994)
Proc Natl Acad Sci
, vol.91
, pp. 8378-8382
-
-
Näslund, J.1
Schierhorn, A.2
Hellman, U.3
Lannfelt, L.4
Roses, A.D.5
Tjernberg, L.O.6
Silberring, J.7
Gandy, S.E.8
Winblad, B.9
Greengard, P.10
-
16
-
-
0028855851
-
Dominant and differential deposition of distinct beta-amyloid peptide species, Abeta N3(pE), in senile plaques
-
Saido TC, Iwatsubo T, Mann DM, Shimada H, Ihara Y, Kawashima S: Dominant and differential deposition of distinct beta-amyloid peptide species, Abeta N3(pE), in senile plaques. Neuron 1995, 14: 457-466. 10.1016/0896-6273(95)90301-1
-
(1995)
Neuron
, vol.14
, pp. 457-466
-
-
Saido, T.C.1
Iwatsubo, T.2
Mann, D.M.3
Shimada, H.4
Ihara, Y.5
Kawashima, S.6
-
17
-
-
0027184611
-
Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease
-
Miller DL, Papayannopoulos IA, Styles J, Bobin SA, Lin YY, Biemann K, Iqbal K: Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease. Arch Biochem Biophys 1993, 301: 41-52. 10.1006/abbi.1993.1112
-
(1993)
Arch Biochem Biophys
, vol.301
, pp. 41-52
-
-
Miller, D.L.1
Papayannopoulos, I.A.2
Styles, J.3
Bobin, S.A.4
Lin, Y.Y.5
Biemann, K.6
Iqbal, K.7
-
18
-
-
0023684537
-
Differences between vascular and plaque core amyloid in Alzheimer's disease
-
Prelli F, Castano E, Glenner GG, Frangione B: Differences between vascular and plaque core amyloid in Alzheimer's disease. J Neurochem 1988, 51: 648-651. 10.1111/j.1471-4159.1988.tb01087.x
-
(1988)
J Neurochem
, vol.51
, pp. 648-651
-
-
Prelli, F.1
Castano, E.2
Glenner, G.G.3
Frangione, B.4
-
19
-
-
0033578402
-
The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta
-
He W, Barrow CJ: The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta. Biochemistry 1999, 38: 10871-10877. 10.1021/bi990563r
-
(1999)
Biochemistry
, vol.38
, pp. 10871-10877
-
-
He, W.1
Barrow, C.J.2
-
20
-
-
0028169925
-
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific Abeta monoclonals: evidence that an initially deposited species is A beta 42(43)
-
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y: Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific Abeta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 1994, 13: 45-53. 10.1016/0896-6273(94)90458-8
-
(1994)
Neuron
, vol.13
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
Mizusawa, H.4
Nukina, N.5
Ihara, Y.6
-
21
-
-
0028885682
-
Amino-terminal Deletions Enhance Aggregation of beta-Amyloid Peptides in Vitro
-
Pike CJ, Overman MJ, Cotman CW: Amino-terminal Deletions Enhance Aggregation of beta-Amyloid Peptides in Vitro. J Biol Chem 1995, 270: 23895-23898. 10.1074/jbc.270.41.23895
-
(1995)
J Biol Chem
, vol.270
, pp. 23895-23898
-
-
Pike, C.J.1
Overman, M.J.2
Cotman, C.W.3
-
22
-
-
33644942362
-
Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-β(42) peptide in vascular dementia
-
Lewis H, Beher D, Cookson N, Oakley A, Piggott M, Morris CM, Jaros E, Perry R, Ince P, Kenny RA, Ballard CG, Shearman MS, Kalaria RN: Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-β(42) peptide in vascular dementia. Neuropathol Appl Neurobiol 2006, 32: 103-118. 10.1111/j.1365-2990.2006.00696.x
-
(2006)
Neuropathol Appl Neurobiol
, vol.32
, pp. 103-118
-
-
Lewis, H.1
Beher, D.2
Cookson, N.3
Oakley, A.4
Piggott, M.5
Morris, C.M.6
Jaros, E.7
Perry, R.8
Ince, P.9
Kenny, R.A.10
Ballard, C.G.11
Shearman, M.S.12
Kalaria, R.N.13
-
23
-
-
0026794746
-
Mass spectrometry of purified amyloid beta protein in Alzheimer's disease
-
Mori H, Takio K, Ogawara M, Selkoe DJ: Mass spectrometry of purified amyloid beta protein in Alzheimer's disease. J Biol Chem 1992, 267: 17082-17086.
-
(1992)
J Biol Chem
, vol.267
, pp. 17082-17086
-
-
Mori, H.1
Takio, K.2
Ogawara, M.3
Selkoe, D.J.4
-
24
-
-
0030582387
-
Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain
-
Saido TC, Yamao-Harigaya W, Iwatsubo T, Kawashima S: Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain. Neurosci Lett 1996, 215: 173-176. 10.1016/0304-3940(96)12970-0
-
(1996)
Neurosci Lett
, vol.215
, pp. 173-176
-
-
Saido, T.C.1
Yamao-Harigaya, W.2
Iwatsubo, T.3
Kawashima, S.4
-
25
-
-
77957279325
-
Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease
-
Portelius E, Bogdanovic N, Gustavsson MK, Volkmann I, Brinkmalm G, Zetterberg H, Winblad B, Blennow K: Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease. Acta Neuropathol 2010, 120: 185-193. 10.1007/s00401-010-0690-1
-
(2010)
Acta Neuropathol
, vol.120
, pp. 185-193
-
-
Portelius, E.1
Bogdanovic, N.2
Gustavsson, M.K.3
Volkmann, I.4
Brinkmalm, G.5
Zetterberg, H.6
Winblad, B.7
Blennow, K.8
-
26
-
-
34248190279
-
A beta oligomers - a decade of discovery
-
Walsh DM, Selkoe DJ: A beta oligomers - a decade of discovery. J Neurochem 2007, 101: 1172-1184. 10.1111/j.1471-4159.2006.04426.x
-
(2007)
J Neurochem
, vol.101
, pp. 1172-1184
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
27
-
-
1842732209
-
Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain
-
Takahashi RH, Almeida CG, Kearney PF, Yu F, Lin MT, Milner TA, Gouras GK: Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain. J Neurosci 2004, 24: 3592-3599. 10.1523/JNEUROSCI.5167-03.2004
-
(2004)
J Neurosci
, vol.24
, pp. 3592-3599
-
-
Takahashi, R.H.1
Almeida, C.G.2
Kearney, P.F.3
Yu, F.4
Lin, M.T.5
Milner, T.A.6
Gouras, G.K.7
-
28
-
-
0034609516
-
The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain
-
Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ: The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry 2000, 39: 10831-10839. 10.1021/bi001048s
-
(2000)
Biochemistry
, vol.39
, pp. 10831-10839
-
-
Walsh, D.M.1
Tseng, B.P.2
Rydel, R.E.3
Podlisny, M.B.4
Selkoe, D.J.5
-
29
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, Beach T, Kurth JH, Rydel RE, Rogers J: Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 1999, 155: 853-862. 10.1016/S0002-9440(10)65184-X
-
(1999)
Am J Pathol
, vol.155
, pp. 853-862
-
-
Lue, L.F.1
Kuo, Y.M.2
Roher, A.E.3
Brachova, L.4
Shen, Y.5
Sue, L.6
Beach, T.7
Kurth, J.H.8
Rydel, R.E.9
Rogers, J.10
-
30
-
-
0032590054
-
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
-
McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, Masters CL: Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 1999, 46: 860-866. 10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M
-
(1999)
Ann Neurol
, vol.46
, pp. 860-866
-
-
McLean, C.A.1
Cherny, R.A.2
Fraser, F.W.3
Fuller, S.J.4
Smith, M.J.5
Beyreuther, K.6
Bush, A.I.7
Masters, C.L.8
-
31
-
-
0029671451
-
Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains
-
Kuo YM, Emmerling MR, Vigo-Pelfrey C, Kasunic TC, Kirkpatrick JB, Murdoch GH, Ball MJ, Roher AE: Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains. J Biol Chem 1996, 271: 4077-4081. 10.1074/jbc.271.8.4077
-
(1996)
J Biol Chem
, vol.271
, pp. 4077-4081
-
-
Kuo, Y.M.1
Emmerling, M.R.2
Vigo-Pelfrey, C.3
Kasunic, T.C.4
Kirkpatrick, J.B.5
Murdoch, G.H.6
Ball, M.J.7
Roher, A.E.8
-
32
-
-
0028181396
-
Soluble amyloid beta-protein is a marker of Alzheimer amyloid in brain but not in cerebrospinal fluid
-
Tabaton M, Nunzi MG, Xue R, Usiak M, Autilio-Gambetti L, Gambetti P: Soluble amyloid beta-protein is a marker of Alzheimer amyloid in brain but not in cerebrospinal fluid. Biochem Biophys Res Commun 1994, 200: 1598-1603. 10.1006/bbrc.1994.1634
-
(1994)
Biochem Biophys Res Commun
, vol.200
, pp. 1598-1603
-
-
Tabaton, M.1
Nunzi, M.G.2
Xue, R.3
Usiak, M.4
Autilio-Gambetti, L.5
Gambetti, P.6
-
33
-
-
77950617631
-
A Mouse Model of Amyloid beta Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo
-
Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori H: A Mouse Model of Amyloid beta Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo. J Neurosci 2010, 30: 4845-4856. 10.1523/JNEUROSCI.5825-09.2010
-
(2010)
J Neurosci
, vol.30
, pp. 4845-4856
-
-
Tomiyama, T.1
Matsuyama, S.2
Iso, H.3
Umeda, T.4
Takuma, H.5
Ohnishi, K.6
Ishibashi, K.7
Teraoka, R.8
Sakama, N.9
Yamashita, T.10
Nishitsuji, K.11
Ito, K.12
Shimada, H.13
Lambert, M.P.14
Klein, W.L.15
Mori, H.16
-
34
-
-
84881099652
-
N-truncated amyloid beta (Abeta) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits
-
Bouter Y, Dietrich K, Wittnam JL, Rezaei-Ghaleh N, Pillot T, Papot-Couturier S, Lefebvre T, Sprenger F, Wirths O, Zweckstetter M, Bayer TA: N-truncated amyloid beta (Abeta) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits. Acta Neuropathol 2013, 126: 189-205. 10.1007/s00401-013-1129-2
-
(2013)
Acta Neuropathol
, vol.126
, pp. 189-205
-
-
Bouter, Y.1
Dietrich, K.2
Wittnam, J.L.3
Rezaei-Ghaleh, N.4
Pillot, T.5
Papot-Couturier, S.6
Lefebvre, T.7
Sprenger, F.8
Wirths, O.9
Zweckstetter, M.10
Bayer, T.A.11
-
35
-
-
78651316278
-
Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure
-
Hahn S, Brüning T, Ness J, Czirr E, Baches S, Gijsen H, Korth C, Pietrzik CU, Bulic B, Weggen S: Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure. J Neurochem 2011, 116: 385-395. 10.1111/j.1471-4159.2010.07118.x
-
(2011)
J Neurochem
, vol.116
, pp. 385-395
-
-
Hahn, S.1
Brüning, T.2
Ness, J.3
Czirr, E.4
Baches, S.5
Gijsen, H.6
Korth, C.7
Pietrzik, C.U.8
Bulic, B.9
Weggen, S.10
-
36
-
-
76949102099
-
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases
-
Wirths O, Bethge T, Marcello A, Harmeier A, Jawhar S, Lucassen PJ, Multhaup G, Brody DL, Esparza T, Ingelsson M, Kalimo H, Lannfelt L, Bayer TA: Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. J Neural Transm 2010, 117: 85-96. 10.1007/s00702-009-0314-x
-
(2010)
J Neural Transm
, vol.117
, pp. 85-96
-
-
Wirths, O.1
Bethge, T.2
Marcello, A.3
Harmeier, A.4
Jawhar, S.5
Lucassen, P.J.6
Multhaup, G.7
Brody, D.L.8
Esparza, T.9
Ingelsson, M.10
Kalimo, H.11
Lannfelt, L.12
Bayer, T.A.13
-
37
-
-
0032845739
-
The Nonfibrillar Amyloid β-Peptide Induces Apoptotic Neuronal Cell Death
-
Pillot T, Drouet B, Queillé S, Labeur C, Vandekerckhove J, Rosseneu M, Pinçon-Raymond M, Chambaz J: The Nonfibrillar Amyloid β-Peptide Induces Apoptotic Neuronal Cell Death. J Neurochem 1999, 73: 1626-1634.
-
(1999)
J Neurochem
, vol.73
, pp. 1626-1634
-
-
Pillot, T.1
Drouet, B.2
Queillé, S.3
Labeur, C.4
Vandekerckhove, J.5
Rosseneu, M.6
Pinçon-Raymond, M.7
Chambaz, J.8
-
38
-
-
47249113393
-
N-truncated amyloid-β oligomers induce learning impairment and neuronal apoptosis
-
Youssef I, Florent-Béchard S, Malaplate-Armand C, Koziel V, Bihain B, Olivier J-L, Leininger-Muller B, Kriem B, Oster T, Pillot T: N-truncated amyloid-β oligomers induce learning impairment and neuronal apoptosis. Neurobiol Aging 2008, 29: 1319-1333. 10.1016/j.neurobiolaging.2007.03.005
-
(2008)
Neurobiol Aging
, vol.29
, pp. 1319-1333
-
-
Youssef, I.1
Florent-Béchard, S.2
Malaplate-Armand, C.3
Koziel, V.4
Bihain, B.5
Olivier, J.-L.6
Leininger-Muller, B.7
Kriem, B.8
Oster, T.9
Pillot, T.10
-
39
-
-
33749521100
-
Intraneuronal beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
-
Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R: Intraneuronal beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation. J Neurosci 2006, 26: 10129-10140. 10.1523/JNEUROSCI.1202-06.2006
-
(2006)
J Neurosci
, vol.26
, pp. 10129-10140
-
-
Oakley, H.1
Cole, S.L.2
Logan, S.3
Maus, E.4
Shao, P.5
Craft, J.6
Guillozet-Bongaarts, A.7
Ohno, M.8
Disterhoft, J.9
Van Eldik, L.10
Berry, R.11
Vassar, R.12
-
40
-
-
81355124089
-
Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Abeta aggregation in the 5XFAD mouse model of Alzheimer's disease
-
Jawhar S, Trawicka A, Jenneckens C, Bayer TA, Wirths O: Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Abeta aggregation in the 5XFAD mouse model of Alzheimer's disease. Neurobiol Aging 2012,33(196):e129-196. e140
-
(2012)
Neurobiol Aging
, vol.33
, Issue.196
-
-
Jawhar, S.1
Trawicka, A.2
Jenneckens, C.3
Bayer, T.A.4
Wirths, O.5
-
41
-
-
56749152364
-
Transient intraneuronal Abeta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice
-
Christensen DZ, Kraus SL, Flohr A, Cotel MC, Wirths O, Bayer TA: Transient intraneuronal Abeta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice. Acta Neuropathol 2008, 116: 647-655. 10.1007/s00401-008-0451-6
-
(2008)
Acta Neuropathol
, vol.116
, pp. 647-655
-
-
Christensen, D.Z.1
Kraus, S.L.2
Flohr, A.3
Cotel, M.C.4
Wirths, O.5
Bayer, T.A.6
-
42
-
-
0031949628
-
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1 [see comments]
-
Crook R, Verkkoniemi A, Perez-Tur J, Mehta N, Baker M, Houlden H, Farrer M, Hutton M, Lincoln S, Hardy J, Gwinn K, Somer M, Paetau A, Kalimo H, Ylikoski R, Poyhonen M, Kucera S, Haltia M: A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1 [see comments]. Nat Med 1998, 4: 452-455. 10.1038/nm0498-452
-
(1998)
Nat Med
, vol.4
, pp. 452-455
-
-
Crook, R.1
Verkkoniemi, A.2
Perez-Tur, J.3
Mehta, N.4
Baker, M.5
Houlden, H.6
Farrer, M.7
Hutton, M.8
Lincoln, S.9
Hardy, J.10
Gwinn, K.11
Somer, M.12
Paetau, A.13
Kalimo, H.14
Ylikoski, R.15
Poyhonen, M.16
Kucera, S.17
Haltia, M.18
-
43
-
-
42249102801
-
CLinical and neuropathological features of the arctic app gene mutation causing early-onset alzheimer disease
-
Basun HBNIM, et al.: CLinical and neuropathological features of the arctic app gene mutation causing early-onset alzheimer disease. Arch Neurol 2008, 65: 499-505. 10.1001/archneur.65.4.499
-
(2008)
Arch Neurol
, vol.65
, pp. 499-505
-
-
Basun, H.B.N.I.M.1
-
44
-
-
17944368176
-
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced A[beta] protofibril formation
-
Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, Forsell C, Stenh C, Luthman J, Teplow DB, Younkin SG, Naslund J, Lannfelt L: The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced A[beta] protofibril formation. Nat Neurosci 2001, 4: 887-893. 10.1038/nn0901-887
-
(2001)
Nat Neurosci
, vol.4
, pp. 887-893
-
-
Nilsberth, C.1
Westlind-Danielsson, A.2
Eckman, C.B.3
Condron, M.M.4
Axelman, K.5
Forsell, C.6
Stenh, C.7
Luthman, J.8
Teplow, D.B.9
Younkin, S.G.10
Naslund, J.11
Lannfelt, L.12
-
45
-
-
0026907151
-
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
-
Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B, Lannfelt L: A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet 1992, 1: 345-347. 10.1038/ng0892-345
-
(1992)
Nat Genet
, vol.1
, pp. 345-347
-
-
Mullan, M.1
Crawford, F.2
Axelman, K.3
Houlden, H.4
Lilius, L.5
Winblad, B.6
Lannfelt, L.7
-
46
-
-
0030964397
-
Aging and Alzheimer's disease: lessons from the Nun Study
-
Snowdon DA: Aging and Alzheimer's disease: lessons from the Nun Study. Gerontologist 1997, 37: 150-156. 10.1093/geront/37.2.150
-
(1997)
Gerontologist
, vol.37
, pp. 150-156
-
-
Snowdon, D.A.1
-
47
-
-
84899571989
-
Intracellular accumulation of amyloid-beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease
-
Bayer TA, Wirths O: Intracellular accumulation of amyloid-beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease. Front Aging Neurosci 2010, 2: 1-10.
-
(2010)
Front Aging Neurosci
, vol.2
, pp. 1-10
-
-
Bayer, T.A.1
Wirths, O.2
-
49
-
-
73949089674
-
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide
-
Hu X, Crick SL, Bu G, Frieden C, Pappu RV, Lee J-M: Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc Natl Acad Sci 2009, 106: 20324-20329. 10.1073/pnas.0911281106
-
(2009)
Proc Natl Acad Sci
, vol.106
, pp. 20324-20329
-
-
Hu, X.1
Crick, S.L.2
Bu, G.3
Frieden, C.4
Pappu, R.V.5
Lee, J.-M.6
-
50
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH: A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006, 440: 352-357. 10.1038/nature04533
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesne, S.1
Koh, M.T.2
Kotilinek, L.3
Kayed, R.4
Glabe, C.G.5
Yang, A.6
Gallagher, M.7
Ashe, K.H.8
-
51
-
-
0037059598
-
Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus
-
Wang HW, Pasternak JF, Kuo H, Ristic H, Lambert MP, Chromy B, Viola KL, Klein WL, Stine WB, Krafft GA, Trommer BL: Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Res 2002, 924: 133-140. 10.1016/S0006-8993(01)03058-X
-
(2002)
Brain Res
, vol.924
, pp. 133-140
-
-
Wang, H.W.1
Pasternak, J.F.2
Kuo, H.3
Ristic, H.4
Lambert, M.P.5
Chromy, B.6
Viola, K.L.7
Klein, W.L.8
Stine, W.B.9
Krafft, G.A.10
Trommer, B.L.11
-
52
-
-
68249134074
-
The Role of Apolipoprotein E in Alzheimer's Disease
-
Kim J, Basak JM, Holtzman DM: The Role of Apolipoprotein E in Alzheimer's Disease. Neuron 2009, 63: 287-303. 10.1016/j.neuron.2009.06.026
-
(2009)
Neuron
, vol.63
, pp. 287-303
-
-
Kim, J.1
Basak, J.M.2
Holtzman, D.M.3
-
53
-
-
80655144756
-
Pyroglutamate Abeta - a hatchet man in Alzheimer disease
-
Jawhar S, Wirths O, Bayer TA: Pyroglutamate Abeta - a hatchet man in Alzheimer disease. J Biol Chem 2011, 286: 38825-38832. 10.1074/jbc.R111.288308
-
(2011)
J Biol Chem
, vol.286
, pp. 38825-38832
-
-
Jawhar, S.1
Wirths, O.2
Bayer, T.A.3
-
54
-
-
80052578595
-
Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated Aβ Is Induced by Pyroglutamate-Aβ Formation
-
Alexandru A, Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Rönicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rübsamen M, Waniek A, Rossner S, Schilling S, Osmand AP, Demuth H-U, von Hörsten S: Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated Aβ Is Induced by Pyroglutamate-Aβ Formation. J Neurosci 2011, 31: 12790-12801. 10.1523/JNEUROSCI.1794-11.2011
-
(2011)
J Neurosci
, vol.31
, pp. 12790-12801
-
-
Alexandru, A.1
Jagla, W.2
Graubner, S.3
Becker, A.4
Bäuscher, C.5
Kohlmann, S.6
Sedlmeier, R.7
Raber, K.A.8
Cynis, H.9
Rönicke, R.10
Reymann, K.G.11
Petrasch-Parwez, E.12
Hartlage-Rübsamen, M.13
Waniek, A.14
Rossner, S.15
Schilling, S.16
Osmand, A.P.17
Demuth, H.-U.18
von Hörsten, S.19
-
55
-
-
4644276796
-
Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated A(beta)42 Accumulation in a Novel Alzheimer Transgenic Model
-
Casas C, Sergeant N, Itier JM, Blanchard V, Wirths O, van der Kolk N, Vingtdeux V, van de Steeg E, Ret G, Canton T, Drobecq H, Clark A, Bonici B, Delacourte A, Benavides J, Schmitz C, Tremp G, Bayer TA, Benoit P, Pradier L: Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated A(beta)42 Accumulation in a Novel Alzheimer Transgenic Model. Am J Pathol 2004, 165: 1289-1300. 10.1016/S0002-9440(10)63388-3
-
(2004)
Am J Pathol
, vol.165
, pp. 1289-1300
-
-
Casas, C.1
Sergeant, N.2
Itier, J.M.3
Blanchard, V.4
Wirths, O.5
van der Kolk, N.6
Vingtdeux, V.7
van de Steeg, E.8
Ret, G.9
Canton, T.10
Drobecq, H.11
Clark, A.12
Bonici, B.13
Delacourte, A.14
Benavides, J.15
Schmitz, C.16
Tremp, G.17
Bayer, T.A.18
Benoit, P.19
Pradier, L.20
more..
-
56
-
-
77952882727
-
Intracellular Abeta triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease
-
Christensen DZ, Bayer TA, Wirths O: Intracellular Abeta triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease. Neurobiol Aging 2010, 31: 1153-1163. 10.1016/j.neurobiolaging.2008.07.022
-
(2010)
Neurobiol Aging
, vol.31
, pp. 1153-1163
-
-
Christensen, D.Z.1
Bayer, T.A.2
Wirths, O.3
-
57
-
-
69949135716
-
Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
-
Wirths O, Breyhan H, Cynis H, Schilling S, Demuth HU, Bayer TA: Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model. Acta Neuropathol 2009, 118: 487-496. 10.1007/s00401-009-0557-5
-
(2009)
Acta Neuropathol
, vol.118
, pp. 487-496
-
-
Wirths, O.1
Breyhan, H.2
Cynis, H.3
Schilling, S.4
Demuth, H.U.5
Bayer, T.A.6
-
58
-
-
0035997524
-
Intraneuronal Abeta42 accumulation in Down syndrome brain
-
Mori C, Spooner ET, Wisniewsk KE, Wisniewski TM, Yamaguch H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA: Intraneuronal Abeta42 accumulation in Down syndrome brain. Amyloid 2002, 9: 88-102.
-
(2002)
Amyloid
, vol.9
, pp. 88-102
-
-
Mori, C.1
Spooner, E.T.2
Wisniewsk, K.E.3
Wisniewski, T.M.4
Yamaguch, H.5
Saido, T.C.6
Tolan, D.R.7
Selkoe, D.J.8
Lemere, C.A.9
-
59
-
-
78650637437
-
Identification of low molecular weight pyroglutamate Abeta oligomers in Alzheimer disease: a novel tool for therapy and diagnosis
-
Wirths O, Erck C, Martens H, Harmeier A, Geumann C, Jawhar S, Kumar S, Multhaup G, Walter J, Ingelsson M, Degerman-Gunnarsson M, Kalimo H, Huitinga I, Lannfelt L, Bayer TA: Identification of low molecular weight pyroglutamate Abeta oligomers in Alzheimer disease: a novel tool for therapy and diagnosis. J Biol Chem 2010, 285: 41517-41524. 10.1074/jbc.M110.178707
-
(2010)
J Biol Chem
, vol.285
, pp. 41517-41524
-
-
Wirths, O.1
Erck, C.2
Martens, H.3
Harmeier, A.4
Geumann, C.5
Jawhar, S.6
Kumar, S.7
Multhaup, G.8
Walter, J.9
Ingelsson, M.10
Degerman-Gunnarsson, M.11
Kalimo, H.12
Huitinga, I.13
Lannfelt, L.14
Bayer, T.A.15
-
60
-
-
0035918312
-
Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains
-
Kuo YM, Kokjohn TA, Beach TG, Sue LI, Brune D, Lopez JC, Kalback WM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Roher AE: Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains. J Biol Chem 2001, 276: 12991-12998. 10.1074/jbc.M007859200
-
(2001)
J Biol Chem
, vol.276
, pp. 12991-12998
-
-
Kuo, Y.M.1
Kokjohn, T.A.2
Beach, T.G.3
Sue, L.I.4
Brune, D.5
Lopez, J.C.6
Kalback, W.M.7
Abramowski, D.8
Sturchler-Pierrat, C.9
Staufenbiel, M.10
Roher, A.E.11
-
61
-
-
42949155299
-
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization
-
Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ: Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. J Neurosci 2008, 28: 4231-4237. 10.1523/JNEUROSCI.5161-07.2008
-
(2008)
J Neurosci
, vol.28
, pp. 4231-4237
-
-
Klyubin, I.1
Betts, V.2
Welzel, A.T.3
Blennow, K.4
Zetterberg, H.5
Wallin, A.6
Lemere, C.A.7
Cullen, W.K.8
Peng, Y.9
Wisniewski, T.10
Selkoe, D.J.11
Anwyl, R.12
Walsh, D.M.13
Rowan, M.J.14
-
62
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ: Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002, 416: 535-539. 10.1038/416535a
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
63
-
-
84857642949
-
The toxic A[beta] oligomer and Alzheimer's disease: an emperor in need of clothes
-
Benilova I, Karran E, De Strooper B: The toxic A[beta] oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci 2012, 29: 349-357.
-
(2012)
Nat Neurosci
, vol.29
, pp. 349-357
-
-
Benilova, I.1
Karran, E.2
De Strooper, B.3
-
64
-
-
22144462135
-
Neurotoxic protein oligomers-what you see is not always what you get
-
Bitan G, Fradinger EA, Spring SM, Teplow DB: Neurotoxic protein oligomers-what you see is not always what you get. Amyloid 2005, 12: 88-95. 10.1080/13506120500106958
-
(2005)
Amyloid
, vol.12
, pp. 88-95
-
-
Bitan, G.1
Fradinger, E.A.2
Spring, S.M.3
Teplow, D.B.4
-
65
-
-
33845935564
-
Solution state characterization of amyloid beta-derived diffusible ligands
-
Hepler RW, Grimm KM, Nahas DD, Breese R, Dodson EC, Acton P, Keller PM, Yeager M, Wang H, Shughrue P, Kinney G, Joyce JG: Solution state characterization of amyloid beta-derived diffusible ligands. Biochemistry 2006, 45: 15157-15167. 10.1021/bi061850f
-
(2006)
Biochemistry
, vol.45
, pp. 15157-15167
-
-
Hepler, R.W.1
Grimm, K.M.2
Nahas, D.D.3
Breese, R.4
Dodson, E.C.5
Acton, P.6
Keller, P.M.7
Yeager, M.8
Wang, H.9
Shughrue, P.10
Kinney, G.11
Joyce, J.G.12
-
66
-
-
0025779179
-
Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition
-
Barrow CJ, Zagorski MG: Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition. Science 1991, 253: 179-182. 10.1126/science.1853202
-
(1991)
Science
, vol.253
, pp. 179-182
-
-
Barrow, C.J.1
Zagorski, M.G.2
-
67
-
-
79960819248
-
Potent amyloidogenicity and pathogenicity of A[beta]43
-
Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC: Potent amyloidogenicity and pathogenicity of A[beta]43. Nat Neurosci 2011, 14: 1023-1032. 10.1038/nn.2858
-
(2011)
Nat Neurosci
, vol.14
, pp. 1023-1032
-
-
Saito, T.1
Suemoto, T.2
Brouwers, N.3
Sleegers, K.4
Funamoto, S.5
Mihira, N.6
Matsuba, Y.7
Yamada, K.8
Nilsson, P.9
Takano, J.10
Nishimura, M.11
Iwata, N.12
Van Broeckhoven, C.13
Ihara, Y.14
Saido, T.C.15
-
68
-
-
67649488309
-
Aβ43 is more frequent than Aβ40 in amyloid plaque cores from Alzheimer disease brains
-
Welander H, Frånberg J, Graff C, Sundström E, Winblad B, Tjernberg LO: Aβ43 is more frequent than Aβ40 in amyloid plaque cores from Alzheimer disease brains. J Neurochem 2009, 110: 697-706. 10.1111/j.1471-4159.2009.06170.x
-
(2009)
J Neurochem
, vol.110
, pp. 697-706
-
-
Welander, H.1
Frånberg, J.2
Graff, C.3
Sundström, E.4
Winblad, B.5
Tjernberg, L.O.6
-
69
-
-
0027332081
-
beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease
-
Roher AE, Lowenson JD, Clarke S, Woods AS, Cotter RJ, Gowing E, Ball MJ: beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc Natl Acad Sci 1993, 90: 10836-10840. 10.1073/pnas.90.22.10836
-
(1993)
Proc Natl Acad Sci
, vol.90
, pp. 10836-10840
-
-
Roher, A.E.1
Lowenson, J.D.2
Clarke, S.3
Woods, A.S.4
Cotter, R.J.5
Gowing, E.6
Ball, M.J.7
-
70
-
-
84858040971
-
Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease
-
Wittnam JL, Portelius E, Zetterberg H, Gustavsson MK, Schilling S, Koch B, Demuth H-U, Blennow K, Wirths O, Bayer TA: Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease. J Biol Chem 2012, 287: 8154-8162. 10.1074/jbc.M111.308601
-
(2012)
J Biol Chem
, vol.287
, pp. 8154-8162
-
-
Wittnam, J.L.1
Portelius, E.2
Zetterberg, H.3
Gustavsson, M.K.4
Schilling, S.5
Koch, B.6
Demuth, H.-U.7
Blennow, K.8
Wirths, O.9
Bayer, T.A.10
-
71
-
-
12444337654
-
Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach
-
Sergeant N, Bombois S, Ghestem A, Drobecq H, Kostanjevecki V, Missiaen C, Wattez A, David JP, Vanmechelen E, Sergheraert C, Delacourte A: Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach. J Neurochem 2003, 85: 1581-1591. 10.1046/j.1471-4159.2003.01818.x
-
(2003)
J Neurochem
, vol.85
, pp. 1581-1591
-
-
Sergeant, N.1
Bombois, S.2
Ghestem, A.3
Drobecq, H.4
Kostanjevecki, V.5
Missiaen, C.6
Wattez, A.7
David, J.P.8
Vanmechelen, E.9
Sergheraert, C.10
Delacourte, A.11
-
72
-
-
84856986423
-
Structural basis of beta-amyloid-dependent synaptic dysfunctions
-
Haupt C, Leppert J, Ronicke R, Meinhardt J, Yadav JK, Ramachandran R, Ohlenschlager O, Reymann KG, Gorlach M, Fandrich M: Structural basis of beta-amyloid-dependent synaptic dysfunctions. Angew Chem Int Ed Engl 2012, 51: 1576-1579. 10.1002/anie.201105638
-
(2012)
Angew Chem Int Ed Engl
, vol.51
, pp. 1576-1579
-
-
Haupt, C.1
Leppert, J.2
Ronicke, R.3
Meinhardt, J.4
Yadav, J.K.5
Ramachandran, R.6
Ohlenschlager, O.7
Reymann, K.G.8
Gorlach, M.9
Fandrich, M.10
-
73
-
-
77951975748
-
Structural conversion of neurotoxic amyloid-[beta]1-42 oligomers to fibrils
-
Ahmed M, Davis J, Aucoin D, Sato T, Ahuja S, Aimoto S, Elliott JI, Van Nostrand WE, Smith SO: Structural conversion of neurotoxic amyloid-[beta]1-42 oligomers to fibrils. Nat Struct Mol Biol 2010, 17: 561-567. 10.1038/nsmb.1799
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 561-567
-
-
Ahmed, M.1
Davis, J.2
Aucoin, D.3
Sato, T.4
Ahuja, S.5
Aimoto, S.6
Elliott, J.I.7
Van Nostrand, W.E.8
Smith, S.O.9
-
74
-
-
36849084640
-
Evidence of fibril-like beta-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's beta-amyloid
-
Chimon S, Shaibat MA, Jones CR, Calero DC, Aizezi B, Ishii Y: Evidence of fibril-like beta-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's beta-amyloid. Nat Struct Mol Biol 2007, 14: 1157-1164. 10.1038/nsmb1345
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 1157-1164
-
-
Chimon, S.1
Shaibat, M.A.2
Jones, C.R.3
Calero, D.C.4
Aizezi, B.5
Ishii, Y.6
-
75
-
-
0037168655
-
A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR
-
Petkova AT, Ishii Y, Balbach JJ, Antzutkin ON, Leapman RD, Delaglio F, Tycko R: A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR. Proc Natl Acad Sci USA 2002, 99: 16742-16747. 10.1073/pnas.262663499
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 16742-16747
-
-
Petkova, A.T.1
Ishii, Y.2
Balbach, J.J.3
Antzutkin, O.N.4
Leapman, R.D.5
Delaglio, F.6
Tycko, R.7
-
76
-
-
79952498441
-
Solid-state NMR spectroscopic investigation of Abeta protofibrils: implication of a beta-sheet remodeling upon maturation into terminal amyloid fibrils
-
Scheidt HA, Morgado I, Rothemund S, Huster D, Fandrich M: Solid-state NMR spectroscopic investigation of Abeta protofibrils: implication of a beta-sheet remodeling upon maturation into terminal amyloid fibrils. Angew Chem Int Ed Engl 2011, 50: 2837-2840. 10.1002/anie.201007265
-
(2011)
Angew Chem Int Ed Engl
, vol.50
, pp. 2837-2840
-
-
Scheidt, H.A.1
Morgado, I.2
Rothemund, S.3
Huster, D.4
Fandrich, M.5
-
77
-
-
84855835096
-
Dynamics of amyloid beta fibrils revealed by solid-state NMR
-
Scheidt HA, Morgado I, Rothemund S, Huster D: Dynamics of amyloid beta fibrils revealed by solid-state NMR. J Biol Chem 2012, 287: 2017-2021. 10.1074/jbc.M111.308619
-
(2012)
J Biol Chem
, vol.287
, pp. 2017-2021
-
-
Scheidt, H.A.1
Morgado, I.2
Rothemund, S.3
Huster, D.4
-
78
-
-
61849084232
-
Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide
-
Sevalle J, Amoyel A, Robert P, Fournie-Zaluski MC, Roques B, Checler F: Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide. J Neurochem 2009, 109: 248-256. 10.1111/j.1471-4159.2009.05950.x
-
(2009)
J Neurochem
, vol.109
, pp. 248-256
-
-
Sevalle, J.1
Amoyel, A.2
Robert, P.3
Fournie-Zaluski, M.C.4
Roques, B.5
Checler, F.6
-
79
-
-
33749615367
-
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells
-
Cynis H, Schilling S, Bodnar M, Hoffmann T, Heiser U, Saido TC, Demuth HU: Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells. Biochim Biophys Acta 2006, 1764: 1618-1625. 10.1016/j.bbapap.2006.08.003
-
(2006)
Biochim Biophys Acta
, vol.1764
, pp. 1618-1625
-
-
Cynis, H.1
Schilling, S.2
Bodnar, M.3
Hoffmann, T.4
Heiser, U.5
Saido, T.C.6
Demuth, H.U.7
-
80
-
-
79953002787
-
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A(beta) formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice
-
Jawhar S, Wirths O, Schilling S, Graubner S, Demuth HU, Bayer TA: Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A(beta) formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice. J Biol Chem 2011, 286: 4454-4460. 10.1074/jbc.M110.185819
-
(2011)
J Biol Chem
, vol.286
, pp. 4454-4460
-
-
Jawhar, S.1
Wirths, O.2
Schilling, S.3
Graubner, S.4
Demuth, H.U.5
Bayer, T.A.6
-
81
-
-
1842636794
-
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions
-
Schilling S, Hoffmann T, Manhart S, Hoffmann M, Demuth HU: Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions. FEBS Lett 2004, 563: 191-196. 10.1016/S0014-5793(04)00300-X
-
(2004)
FEBS Lett
, vol.563
, pp. 191-196
-
-
Schilling, S.1
Hoffmann, T.2
Manhart, S.3
Hoffmann, M.4
Demuth, H.U.5
-
82
-
-
53549099647
-
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology
-
Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H, Montag D, Demuth HU, Rossner S: Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. Nat Med 2008, 14: 1106-1111. 10.1038/nm.1872
-
(2008)
Nat Med
, vol.14
, pp. 1106-1111
-
-
Schilling, S.1
Zeitschel, U.2
Hoffmann, T.3
Heiser, U.4
Francke, M.5
Kehlen, A.6
Holzer, M.7
Hutter-Paier, B.8
Prokesch, M.9
Windisch, M.10
Jagla, W.11
Schlenzig, D.12
Lindner, C.13
Rudolph, T.14
Reuter, G.15
Cynis, H.16
Montag, D.17
Demuth, H.U.18
Rossner, S.19
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