Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2

Free Radical Research

Volumn 42, Issue 4, 2008, Pages 362-371

  Zhang, Yanlin ^a   Guan, Li ^a   Wang, Xifu ^a   Wen, Tao ^a   Xing, Junjie ^a   Zhao, Jinyuan ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

Chlorophyllin; Free radicals; HO 1; NQO1; Nrf2; PI3K Akt

Indexed keywords

CHLOROPHYLL; HEME OXYGENASE 1; HYDROGEN PEROXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; AKT1 PROTEIN, HUMAN; ANTIOXIDANT; CHLOROPHYLLIDE; FREE RADICAL; HMOX1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; NQO1 PROTEIN, HUMAN;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; CELL NUCLEUS; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UMBILICAL VEIN; BIOSYNTHESIS; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; CYTOPLASM; DOSE RESPONSE; METABOLISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIOXIDANTS; CELL NUCLEUS; CELL SURVIVAL; CHLOROPHYLLIDES; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICALS; HEME OXYGENASE-1; HUMANS; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; UMBILICAL VEINS;

EID: 48849111682     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760801993076     Document Type: Article

References (42)

1. Poli, G., Leonarduzzi, G., Biasi, F. and Chiarpotto, E. (2004) Oxidative stress and cell signalling. Curr Med Chem, 11, pp. 1163-1182.
2. Liu, H., Colavitti, R., Rovira, II and Finkel, T. (2005) Redox-dependent transcriptional regulation. Circ Res, 97, pp. 967-974.
3. Fruehauf, JP and Meyskens Jr, FL (2007) Reactive oxygen species: A breath of life or death?. Clin Cancer Res, 13, pp. 789-794.
4. Esposito, F., Ammendola, R., Faraonio, R., Russo, T. and Cimino, F. (2004) Redox control of signal transduction, gene expression and cellular senescence. Neurochem Res, 29, pp. 617-628.
5. Hensley, K., Robinson, KA, Gabbita, SP, Salsman, S. and Floyd, RA. (2000) Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med, 28, pp. 1456-1462.
6. Fahey, JW, Stephenson, KK, Dinkova-Kostova, AT, Egner, PA, Kensler, TW and Talalay, P. (2005) Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes. Carcinogenesis, 26, pp. 1247-1255.
7. Sharma, D., Kumar, SS and Sainis, KB. (2007) Antiapoptotic and immunomodulatory effects of chlorophyllin. Mol Immunol, 44, pp. 347-359.
8. Lam, CR and Brush, BE. (1950) Chlorophyll and wound healing; experimental and clinical study. Am J Surg, 80, pp. 204-210.
9. Sato, M., Imai, K., Kimura, R. and Murata, T. (1985) Effect of sodium copper chlorophyllin on lipid peroxidation. VIII. Its effect on carbon tetrachloride-induced liver injury in rats. Chem Pharm Bull, 33, pp. 3530-3533.
10. Yun, CH, Jeon, YJ, Yang, Y., Ju, HR and Han, SH. (2006) Chlorophyllin suppresses interleukin-1 beta expression in lipopolysaccharide-activated RAW 264.7 cells. Int Immunopharmacol, 6, pp. 252-259.
11. Mario, GF and Joshua, B. (2007) Digestion, absorption, and cancer preventative activity of dietary chlorophyll derivatives. Nutr Res, 27, pp. 1-12.
12. World cancer research fund/American institute for cancer research (1997) Food, nutrition and the prevention of cancer: A global perspective. Washington, DC
13. Lee, JS and Surh, YJ. (2005) Nrf2 as a novel molecular target for chemoprevention. Cancer Lett, 224, pp. 171-184.
14. Cho, HY, Reddy, SP, Debiase, A., Yamamoto, M. and Kleeberger, SR. (2005) Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med, 38, pp. 325-343.
15. Jaiswal, AK. (2004) Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med, 36, pp. 1199-1207.
16. Ryter, SW, Alam, J. and Choi, AM. (2006) Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications. Physiol Rev, 86, pp. 583-650.
17. Wagener, FA, Volk, HD, Willis, D., Abraham, NG, Soares, MP, Adema, GJ and Figdor, CG. (2003) Different faces of the heme-heme oxygenase system in inflammation. Pharmacol Rev, 55, pp. 551-571.
18. Monks, TJ, Hanzlik, RP, Cohen, GM, Ross, D. and Graham, DG. (1992) Quinone chemistry and toxicity. Toxicol Appl Pharmacol, 112, pp. 2-16.
19. Nioi, P. and Hayes, JD. (2004) Contribution of NAD(P)H:qUinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. Mutat Res, 555, pp. 149-171.
20. Ross, D. (2004) Quinone reductases multitasking in the metabolic world. Drug Metab Rev, 36, pp. 639-654.
21. Jaiswal, AK. (2000) Regulation of genes encoding NAD(P)H:qUinone oxidoreductases. Free Radic Biol Med, 29, pp. 254-262.
22. Nakaso, K., Yano, H., Fukuhara, Y., Takeshima, T., Wada-Isoe, K. and Nakashima, K. (2003) PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells. FEBS Lett, 546, pp. 181-184.
23. Kang, ES, Woo, IS, Kim, HJ, Eun, SY, Paek, KS, Kim, HJ, Chang, KC, Lee, JH, Lee, HT, Kim, JH, Nishinaka, T., Yabe-Nishimura, C. and Seo, HG. (2007) Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage. Free Radic Biol Med, 43, pp. 535-545.
24. Martin, D., Rojo, AI, Salinas, M., Diaz, R., Gallardo, G., Alam, J., De Galarreta, CM and Cuadrado, A. (2004) Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J Biol Chem, 279, pp. 8919-8929.
25. Putics, A., Vegh, EM, Csermely, P. and Soti, C. (2008) Resveratrol induces the heat-shock response and protects human cells from severe heat stress. Antioxid Redox Signal, 10, pp. 65-76.
26. Buettner, GR. (1987) Spin trapping: ESR parameters of spin adducts. Free Radic Biol Med, 3, pp. 259-303.
27. Zhang, Y., Xing, J., Ai, T., Wen, T., Guan, L. and Zhao, J. (2007) Protection of echinacoside against acute lung injury caused by oleic acid in rats. Free Radic Res, 41, pp. 798-805.
28. Ryter, SW, Kvam, E. and Tyrrell, RM. (2000) Heme oxygenase activity. Current methods and applications. Methods Mol Biol, 99, pp. 369-391.
29. Fahey, JW, Dinkova-Kostova, AT, Stephenson, KK and Talalay, P. (2004) The 'Prochaska' microtiter plate bioassay for inducers of NQO1. Methods Enzymol, 382, pp. 243-258.
30. Prochaska, HJ and Santamaria, AB. (1988) Direct measurement of NAD(P)H:qUinone reductase from cells cultured in micAotiter wells: a screening assay for anticarcinogenic enzyme inducers. Anal Biochem, 169, pp. 328-336.
31. Wagener, FA, Eggert, A., Boerman, OC, Oyen, WJ, Verhofstad, A., Abraham, NG, Adema, G., van Kooyk, Y., de Witte, T. and Figdor, CG. (2001) Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood, 98, pp. 1802-1811.
32. Jeney, V., Balla, J., Yachie, A., Varga, Z., Vercellotti, GM, Eaton, JW and Balla, G. (2002) Pro-oxidant and cytotoxic effects of circulating heme. Blood, 100, pp. 879-887.
33. Tilton, SC, Givan, SA, Pereira, CB, Bailey, GS and Williams, DE. (2006) Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout. Toxicol Sci, 90, pp. 61-72.
34. Dashwood, R., Negishi, T., Hayatsu, H., Breinholt, V., Hendricks, J. and Bailey, G. (1998) Chemopreventive properties of chlorophylls towards aflatoxin B1: A review of the antimutagenicity and anticarcinogenicity data in rainbow trout. Mutat Res, 399, pp. 245-253.
35. Nguyen, T., Yang, CS and Pickett, CB. (2004) The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress. Free Radic Biol Med, 37, pp. 433-441.
36. Kweon, MH, Park, Y In, Sung, HC and Mukhtar, H. (2006) The novel antioxidant 3-O-caffeoyl-1-methylquinic acid induces Nrf2-dependent phase II detoxifying genes and alters intracellular glutathione redox. Free Radic Biol Med, 40, pp. 1349-1361.
37. Pietrzak, M., Wieczorek, Z., Wieczorek, J. and Darzynkiewicz, Z. (2006) The 'interceptor' properties of chlorophyllin measured within the three-component system: Intercalator-DNA-chlorophyllin. Biophys Chem, 123, pp. 11-19.
38. Egner, PA, Wang, JB, Zhu, YR, Zhang, BC, Wu, Y., Zhang, QN, Qian, GS, Kuang, SY, Gange, SJ, Jacobson, LP, Helzlsouer, KJ, Bailey, GS, Groopman, JD and Kensler, TW. (2001) Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Proc Natl Acad Sci USA, 98, pp. 14601-14606.
39. Breinholt, V., Arbogast, D., Loveland, P., Pereira, C., Dashwood, R., Hendricks, J. and Bailey, G. (1999) Chlorophyllin chemoprevention in trout initiated by aflatoxin B(1) bath treatment: An evaluation of reduced bioavailability vs. target organ protective mechanisms. Toxicol Appl Pharmacol, 158, pp. 141-151.
40. Kamat, JP, Boloor, KK and Devasagayam, TP. (2000) Chlorophyllin as an effective antioxidant against membrane damage in vitro and ex vivo. Biochim Biophys Acta, 1487, pp. 113-127.
41. Kumar, SS, Shankar, B. and Sainis, KB. (2004) Effect of chlorophyllin against oxidative stress in splenic lymphocytes in vitro and in vivo. Biochim Biophys Acta, 1672, pp. 100-111.
42. Kapiotis, S., Hermann, M., Exner, M., Laggner, H. and Gmeiner, BM. (2005) Copper- and magnesium protoporphyrin complexes inhibit oxidative modification of LDL induced by hemin, transition metal ions and tyrosyl radicals. Free Radic Res, 39, pp. 1193-1202.