Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin

Journal of the American Heart Association

Volumn 4, Issue 2, 2015, Pages

  Schisler, Jonathan C ^a   Grevengoed, Trisha J ^b   Pascual, Florencia ^b   Cooper, Daniel E ^b   Ellis, Jessica M ^b   Paul, David S ^b   Willis, Monte S ^a   Patterson, Cam ^a   Jia, Wei ^c   Coleman, Rosalind A ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

acyl CoA synthetase; Fuel switching; Glutathione; MTOR; Oxidative stress

Indexed keywords

ACYL COENZYME A SYNTHETASE 1; ASPARTATE AMMONIA LIGASE; CYSTEINE; FIBROBLAST GROWTH FACTOR 21; GLUCOSE; GLUTATHIONE; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE A2; GROWTH DIFFERENTIATION FACTOR 15; LONG CHAIN FATTY ACID COENZYME A LIGASE; MAMMALIAN TARGET OF RAPAMYCIN; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; UNCLASSIFIED DRUG; ACSL1 PROTEIN, MOUSE; COENZYME A LIGASE; FATTY ACID; MTOR PROTEIN, HUMAN; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARAGINE SYNTHETASE GENE; CONTROLLED STUDY; FATTY ACID OXIDATION; FIBROBLAST GROWTH FACTOR 21 GENE; GENE; GENE EXPRESSION; GLUCOSE METABOLISM; GLUTATHIONE METABOLISM; GLUTATHIONE S TRANSFERASE ALPHA GENE; GLYCOLYSIS; GROWTH DIFFERENTIATION FACTOR 15 GENE; HEART MUSCLE METABOLISM; HEART VENTRICLE HYPERTROPHY; MALE; METABOLOMICS; METHYLENE TETRAHYDROFOLATE DEHYDROGENASE GENE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SCL7A5 GENE; SIGNAL TRANSDUCTION; TRIBBLES HOMOLOG 3 GENE; ANIMAL; CARBOHYDRATE METABOLISM; CARDIAC MUSCLE; DEFICIENCY; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; LIPID METABOLISM; METABOLISM; OXIDATION REDUCTION REACTION;

ANIMALS; CARBOHYDRATE METABOLISM; COENZYME A LIGASES; CYSTEINE; FATTY ACIDS; GLUCOSE; GLUTATHIONE; LIPID METABOLISM; MICE; MICE, KNOCKOUT; MYOCARDIUM; OXIDATION-REDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 85003906012     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.114.001136     Document Type: Article

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