Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury

Journal of Clinical Investigation

Volumn 118, Issue 10, 2008, Pages 3503-3512

  Lewis, Gregory D ^a,b,c   Wei, Ru ^c   Liu, Emerson ^a,b   Yang, Elaine ^c   Shi, Xu ^a   Martinovic, Maryann ^a   Farrell, Laurie ^a   Asnani, Aarti ^a,c   Cyrille, Marcoli ^a   Ramanathan, Arvind ^c   Shaham, Oded ^a,c   Berriz, Gabriel ^b   Lowry, Patricia A ^a   Palacios, Igor F ^a   Taşan, Murat ^b   Roth, Frederick P ^b   Min, Jiangyong ^d   Baumgartner, Christian ^e   Keshishian, Hasmik ^c   Addona, Terri ^c   Mootha, Vamsi K ^a,c   Rosenzweig, Anthony ^d   Carr, Steven A ^c   Fifer, Michael A ^a   Sabatine, Marc S ^a,b,f   Gerszten, Robert E ^a,b,c   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^e UNIVERSITY FOR HEALTH SCIENCES   (Austria)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACONITIC ACID; BIOLOGICAL MARKER; HYPOXANTHINE; NITRIC OXIDE; PENTOSE PHOSPHATE; PYRIMIDINE; THREONINE; TRICARBOXYLIC ACID; TRIMETHYLAMINE;

ADULT; AGED; ANGIOCARDIOGRAPHY; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CITRIC ACID CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY SINUS; DIAGNOSTIC ACCURACY; FEMALE; HEART INFARCTION; HEART MUSCLE INJURY; HUMAN; MALE; METABOLITE; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PYRIMIDINE METABOLISM; VALIDATION PROCESS;

AGED; ANIMALS; BIOLOGICAL MARKERS; CELLS, CULTURED; CORONARY SINUS; FEMALE; HEART INJURIES; HUMANS; ISOTOPES; KINETICS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RATS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; TIME FACTORS;

EID: 55849144043     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI35111     Document Type: Article

References (47)

1. Nicholson, J.K., and Wilson, I.D. 2003. Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. 2:668-676.
2. Raamsdonk, L.M., et al. 2001. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat. Biotechnol. 19:45-50.
3. Allen, J., et al. 2003. High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nat. Biotechnol. 21:692-696.
4. An, J., et al. 2004. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat. Med. 10:268-274.
5. Beecher, C.W.W. 2003. Chap. 17 in The human metabolome. Kluwer Academic Publishers. Boston, Massachusetts, USA. 311-319.
6. He, W., et al. 2004. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature. 429:188-193.
7. Brindle, J.T., et al. 2002. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat. Med. 8:1439-1444.
8. Kirschenlohr, H.L., et al. 2006. Proton NMR analysis of plasma is a weak predictor of coronary artery disease. Nat. Med. 12:705-710.
9. Lee, M.S., and Kerns, E.H. 1999. LC/MS applications in drug development. Mass. Spectrom. Rev. 18:187-279.
10. Sabatine, M.S., et al. 2005. Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation. 112:3868-3875.
11. Sigwart, U. 1995. Non-surgical myocardial reduction for hypertrophic obstructive cardiomyopathy. Lancet. 346:211-214.
12. Knight, C., et al. 1997. Nonsurgical septal reduction for hypertrophic obstructive cardiomyopathy: outcome in the first series of patients. Circulation. 95:2075-2081.
13. Lakkis, N.M., et al. 1998. Echocardiography-guided ethanol septal reduction for hypertrophic obstructive cardiomyopathy. Circulation. 98:1750-1755.
14. Lakkis, N.M., Nagueh, S.F., Dunn, J.K., Killip, D., and Spencer, W.H., 3rd. 2000. Nonsurgical septal reduction therapy for hypertrophic obstructive cardiomyopathy: one-year follow-up. J. Am. Coll. Cardiol. 36:852-855.
15. Yoerger, D.M., et al. 2006. Time course of pressure gradient response after first alcohol septal ablation for obstructive hypertrophic cardiomyopathy. Am. J. Cardiol. 97:1511-1514.
16. Zimmerman, J., et al. 1999. Diagnostic marker cooperative study for the diagnosis of myocardial infarction. Circulation. 99:1671-1677.
17. Ransohoff, D.F. 2005. Bias as a threat to the validity of cancer molecular-marker research. Nat. Rev. Cancer. 5:142-149.
18. Ransohoff, D.F. 2004. Rules of evidence for cancer molecular-marker discovery and validation. Nat. Rev. Cancer. 4:309-314.
19. Roberts, R., Gowda, K.S., Ludbrook, P.A., and Sobel, B.E. 1975. Specificity of elevated serum MB creatine phosphokinase activity in the diagnosis of acute myocardial infarction. Am. J. Cardiol. 36:433-437.
20. Matsui, T., et al. 1999. Adenoviral gene transfer of activated PI 3-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation. 100:2373-2379.
21. Albert, J.D., et al. 1986. Extremity amino acid metabolism during starvation and intravenous refeeding in humans. Am. J. Physiol. 251:E604-E610.
22. Scriver, C.R., Gregory, D.M., Sovetts, D., and Tissenbaum, G. 1985. Normal plasma free amino acid values in adults: the influence of some common physiological variables. Metabolism. 34:868-873.
23. Traut, T.W. 1994. Physiological concentrations of purines and pyrimidines. Mol. Cell. Biochem. 140:1-22.
24. Wevers, R.A., Engelke, U., and Heerschap, A. 1994. High-resolution 1H-NMR spectroscopy of blood plasma for metabolic studies. Clin. Chem. 40:1245-1250.
25. Wishart, D.S., et al. 2007. HMDB: The Human Metabolome Database. Nucleic Acids Res. 35:D521-D526.
26. Goldhaber, S.Z., et al. 1982. Inosine: a protective agent in an organ culture model of myocardial ischemia. Circ. Res. 51:181-188.
27. Xia, Y., and Zweier, J.L. 1995. Substrate control of free radical generation from xanthine oxidase in the postischemic heart. J. Biol. Chem. 270:18797-18803.
28. Song, D., O'Regan, M.H., and Phillis, J.W. 1998. Mechanisms of amino acid release from the isolated anoxic/reperfused rat heart. Eur. J. Pharmacol. 351:313-322.
29. Dorheim, T.A., Wang, T., Mentzer, R.M., Jr., and Van Wylen, D.G. 1990. Interstitial purine metabolites during regional myocardial ischemia. J. Surg. Res. 48:491-497.
30. Delyani, J.A., and Van Wylen, D.G. 1994. Endocardial and epicardial interstitial purines and lactate during graded ischemia. Am. J. Physiol. 266:H1019-H1026.
31. Mei, D.A., Gross, G.J., and Nithipatikom, K. 1996. Simultaneous determination of adenosine, inosine, hypoxanthine, xanthine, and uric acid in microdialysis samples using microbore column high-performance liquid chromatography with a diode array detector. Anal. Biochem. 238:34-39.
32. Backstrom, T., et al. 2003. Cardiac outflow of amino acids and purines during myocardial ischemia and reperfusion. J. Appl. Physiol. 94:1122-1128.
33. Zemgulis, V., et al. 2001. Energy-related metabolites during and after induced myocardial infarction with special emphasis on the reperfusion injury after extracorporeal circulation. Acta. Physiol. Scand. 171:129-143.
34. Hassel, B., Ilebekk, A., and Tonnessen, T. 1998. Cardiac accumulation of citrate during brief myocardial ischaemia and reperfusion in the pig in vivo. Acta. Physiol. Scand. 164:53-59.
35. Osterlund, B., et al. 2002. Myocardial ischemia induces coronary t-PA release in the pig. Acta. Anaesthesiol. Scand. 46:271-278.
36. Mudge, G.H., Jr., Mills, R.M., Jr., Taegtmeyer, H., Gorlin, R., and Lesch, M. 1976. Alterations of myocardial amino acid metabolism in chronic ischemic heart disease. J. Clin. Invest. 58:1185-1192.
37. Srinivasan, K.N., et al. 1998. Comparison of glycoprotein components, tryptophan, lipid peroxidation and antioxidants in borderline and severe hypertension and myocardial infarction. Clin. Chim. Acta. 275:197-203.
38. Wirleitner, B., et al. 2003. Immune activation and degradation of tryptophan in coronary heart disease. Eur. J. Clin. Invest. 33:550-554.
39. Turgan, N., et al. 1999. Urinary hypoxanthine and xanthine levels in acute coronary syndromes. Int. J. Clin. Lab. Res. 29:162-165.
40. Pisarenko, O.I., et al. 1989. Features of myocardial metabolism of some amino acids and ammonia in patients with coronary artery disease. Eur. Heart J. 10:209-217.
41. Smolenski, R.T., et al. 1993. Formation and breakdown of uridine in ischemic hearts of rats and humans. J. Mol. Cell. Cardiol. 25:67-74.
42. Kennergren, C., et al. 1999. Extracellular amino acids as markers of myocardial ischemia during cardioplegic heart arrest. Cardiology. 91:31-40.
43. Svedjeholm, R., et al. 1991. Myocardial uptake of amino acids and other substrates in relation to myocardial oxygen consumption four hours after cardiac operations. J. Thorac. Cardiovasc. Surg. 101:688-694.
44. Keyzer, J.J., Breukelman, H., Wolthers, B.G., Richardson, F.J., and de Monchy, J.G. 1985. Measurement of N tau-methylhistamine concentrations in plasma and urine as a parameter for histamine release during anaphylactoid reactions. Agents Actions. 16:76-79.
45. Morrow, D.A., de Lemos, J.A., Sabatine, M.S., and Antman, E.M. 2003. The search for a biomarker of cardiac ischemia. Clin. Chem. 49:537-539.
46. Baggish, A.L., et al. 2006. Pathological effects of alcohol septal ablation for hypertrophic obstructive cardiomyopathy. Heart. 92:1773-1778.
47. Benjamini, Y., and Hochberg, Y. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society, Series B. 57:289-300.