Efficient CRM197-mediated drug targeting to monocytes

Journal of Controlled Release

Volumn 158, Issue 1, 2012, Pages 139-147

  Schenk, Geert J ^a   Haasnoot, P C Joost ^b,d   Centlivre, Mireille ^b   Legrand, Nicolas ^c,e   Rip, Jaap ^a,f   De Boer, Albertus G ^a   Berkhout, Ben ^b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b Center for Infection and Immunity Amsterdam CINIMA   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d CRUCELL HOLLAND BV   (Netherlands)

^e AIMM Therapeutics   (Netherlands)

^f to BBB Technologies BV   (Netherlands)

Author keywords

CRM197; Drug targeting; HB EGF; Human immune system mouse; Monocytes

Indexed keywords

BODY FLUIDS; MACROINVERTEBRATES;

CRM197; DRUG-TARGETING; EPIDERMAL GROWTH FACTORS; HEPARIN BINDING; HEPARIN-BINDING EPIDERMAL GROWTH FACTOR; HUMAN IMMUNE SYSTEM MOUSE; HUMAN IMMUNE SYSTEMS; MONOCYTE;

MAMMALS;

DIPHTHERIA TOXOID CRM197; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; LIPOSOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SURFACE; DENDRITIC CELL; DRUG TARGETING; ENDOCYTOSIS; FEMALE; HAMSTER; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNE SYSTEM; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

EID: 84857809172     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.09.091     Document Type: Article

References (50)

1. J.A. Abraham, D. Damm, A. Bajardi, J. Miller, M. Klagsbrun, and R.A. Ezekowitz Heparin-binding EGF-like growth factor: characterization of rat and mouse cDNA clones, protein domain conservation across species, and transcript expression in tissues Biochem. Biophys. Res. Commun. 190 1 1993 125 133 (Pubitemid 23227297)
2. Y. Nakamura, K. Handa, R. Iwamoto, T. Tsukamoto, M. Takahasi, and E. Mekada Immunohistochemical distribution of CD9, heparin binding epidermal growth factor-like growth factor, and integrin alpha3beta1 in normal human tissues J. Histochem. Cytochem. 49 4 2001 439 444 (Pubitemid 32295165)
3. S. Higashiyama, J.A. Abraham, J. Miller, J.C. Fiddes, and M. Klagsbrun A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF Science 251 4996 1991 936 939 (Pubitemid 21926188)
4. E. Nishi, N. Kume, H. Ochi, H. Moriwaki, S. Higashiyama, N. Taniguchi, and T. Kita Lysophosphatidylcholine induces heparin-binding epidermal growth factor-like growth factor and interferon-gamma in human T-lymphocytes Ann. N. Y. Acad. Sci. 811 1997 519 524 (Pubitemid 27308361)
5. E. Nishi, N. Kume, H. Ochi, H. Moriwaki, Y. Wakatsuki, S. Higashiyama, N. Taniguchi, and T. Kita Lysophosphatidylcholine increases expression of heparin-binding epidermal growth factor-like growth factor in human T lymphocytes Circ. Res. 80 5 1997 638 644 (Pubitemid 27181346)
6. Z. Pan, V.V. Kravchenko, and R.D. Ye Platelet-activating factor stimulates transcription of the heparin-binding epidermal growth factor-like growth factor in monocytes. Correlation with an increased kappa B binding activity J. Biol. Chem. 270 14 1995 7787 7790
7. P.P. Powell, M. Klagsbrun, J.A. Abraham, and R.C. Jones Eosinophils expressing heparin-binding EGF-like growth factor mRNA localize around lung microvessels in pulmonary hypertension Am. J. Pathol. 143 3 1993 784 793 (Pubitemid 24058234)
8. F. Vinante, M. Marchi, A. Rigo, P. Scapini, G. Pizzolo, and M.A. Cassatella Granulocyte-macrophage colony-stimulating factor induces expression of heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor and sensitivity to diphtheria toxin in human neutrophils Blood 94 9 1999 3169 3177 (Pubitemid 29512725)
9. F. Vinante, A. Rigo, E. Papini, M.A. Cassatella, and G. Pizzolo Heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor expression by acute myeloid leukemia cells Blood 93 5 1999 1715 1723 (Pubitemid 29102500)
10. Y. Shishido, K.D. Sharma, S. Higashiyama, M. Klagsbrun, and E. Mekada Heparin-like molecules on the cell surface potentiate binding of diphtheria toxin to the diphtheria toxin receptor/membrane-anchored heparin-binding epidermal growth factor-like growth factor J. Biol. Chem. 270 49 1995 29578 29585
11. J.S. Brooke, J.H. Cha, and L. Eidels Diphtheria toxin:receptor interaction: association, dissociation, and effect of pH Biochem. Biophys. Res. Commun. 248 2 1998 297 302 (Pubitemid 28386416)
12. P. Anderson Antibody responses to Haemophilus influenzae type b and diphtheria toxin induced by conjugates of oligosaccharides of the type b capsule with the nontoxic protein CRM197 Infect. Immun. 39 1 1983 233 238 (Pubitemid 13212521)
13. A.G. de Boer, and P.J. Gaillard Strategies to improve drug delivery across the blood-brain barrier Clin. Pharmacokinet. 46 7 2007 553 576 (Pubitemid 47025357)
14. P.J. Gaillard, and A.G. de Boer A novel opportunity for targeted drug delivery to the brain J. Control. Release 116 2 2006 e60 e62
15. P.J. Gaillard, and A.G. de Boer 2B-Trans technology: targeted drug delivery across the blood-brain barrier Meth. Mol. Biol. 437 2008 161 175
16. P.J. Gaillard, C.C. Visser, and A.G. de Boer Targeted delivery across the blood-brain barrier Expert Opin. Drug Deliv. 2 2 2005 299 309 (Pubitemid 41130884)
17. J. Rip, G.J. Schenk, and A.G. de Boer Differential receptor-mediated drug targeting to the diseased brain Expert Opin. Drug Deliv 6 3 2009 227 237
18. D.B. Buxton Nanomedicine for the management of lung and blood diseases Nanomedicine (Lond.) 4 3 2009 331 339
19. P. Sapra, and T.M. Allen Improved outcome when B-cell lymphoma is treated with combinations of immunoliposomal anticancer drugs targeted to both the CD19 and CD20 epitopes Clin. Cancer Res. 10 7 2004 2530 2537 (Pubitemid 38445715)
20. P. Kumar, H.S. Ban, S.S. Kim, H. Wu, T. Pearson, D.L. Greiner, A. Laouar, J. Yao, V. Haridas, K. Habiro, Y.G. Yang, J.H. Jeong, K.Y. Lee, Y.H. Kim, S.W. Kim, M. Peipp, G.H. Fey, N. Manjunath, L.D. Shultz, S.K. Lee, and P. Shankar T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice Cell 134 4 2008 577 586
21. Z. Lei, G.M. Zhang, M. Hong, Z.H. Feng, and B. Huang Fusion of dendritic cells and CD34+CD38- acute myeloid leukemia (AML) cells potentiates targeting AML-initiating cells by specific CTL induction J. Immunother. 32 4 2009 408 414
22. A.J. Steele, A.G. Prentice, A.V. Hoffbrand, B.C. Yogashangary, S.M. Hart, M.W. Lowdell, E.R. Samuel, J.M. North, E.P. Nacheva, A. Chanalaris, P. Kottaridis, K. Cwynarski, and R.G. Wickremasinghe 2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells Blood 114 6 2009 1217 1225
23. D. Peer, and M. Shimaoka Systemic siRNA delivery to leukocyte-implicated diseases Cell cycle (Georgetown, Tex) 8 6 2009 853 859
24. C.C. Visser, S. Stevanovic, L.H. Voorwinden, L. van Bloois, P.J. Gaillard, M. Danhof, D.J. Crommelin, and A.G. de Boer Targeting liposomes with protein drugs to the blood-brain barrier in vitro Eur. J. Pharm. Sci. 25 2-3 2005 299 305 (Pubitemid 40725060)
25. J.H. Cha, J.S. Brooke, and L. Eidels Toxin binding site of the diphtheria toxin receptor: loss and gain of diphtheria toxin binding of monkey and mouse heparin-binding, epidermal growth factor-like growth factor precursors by reciprocal site-directed mutagenesis Mol. Microbiol. 29 5 1998 1275 1284 (Pubitemid 28408849)
26. J.H. Cha, M.Y. Chang, J.A. Richardson, and L. Eidels Transgenic mice expressing the diphtheria toxin receptor are sensitive to the toxin Mol. Microbiol. 49 1 2003 235 240 (Pubitemid 36792017)
27. K. Weijer, C.H. Uittenbogaart, A. Voordouw, F. Couwenberg, J. Seppen, B. Blom, F.A. Vyth-Dreese, and H. Spits Intrathymic and extrathymic development of human plasmacytoid dendritic cell precursors in vivo Blood 99 8 2002 2752 2759 (Pubitemid 34525362)
28. R. Gimeno, K. Weijer, A. Voordouw, C.H. Uittenbogaart, N. Legrand, N.L. Alves, E. Wijnands, B. Blom, and H. Spits Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells Blood 104 13 2004 3886 3893 (Pubitemid 39620134)
29. N. Legrand, K. Weijer, and H. Spits Experimental model for the study of the human immune system: production and monitoring of "human immune system" Rag2-/-gamma c-/- mice Meth. Mol. Biol. 415 2008 65 82
30. E. Traggiai, L. Chicha, L. Mazzucchelli, L. Bronz, J.C. Piffaretti, A. Lanzavecchia, and M.G. Manz Development of a human adaptive immune system in cord blood cell-transplanted mice Science 304 5667 2004 104 107 (Pubitemid 38451466)
31. R.B. Dorland, J.L. Middlebrook, and S.H. Leppla Receptor-mediated internalization and degradation of diphtheria toxin by monkey kidney cells J. Biol. Chem. 254 22 1979 11337 11342 (Pubitemid 10136147)
32. G. Raab, and M. Klagsbrun Heparin-binding EGF-like growth factor Biochim. Biophys. Acta 1333 3 1997 F179 F199
33. S. Higashiyama, R. Iwamoto, K. Goishi, G. Raab, N. Taniguchi, M. Klagsbrun, and E. Mekada The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor J. Cell Biol. 128 5 1995 929 938
34. R. Iwamoto, S. Higashiyama, T. Mitamura, N. Taniguchi, M. Klagsbrun, and E. Mekada Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity EMBO J. 13 10 1994 2322 2330
35. K. Nakamura, R. Iwamoto, and E. Mekada Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) and diphtheria toxin receptor-associated protein (DRAP27)/CD9 form a complex with integrin alpha 3 beta 1 at cell-cell contact sites J. Cell Biol. 129 6 1995 1691 1705
36. Y. Kinugasa, M. Hieda, M. Hori, and S. Higashiyama The carboxyl-terminal fragment of pro-HB-EGF reverses Bcl6-mediated gene repression J. Biol. Chem. 282 20 2007 14797 14806 (Pubitemid 47093367)
37. D. Nanba, A. Mammoto, K. Hashimoto, and S. Higashiyama Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF J. Cell Biol. 163 3 2003 489 502 (Pubitemid 37429863)
38. T. Shimura, H. Kataoka, N. Ogasawara, E. Kubota, M. Sasaki, S. Tanida, and T. Joh Suppression of proHB-EGF carboxy-terminal fragment nuclear translocation: a new molecular target therapy for gastric cancer Clin. Cancer Res. 14 12 2008 3956 3965
39. S.M. Demos, S. Dagar, M. Klegerman, A. Nagaraj, D.D. McPherson, and H. Onyuksel In vitro targeting of acoustically reflective immunoliposomes to fibrin under various flow conditions J. Drug Target. 5 6 1998 507 518 (Pubitemid 28499684)
40. S.R. Chakravarthy, and T.D. Giorgio Shear stress-facilitated calcium ion transport across lipid bilayers Biochim. Biophys. Acta 1112 2 1992 197 204
41. F. Yotsumoto, H. Yagi, S.O. Suzuki, E. Oki, H. Tsujioka, T. Hachisuga, K. Sonoda, T. Kawarabayashi, E. Mekada, and S. Miyamoto Validation of HB-EGF and amphiregulin as targets for human cancer therapy Biochem. Biophys. Res. Commun. 365 3 2008 555 561 (Pubitemid 350181687)
42. S. Miyamoto, H. Yagi, F. Yotsumoto, S. Horiuchi, T. Yoshizato, T. Kawarabayashi, M. Kuroki, and E. Mekada New approach to cancer therapy: heparin binding-epidermal growth factor-like growth factor as a novel targeting molecule Anticancer. Res. 27 6A 2007 3713 3721 (Pubitemid 47598435)
43. F. Yotsumoto, E. Oki, E. Tokunaga, Y. Maehara, M. Kuroki, S. Miyamoto, HB-EGF orchestrates the complex signals involved in triple-negative and trastuzumab-resistant breast cancer. International journal of cancer 127(11) 2707-2717.
44. H. Yagi, F. Yotsumoto, K. Sonoda, M. Kuroki, E. Mekada, and S. Miyamoto Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer Int. J. Cancer 124 6 2009 1429 1439
45. D. Franciotta, M. Salvetti, F. Lolli, B. Serafini, and F. Aloisi B cells and multiple sclerosis Lancet Neurol. 7 9 2008 852 858
46. B. Kornek, and H. Lassmann Neuropathology of multiple sclerosis-new concepts Brain Res. Bull. 61 3 2003 321 326
47. J. van Horssen, G. Schreibelt, J. Drexhage, T. Hazes, C.D. Dijkstra, P. van der Valk, and H.E. de Vries Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression Free Radic. Biol. Med. 45 12 2008 1729 1737
48. B. Engelhardt The blood-central nervous system barriers actively control immune cell entry into the central nervous system Curr. Pharm. Des. 14 16 2008 1555 1565 (Pubitemid 352002983)
49. J. Haasnoot, and B. Berkhout Nucleic acids-based therapeutics in the battle against pathogenic viruses Handb. Exp. Pharmacol. 189 2009 243 263
50. V. Terzieva Regulatory T cells and HIV-1 infection Viral Immunol. 21 3 2008 285 291