Characteristics of dyshoric capillary cerebral amyloid angiopathy

Journal of Neuropathology and Experimental Neurology

Volumn 69, Issue 11, 2010, Pages 1158-1167

  Richard, Edo ^a   Carrano, Anna ^b   Hoozemans, Jeroen J ^b   Van Horssen, Jack ^b   Van Haastert, Elise S ^b   Eurelings, Lisa S ^a   De Vries, Helga E ^b   Thal, Dietmar R ^c   Eikelenboom, Piet ^a   Van Gool, Willem A ^a   Rozemuller, Annemieke J M ^b,d  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF ULM   (Germany)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Alzheimer; Capillary cerebral amyloid angiopathy; Cerebral amyloid angiopathy; Dementia; Dyshoric; Neuroinflammation

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E; APOLIPOPROTEIN E4; TAU PROTEIN; UBIQUITIN;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BRAIN BLOOD VESSEL; BRAIN CAPILLARY; BRAIN CIRCULATION; CAPILLARY WALL; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DEMENTIA; DEPRESSION; DISEASE SEVERITY; DYSHORIC CAPILLARY CEREBRAL AMYLOID ANGIOPATHY; FEMALE; GENE FREQUENCY; GENOTYPE; HISTOPATHOLOGY; HOMOZYGOSITY; HUMAN; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEWY BODY; MALE; MICROGLIA; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NEUROPIL; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; VASCULAR AMYLOIDOSIS;

AGED; AGED, 80 AND OVER; AMYLOID BETA-PROTEIN; APOLIPOPROTEIN E4; BRAIN; CAPILLARIES; CEREBRAL AMYLOID ANGIOPATHY; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HLA-DR ANTIGENS; HUMANS; MALE; MENINGEAL ARTERIES; TAU PROTEINS; UBIQUITIN;

EID: 78049344281     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181fab558     Document Type: Article

References (40)

1. Revesz T, Ghiso J, Lashley T, et al. Cerebral amyloid angiopathies: A pathologic, biochemical, and genetic view. J Neuropathol Exp Neurol 2003;62:885-98
2. Bergeron C, Ranalli PJ, Miceli PN. Amyloid angiopathy in Alzheimer's disease. Can J Neurol Sci 1987;14:564-69
3. Ellis RJ, Olichney JM, Thal LJ, et al. Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, Part XV. Neurology 1996;46:1592-96
4. Alafuzoff I, Thal DR, Arzberger T, et al. Assessment of beta-amyloid deposits in human brain: A study of the BrainNet Europe Consortium. Acta Neuropathol 2009;117:309-20
5. Thal DR, Ghebremedhin E, Orantes M, et al. Vascular pathology in Alzheimer disease: Correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline. J Neuropathol Exp Neurol 2003;62:1287-301
6. Thal DR, Ghebremedhin E, Rub U, et al. Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol 2002;61:282-93
7. Attems J, Jellinger KA. Only cerebral capillary amyloid angiopathy correlates with Alzheimer pathology: A pilot study. Acta Neuropathol 2004;107:83-90
8. Jellinger KA, Attems J. Prevalence and pathogenic role of cerebrovascular lesions in Alzheimer disease. J Neurol Sci 2005;229-230:37-41
9. Thal DR, Griffin WS, De Vos RA, et al. Cerebral amyloid angiopathy and its relationship to Alzheimer's disease. Acta Neuropathol 2008;115: 599-609
10. Vidal R, Calero M, Piccardo P, et al. Senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-epsilon4 allele. Acta Neuropathol 2000;100:1-12
11. Attems J. Sporadic cerebral amyloid angiopathy: Pathology, clinical implications, and possible pathomechanisms. Acta Neuropathol 2005;110: 345-59
12. Surbek B. L'angiopathie dyshorique (Morel) De l'écorce cérébrale. Etude anatomo-clinique et statistique, aspect génétique. Acta Neuropathologica 1961;1:168-97
13. Morel F. Petite contribution a l'etude d'une angiopathie apparemment dyshorique et topistique. Rev Mens Psychiat Neurol 1950;120:352-57
14. Pantelakis S. [A particular type of senile angiopathy of the central nervous system: Congophilic angiopathy, topography and frequency]. Monatsschr Psychiatr Neurol 1954;128:219-56
15. Scholz W. Studien zur Pathologie der HirngefäAe. II. Die drusige Entartung der Hirnarterien und Ycapillaren (eine Form seniler GefäAerkrankung). Z Ges Neurol Psychiatr 1938;162:694-715
16. Schlote W. Die Amyloidnatur der kongophilen, drusige entartung der Hirnarterien (Scholz) im Senium. Acta Neuropathologica 1965;4:449-68
17. Attems J, Lintner F, Jellinger KA. Amyloid beta peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology. Acta Neuropathol 2004;107:283-91 (Pubitemid 38477354)
18. Jeynes B, Provias J. The possible role of capillary cerebral amyloid angiopathy in Alzheimer lesion development: A regional comparison. Acta Neuropathol 2006;112:417-27
19. Oshima K, Akiyama H, Tsuchiya K, et al. Relative paucity of tau accumulation in the small areas with abundant Abeta42-positive capillary amyloid angiopathy within a given cortical region in the brain of patients with Alzheimer pathology. Acta Neuropathol 2006;111:510-18
20. Delacourte A, Defossez A, Persuy P, et al. Observation of morphological relationships between angiopathic blood vessels and degenerative neu-rites in Alzheimer's disease. Virchows Arch A Pathol Anat Histopathol 1987;411:199-204
21. Williams S, Chalmers K, Wilcock GK, et al. Relationship of neuro-fibrillary pathology to cerebral amyloid angiopathy in Alzheimer's disease. Neuropathol Appl Neurobiol 2005;31:414-21
22. Oshima K, Uchikado H, Dickson DW. Perivascular neuritic dystrophy associated with cerebral amyloid angiopathy in Alzheimer's disease. Int J Clin Exp Pathol 2008;1:403-8
23. Rozemuller JM, Eikelenboom P, Stam FC, et al. A4 protein in Alzheimer's disease: Primary and secondary cellular events in extracellular amyloid deposition. J Neuropathol Exp Neurol 1989;48:674-91
24. Akiyama H, Barger S, Barnum S, et al. Inflammation and Alzheimer's disease. Neurobiol Aging 2000;21:383-21
25. Eikelenboom P, Veerhuis R, Familian A, et al. Neuroinflammation in plaque and vascular beta-amyloid disorders: Clinical and therapeutic implications. Neurodegener Dis 2008;5:190-93
26. Yamada M, Itoh Y, Suematsu N, et al. Vascular variant of Alzheimer's disease characterized by severe plaque-like beta protein angiopathy. Dement Geriatr Cogn Disord 1997;8:163-68
27. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239-59
28. Braak H, Alafuzoff I, Arzberger T, et al. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immuno-cytochemistry. Acta Neuropathol 2006;112:389-404
29. Copani A, Hoozemans JJ, Caraci F, et al. DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid. J Neurosci 2006;26:10949-57
30. Hoozemans JJ, van Haastert ES, Nijholt DA, et al. The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus. Am J Pathol 2009;174:1241-51
31. Pollio G, Hoozemans JJ, Andersen CA, et al. Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity. Neurobiol Dis 2008;31:145-58
32. Slooter AJ, van Duijn CM. Genetic epidemiology of Alzheimer disease. Epidemiol Rev 1997;19:107-19
33. Poirier J, Davignon J, Bouthillier D, et al. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 1993;342:697-99
34. Arends YM, Duyckaerts C, Rozemuller JM, et al. Microglia, amyloid and dementia in alzheimer disease. A correlative study. Neurobiol Aging 2000;21:39-47
35. Rozemuller AJ, van Gool WA, Eikelenboom P. The neuroinflammatory response in plaques and amyloid angiopathy in Alzheimer's disease: Therapeutic implications. Curr Drug Targets CNS Neurol Disord 2005;4: 223-33
36. Boche D, Zotova E, Weller RO, et al. Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain 2008;131:3299-310
37. Deane R, Zlokovic BV. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Curr Alzheimer Res 2007;4:191-97
38. Shibata M, Yamada S, Kumar SR, et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 2000;106:1489-99
39. Tanzi RE, Moir RD, Wagner SL. Clearance of Alzheimer's Abeta peptide: The many roads to perdition. Neuron 2004;43:605-8
40. Weller RO, Subash M, Preston SD, et al. Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol 2008;18:253-66