SCOPUS 정보 검색 플랫폼

Volumn 7, Issue 12, 2016, Pages 2349-2363

Design, synthesis and anticancer activity of dihydropyrimidinone-semicarbazone hybrids as potential human DNA ligase 1 inhibitors

(10) Sashidhara, Koneni V a Singh, L Ravithej a Shameem, Mohammad a Shakya, Sarika a Kumar, Anoop a Laxman, Tulsankar Sachin a Krishna, Shagun a Siddiqi, Mohammad Imran a Bhatta, Rabi S a Banerjee, Dibyendu a

a CENTRAL DRUG RESEARCH INSTITUTE (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTINEOPLASTIC AGENT; DIHYDROPYRIMIDINONE SEMICARBAZONE HYBRID; DOXORUBICIN; ENZYME INHIBITOR; GAMMA HISTONE H2AX; HISTONE H2AX; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING SITE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING MOTIF; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA BINDING; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HEPG2 CELL LINE; HYDROGEN BOND; IC50; IN VITRO STUDY; INFRARED SPECTROSCOPY; MALE; MASS SPECTROMETRY; MOLECULAR DOCKING; NONHUMAN; PHARMACOKINETIC PARAMETERS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SINGLE STRANDED DNA BREAK; UPREGULATION; WESTERN BLOTTING;

EID: 85003608936 PISSN: 20402503 EISSN: 20402511 Source Type: Journal
DOI: 10.1039/c6md00447d Document Type: Article

Times cited : (26)

References (50)

1
- 0023904730
- J. J. Blow R. A. Laskey Nature 1988 332 546-548
- (1988) Nature , vol.332 , pp. 546-548
- Blow, J.J.¹ Laskey, R.A.²

2
- 48249095920
- K. W. Caldecott Nat. Rev. Genet. 2008 9 619-631
- (2008) Nat. Rev. Genet. , vol.9 , pp. 619-631
- Caldecott, K.W.¹

3
- 0014251791
- R. Okazaki T. Okazaki K. Sakabe K. Sugimoto A. Sugino Proc. Natl. Acad. Sci. U. S. A. 1968 59 598-605
- (1968) Proc. Natl. Acad. Sci. U. S. A. , vol.59 , pp. 598-605
- Okazaki, R.¹ Okazaki, T.² Sakabe, K.³ Sugimoto, K.⁴ Sugino, A.⁵

4
- 0016273515
- I. R. Lehman Science 1974 186 790-797
- (1974) Science , vol.186 , pp. 790-797
- Lehman, I.R.¹

5
- 0018293351
- F. Fabre H. Roman Proc. Natl. Acad. Sci. U. S. A. 1979 76 4586-4588
- (1979) Proc. Natl. Acad. Sci. U. S. A. , vol.76 , pp. 4586-4588
- Fabre, F.¹ Roman, H.²

6
- 0028047308
- C. Prigent M. S. Satoh G. Daly D. E. Barnes T. Lindahl Mol. Cell. Biol. 1994 14 310-317
- (1994) Mol. Cell. Biol. , vol.14 , pp. 310-317
- Prigent, C.¹ Satoh, M.S.² Daly, G.³ Barnes, D.E.⁴ Lindahl, T.⁵

7
- 33644624369
- A. E. Tomkinson S. Vijayakumar J. M. Pascal T. Ellenberger Chem. Rev. 2006 106 687-699
- (2006) Chem. Rev. , vol.106 , pp. 687-699
- Tomkinson, A.E.¹ Vijayakumar, S.² Pascal, J.M.³ Ellenberger, T.⁴

8
- 9644289536
- J. M. Pascal P. J. O'Brien A. E. Tomkinson T. Ellenberger Nature 2004 432 473-478
- (2004) Nature , vol.432 , pp. 473-478
- Pascal, J.M.¹ O'Brien, P.J.² Tomkinson, A.E.³ Ellenberger, T.⁴

9
- 0342350255
- D. S. Levin A. E. McKenna T. A. Motycka Y. Matsumoto A. E. Tomkinson Curr. Biol. 2000 10 919-922
- (2000) Curr. Biol. , vol.10 , pp. 919-922
- Levin, D.S.¹ McKenna, A.E.² Motycka, T.A.³ Matsumoto, Y.⁴ Tomkinson, A.E.⁵

10
- 0021839392
- L. M. Henderson C. F. Arlett S. A. Harcourt A. R. Lehmann B. C. Broughton Proc. Natl. Acad. Sci. U. S. A. 1985 82 2044-2048
- (1985) Proc. Natl. Acad. Sci. U. S. A. , vol.82 , pp. 2044-2048
- Henderson, L.M.¹ Arlett, C.F.² Harcourt, S.A.³ Lehmann, A.R.⁴ Broughton, B.C.⁵

11
- 0026680743
- D. E. Barnes A. E. Tomkinson A. R. Lehmann A. D. B. Webster T. Lindahl Cell 1992 69 495-503
- (1992) Cell , vol.69 , pp. 495-503
- Barnes, D.E.¹ Tomkinson, A.E.² Lehmann, A.R.³ Webster, A.D.B.⁴ Lindahl, T.⁵

12
- 79955934251
- sup pp 71-20
- S. Das-Bradoo H. D. Nguyen J. L. Wood R. M. Ricke J. C. Haworth A. K. Bielinsky Nat. Cell Biol. 2010 12 74-79; sup pp 71-20
- (2010) Nat. Cell Biol. , vol.12 , pp. 74-79
- Das-Bradoo, S.¹ Nguyen, H.D.² Wood, J.L.³ Ricke, R.M.⁴ Haworth, J.C.⁵ Bielinsky, A.K.⁶

13
- 0035675836
- D. Y. Sun R. Urrabaz M. Nguyen J. Marty S. Stringer E. Cruz L. Medina-Gundrum S. Weitman Clin. Cancer Res. 2001 7 4143-4148
- (2001) Clin. Cancer Res. , vol.7 , pp. 4143-4148
- Sun, D.Y.¹ Urrabaz, R.² Nguyen, M.³ Marty, J.⁴ Stringer, S.⁵ Cruz, E.⁶ Medina-Gundrum, L.⁷ Weitman, S.⁸

14
- 84871550828
- M. Srivastava M. Nambiar S. Sharma S. S. Karki G. Goldsmith M. Hegde S. Kumar M. Pandey R. K. Singh P. Ray R. Natarajan M. Kelkar A. De B. Choudhary S. C. Raghavan Cell 2012 151 1474-1487
- (2012) Cell , vol.151 , pp. 1474-1487
- Srivastava, M.¹ Nambiar, M.² Sharma, S.³ Karki, S.S.⁴ Goldsmith, G.⁵ Hegde, M.⁶ Kumar, S.⁷ Pandey, M.⁸ Singh, R.K.⁹ Ray, P.¹⁰ Natarajan, R.¹¹ Kelkar, M.¹² De, A.¹³ Choudhary, B.¹⁴ Raghavan, S.C.¹⁵

15
- 84961113305
- D. Mandalapu D. K. Singh S. Gupta V. M. Balaramnavar M. Shafiq D. Banerjee V. L. Sharma RSC Adv. 2016 6 26003-26018
- (2016) RSC Adv. , vol.6 , pp. 26003-26018
- Mandalapu, D.¹ Singh, D.K.² Gupta, S.³ Balaramnavar, V.M.⁴ Shafiq, M.⁵ Banerjee, D.⁶ Sharma, V.L.⁷

16
- 84961144836
- P. Samadder R. Aithal O. Belan L. Krejci Pharmacol. Ther. 2016 161 111-131
- (2016) Pharmacol. Ther. , vol.161 , pp. 111-131
- Samadder, P.¹ Aithal, R.² Belan, O.³ Krejci, L.⁴

17
- 0019146489
- B. V. Palmer G. A. Walsh J. A. McKinna W. P. Greening Br. Med. J. 1980 281 1594-1597
- (1980) Br. Med. J. , vol.281 , pp. 1594-1597
- Palmer, B.V.¹ Walsh, G.A.² McKinna, J.A.³ Greening, W.P.⁴

18
- 84870527677
- K. S. Chan C. G. Koh H. Y. Li Cell Death Dis. 2012 3 e411
- (2012) Cell Death Dis. , vol.3 , pp. e411
- Chan, K.S.¹ Koh, C.G.² Li, H.Y.³

19
- 84901648819
- B. Bahrami T. Greenwell J. S. Muecke Clin. Exp. Ophthalmol. 2014 42 317-322
- (2014) Clin. Exp. Ophthalmol. , vol.42 , pp. 317-322
- Bahrami, B.¹ Greenwell, T.² Muecke, J.S.³

20
- 84860455486
- S. Hoelder P. A. Clarke P. Workman Mol. Oncol. 2012 6 155-176
- (2012) Mol. Oncol. , vol.6 , pp. 155-176
- Hoelder, S.¹ Clarke, P.A.² Workman, P.³

21
- 33947596504
- A. Kamb S. Wee C. Lengauer Nat. Rev. Drug Discovery 2007 6 115-120
- (2007) Nat. Rev. Drug Discovery , vol.6 , pp. 115-120
- Kamb, A.¹ Wee, S.² Lengauer, C.³

22
- 84960883744
- G. Menchon O. Bombarde M. Trivedi A. Negrel C. Inard B. Giudetti M. Baltas A. Milon M. Modesti G. Czaplicki P. Calsou Sci. Rep. 2016 6 22878
- (2016) Sci. Rep. , vol.6 , pp. 22878
- Menchon, G.¹ Bombarde, O.² Trivedi, M.³ Negrel, A.⁴ Inard, C.⁵ Giudetti, B.⁶ Baltas, M.⁷ Milon, A.⁸ Modesti, M.⁹ Czaplicki, G.¹⁰ Calsou, P.¹¹

23
- 84890455263
- S. Howard N. Amin A. B. Benowitz E. Chiarparin H. F. Cui X. D. Deng T. D. Heightman D. J. Holmes A. Hopkins J. Z. Huang Q. Jin C. Kreatsoulas A. C. L. Martin F. Massey L. McCloskey P. N. Mortenson P. Pathuri D. Tisi P. A. Williams ACS Med. Chem. Lett. 2013 4 1208-1212
- (2013) ACS Med. Chem. Lett. , vol.4 , pp. 1208-1212
- Howard, S.¹ Amin, N.² Benowitz, A.B.³ Chiarparin, E.⁴ Cui, H.F.⁵ Deng, X.D.⁶ Heightman, T.D.⁷ Holmes, D.J.⁸ Hopkins, A.⁹ Huang, J.Z.¹⁰ Jin, Q.¹¹ Kreatsoulas, C.¹² Martin, A.C.L.¹³ Massey, F.¹⁴ McCloskey, L.¹⁵ Mortenson, P.N.¹⁶ Pathuri, P.¹⁷ Tisi, D.¹⁸ Williams, P.A.¹⁹

24
- 84655169809
- S. S. Stokes M. Gowravaram H. Huynh M. Lu G. B. Mullen B. Chen R. Albert T. J. O'Shea M. T. Rooney H. Hu J. V. Newman S. D. Mills Bioorg. Med. Chem. Lett. 2012 22 85-89
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 85-89
- Stokes, S.S.¹ Gowravaram, M.² Huynh, H.³ Lu, M.⁴ Mullen, G.B.⁵ Chen, B.⁶ Albert, R.⁷ O'Shea, T.J.⁸ Rooney, M.T.⁹ Hu, H.¹⁰ Newman, J.V.¹¹ Mills, S.D.¹²

25
- 79960374372
- S. S. Stokes H. Huynh M. Gowravaram R. Albert M. Cavero-Tomas B. Chen J. Harang J. T. Loch 3rd M. Lu G. B. Mullen S. Zhao C. F. Liu S. D. Mills Bioorg. Med. Chem. Lett. 2011 21 4556-4560
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 4556-4560
- Stokes, S.S.¹ Huynh, H.² Gowravaram, M.³ Albert, R.⁴ Cavero-Tomas, M.⁵ Chen, B.⁶ Harang, J.⁷ Loch, J.T.⁸ Lu, M.⁹ Mullen, G.B.¹⁰ Zhao, S.¹¹ Liu, C.F.¹² Mills, S.D.¹³

26
- 84864973325
- E. T. Buurman V. A. Laganas C. F. Liu J. I. Manchester ACS Med. Chem. Lett. 2012 3 663-667
- (2012) ACS Med. Chem. Lett. , vol.3 , pp. 663-667
- Buurman, E.T.¹ Laganas, V.A.² Liu, C.F.³ Manchester, J.I.⁴

27
- 84935914003
- M. Shameem R. Kumar S. Krishna C. Kumar M. I. Siddiqi B. Kundu D. Banerjee Chem.-Biol. Interact. 2015 237 115-124
- (2015) Chem.-Biol. Interact. , vol.237 , pp. 115-124
- Shameem, M.¹ Kumar, R.² Krishna, S.³ Kumar, C.⁴ Siddiqi, M.I.⁵ Kundu, B.⁶ Banerjee, D.⁷

28
- 84896914708
- S. Krishna D. K. Singh S. Meena D. Datta M. I. Siddiqi D. Banerjee J. Chem. Inf. Model. 2014 54 781-792
- (2014) J. Chem. Inf. Model. , vol.54 , pp. 781-792
- Krishna, S.¹ Singh, D.K.² Meena, S.³ Datta, D.⁴ Siddiqi, M.I.⁵ Banerjee, D.⁶

29
- 84908682108
- K. V. Sashidhara S. R. Avula V. Mishra G. R. Palnati L. R. Singh N. Singh Y. S. Chhonker P. Swami R. S. Bhatta G. Palit Eur. J. Med. Chem. 2015 89 638-653
- (2015) Eur. J. Med. Chem. , vol.89 , pp. 638-653
- Sashidhara, K.V.¹ Avula, S.R.² Mishra, V.³ Palnati, G.R.⁴ Singh, L.R.⁵ Singh, N.⁶ Chhonker, Y.S.⁷ Swami, P.⁸ Bhatta, R.S.⁹ Palit, G.¹⁰

30
- 84936773771
- K. V. Sashidhara G. R. Palnati L. R. Singh A. Upadhyay S. R. Avula A. Kumar R. Kant Green Chem. 2015 17 3766-3770
- (2015) Green Chem. , vol.17 , pp. 3766-3770
- Sashidhara, K.V.¹ Palnati, G.R.² Singh, L.R.³ Upadhyay, A.⁴ Avula, S.R.⁵ Kumar, A.⁶ Kant, R.⁷

31
- 84941923719
- K. V. Sashidhara S. R. Avula P. K. Doharey L. R. Singh V. M. Balaramnavar J. Gupta S. Misra-Bhattacharya S. Rathaur A. K. Saxena J. K. Saxena Eur. J. Med. Chem. 2015 103 418-428
- (2015) Eur. J. Med. Chem. , vol.103 , pp. 418-428
- Sashidhara, K.V.¹ Avula, S.R.² Doharey, P.K.³ Singh, L.R.⁴ Balaramnavar, V.M.⁵ Gupta, J.⁶ Misra-Bhattacharya, S.⁷ Rathaur, S.⁸ Saxena, A.K.⁹ Saxena, J.K.¹⁰

32
- 84908013710
- K. V. Sashidhara R. K. Modukuri P. Jadiya K. B. Rao T. Sharma R. Haque D. K. Singh D. Banerjee M. I. Siddiqi A. Nazir ACS Med. Chem. Lett. 2014 5 1099-1103
- (2014) ACS Med. Chem. Lett. , vol.5 , pp. 1099-1103
- Sashidhara, K.V.¹ Modukuri, R.K.² Jadiya, P.³ Rao, K.B.⁴ Sharma, T.⁵ Haque, R.⁶ Singh, D.K.⁷ Banerjee, D.⁸ Siddiqi, M.I.⁹ Nazir, A.¹⁰

33
- 84915758773
- K. V. Sashidhara R. K. Modukuri P. Jadiya R. P. Dodda M. Kumar B. Sridhar V. Kumar R. Haque M. I. Siddiqi A. Nazir ChemMedChem 2014 9 2671-2684
- (2014) ChemMedChem , vol.9 , pp. 2671-2684
- Sashidhara, K.V.¹ Modukuri, R.K.² Jadiya, P.³ Dodda, R.P.⁴ Kumar, M.⁵ Sridhar, B.⁶ Kumar, V.⁷ Haque, R.⁸ Siddiqi, M.I.⁹ Nazir, A.¹⁰

34
- 85016235624
- K. V. Sashidhara L. R. Singh D. Choudhary A. Arun S. Gupta S. Adhikary G. R. Palnati R. Konwar R. Trivedi RSC Adv. 2016 6 80037-80048
- (2016) RSC Adv. , vol.6 , pp. 80037-80048
- Sashidhara, K.V.¹ Singh, L.R.² Choudhary, D.³ Arun, A.⁴ Gupta, S.⁵ Adhikary, S.⁶ Palnati, G.R.⁷ Konwar, R.⁸ Trivedi, R.⁹

35
- 84880823706
- K. V. Sashidhara G. R. Palnati R. P. Dodda S. R. Avula P. Swami Synlett 2013 24 1795-1800
- (2013) Synlett , vol.24 , pp. 1795-1800
- Sashidhara, K.V.¹ Palnati, G.R.² Dodda, R.P.³ Avula, S.R.⁴ Swami, P.⁵

36
- 0038101333
- M. W. Beukers M. J. Wanner J. K. V. Kunzel E. C. Klaasse A. P. IJzerman G. J. Koomen J. Med. Chem. 2003 46 1492-1503
- (2003) J. Med. Chem. , vol.46 , pp. 1492-1503
- Beukers, M.W.¹ Wanner, M.J.² Kunzel, J.K.V.³ Klaasse, E.C.⁴ IJzerman, A.P.⁵ Koomen, G.J.⁶

37
- 84883416981
- A. Y. Lukmantara D. S. Kalinowski N. Kumar D. R. Richardson Org. Biomol. Chem. 2013 11 6414-6425
- (2013) Org. Biomol. Chem. , vol.11 , pp. 6414-6425
- Lukmantara, A.Y.¹ Kalinowski, D.S.² Kumar, N.³ Richardson, D.R.⁴

38
- 84877661611
- L. Tripathi P. Kumar Eur. J. Med. Chem. 2013 64 477-487
- (2013) Eur. J. Med. Chem. , vol.64 , pp. 477-487
- Tripathi, L.¹ Kumar, P.²

39
- 84945176307
- J. F. de Oliveira A. L. da Silva D. B. Vendramini-Costa C. A. da Cruz Amorim J. F. Campos A. G. Ribeiro R. O. de Moura J. L. Neves A. L. Ruiz J. E. de Carvalho C. A. de Lima Mdo Eur. J. Med. Chem. 2015 104 148-156
- (2015) Eur. J. Med. Chem. , vol.104 , pp. 148-156
- De Oliveira, J.F.¹ Da Silva, A.L.² Vendramini-Costa, D.B.³ Da Cruz Amorim, C.A.⁴ Campos, J.F.⁵ Ribeiro, A.G.⁶ De Moura, R.O.⁷ Neves, J.L.⁸ Ruiz, A.L.⁹ De Carvalho, J.E.¹⁰ De Lima Mdo, C.A.¹¹

40
- 84896905278
- D. K. Singh S. Krishna S. Chandra M. Shameem A. L. Deshmukh D. Banerjee Med. Res. Rev. 2014 34 567-595
- (2014) Med. Res. Rev. , vol.34 , pp. 567-595
- Singh, D.K.¹ Krishna, S.² Chandra, S.³ Shameem, M.⁴ Deshmukh, A.L.⁵ Banerjee, D.⁶

41
- 84885399978
- J. Montero C. Dutta D. van Bodegom D. Weinstock A. Letai Cell Death Differ. 2013 20 1465-1474
- (2013) Cell Death Differ. , vol.20 , pp. 1465-1474
- Montero, J.¹ Dutta, C.² Van Bodegom, D.³ Weinstock, D.⁴ Letai, A.⁵

42
- 0027420787
- H. Teraoka H. Minami S. Iijima K. Tsukada O. Koiwai T. Date J. Biol. Chem. 1993 268 24156-24162
- (1993) J. Biol. Chem. , vol.268 , pp. 24156-24162
- Teraoka, H.¹ Minami, H.² Iijima, S.³ Tsukada, K.⁴ Koiwai, O.⁵ Date, T.⁶

43
- 0036842473
- R. L. A. Furlan L. M. Garrido G. Brumatti G. P. Amarante-Mendes R. A. Martins M. C. R. Facciotti G. Padilla Biotechnol. Lett. 2002 24 1807-1813
- (2002) Biotechnol. Lett. , vol.24 , pp. 1807-1813
- Furlan, R.L.A.¹ Garrido, L.M.² Brumatti, G.³ Amarante-Mendes, G.P.⁴ Martins, R.A.⁵ Facciotti, M.C.R.⁶ Padilla, G.⁷

44
- 0014202608
- J. B. LePecq C. Paoletti J. Mol. Biol. 1967 27 87-106
- (1967) J. Mol. Biol. , vol.27 , pp. 87-106
- LePecq, J.B.¹ Paoletti, C.²

45
- 0034655372
- C. D. Bevan R. S. Lloyd Anal. Chem. 2000 72 1781-1787
- (2000) Anal. Chem. , vol.72 , pp. 1781-1787
- Bevan, C.D.¹ Lloyd, R.S.²

46
- 33748636018
- P. Baranczewski A. Stanczak K. Sundberg R. Svensson A. Wallin J. Jansson P. Garberg H. Postlind Pharmacol. Rep. 2006 58 453-472
- (2006) Pharmacol. Rep. , vol.58 , pp. 453-472
- Baranczewski, P.¹ Stanczak, A.² Sundberg, K.³ Svensson, R.⁴ Wallin, A.⁵ Jansson, J.⁶ Garberg, P.⁷ Postlind, H.⁸

47
- 84922740087
- H. Chandasana Y. S. Chhonker V. Bala Y. D. Prasad T. K. Chaitanya V. L. Sharma R. S. Bhatta J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2015 985 180-188
- (2015) J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. , vol.985 , pp. 180-188
- Chandasana, H.¹ Chhonker, Y.S.² Bala, V.³ Prasad, Y.D.⁴ Chaitanya, T.K.⁵ Sharma, V.L.⁶ Bhatta, R.S.⁷

48
- 9644289536
- J. M. Pascal P. J. O'Brien A. E. Tomkinson T. Ellenberger Nature 2004 432 473-478
- (2004) Nature , vol.432 , pp. 473-478
- Pascal, J.M.¹ O'Brien, P.J.² Tomkinson, A.E.³ Ellenberger, T.⁴

49
- 33746864357
- Tripos, Inc., St. Louis, MO
- Sybyl, version 7.1, Tripos, Inc., St. Louis, MO, 2005
- (2005) Sybyl, version 7.1

50
- 0030599010
- M. Rarey B. Kramer T. Lengauer G. Klebe J. Mol. Biol. 1996 261 470-489
- (1996) J. Mol. Biol. , vol.261 , pp. 470-489
- Rarey, M.¹ Kramer, B.² Lengauer, T.³ Klebe, G.⁴

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.