N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptor

Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2003, Pages 1492-1503

  Beukers, Margot W ^a   Wanner, Martin J ^b   Von Frijtag Drabbe Künzel, Jacobien K ^a   Klaasse, Elisabeth C ^a   IJzerman, Adriaan P ^a   Koomen, Gerrit Jan ^b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 PHENYLAMINOCARBONYLTRIAZEN 1 YL)ADENOSINE; 2 NITROSOADENOSINE; 2 PHENYLDIAZOADENOSINE; 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 6 N CYCLOPENTYL 2 (3 PHENYLAMINOCARBONYLTRIAZEN 1 YL)ADENOSINE; 6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DERIVATIVE; CYCLIC AMP; FORSKOLIN; LIGAND; TRIAZENE DERIVATIVE; UNCLASSIFIED DRUG; ADENOSINE; ADENOSINE RECEPTOR; DRUG DERIVATIVE; N(6) CYCLOPENTYL 2 (3 PHENYLAMINOCARBONYLTRIAZENE 1 YL)ADENOSINE; N(6)-CYCLOPENTYL-2-(3-PHENYLAMINOCARBONYLTRIAZENE-1-YL)ADENOSINE;

ARTICLE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SELECTIVITY; DRUG SYNTHESIS; GENETIC TRANSFECTION; HUMAN; LIGAND BINDING; NONHUMAN; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANIMAL; BIOSYNTHESIS; CHEMISTRY; DRUG POTENTIATION; HAMSTER; RADIOASSAY; SYNTHESIS;

ADENOSINE; ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; HUMANS; RADIOLIGAND ASSAY; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZENES;

EID: 0038101333     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm021074j     Document Type: Article

References (26)

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