Long-term outcomes after adjunctive topical 5-flurouracil or mitomycin C for the treatment of surgically excised, localized ocular surface squamous neoplasia

Clinical and Experimental Ophthalmology

Volumn 42, Issue 4, 2014, Pages 317-322

  Bahrami, Bobak ^a,b   Greenwell, Timothy ^a,b   Muecke, James S ^a,b  

^a South Australian Institute of Ophthalmology   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Chemotherapy; Ocular oncology; Ocular surface tumours; OSSN

Indexed keywords

FLUOROURACIL; MITOMYCIN;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER RECURRENCE; CANCER SURGERY; CONTROLLED STUDY; CORNEA DISEASE; CORNEAL EPITHELIAL DEFECT; CRYOTHERAPY; DACRYOCYSTORHINOSTOMY; DRUG CYTOTOXICITY; DRUG HYPERSENSITIVITY; DRUG INDUCED DISEASE; DRUG WITHDRAWAL; ECTROPION; EPIPHORA; EYE CANCER; EYE SURGERY; EYE TOXICITY; EYELID DISEASE; FEMALE; FOLLOW UP; HUMAN; KERATITIS; KERATOCONJUNCTIVITIS; LID TOXICITY; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; OCULAR SURFACE DISEASE; OCULAR SURFACE SQUAMOUS NEOPLASIA; OUTCOME ASSESSMENT; PTOSIS; PUNCTOPLASTY; SUPERFICIAL KERATITIS; TOPICAL TREATMENT;

CHEMOTHERAPY; OCULAR ONCOLOGY; OCULAR SURFACE TUMOURS; OSSN;

ADMINISTRATION, TOPICAL; AGED; ALKYLATING AGENTS; CARCINOMA IN SITU; CHEMOTHERAPY, ADJUVANT; CONJUNCTIVAL NEOPLASMS; CORNEAL DISEASES; CRYOTHERAPY; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; INTERVENTION STUDIES; MALE; MIDDLE AGED; MITOMYCIN; NEOPLASM RECURRENCE, LOCAL; OPHTHALMIC SOLUTIONS; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84901648819     PISSN: 14426404     EISSN: 14429071     Source Type: Journal    
DOI: 10.1111/ceo.12184     Document Type: Article

References (33)

1. Cerezo L, Otero J, Aragon G etal. Conjunctival intraepithelial and invasive squamous cell carcinomas treated with strontium-90. Radiother Oncol 1990; 17: 191-197.
2. Seale ER. Carcinoma of limbus; report of 19 cases treated with radium and effect of gamma radiation upon eye. AMA Arch Derm Syphilol 1953; 68: 286-295.
3. Kim HJ, Shields CL, Shah SU, Kaliki S, Lally SE. Giant ocular surface squamous neoplasia managed with interferon alpha-2b as immunotherapy or immunoreduction. Ophthalmology 2012; 119: 938-944.
4. Shah SU, Kaliki S, Kim HJ, Lally SE, Shields JA, Shields CL. Topical interferon alfa-2b for management of ocular surface squamous neoplasia in 23 cases: outcomes based on American Joint Committee on Cancer classification. Arch Ophthalmol 2012; 130: 159-164.
5. Russell HC, Chadha V, Lockington D, Kemp EG. Topical mitomycin C chemotherapy in the management of ocular surface neoplasia: a 10-year review of treatment outcomes and complications. Br J Ophthalmol 2010; 94: 1316-1321.
6. Esquenazi S, Fry CL, Holley E. Treatment of biopsy proved conjunctival intraepithelial neoplasia with topical interferon alfa-2b. Br J Ophthalmol 2005; 89: 1221.
7. Karp CL, Galor A, Chhabra S, Barnes SD, Alfonso EC. Subconjunctival/perilesional recombinant interferon alpha2b for ocular surface squamous neoplasia: a 10-year review. Ophthalmology 2010; 117: 2241-2246.
8. Al-Barrag A, Al-Shaer M, Al-Matary N, Al-Hamdani M. 5-Fluorouracil for the treatment of intraepithelial neoplasia and squamous cell carcinoma of the conjunctiva, and cornea. Clin Ophthalmol 2010; 4: 801-808.
9. Ballalai PL, Erwenne CM, Martins MC, Lowen MS, Barros JN. Long-term results of topical mitomycin C 0.02% for primary and recurrent conjunctival-corneal intraepithelial neoplasia. Ophthal Plast Reconstr Surg 2009; 25: 296-299.
10. Daniell M, Maini R, Tole D. Use of mitomycin C in the treatment of corneal conjunctival intraepithelial neoplasia. Clin Experiment Ophthalmol 2002; 30: 94-98.
11. Frucht-Pery J, Sugar J, Baum J etal. Mitomycin C treatment for conjunctival-corneal intraepithelial neoplasia: a multicenter experience. Ophthalmology 1997; 104: 2085-2093.
12. Hirst LW. Randomized controlled trial of topical mitomycin C for ocular surface squamous neoplasia: early resolution. Ophthalmology 2007; 114: 976-982.
13. Krilis M, Tsang H, Coroneo M. Treatment of conjunctival and corneal epithelial neoplasia with retinoic acid and topical interferon alfa-2b: long-term follow-up. Ophthalmology 2012; 119: 1969-1973.
14. Parrozzani R, Lazzarini D, Alemany-Rubio E, Urban F, Midena E. Topical 1% 5-fluorouracil in ocular surface squamous neoplasia: a long-term safety study. Br J Ophthalmol 2011; 95: 355-359.
15. Yeatts RP, Engelbrecht NE, Curry CD, Ford JG, Walter KA. 5-Fluorouracil for the treatment of intraepithelial neoplasia of the conjunctiva and cornea. Ophthalmology 2000; 107: 2190-2195.
16. Tabin G, Levin S, Snibson G, Loughnan M, Taylor H. Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology 1997; 104: 485-492.
17. Peksayar G, Soyturk MK, Demiryont M. Long-term results of cryotherapy on malignant epithelial tumors of the conjunctiva. Am J Ophthalmol 1989; 107: 337-340.
18. Galor A, Karp CL, Oellers P etal. Predictors of ocular surface squamous neoplasia recurrence after excisional surgery. Ophthalmology 2012; 119: 1974-1981.
19. Chen C, Louis D, Dodd T, Muecke J. Mitomycin C as an adjunct in the treatment of localised ocular surface squamous neoplasia. Br J Ophthalmol 2004; 88: 17-18.
20. Birkholz ES, Goins KM, Sutphin JE, Kitzmann AS, Wagoner MD. Treatment of ocular surface squamous cell intraepithelial neoplasia with and without mitomycin C. Cornea 2011; 30: 37-41.
21. Rudkin AK, Muecke JS. Adjuvant 5-fluorouracil in the treatment of localised ocular surface squamous neoplasia. Br J Ophthalmol 2011; 95: 947-950.
22. Midena E, Angeli CD, Valenti M, de Belvis V, Boccato P. Treatment of conjunctival squamous cell carcinoma with topical 5-fluorouracil. Br J Ophthalmol 2000; 84: 268-272.
23. Heigle TJ, Stulting RD, Palay DA. Treatment of recurrent conjunctival epithelial neoplasia with topical mitomycin C. Am J Ophthalmol 1997; 124: 397-399.
24. Wilson MW, Hungerford JL, George SM, Madreperla SA. Topical mitomycin C for the treatment of conjunctival and corneal epithelial dysplasia and neoplasia. Am J Ophthalmol 1997; 124: 303-311.
25. Tananuvat N, Lertprasertsuk N, Mahanupap P, Noppanakeepong P. Role of impression cytology in diagnosis of ocular surface neoplasia. Cornea 2008; 27: 269-274.
26. Khong JJ, Muecke J. Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia. Br J Ophthalmol 2006; 90: 819-822.
27. Kurli M, Finger PT. Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years' experience. Graefes Arch Clin Exp Ophthalmol 2005; 243: 1108-1114.
28. Shields CL, Naseripour M, Shields JA, Eagle RC, Jr. Topical mitomycin-C for pagetoid invasion of the conjunctiva by eyelid sebaceous gland carcinoma. Ophthalmology 2002; 109: 2129-2133.
29. Pe'er J, Frucht-Pery J. The treatment of primary acquired melanosis (PAM) with atypia by topical Mitomycin C. Am J Ophthalmol 2005; 139: 229-234.
30. Knapp A, Heuer DK, Stern GA, Driebe WT, Jr. Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil. Am J Ophthalmol 1987; 103: 183-187.
31. Boehm MD, Huang AJ. Treatment of recurrent corneal and conjunctival intraepithelial neoplasia with topical interferon alfa 2b. Ophthalmology 2004; 111: 1755-1761.
32. Karp CL, Moore JK, Rosa RH, Jr. Treatment of conjunctival and corneal intraepithelial neoplasia with topical interferon alpha-2b. Ophthalmology 2001; 108: 1093-1098.
33. Schechter BA, Koreishi AF, Karp CL, Feuer W. Long-term follow-up of conjunctival and corneal intraepithelial neoplasia treated with topical interferon alfa-2b. Ophthalmology 2008; 115: 1291-1296. 6 e1.