Human DNA ligase I completely encircles and partially unwinds nicked DNA

Nature

Volumn 432, Issue 7016, 2004, Pages 473-478

  Pascal, John M ^a   O'Brien, Patrick J ^a,c   Tomkinson, Alan E ^b   Ellenberger, Tom ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIODIVERSITY; CATALYSIS; CELLS; CRYSTAL STRUCTURE; ENZYMES;

DNA REPLICATION; DOUBLE HELIX; MAMMALIAN LIGASES; OKAZAKI FRAGMENTS;

DNA;

CELL DNA; DNA LIGASE I; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; UNCLASSIFIED DRUG;

DNA;

ARTICLE; CONFORMATIONAL TRANSITION; DNA REPLICATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DNA; DNA DAMAGE; DNA LIGASES; HUMANS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 9644289536     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03082     Document Type: Article

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