Designing, synthesis of selective and high-affinity chalcone-benzothiazole hybrids as Brugia malayi thymidylate kinase inhibitors: In vitro validation and docking studies

European Journal of Medicinal Chemistry

Volumn 103, Issue , 2015, Pages 418-428

  Sashidhara, Koneni V ^a   Avula, Srinivasa Rao ^a   Doharey, Pawan Kumar ^b   Singh, L Ravithej ^a   Balaramnavar, Vishal M ^a,e   Gupta, Jyoti ^c   Misra Bhattacharya, Shailja ^c   Rathaur, Sushma ^d   Saxena, Anil K ^a   Saxena, Jitendra Kumar ^b  

^a Medicinal and Process Chemistry Division   (India)

^b Division of Biochemistry   (India)

^c CENTRAL DRUG RESEARCH INSTITUTE   (India)

^d BANARAS HINDU UNIVERSITY   (India)

^e Affiliated to Uttarakhand Technical University   (India)

Author keywords

Antifilarial activity; Benzothiazole; Brugia malayi; Chalcone; Docking studies; Thymidylate kinase

Indexed keywords

3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 2 HYDROXY 3 ISOPROPYLPHENYL] 1 (3,4 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 2 HYDROXY 3 ISOPROPYLPHENYL] 1 (4 CHLOROPHENYL)PROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 2 HYDROXY 3 ISOPROPYLPHENYL] 1 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 2 HYDROXY 3 ISOPROPYLPHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 2 HYDROXY 3 ISOPROPYLPHENYL] 1 (THIOPHEN 2 YL)PROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 2 HYDROXY 3 METHYLPHENYL] 1 PHENYLPROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 2 HYDROXY 3 PROPYLPHENYL] 1 (3,4 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 2 HYDROXY 3 PROPYLPHENYL] 1 (4 CHLOROPHENYL)PROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 3 ETHYL 2 HYDROXYPHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 3 ETHYL 2 HYDROXYPHENYL] 1 PHENYLPROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 3 SEC BUTYL 2 HYDROXYPHENYL] 1 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 3 SEC BUTYL 2 HYDROXYPHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 3 TERT BUTYL 2 HYDROXYPHENYL] 1 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 3 TERT BUTYL 2 HYDROXYPHENYL] 1 PARA TOLYPROP 2 EN 1 ONE; 3 [5 [[2 (BENZO[D]THIAZOL 2 YL)HYDRAZONO]METHYL] 3 TERT BUTYL 2 HYDROXYPHENYL] 1 PHENYLPROP 2 EN 1 ONE; ANTIFILARIAL AGENT; BENZOTHIAZOLE; BRUGIA MALAYI THYMIDYLATE KINASE INHIBITOR; CHALCONE; CHALCONE BENZOTHIAZOLE HYBRID; IVERMECTIN; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; BENZOTHIAZOLE DERIVATIVE; DTMP KINASE; NUCLEOSIDE MONOPHOSPHATE KINASE; PROTEIN KINASE INHIBITOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; ANIMAL; ANTAGONISTS AND INHIBITORS; BRUGIA MALAYI; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SENSITIVITY; ENZYMOLOGY; FILARIASIS; METABOLISM; PARASITOLOGY; REPRODUCIBILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BENZOTHIAZOLES; BRUGIA MALAYI; CHALCONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FILARIASIS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; NUCLEOSIDE-PHOSPHATE KINASE; PARASITIC SENSITIVITY TESTS; PROTEIN KINASE INHIBITORS; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84941923719     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.09.004     Document Type: Article

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