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Volumn 34, Issue 3, 2014, Pages 567-595

Human DNA Ligases: A Comprehensive New Look for Cancer Therapy

Author keywords

Cancer drug; Cancer target; DNA ligase; Inhibitor; Ligase; Ligase inhibitor

Indexed keywords

LIGASE INHIBITOR; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

EID: 84896905278     PISSN: 01986325     EISSN: 10981128     Source Type: Journal    
DOI: 10.1002/med.21298     Document Type: Article
Times cited : (30)

References (70)
  • 1
    • 0016273515 scopus 로고
    • DNA ligase: Structure, mechanism, and function
    • Lehman IR. DNA ligase: Structure, mechanism, and function. Science 1974;186(4166):790-797.
    • (1974) Science , vol.186 , Issue.4166 , pp. 790-797
    • Lehman, I.R.1
  • 2
    • 39149142191 scopus 로고    scopus 로고
    • DNA and RNA ligases: Structural variations and shared mechanisms
    • Pascal JM. DNA and RNA ligases: Structural variations and shared mechanisms. Curr Opin Struct Biol 2008;18(1):96-105.
    • (2008) Curr Opin Struct Biol , vol.18 , Issue.1 , pp. 96-105
    • Pascal, J.M.1
  • 4
    • 34447302016 scopus 로고    scopus 로고
    • Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner
    • Moser J, Kool H, Giakzidis I, Caldecott K, Mullenders LH, Fousteri MI. Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner. Mol Cell 2007;27(2):311-323.
    • (2007) Mol Cell , vol.27 , Issue.2 , pp. 311-323
    • Moser, J.1    Kool, H.2    Giakzidis, I.3    Caldecott, K.4    Mullenders, L.H.5    Fousteri, M.I.6
  • 5
    • 62349120246 scopus 로고    scopus 로고
    • DNA repair in mammalian cells: Base excision repair: The long and short of it
    • Robertson AB, Klungland A, Rognes T, Leiros I. DNA repair in mammalian cells: Base excision repair: The long and short of it. Cell Mol Life Sci 2009;66(6):981-993.
    • (2009) Cell Mol Life Sci , vol.66 , Issue.6 , pp. 981-993
    • Robertson, A.B.1    Klungland, A.2    Rognes, T.3    Leiros, I.4
  • 6
    • 84870400503 scopus 로고    scopus 로고
    • Base excision repair targets for cancer therapy
    • Dianov GL. Base excision repair targets for cancer therapy. Am J Cancer Res 2011;1(7):845-851.
    • (2011) Am J Cancer Res , vol.1 , Issue.7 , pp. 845-851
    • Dianov, G.L.1
  • 7
    • 0030811523 scopus 로고    scopus 로고
    • Yeast DNA ligase IV mediates non-homologous DNA end joining
    • Wilson TE, Grawunder U, Lieber MR. Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature 1997;388(6641):495-498.
    • (1997) Nature , vol.388 , Issue.6641 , pp. 495-498
    • Wilson, T.E.1    Grawunder, U.2    Lieber, M.R.3
  • 8
    • 45549094090 scopus 로고    scopus 로고
    • Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks
    • Liang L, Deng L, Nguyen SC, Zhao X, Maulion CD, Shao C, Tischfield JA. Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks. Nucleic Acids Res 2008;36(10):3297-3310.
    • (2008) Nucleic Acids Res , vol.36 , Issue.10 , pp. 3297-3310
    • Liang, L.1    Deng, L.2    Nguyen, S.C.3    Zhao, X.4    Maulion, C.D.5    Shao, C.6    Tischfield, J.A.7
  • 9
    • 50649116450 scopus 로고    scopus 로고
    • Eukaryotic DNA ligases: Structural and functional insights
    • Ellenberger T, Tomkinson AE. Eukaryotic DNA ligases: Structural and functional insights. Annu Rev Biochem 2008;77:313-338.
    • (2008) Annu Rev Biochem , vol.77 , pp. 313-338
    • Ellenberger, T.1    Tomkinson, A.E.2
  • 12
    • 0026550351 scopus 로고
    • DNA ligase I mRNA and enzyme levels in human hematopoietic cells under dimethyl sulfoxide-induced growth-arrest and differentiation
    • Teraoka H, Sawai M, Yamamoto K, Tsukada K. DNA ligase I mRNA and enzyme levels in human hematopoietic cells under dimethyl sulfoxide-induced growth-arrest and differentiation. Biochem Int 1992;26(5):963-971.
    • (1992) Biochem Int , vol.26 , Issue.5 , pp. 963-971
    • Teraoka, H.1    Sawai, M.2    Yamamoto, K.3    Tsukada, K.4
  • 13
    • 0030771156 scopus 로고    scopus 로고
    • Regulation of DNA metabolic enzymes upon induction of preB cell development and V(D)J recombination: Up-regulation of DNA polymerase delta
    • Jessberger R, Schar P, Robins P, Ferrari E, Riwar B, Hubscher U. Regulation of DNA metabolic enzymes upon induction of preB cell development and V(D)J recombination: Up-regulation of DNA polymerase delta. Nucleic Acids Res 1997;25(2):289-296.
    • (1997) Nucleic Acids Res , vol.25 , Issue.2 , pp. 289-296
    • Jessberger, R.1    Schar, P.2    Robins, P.3    Ferrari, E.4    Riwar, B.5    Hubscher, U.6
  • 15
    • 0026680743 scopus 로고
    • Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents
    • Barnes DE, Tomkinson AE, Lehmann AR, Webster AD, Lindahl T. Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents. Cell 1992;69(3):495-503.
    • (1992) Cell , vol.69 , Issue.3 , pp. 495-503
    • Barnes, D.E.1    Tomkinson, A.E.2    Lehmann, A.R.3    Webster, A.D.4    Lindahl, T.5
  • 16
    • 0026772876 scopus 로고
    • Growth retardation and immunodeficiency in a patient with mutations in the DNA ligase I gene
    • Webster AD, Barnes DE, Arlett CF, Lehmann AR, Lindahl T. Growth retardation and immunodeficiency in a patient with mutations in the DNA ligase I gene. Lancet 1992;339(8808):1508-1509.
    • (1992) Lancet , vol.339 , Issue.8808 , pp. 1508-1509
    • Webster, A.D.1    Barnes, D.E.2    Arlett, C.F.3    Lehmann, A.R.4    Lindahl, T.5
  • 17
    • 0028047308 scopus 로고
    • Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I
    • Prigent C, Satoh MS, Daly G, Barnes DE, Lindahl T. Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I. Mol Cell Biol 1994;14(1):310-317.
    • (1994) Mol Cell Biol , vol.14 , Issue.1 , pp. 310-317
    • Prigent, C.1    Satoh, M.S.2    Daly, G.3    Barnes, D.E.4    Lindahl, T.5
  • 18
    • 0027304013 scopus 로고
    • V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder
    • Hsieh CL, Arlett CF, Lieber MR. V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder. J Biol Chem 1993;268(27):20105-20109.
    • (1993) J Biol Chem , vol.268 , Issue.27 , pp. 20105-20109
    • Hsieh, C.L.1    Arlett, C.F.2    Lieber, M.R.3
  • 20
    • 0032960864 scopus 로고    scopus 로고
    • The human DNA ligase III gene encodes nuclear and mitochondrial proteins
    • Lakshmipathy U, Campbell C. The human DNA ligase III gene encodes nuclear and mitochondrial proteins. Mol Cell Biol 1999;19(5):3869-3876.
    • (1999) Mol Cell Biol , vol.19 , Issue.5 , pp. 3869-3876
    • Lakshmipathy, U.1    Campbell, C.2
  • 21
    • 0030863307 scopus 로고    scopus 로고
    • Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair
    • Cappelli E, Taylor R, Cevasco M, Abbondandolo A, Caldecott K, Frosina G. Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair. J Biol Chem 1997;272(38):23970-23975.
    • (1997) J Biol Chem , vol.272 , Issue.38 , pp. 23970-23975
    • Cappelli, E.1    Taylor, R.2    Cevasco, M.3    Abbondandolo, A.4    Caldecott, K.5    Frosina, G.6
  • 22
    • 0032185230 scopus 로고    scopus 로고
    • DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes
    • Grawunder U, Zimmer D, Fugmann S, Schwarz K, Lieber MR. DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol Cell 1998;2(4):477-484.
    • (1998) Mol Cell , vol.2 , Issue.4 , pp. 477-484
    • Grawunder, U.1    Zimmer, D.2    Fugmann, S.3    Schwarz, K.4    Lieber, M.R.5
  • 24
    • 0028862933 scopus 로고
    • Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells
    • Caldecott KW, Tucker JD, Stanker LH, Thompson LH. Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells. Nucleic Acids Res 1995;23(23):4836-4843.
    • (1995) Nucleic Acids Res , vol.23 , Issue.23 , pp. 4836-4843
    • Caldecott, K.W.1    Tucker, J.D.2    Stanker, L.H.3    Thompson, L.H.4
  • 25
    • 80053212145 scopus 로고    scopus 로고
    • Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway
    • Della-Maria J, Zhou Y, Tsai MS, Kuhnlein J, Carney JP, Paull TT, Tomkinson AE. Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway. J Biol Chem 2011;286(39):33845-33853.
    • (2011) J Biol Chem , vol.286 , Issue.39 , pp. 33845-33853
    • Della-Maria, J.1    Zhou, Y.2    Tsai, M.S.3    Kuhnlein, J.4    Carney, J.P.5    Paull, T.T.6    Tomkinson, A.E.7
  • 27
    • 84865004900 scopus 로고    scopus 로고
    • Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells
    • Le Chalony C, Hoffschir F, Gauthier LR, Gross J, Biard DS, Boussin FD, Pennaneach V. Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells. Cell Mol Life Sci 2012;69(17):2933-2949.
    • (2012) Cell Mol Life Sci , vol.69 , Issue.17 , pp. 2933-2949
    • Le Chalony, C.1    Hoffschir, F.2    Gauthier, L.R.3    Gross, J.4    Biard, D.S.5    Boussin, F.D.6    Pennaneach, V.7
  • 28
    • 0026489345 scopus 로고
    • DNA ligase I from Saccharomyces cerevisiae: Physical and biochemical characterization of the CDC9 gene product
    • Tomkinson AE, Tappe NJ, Friedberg EC. DNA ligase I from Saccharomyces cerevisiae: Physical and biochemical characterization of the CDC9 gene product. Biochemistry 1992;31(47):11762-11771.
    • (1992) Biochemistry , vol.31 , Issue.47 , pp. 11762-11771
    • Tomkinson, A.E.1    Tappe, N.J.2    Friedberg, E.C.3
  • 29
    • 54849404458 scopus 로고    scopus 로고
    • MMEJ repair of double-strand breaks (director's cut): Deleted sequences and alternative endings
    • McVey M, Lee SE. MMEJ repair of double-strand breaks (director's cut): Deleted sequences and alternative endings. Trends Genet 2008;24(11):529-538.
    • (2008) Trends Genet , vol.24 , Issue.11 , pp. 529-538
    • McVey, M.1    Lee, S.E.2
  • 30
    • 0034734323 scopus 로고    scopus 로고
    • DNA ligases in the repair and replication of DNA
    • Timson DJ, Singleton MR, Wigley DB. DNA ligases in the repair and replication of DNA. Mutat Res 2000;460(3-4):301-318.
    • (2000) Mutat Res , vol.460 , Issue.3-4 , pp. 301-318
    • Timson, D.J.1    Singleton, M.R.2    Wigley, D.B.3
  • 31
    • 0033592643 scopus 로고    scopus 로고
    • DNA double-strand break repair
    • Featherstone C, Jackson SP. DNA double-strand break repair. Curr Biol 1999;9(20):R759-761.
    • (1999) Curr Biol , vol.9 , Issue.20
    • Featherstone, C.1    Jackson, S.P.2
  • 33
    • 0029817836 scopus 로고    scopus 로고
    • DNA ligase IV from HeLa cell nuclei
    • Robins P, Lindahl T. DNA ligase IV from HeLa cell nuclei. J Biol Chem 1996;271(39):24257-24261.
    • (1996) J Biol Chem , vol.271 , Issue.39 , pp. 24257-24261
    • Robins, P.1    Lindahl, T.2
  • 35
    • 0030743386 scopus 로고    scopus 로고
    • Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
    • Grawunder U, Wilm M, Wu X, Kulesza P, Wilson TE, Mann M, Lieber MR. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 1997;388(6641):492-495.
    • (1997) Nature , vol.388 , Issue.6641 , pp. 492-495
    • Grawunder, U.1    Wilm, M.2    Wu, X.3    Kulesza, P.4    Wilson, T.E.5    Mann, M.6    Lieber, M.R.7
  • 36
    • 0032585526 scopus 로고    scopus 로고
    • Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice
    • Barnes DE, Stamp G, Rosewell I, Denzel A, Lindahl T. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr Biol 1998;8(25):1395-1398.
    • (1998) Curr Biol , vol.8 , Issue.25 , pp. 1395-1398
    • Barnes, D.E.1    Stamp, G.2    Rosewell, I.3    Denzel, A.4    Lindahl, T.5
  • 38
    • 9644289536 scopus 로고    scopus 로고
    • Human DNA ligase I completely encircles and partially unwinds nicked DNA
    • Pascal JM, O'Brien PJ, Tomkinson AE, Ellenberger T. Human DNA ligase I completely encircles and partially unwinds nicked DNA. Nature 2004;432(7016):473-478.
    • (2004) Nature , vol.432 , Issue.7016 , pp. 473-478
    • Pascal, J.M.1    O'Brien, P.J.2    Tomkinson, A.E.3    Ellenberger, T.4
  • 40
    • 0026011091 scopus 로고
    • Location of the active site for enzyme-adenylate formation in DNA ligases
    • Tomkinson AE, Totty NF, Ginsburg M, Lindahl T. Location of the active site for enzyme-adenylate formation in DNA ligases. Proc Natl Acad Sci USA 1991;88(2):400-404.
    • (1991) Proc Natl Acad Sci USA , vol.88 , Issue.2 , pp. 400-404
    • Tomkinson, A.E.1    Totty, N.F.2    Ginsburg, M.3    Lindahl, T.4
  • 41
    • 0029744128 scopus 로고    scopus 로고
    • Inhibition of human DNA ligase I activity by zinc and cadmium and the fidelity of ligation
    • Yang SW, Becker FF, Chan JY. Inhibition of human DNA ligase I activity by zinc and cadmium and the fidelity of ligation. Environ Mol Mutagen 1996;28(1):19-25.
    • (1996) Environ Mol Mutagen , vol.28 , Issue.1 , pp. 19-25
    • Yang, S.W.1    Becker, F.F.2    Chan, J.Y.3
  • 43
    • 0026801110 scopus 로고
    • Dual mode of inhibition of purified DNA ligase I from human cells by 9-beta-D-arabinofuranosyl-2-fluoroadenine triphosphate
    • Yang SW, Huang P, Plunkett W, Becker FF, Chan JY. Dual mode of inhibition of purified DNA ligase I from human cells by 9-beta-D-arabinofuranosyl-2-fluoroadenine triphosphate. J Biol Chem 1992;267(4):2345-2349.
    • (1992) J Biol Chem , vol.267 , Issue.4 , pp. 2345-2349
    • Yang, S.W.1    Huang, P.2    Plunkett, W.3    Becker, F.F.4    Chan, J.Y.5
  • 44
    • 84871686867 scopus 로고    scopus 로고
    • Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining
    • De
    • De Ioannes P, Malu S, Cortes P, Aggarwal AK. Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining. Cell Rep 2012;2(6):1505-1512.
    • (2012) Cell Rep , vol.2 , Issue.6 , pp. 1505-1512
    • Ioannes, P.1    Malu, S.2    Cortes, P.3    Aggarwal, A.K.4
  • 47
    • 0021232829 scopus 로고
    • Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review
    • Aubel-Sadron G, Londos-Gagliardi D. Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie 1984;66(5):333-352.
    • (1984) Biochimie , vol.66 , Issue.5 , pp. 333-352
    • Aubel-Sadron, G.1    Londos-Gagliardi, D.2
  • 48
    • 0025832340 scopus 로고
    • Correlation between anthracycline structure and human DNA ligase inhibition
    • Ciarrocchi G, Lestingi M, Fontana M, Spadari S, Montecucco A. Correlation between anthracycline structure and human DNA ligase inhibition. Biochem J 1991;279(Pt 1):141-146.
    • (1991) Biochem J , vol.279 , Issue.PART 1 , pp. 141-146
    • Ciarrocchi, G.1    Lestingi, M.2    Fontana, M.3    Spadari, S.4    Montecucco, A.5
  • 49
    • 0026062591 scopus 로고
    • Specific inhibition of human DNA ligase adenylation by a distamycin derivative possessing antitumor activity
    • Montecucco A, Fontana M, Focher F, Lestingi M, Spadari S, Ciarrocchi G. Specific inhibition of human DNA ligase adenylation by a distamycin derivative possessing antitumor activity. Nucleic Acids Res 1991;19(5):1067-1072.
    • (1991) Nucleic Acids Res , vol.19 , Issue.5 , pp. 1067-1072
    • Montecucco, A.1    Fontana, M.2    Focher, F.3    Lestingi, M.4    Spadari, S.5    Ciarrocchi, G.6
  • 50
    • 67649655648 scopus 로고    scopus 로고
    • Historical perspectives on cadmium toxicology
    • Nordberg GF. Historical perspectives on cadmium toxicology. Toxicol Appl Pharmacol 2009;238(3):192-200.
    • (2009) Toxicol Appl Pharmacol , vol.238 , Issue.3 , pp. 192-200
    • Nordberg, G.F.1
  • 51
    • 0017264479 scopus 로고
    • Inhibition of RNA-directed DNA polymerase by aurintricarboxylic acid
    • Givens JF, Manly KF. Inhibition of RNA-directed DNA polymerase by aurintricarboxylic acid. Nucleic Acids Res 1976;3(2):405-418.
    • (1976) Nucleic Acids Res , vol.3 , Issue.2 , pp. 405-418
    • Givens, J.F.1    Manly, K.F.2
  • 52
    • 2342657883 scopus 로고    scopus 로고
    • Development of non-electrophoretic assay method for DNA ligases and its application to screening of chemical inhibitors of DNA ligase I
    • Sun D, Urrabaz R. Development of non-electrophoretic assay method for DNA ligases and its application to screening of chemical inhibitors of DNA ligase I. J Biochem Biophys Methods 2004;59(1):49-59.
    • (2004) J Biochem Biophys Methods , vol.59 , Issue.1 , pp. 49-59
    • Sun, D.1    Urrabaz, R.2
  • 54
    • 0022587259 scopus 로고
    • Nonintercalating DNA-binding ligands: Specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material
    • Zimmer C, Wahnert U. Nonintercalating DNA-binding ligands: Specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material. Prog Biophys Mol Biol 1986;47(1):31-112.
    • (1986) Prog Biophys Mol Biol , vol.47 , Issue.1 , pp. 31-112
    • Zimmer, C.1    Wahnert, U.2
  • 55
    • 0003926978 scopus 로고
    • In vivo antitumor activity of FCE24517, a novel distamycin A derivative with specificity for ATP dependent DNA ligase
    • Barbieri B GF, Pozzoni G, Lazzari E, Arcamone F, Mongelli N. In vivo antitumor activity of FCE24517, a novel distamycin A derivative with specificity for ATP dependent DNA ligase. Proc Am Assoc Cancer Res 1988;29:330.
    • (1988) Proc Am Assoc Cancer Res , vol.29 , pp. 330
    • Barbieri, B.G.1    Pozzoni, G.2    Lazzari, E.3    Arcamone, F.4    Mongelli, N.5
  • 57
  • 58
    • 0021810554 scopus 로고
    • Inhibition of DNA ligase from human thymocytes and normal or leukemic lymphocytes by antileukemic drugs
    • David JC, Bassez T, Bonhommet M, Rusquet R. Inhibition of DNA ligase from human thymocytes and normal or leukemic lymphocytes by antileukemic drugs. Cancer Res 1985;45(5):2177-2183.
    • (1985) Cancer Res , vol.45 , Issue.5 , pp. 2177-2183
    • David, J.C.1    Bassez, T.2    Bonhommet, M.3    Rusquet, R.4
  • 62
    • 80052535308 scopus 로고    scopus 로고
    • PARP inhibitors stumble in breast cancer
    • Guha M. PARP inhibitors stumble in breast cancer. Nat Biotechnol 2011;29(5):373-374.
    • (2011) Nat Biotechnol , vol.29 , Issue.5 , pp. 373-374
    • Guha, M.1
  • 63
    • 84886717487 scopus 로고    scopus 로고
    • Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond
    • In press. doi: 10.1016/j.mam.2013.01.006.
    • Curtin NJ, Szabo C. Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond. Mol Aspects Med 2013. In press. doi: 10.1016/j.mam.2013.01.006.
    • (2013) Mol Aspects Med
    • Curtin, N.J.1    Szabo, C.2
  • 64
    • 84876130803 scopus 로고    scopus 로고
    • Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias
    • Tobin LA, Robert C, Rapoport AP, Gojo I, Baer MR, Tomkinson AE, Rassool FV. Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias. Oncogene 2013;32(14):1784-1793.
    • (2013) Oncogene , vol.32 , Issue.14 , pp. 1784-1793
    • Tobin, L.A.1    Robert, C.2    Rapoport, A.P.3    Gojo, I.4    Baer, M.R.5    Tomkinson, A.E.6    Rassool, F.V.7
  • 65
    • 33847394968 scopus 로고    scopus 로고
    • Lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs
    • Porter CJ, Trevaskis NL, Charman WN. Lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 2007;6(3):231-248.
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.3 , pp. 231-248
    • Porter, C.J.1    Trevaskis, N.L.2    Charman, W.N.3
  • 66
    • 0032126647 scopus 로고    scopus 로고
    • DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: Identification of a common targeting mechanism for the assembly of replication factories
    • Montecucco A, Rossi R, Levin DS, Gary R, Park MS, Motycka TA, Ciarrocchi G, Villa A, Biamonti G, Tomkinson AE. DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: Identification of a common targeting mechanism for the assembly of replication factories. EMBO J 1998;17(13):3786-3795.
    • (1998) EMBO J , vol.17 , Issue.13 , pp. 3786-3795
    • Montecucco, A.1    Rossi, R.2    Levin, D.S.3    Gary, R.4    Park, M.S.5    Motycka, T.A.6    Ciarrocchi, G.7    Villa, A.8    Biamonti, G.9    Tomkinson, A.E.10
  • 69
    • 0141844487 scopus 로고    scopus 로고
    • Cell cycle-dependent phosphorylation of human DNA ligase I at the cyclin-dependent kinase sites
    • Ferrari G, Rossi R, Arosio D, Vindigni A, Biamonti G, Montecucco A. Cell cycle-dependent phosphorylation of human DNA ligase I at the cyclin-dependent kinase sites. J Biol Chem 2003;278(39):37761-37767.
    • (2003) J Biol Chem , vol.278 , Issue.39 , pp. 37761-37767
    • Ferrari, G.1    Rossi, R.2    Arosio, D.3    Vindigni, A.4    Biamonti, G.5    Montecucco, A.6
  • 70
    • 84869209775 scopus 로고    scopus 로고
    • Accelerating cancer therapy development: The importance of combination strategies and collaboration. Summary of an institute of medicine workshop
    • LoRusso PM, Canetta R, Wagner JA, Balogh EP, Nass SJ, Boerner SA, Hohneker J. Accelerating cancer therapy development: The importance of combination strategies and collaboration. Summary of an institute of medicine workshop. Clin Cancer Res 2012;18(22):6101-6109.
    • (2012) Clin Cancer Res , vol.18 , Issue.22 , pp. 6101-6109
    • LoRusso, P.M.1    Canetta, R.2    Wagner, J.A.3    Balogh, E.P.4    Nass, S.J.5    Boerner, S.A.6    Hohneker, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.