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Volumn 30, Issue 12, 2016, Pages 4159-4171

Role of neutral ceramidase in colon cancer

Author keywords

Aberrant crypt foci; Apoptosis; Azoxymethane; Sphingolipids ceramide

Indexed keywords

AZOXYMETHANE; BETA CATENIN; C 6 UREA CERAMIDE; CERAMIDE; CERAMIDE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; NEUTRAL CERAMIDASE; UNCLASSIFIED DRUG; UREA DERIVATIVE; SPHINGOLIPID;

EID: 85002213807     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.201600611R     Document Type: Article
Times cited : (57)

References (64)
  • 2
    • 27644564307 scopus 로고    scopus 로고
    • Molecular pathogenesis of colorectal cancer: Implications for molecular diagnosis
    • Arnold, C. N., Goel, A., Blum, H. E., and Boland, C. R. (2005) Molecular pathogenesis of colorectal cancer: implications for molecular diagnosis. Cancer 104, 2035-2047
    • (2005) Cancer , vol.104 , pp. 2035-2047
    • Arnold, C.N.1    Goel, A.2    Blum, H.E.3    Boland, C.R.4
  • 4
    • 0030448021 scopus 로고    scopus 로고
    • Functions of ceramide in coordinating cellular responses to stress
    • Hannun, Y. A. (1996) Functions of ceramide in coordinating cellular responses to stress. Science 274, 1855-1859
    • (1996) Science , vol.274 , pp. 1855-1859
    • Hannun, Y.A.1
  • 6
    • 77951910348 scopus 로고    scopus 로고
    • Ceramide-rich platforms in transmembrane signaling
    • Stancevic, B., and Kolesnick, R. (2010) Ceramide-rich platforms in transmembrane signaling. FEBS Lett. 584, 1728-1740
    • (2010) FEBS Lett. , vol.584 , pp. 1728-1740
    • Stancevic, B.1    Kolesnick, R.2
  • 7
    • 33748047499 scopus 로고    scopus 로고
    • Bioactive sphingolipids in the modulation of the inflammatory response
    • El Alwani, M., Wu, B. X., Obeid, L. M., and Hannun, Y. A. (2006) Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol. Ther. 112, 171-183
    • (2006) Pharmacol. Ther. , vol.112 , pp. 171-183
    • El Alwani, M.1    Wu, B.X.2    Obeid, L.M.3    Hannun, Y.A.4
  • 10
    • 84893917906 scopus 로고    scopus 로고
    • Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in south asian population
    • Tan, S. S., Khin, L. W., Wong, L., Yan, B., Ong, C. W., Datta, A., Salto-Tellez, M., Lam, Y., and Yap, C. T. (2014) Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South Asian population. Clin. Transl. Gastroenterol. 5, e51
    • (2014) Clin. Transl. Gastroenterol. , vol.5 , pp. e51
    • Tan, S.S.1    Khin, L.W.2    Wong, L.3    Yan, B.4    Ong, C.W.5    Datta, A.6    Salto-Tellez, M.7    Lam, Y.8    Yap, C.T.9
  • 11
    • 33947314618 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: Lipid signaling strikes again
    • Oskouian, B., and Saba, J. (2007) Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again. Cell Cycle 6, 522-527
    • (2007) Cell Cycle , vol.6 , pp. 522-527
    • Oskouian, B.1    Saba, J.2
  • 12
    • 0031023763 scopus 로고    scopus 로고
    • Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma
    • Hertervig, E., Nilsson, A., Nyberg, L., and Duan, R. D. (1997) Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma. Cancer 79, 448-453
    • (1997) Cancer , vol.79 , pp. 448-453
    • Hertervig, E.1    Nilsson, A.2    Nyberg, L.3    Duan, R.D.4
  • 13
    • 0028304788 scopus 로고
    • Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice
    • Dillehay, D. L., Webb, S. K., Schmelz, E. M., and Merrill, A. H., Jr. (1994) Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice. J. Nutr. 124, 615-620
    • (1994) J. Nutr. , vol.124 , pp. 615-620
    • Dillehay, D.L.1    Webb, S.K.2    Schmelz, E.M.3    Merrill, A.H.4
  • 14
    • 0029953485 scopus 로고    scopus 로고
    • Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treatedwith 1,2-dimethylhydrazine: Implications for dietary sphingolipids and colon carcinogenesis
    • Schmelz, E.M., Dillehay, D. L., Webb, S. K., Reiter, A., Adams, J., and Merrill, A. H., Jr. (1996) Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treatedwith 1,2-dimethylhydrazine: implications for dietary sphingolipids and colon carcinogenesis. Cancer Res. 56, 4936-4941
    • (1996) Cancer Res. , vol.56 , pp. 4936-4941
    • Schmelz, E.M.1    Dillehay, D.L.2    Webb, S.K.3    Reiter, A.4    Adams, J.5    Merrill, A.H.6
  • 17
    • 84897954357 scopus 로고    scopus 로고
    • New insight into the structure, reaction mechanism, and biological functions of neutral ceramidase
    • Ito, M., Okino, N., and Tani, M. (2014) New insight into the structure, reaction mechanism, and biological functions of neutral ceramidase. Biochim. Biophys. Acta 1841, 682-691
    • (2014) Biochim. Biophys. Acta , vol.1841 , pp. 682-691
    • Ito, M.1    Okino, N.2    Tani, M.3
  • 18
    • 79960117964 scopus 로고    scopus 로고
    • Novel pathway of ceramide production in mitochondria: Thioesterase and neutral ceramidase produce ceramide fromsphingosine and acyl-CoA
    • Novgorodov, S. A., Wu, B. X., Gudz, T. I., Bielawski, J., Ovchinnikova, T. V., Hannun, Y. A., and Obeid, L. M. (2011) Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide fromsphingosine and acyl-CoA. J. Biol. Chem. 286, 25352-25362
    • (2011) J. Biol. Chem. , vol.286 , pp. 25352-25362
    • Novgorodov, S.A.1    Wu, B.X.2    Gudz, T.I.3    Bielawski, J.4    Ovchinnikova, T.V.5    Hannun, Y.A.6    Obeid, L.M.7
  • 19
    • 67650239637 scopus 로고    scopus 로고
    • Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation
    • Wu, B.X., Zeidan, Y.H., and Hannun, Y.A. (2009) Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. Biochim. Biophys. Acta 1791, 730-739
    • (2009) Biochim. Biophys. Acta , vol.1791 , pp. 730-739
    • Wu, B.X.1    Zeidan, Y.H.2    Hannun, Y.A.3
  • 22
    • 23044486229 scopus 로고    scopus 로고
    • Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha
    • Osawa, Y., Uchinami, H., Bielawski, J., Schwabe, R. F., Hannun, Y. A., and Brenner, D.A. (2005) Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J. Biol. Chem. 280, 27879-27887
    • (2005) J. Biol. Chem. , vol.280 , pp. 27879-27887
    • Osawa, Y.1    Uchinami, H.2    Bielawski, J.3    Schwabe, R.F.4    Hannun, Y.A.5    Brenner, D.A.6
  • 24
    • 78049519702 scopus 로고    scopus 로고
    • Sphingolipid analysis by high performance liquid chromatography-tandemmass spectrometry (HPLC-MS/MS)
    • Bielawski, J., Pierce, J. S., Snider, J., Rembiesa, B., Szulc, Z. M., and Bielawska, A. (2010) Sphingolipid analysis by high performance liquid chromatography-tandemmass spectrometry (HPLC-MS/MS). Adv. Exp. Med. Biol. 688, 46-59
    • (2010) Adv. Exp. Med. Biol. , vol.688 , pp. 46-59
    • Bielawski, J.1    Pierce, J.S.2    Snider, J.3    Rembiesa, B.4    Szulc, Z.M.5    Bielawska, A.6
  • 25
    • 84944407529 scopus 로고    scopus 로고
    • Tumor necrosis factor-α (TNFα)-induced ceramide generation via ceramide synthases regulates loss of focal adhesion kinase (FAK) and programmed cell death
    • Hernández-Corbacho, M. J., Canals, D., Adada, M.M., Liu, M., Senkal, C. E., Yi, J. K., Mao, C., Luberto, C., Hannun, Y. A., and Obeid, L. M. (2015) Tumor necrosis factor-α (TNFα)-induced ceramide generation via ceramide synthases regulates loss of focal adhesion kinase (FAK) and programmed cell death. J. Biol. Chem. 290, 25356-25373
    • (2015) J. Biol. Chem. , vol.290 , pp. 25356-25373
    • Hernández-Corbacho, M.J.1    Canals, D.2    Adada, M.M.3    Liu, M.4    Senkal, C.E.5    Yi, J.K.6    Mao, C.7    Luberto, C.8    Hannun, Y.A.9    Obeid, L.M.10
  • 27
    • 84872442078 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins
    • Gandy, K. A., Canals, D., Adada, M., Wada, M., Roddy, P., Snider, A. J., Hannun, Y. A., and Obeid, L. M. (2013) Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem. J. 449, 661-672
    • (2013) Biochem. J. , vol.449 , pp. 661-672
    • Gandy, K.A.1    Canals, D.2    Adada, M.3    Wada, M.4    Roddy, P.5    Snider, A.J.6    Hannun, Y.A.7    Obeid, L.M.8
  • 28
    • 0022553294 scopus 로고
    • Potentiation of radiation effects on two murine tumors by lonidamine
    • Kim, J. H., Alfieri, A. A., Kim, S. H., and Young, C. W. (1986) Potentiation of radiation effects on two murine tumors by lonidamine. Cancer Res. 46, 1120-1123
    • (1986) Cancer Res. , vol.46 , pp. 1120-1123
    • Kim, J.H.1    Alfieri, A.A.2    Kim, S.H.3    Young, C.W.4
  • 29
    • 0023629080 scopus 로고
    • Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings
    • Bird, R. P. (1987) Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett. 37, 147-151
    • (1987) Cancer Lett. , vol.37 , pp. 147-151
    • Bird, R.P.1
  • 31
    • 0035859939 scopus 로고    scopus 로고
    • Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase
    • Usta, J., El Bawab, S., Roddy, P., Szulc, Z.M., Yusuf, Hannun, A., and Bielawska, A. (2001) Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase. Biochemistry 40, 9657-9668
    • (2001) Biochemistry , vol.40 , pp. 9657-9668
    • Usta, J.1    El Bawab, S.2    Roddy, P.3    Szulc, Z.M.4    Yusuf, H.A.5    Bielawska, A.6
  • 32
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • Hannun, Y. A., and Obeid, L. M. (2008) Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 9, 139-150
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 33
    • 66349092892 scopus 로고    scopus 로고
    • Ceramide-induced autophagy: To junk or to protect cells?
    • Pattingre, S., Bauvy, C., Levade, T., Levine, B., and Codogno, P. (2009) Ceramide-induced autophagy: to junk or to protect cells? Autophagy 5, 558-560
    • (2009) Autophagy , vol.5 , pp. 558-560
    • Pattingre, S.1    Bauvy, C.2    Levade, T.3    Levine, B.4    Codogno, P.5
  • 34
    • 0021958588 scopus 로고
    • Functional receptors for epidermal growth factor in an epithelial-cell line derived from the rat small intestine
    • Blay, J., and Brown, K. D. (1985) Functional receptors for epidermal growth factor in an epithelial-cell line derived from the rat small intestine. Biochem. J. 225, 85-94
    • (1985) Biochem. J. , vol.225 , pp. 85-94
    • Blay, J.1    Brown, K.D.2
  • 35
    • 35848967804 scopus 로고    scopus 로고
    • How to interpret LC3 immunoblotting
    • Mizushima, N., and Yoshimori, T. (2007) How to interpret LC3 immunoblotting. Autophagy 3, 542-545
    • (2007) Autophagy , vol.3 , pp. 542-545
    • Mizushima, N.1    Yoshimori, T.2
  • 38
    • 71949111376 scopus 로고    scopus 로고
    • Ceramide induces endothelial cell senescence
    • Venable, M. E., and Yin, X. (2009) Ceramide induces endothelial cell senescence. Cell Biochem. Funct. 27, 547-551
    • (2009) Cell Biochem. Funct. , vol.27 , pp. 547-551
    • Venable, M.E.1    Yin, X.2
  • 40
    • 0142258009 scopus 로고    scopus 로고
    • Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells
    • Kraveka, J. M., Li, L., Bielawski, J., Obeid, L. M., and Ogretmen, B. (2003) Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells. Arch. Biochem. Biophys. 419, 110-119
    • (2003) Arch. Biochem. Biophys. , vol.419 , pp. 110-119
    • Kraveka, J.M.1    Li, L.2    Bielawski, J.3    Obeid, L.M.4    Ogretmen, B.5
  • 41
  • 42
    • 28844506365 scopus 로고    scopus 로고
    • Mutant KRAS in aberrant crypt foci (ACF): Initiation of colorectal cancer?
    • Pretlow, T. P., and Pretlow, T. G. (2005) Mutant KRAS in aberrant crypt foci (ACF): initiation of colorectal cancer? Biochim. Biophys. Acta 1756, 83-96
    • (2005) Biochim. Biophys. Acta , vol.1756 , pp. 83-96
    • Pretlow, T.P.1    Pretlow, T.G.2
  • 43
    • 60149102748 scopus 로고    scopus 로고
    • Mousemodels for the study of colon carcinogenesis
    • Rosenberg, D. W., Giardina, C., and Tanaka, T. (2009) Mousemodels for the study of colon carcinogenesis. Carcinogenesis 30, 183-196
    • (2009) Carcinogenesis , vol.30 , pp. 183-196
    • Rosenberg, D.W.1    Giardina, C.2    Tanaka, T.3
  • 45
    • 0033870244 scopus 로고    scopus 로고
    • Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas
    • Brabletz, T., Herrmann, K., Jung, A., Faller, G., and Kirchner, T. (2000) Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas. Am. J. Pathol. 156, 865-870
    • (2000) Am. J. Pathol. , vol.156 , pp. 865-870
    • Brabletz, T.1    Herrmann, K.2    Jung, A.3    Faller, G.4    Kirchner, T.5
  • 46
    • 0035114217 scopus 로고    scopus 로고
    • Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer
    • Selzner, M., Bielawska, A., Morse, M. A., Rüdiger, H. A., Sindram, D., Hannun, Y. A., and Clavien, P. A. (2001) Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res. 61, 1233-1240
    • (2001) Cancer Res. , vol.61 , pp. 1233-1240
    • Selzner, M.1    Bielawska, A.2    Morse, M.A.3    Rüdiger, H.A.4    Sindram, D.5    Hannun, Y.A.6    Clavien, P.A.7
  • 52
    • 0033600850 scopus 로고    scopus 로고
    • Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain
    • ElBawab, S., Bielawska, A., and Hannun, Y.A. (1999) Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain. J. Biol. Chem. 274, 27948-27955
    • (1999) J. Biol. Chem. , vol.274 , pp. 27948-27955
    • ElBawab, S.1    Bielawska, A.2    Hannun, Y.A.3
  • 53
    • 0035929577 scopus 로고    scopus 로고
    • Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells
    • Franzen, R., Pautz, A., Bräutigam, L., Geisslinger, G., Pfeilschifter, J., and Huwiler, A. (2001) Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells. J. Biol. Chem. 276, 35382-35389
    • (2001) J. Biol. Chem. , vol.276 , pp. 35382-35389
    • Franzen, R.1    Pautz, A.2    Bräutigam, L.3    Geisslinger, G.4    Pfeilschifter, J.5    Huwiler, A.6
  • 54
    • 0033548599 scopus 로고    scopus 로고
    • Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells
    • Huwiler, A., Pfeilschifter, J., and van den Bosch, H. (1999) Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells. J. Biol. Chem. 274, 7190-7195
    • (1999) J. Biol. Chem. , vol.274 , pp. 7190-7195
    • Huwiler, A.1    Pfeilschifter, J.2    Van Den-Bosch, H.3
  • 55
    • 2242423614 scopus 로고    scopus 로고
    • Nitric oxide induces degradation of the neutral ceramidase in rat renalmesangial cells and is counterregulated by protein kinase C
    • Franzen, R., Fabbro, D., Aschrafi, A., Pfeilschifter, J., and Huwiler, A. (2002) Nitric oxide induces degradation of the neutral ceramidase in rat renalmesangial cells and is counterregulated by protein kinase C. J. Biol. Chem. 277, 46184-46190
    • (2002) J. Biol. Chem. , vol.277 , pp. 46184-46190
    • Franzen, R.1    Fabbro, D.2    Aschrafi, A.3    Pfeilschifter, J.4    Huwiler, A.5
  • 56
    • 33644669224 scopus 로고    scopus 로고
    • Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein
    • Voelkel-Johnson, C., Hannun, Y. A., and El-Zawahry, A. (2005) Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Mol. Cancer Ther. 4, 1320-1327
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1320-1327
    • Voelkel-Johnson, C.1    Hannun, Y.A.2    El-Zawahry, A.3
  • 57
    • 61349193762 scopus 로고    scopus 로고
    • Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells
    • White-Gilbertson, S., Mullen, T., Senkal, C., Lu, P., Ogretmen, B., Obeid, L., and Voelkel-Johnson, C. (2009) Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. Oncogene 28, 1132-1141
    • (2009) Oncogene , vol.28 , pp. 1132-1141
    • White-Gilbertson, S.1    Mullen, T.2    Senkal, C.3    Lu, P.4    Ogretmen, B.5    Obeid, L.6    Voelkel-Johnson, C.7
  • 58
    • 79952256046 scopus 로고    scopus 로고
    • Aberrant crypt foci: The case for inclusion as a biomarker for colon cancer
    • Wargovich, M. J., Brown, V. R., and Morris, J. (2010) Aberrant crypt foci: the case for inclusion as a biomarker for colon cancer. Cancers (Basel) 2, 1705-1716
    • (2010) Cancers (Basel) , vol.2 , pp. 1705-1716
    • Wargovich, M.J.1    Brown, V.R.2    Morris, J.3
  • 59
    • 38349056703 scopus 로고    scopus 로고
    • Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma
    • Marchesini, N., Jones, J. A., and Hannun, Y. A. (2007) Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma. Biochim. Biophys. Acta 1771, 1418-1428
    • (2007) Biochim. Biophys. Acta , vol.1771 , pp. 1418-1428
    • Marchesini, N.1    Jones, J.A.2    Hannun, Y.A.3
  • 60
    • 0035884179 scopus 로고    scopus 로고
    • Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids
    • Schmelz, E.M., Roberts, P.C., Kustin, E.M., Lemonnier, L.A., Sullards, M. C., Dillehay, D. L., and Merrill, A. H., Jr. (2001) Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. Cancer Res. 61, 6723-6729
    • (2001) Cancer Res. , vol.61 , pp. 6723-6729
    • Schmelz, E.M.1    Roberts, P.C.2    Kustin, E.M.3    Lemonnier, L.A.4    Sullards, M.C.5    Dillehay, D.L.6    Merrill, A.H.7
  • 61
    • 0037388638 scopus 로고    scopus 로고
    • Small interfering RNAs directed against beta-catenin inhibit the invitro and invivo growth of coloncancer cells
    • Verma, U.N., Surabhi, R.M., Schmaltieg, A., Becerra, C., and Gaynor, R. B. (2003) Small interfering RNAs directed against beta-catenin inhibit the invitro and invivo growth of coloncancer cells. Clin. Cancer Res. 9, 1291-1300
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1291-1300
    • Verma, U.N.1    Surabhi, R.M.2    Schmaltieg, A.3    Becerra, C.4    Gaynor, R.B.5
  • 62
    • 0035420212 scopus 로고    scopus 로고
    • Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells
    • Roh, H., Green, D. W., Boswell, C. B., Pippin, J. A., and Drebin, J. A. (2001) Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells. Cancer Res. 61, 6563-6568
    • (2001) Cancer Res. , vol.61 , pp. 6563-6568
    • Roh, H.1    Green, D.W.2    Boswell, C.B.3    Pippin, J.A.4    Drebin, J.A.5
  • 63
    • 0034760407 scopus 로고    scopus 로고
    • Betacatenin antisense treatment decreases beta-catenin expression and tumor growth rate in colon carcinoma xenografts
    • Green, D. W., Roh, H., Pippin, J. A., and Drebin, J. A. (2001) Betacatenin antisense treatment decreases beta-catenin expression and tumor growth rate in colon carcinoma xenografts. J. Surg. Res. 101, 16-20
    • (2001) J. Surg. Res. , vol.101 , pp. 16-20
    • Green, D.W.1    Roh, H.2    Pippin, J.A.3    Drebin, J.A.4
  • 64
    • 84871720518 scopus 로고    scopus 로고
    • Ceramide-orchestrated signalling in cancer cells
    • Morad, S. A., and Cabot, M. C. (2013) Ceramide-orchestrated signalling in cancer cells. Nat. Rev. Cancer 13, 51-65
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 51-65
    • Morad, S.A.1    Cabot, M.C.2


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