-
1
-
-
78049485263
-
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
-
Ferlay J, Shin HR, Bray F et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893-2917.
-
(2010)
Int J Cancer
, vol.127
, pp. 2893-2917
-
-
Ferlay, J.1
Shin, H.R.2
Bray, F.3
-
2
-
-
0034856316
-
Capecitabine: A novel agent for the treatment of solid tumors
-
Johnston P, Kaye S. Capecitabine: a novel agent for the treatment of solid tumors. Anticancer Drugs 2001; 12: 639-646.
-
(2001)
Anticancer Drugs
, vol.12
, pp. 639-646
-
-
Johnston, P.1
Kaye, S.2
-
3
-
-
77956635500
-
Current issues in the targeted therapy of advanced colorectal cancer
-
Knijn N, Tol J, Punt CJ. Current issues in the targeted therapy of advanced colorectal cancer. Discov Med 2010; 9: 328-336.
-
(2010)
Discov Med
, vol.9
, pp. 328-336
-
-
Knijn, N.1
Tol, J.2
Punt, C.J.3
-
4
-
-
0033143917
-
Ceramide and apoptosis
-
author reply 227
-
Kolesnick R, Hannun Y. Ceramide and apoptosis. Trends Biochem Sci 1999; 24: 224-225; author reply 227.
-
(1999)
Trends Biochem Sci
, vol.24
, pp. 224-225
-
-
Kolesnick, R.1
Hannun, Y.2
-
5
-
-
0029948396
-
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
-
Cuvillier O, Pirianov G, Kleuser B et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 1996; 381: 800-803.
-
(1996)
Nature
, vol.381
, pp. 800-803
-
-
Cuvillier, O.1
Pirianov, G.2
Kleuser, B.3
-
6
-
-
33845692736
-
Sphingosine kinase-1 - A potential therapeutic target in cancer
-
Cuvillier O. Sphingosine kinase-1 - a potential therapeutic target in cancer. Anticancer Drugs 2007; 18: 105-110.
-
(2007)
Anticancer Drugs
, vol.18
, pp. 105-110
-
-
Cuvillier, O.1
-
7
-
-
52449092057
-
Targeting SphK1 as a new strategy against cancer
-
Shida D, Takabe K, Kapitonov D et al. Targeting SphK1 as a new strategy against cancer. Curr Drug Targets 2008; 9: 662-673.
-
(2008)
Curr Drug Targets
, vol.9
, pp. 662-673
-
-
Shida, D.1
Takabe, K.2
Kapitonov, D.3
-
8
-
-
33644526361
-
Sphingosine kinase 1 is up-regulated in colon carcinogenesis
-
Kawamori T, Osta W, Johnson K et al. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J 2006; 20: 386-388.
-
(2006)
FASEB J
, vol.20
, pp. 386-388
-
-
Kawamori, T.1
Osta, W.2
Johnson, K.3
-
9
-
-
59649086217
-
Role for sphingosine kinase 1 in colon carcinogenesis
-
Kawamori T, Kaneshiro T, Okumura M et al. Role for sphingosine kinase 1 in colon carcinogenesis. FASEB J 2009; 23: 405-414.
-
(2009)
FASEB J
, vol.23
, pp. 405-414
-
-
Kawamori, T.1
Kaneshiro, T.2
Okumura, M.3
-
10
-
-
52949143502
-
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
-
Ruckhäberle E, Rody A, Engels K et al. Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. Breast Cancer Res Treat 2008; 112: 41-52.
-
(2008)
Breast Cancer Res Treat
, vol.112
, pp. 41-52
-
-
Ruckhäberle, E.1
Rody, A.2
Engels, K.3
-
11
-
-
63149167365
-
Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients
-
Li W, Yu C, Xia J et al. Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. Clin Cancer Res 2009; 15: 1393-1399.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1393-1399
-
-
Li, W.1
Yu, C.2
Xia, J.3
-
12
-
-
0036586089
-
Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells
-
Ahn E, Schroeder J. Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells. Exp Biol Med (Maywood) 2002; 227: 345-353.
-
(2002)
Exp Biol Med (Maywood)
, vol.227
, pp. 345-353
-
-
Ahn, E.1
Schroeder, J.2
-
13
-
-
0035114217
-
Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer
-
Selzner M, Bielawska A, Morse M et al. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res 2001; 61: 1233-1240.
-
(2001)
Cancer Res
, vol.61
, pp. 1233-1240
-
-
Selzner, M.1
Bielawska, A.2
Morse, M.3
-
14
-
-
33947314618
-
Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: Lipid signaling strikes again
-
Oskouian B, Saba J. Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again. Cell Cycle 2007; 6: 522-527.
-
(2007)
Cell Cycle
, vol.6
, pp. 522-527
-
-
Oskouian, B.1
Saba, J.2
-
15
-
-
59449090359
-
Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway
-
Greenspon J, Li R, Xiao L et al. Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway. Dig Dis Sci 2009; 54: 499-510.
-
(2009)
Dig Dis Sci
, vol.54
, pp. 499-510
-
-
Greenspon, J.1
Li, R.2
Xiao, L.3
-
16
-
-
33751225686
-
Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer
-
Oskouian B, Sooriyakumaran P, Borowsky AD et al. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc Natl Acad Sci USA 2006; 103: 17384-17389.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 17384-17389
-
-
Oskouian, B.1
Sooriyakumaran, P.2
Borowsky, A.D.3
-
17
-
-
33749185077
-
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation
-
Kohno M, Momoi M, Oo M et al. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol 2006; 26: 7211-7223.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 7211-7223
-
-
Kohno, M.1
Momoi, M.2
Oo, M.3
-
18
-
-
33847746287
-
Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours
-
Salto-Tellez M, Nga ME, Han HC et al. Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours. Br J Cancer 2007; 96: 776-782.
-
(2007)
Br J Cancer
, vol.96
, pp. 776-782
-
-
Salto-Tellez, M.1
Nga, M.E.2
Han, H.C.3
-
19
-
-
0033046689
-
Time-dependent covariates in the Cox proportional-hazards regression model
-
Fisher LD, Lin DY. Time-dependent covariates in the Cox proportional-hazards regression model. Annu Rev Public Health 1999; 20: 145-157.
-
(1999)
Annu Rev Public Health
, vol.20
, pp. 145-157
-
-
Fisher, L.D.1
Lin, D.Y.2
-
20
-
-
67549106796
-
Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases
-
Wong L, Tan SS, Lam Y et al. Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. J Med Chem 2009; 52: 3618-3626.
-
(2009)
J Med Chem
, vol.52
, pp. 3618-3626
-
-
Wong, L.1
Tan, S.S.2
Lam, Y.3
-
21
-
-
0842281351
-
Fluorescence-based assay of sphingosine kinases
-
Billich A, Ettmayer P. Fluorescence-based assay of sphingosine kinases. Anal Biochem 2004; 326: 114-119.
-
(2004)
Anal Biochem
, vol.326
, pp. 114-119
-
-
Billich, A.1
Ettmayer, P.2
-
22
-
-
67449098149
-
Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation
-
Nemoto S, Nakamura M, Osawa Y et al. Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation. J Biol Chem 2009; 284: 10422-10432.
-
(2009)
J Biol Chem
, vol.284
, pp. 10422-10432
-
-
Nemoto, S.1
Nakamura, M.2
Osawa, Y.3
-
23
-
-
77949452524
-
The PKB/AKT pathway in cancer
-
Carnero A. The PKB/AKT pathway in cancer. Curr Pharm Des 2010; 16: 34-44.
-
(2010)
Curr Pharm des
, vol.16
, pp. 34-44
-
-
Carnero, A.1
-
24
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004; 304:554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
25
-
-
0030915453
-
Non-parametric inference for cumulative incidence functions in competing risks studies
-
Lin DY. Non-parametric inference for cumulative incidence functions in competing risks studies. Stat Med 1997; 16: 901-910.
-
(1997)
Stat Med
, vol.16
, pp. 901-910
-
-
Lin, D.Y.1
-
26
-
-
67651112075
-
Competing risk regression models for epidemiologic data
-
Lau B, Cole SR, Gange SJ. Competing risk regression models for epidemiologic data. Am J Epidemiol 2009; 170: 244-256.
-
(2009)
Am J Epidemiol
, vol.170
, pp. 244-256
-
-
Lau, B.1
Cole, S.R.2
Gange, S.J.3
-
27
-
-
84871982124
-
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models
-
Rosa R, Marciano R, Malapelle U et al. Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models. Clin Cancer Res 2013; 19: 138-147.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 138-147
-
-
Rosa, R.1
Marciano, R.2
Malapelle, U.3
-
28
-
-
51049121847
-
Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models
-
Pchejetski D, Doumerc N, Golzio M et al. Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models. Mol Cancer Ther 2008; 7: 1836-1845.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1836-1845
-
-
Pchejetski, D.1
Doumerc, N.2
Golzio, M.3
-
29
-
-
33646117016
-
Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: The role of sphingosine kinase-1
-
Sukocheva O, Wadham C, Holmes A et al. Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1. J Cell Biol 2006; 173: 301-310.
-
(2006)
J Cell Biol
, vol.173
, pp. 301-310
-
-
Sukocheva, O.1
Wadham, C.2
Holmes, A.3
-
30
-
-
51749100808
-
The role of sphingosine kinase 1 in cancer: Oncogene or non-oncogene addiction?
-
Vadas M, Xia P, McCaughan G et al. The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction? Biochim Biophys Acta 2008; 1781: 442-447.
-
(2008)
Biochim Biophys Acta
, vol.1781
, pp. 442-447
-
-
Vadas, M.1
Xia, P.2
McCaughan, G.3
-
31
-
-
44949233776
-
Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells
-
Miller AV, Alvarez SE, Spiegel S et al. Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. Mol Cell Biol 2008; 28: 4142-4151.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 4142-4151
-
-
Miller, A.V.1
Alvarez, S.E.2
Spiegel, S.3
-
32
-
-
11844263399
-
Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells
-
Shida D, Kitayama J, Yamaguchi H et al. Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells. Biochem Biophys Res Commun 2005; 327: 907-914.
-
(2005)
Biochem Biophys Res Commun
, vol.327
, pp. 907-914
-
-
Shida, D.1
Kitayama, J.2
Yamaguchi, H.3
-
33
-
-
17044371645
-
Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members
-
Limaye V, Li X, Hahn C et al. Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood 2005; 105: 3169-3177.
-
(2005)
Blood
, vol.105
, pp. 3169-3177
-
-
Limaye, V.1
Li, X.2
Hahn, C.3
-
34
-
-
0033607517
-
Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells
-
Xia P, Wang L, Gamble JR et al. Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. J Biol Chem 1999; 274: 34499-34505.
-
(1999)
J Biol Chem
, vol.274
, pp. 34499-34505
-
-
Xia, P.1
Wang, L.2
Gamble, J.R.3
-
35
-
-
23944509761
-
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression
-
Le Scolan E, Pchejetski D, Banno Y et al. Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression. Blood 2005; 106: 1808-1816.
-
(2005)
Blood
, vol.106
, pp. 1808-1816
-
-
Le Scolan, E.1
Pchejetski, D.2
Banno, Y.3
-
36
-
-
33847702961
-
Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression
-
Radeff-Huang J, Seasholtz T, Chang J et al. Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression. J Biol Chem 2007; 282: 863-870.
-
(2007)
J Biol Chem
, vol.282
, pp. 863-870
-
-
Radeff-Huang, J.1
Seasholtz, T.2
Chang, J.3
-
37
-
-
70149120314
-
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts
-
Kapitonov D, Allegood J, Mitchell C et al. Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res 2009; 69: 6915-6923.
-
(2009)
Cancer Res
, vol.69
, pp. 6915-6923
-
-
Kapitonov, D.1
Allegood, J.2
Mitchell, C.3
-
38
-
-
72949118378
-
Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival
-
Dayon A, Brizuela L, Martin C et al. Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival. PLoS One 2009; 4: e8048.
-
(2009)
PLoS One
, vol.4
-
-
Dayon, A.1
Brizuela, L.2
Martin, C.3
-
39
-
-
77953966511
-
Sphingosine 1-phosphate and cancer
-
Pyne N, Pyne S. Sphingosine 1-phosphate and cancer. Nat Rev Cancer 2010; 10: 489-503.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 489-503
-
-
Pyne, N.1
Pyne, S.2
|