Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs

Journal of Clinical Investigation

Volumn 124, Issue 12, 2014, Pages 5368-5384

  Degagné, Emilie ^a   Pandurangan, Ashok ^a,b   Bandhuvula, Padmavathi ^a,c   Kumar, Ashok ^a,d   Eltanawy, Abeer ^a   Zhang, Meng ^a   Yoshinaga, Yuko ^a   Nefedov, Mikhail ^a,e   De Jong, Pieter J ^a   Fong, Loren G ^f   Young, Stephen G ^f   Bittman, Robert ^g   Ahmedi, Yasmin ^a   Saba, Julie D ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^c MOLECULAR DEVICES CORPORATION   (United States)

^d ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^e UNIVERSITY OF QUEENSLAND   (Australia)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2; MICRORNA; SPHINGADIENE; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE LYASE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; STAT3 PROTEIN; UNCLASSIFIED DRUG; ANION TRANSPORT PROTEIN; LYASE; LYSOPHOSPHOLIPID; MIRN181 MICRORNA, HUMAN; MIRN181 MICRORNA, MOUSE; RNA; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE 1-PHOSPHATE LYASE (ALDOLASE); SPNS2 PROTEIN, MOUSE; STAT3 PROTEIN, HUMAN; STAT3 PROTEIN, MOUSE; TUMOR PROTEIN;

ADENOID CYSTIC CARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER PREVENTION; CARCINOGENESIS; COLITIS; COLON BIOPSY; COLON CARCINOGENESIS; CONTROLLED STUDY; DISEASE ACTIVITY; DOWN REGULATION; FEMALE; FIBROBLAST; HUMAN; INFLAMMATORY BOWEL DISEASE; INTESTINE EPITHELIUM; MOUSE; NONHUMAN; PHENOTYPE; ANALOGS AND DERIVATIVES; ANIMAL; BIOPSY; BIOSYNTHESIS; CELL TRANSFORMATION; COLON TUMOR; EXPERIMENTAL NEOPLASM; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ALDEHYDE-LYASES; ANIMALS; ANION TRANSPORT PROTEINS; BIOPSY; CELL TRANSFORMATION, NEOPLASTIC; COLONIC NEOPLASMS; DOWN-REGULATION; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INFLAMMATORY BOWEL DISEASES; LYSOPHOSPHOLIPIDS; MICE; MICE, TRANSGENIC; MICRORNAS; NEOPLASM PROTEINS; NEOPLASMS, EXPERIMENTAL; RNA, NEOPLASM; SIGNAL TRANSDUCTION; SPHINGOSINE; STAT3 TRANSCRIPTION FACTOR;

EID: 84915748800     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI74188     Document Type: Article

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