A platycoside-rich fraction from the root of Platycodon grandiflorum enhances cell death in A549 human lung carcinoma cells via mainly AMPK/mTOR/AKT signal-mediated autophagy induction

Journal of Ethnopharmacology

Volumn 194, Issue , 2016, Pages 1060-1068

  Yim, Nam Hui ^a   Hwang, Youn Hwan ^a   Liang, Chun ^b   Ma, Jin Yeul ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^b THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

AMPK mTOR AKT; Apoptosis; Autophagy; Lung carcinoma cells; Platycosides rich fraction

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTINEOPLASTIC AGENT; BUTANOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 II; MITOGEN ACTIVATED PROTEIN KINASE; PLANT MEDICINAL PRODUCT; PLATYCODON GRANDIFLORUM EXTRACT; PLATYCOSIDE; PROTEIN KINASE B; UNCLASSIFIED DRUG; ADENYLATE KINASE; MTOR PROTEIN, HUMAN; PLANT EXTRACT; SAPONIN; TARGET OF RAPAMYCIN KINASE;

A-549 CELL LINE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER INHIBITION; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MTT ASSAY; NON SMALL CELL LUNG CANCER; PLANT ROOT; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; CARCINOMA, NON-SMALL-CELL LUNG; CHEMISTRY; DRUG EFFECTS; GENETICS; LUNG NEOPLASMS; METABOLISM; PLATYCODON;

ADENYLATE KINASE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AUTOPHAGY; CARCINOMA, NON-SMALL-CELL LUNG; HUMANS; LUNG NEOPLASMS; PLANT EXTRACTS; PLANT ROOTS; PLATYCODON; PROTO-ONCOGENE PROTEINS C-AKT; SAPONINS; TOR SERINE-THREONINE KINASES;

EID: 85002131998     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.10.078     Document Type: Article

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