Samsoeum, a traditional herbal medicine, elicits apoptotic and autophagic cell death by inhibiting Akt/mTOR and activating the JNK pathway in cancer cells

BMC Complementary and Alternative Medicine

Volumn 13, Issue , 2013, Pages

  Kim, Aeyung ^a   Yim, Nam Hui ^a   Ma, Jin Y ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

Akt mTOR; Apoptosis; Autophagy; Cell cycle arrest; JNK; Samsoeum

Indexed keywords

ADENOSINE PHOSPHATE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; AURANTIIN; BECLIN 1; CYCLIN B1; CYCLIN D1; DAIDZIN; GLYCYRRHIZIC ACID; HERBACEOUS AGENT; HESPERIDIN; LIQUIRITIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 3; MITOGEN ACTIVATED PROTEIN KINASE; NEOHESPERIDIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P21; PROTEIN P27; PUERARIN; SAMSOEUM; STRESS ACTIVATED PROTEIN KINASE; TRYPAN BLUE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CELL CYCLE ARREST; CELL DEATH; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME PHOSPHORYLATION; FEMALE; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HERBAL MEDICINE; HUMAN; HUMAN CELL; LIVER CELL; M PHASE CELL CYCLE CHECKPOINT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE CHECKPOINTS; CELL DEATH; CELL LINE, TUMOR; DRUGS, CHINESE HERBAL; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; PROTO-ONCOGENE PROTEINS C-AKT; TOR SERINE-THREONINE KINASES;

EID: 84884360285     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-13-233     Document Type: Article

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