Enhanced Cellular Internalization and On-Demand Intracellular Release of Doxorubicin by Stepwise pH-/Reduction-Responsive Nanoparticles

ACS Applied Materials and Interfaces

Volumn 8, Issue 47, 2016, Pages 32146-32158

  Li, Fang ^a   Chen, Wei Liang ^a   You, Ben Gang ^a   Liu, Yang ^a   Yang, Shu Di ^a   Yuan, Zhi Qiang ^a   Zhu, Wen Jing ^a   Li, Ji Zhao ^a   Qu, Chen Xi ^a   Zhou, Ye Juan ^a   Zhou, Xiao Feng ^b   Liu, Chun ^c   Zhang, Xue Nong ^a  

^a SOOCHOW UNIVERSITY   (China)

^b Changshu Hospital of Traditional Chinese Medicine   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

charge reversion; chitosan; drug delivery; dually pH reduction responsive; efficient delivery; smart NPs; tumor targeting

Indexed keywords

AMINO ACIDS; CHITIN; CHITOSAN; DISEASES; DRUG DELIVERY; DRUG PRODUCTS; ENZYME ACTIVITY; HISTOLOGY; NANOPARTICLES; PH; PHYSIOLOGY; TISSUE;

CELLULAR INTERNALIZATION; CHARGE REVERSION; CHEMOTHERAPEUTIC DRUGS; DUALLY PH-/REDUCTION-RESPONSIVE; EFFICIENT DELIVERY; PHYSIOLOGICAL CONDITION; SUSTAINED DRUG RELEASE; TUMOR TARGETING;

TUMORS;

DOXORUBICIN; DRUG CARRIER; NANOPARTICLE;

ANIMAL; BAGG ALBINO MOUSE; DRUG DELIVERY SYSTEM; DRUG RELEASE; HUMAN; MOUSE; PH;

ANIMALS; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MICE, INBRED BALB C; NANOPARTICLES;

EID: 84999806649     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.6b09604     Document Type: Article

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