Charge-conversional and reduction-sensitive poly(vinyl alcohol) nanogels for enhanced cell uptake and efficient intracellular doxorubicin release

Journal of Controlled Release

Volumn 205, Issue , 2015, Pages 15-24

  Chen, Wei ^a   Achazi, Katharina ^a   Schade, Boris ^a   Haag, Rainer ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Charge conversion; Drug delivery; Inverse nanoprecipitation; PVA nanogel; Stimuli responsive

Indexed keywords

CELLS; COVALENT BONDS; CYTOLOGY; DRUG DELIVERY; ELECTROSTATIC SEPARATORS; ELECTROSTATICS; ENZYME ACTIVITY; POLYVINYL ALCOHOLS;

AVERAGE DIAMETER; CELL INTERNALIZATION; CONFOCAL LASER SCANNING MICROSCOPY; NANO PRECIPITATIONS; NANOGELS; POLY (VINYL ALCOHOL) (PVA); STIMULI-RESPONSIVE; TUMOR EXTRACELLULAR PH;

NANOSTRUCTURED MATERIALS;

DOXORUBICIN; GLUTATHIONE; POLYVINYL ALCOHOL; ANTINEOPLASTIC ANTIBIOTIC; DELAYED RELEASE FORMULATION; DRUG CARRIER; GEL; NANOPARTICLE;

ARTICLE; CELL GROWTH; CELL KILLING; CELL MEMBRANE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CHEMICAL REACTION KINETICS; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; CYCLOADDITION; CYTOTOXICITY; DRUG RELEASE; GEL; HELA CELL LINE; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; INFRARED SPECTROSCOPY; INTERNALIZATION; MCF 7 CELL LINE; MTT ASSAY; NANOENCAPSULATION; NANOGEL; PH; PRIORITY JOURNAL; REDUCTION; STATIC ELECTRICITY; SURFACE CHARGE; SYNTHESIS; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; BREAST NEOPLASMS; CELL SURVIVAL; CHEMISTRY; CLICK CHEMISTRY; CONFOCAL MICROSCOPY; DELAYED RELEASE FORMULATION; DOSE RESPONSE; DRUG EFFECTS; FEMALE; IC50; MEDICINAL CHEMISTRY; METABOLISM; NANOMEDICINE; OXIDATION REDUCTION REACTION; PARTICLE SIZE; PATHOLOGY; PHARMACEUTICS; PROCEDURES; SOLUBILITY; SURFACE PROPERTY; TIME; TRANSPORT AT THE CELLULAR LEVEL;

ANTIBIOTICS, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; CLICK CHEMISTRY; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG CARRIERS; FEMALE; GELS; HUMANS; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; MCF-7 CELLS; MICROSCOPY, CONFOCAL; NANOMEDICINE; NANOPARTICLES; OXIDATION-REDUCTION; PARTICLE SIZE; POLYVINYL ALCOHOL; SOLUBILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 84926452296     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.11.012     Document Type: Article

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