Intracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditions

Biomaterials

Volumn 34, Issue 21, 2013, Pages 5262-5272

  Wu, Liangliang ^a   Zou, Yan ^a   Deng, Chao ^a   Cheng, Ru ^a   Meng, Fenghua ^a   Zhong, Zhiyuan ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Anticancer drug; Intracellular drug release; Micelles; PH Sensitive; Polypeptide; Reduction sensitive

Indexed keywords

ANTICANCER DRUG; DRUG RELEASE; HIGH SALT CONCENTRATION; INHIBITORY CONCENTRATION; PH SENSITIVE; REDUCTION CONDITIONS; REDUCTION-SENSITIVE; TARGETED CANCER THERAPY;

AMINO ACIDS; BLOCK COPOLYMERS; CELL DEATH; CYTOTOXICITY; LOADING; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYPEPTIDES;

MICELLES;

AMIDE; BUFFER; COPOLYMER; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; DITHIOTHREITOL; DOXORUBICIN; GLUTATHIONE; MACROGOL; NANOPARTICLE; PHOSPHATE; THIOCTIC ACID;

ARTICLE; CATALYSIS; CELL DEATH; CHEMICAL BOND; CHEMICAL INTERACTION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENCAPSULATION; IN VITRO STUDY; INCUBATION TIME; MICELLE; MOLECULARLY TARGETED THERAPY; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION KINETICS;

ANTINEOPLASTIC AGENTS; COLLOIDS; CROSS-LINKING REAGENTS; CYCLOHEXANECARBOXYLIC ACIDS; DICARBOXYLIC ACIDS; DOXORUBICIN; HELA CELLS; HEP G2 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INTRACELLULAR SPACE; LYSINE; MAGNETIC RESONANCE SPECTROSCOPY; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; OXIDATION-REDUCTION; PARTICLE SIZE; PEPTIDES; POLYETHYLENE GLYCOLS; THIOCTIC ACID;

EID: 84877071500     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.03.035     Document Type: Article

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