Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release

Biomaterials

Volumn 60, Issue , 2015, Pages 100-110

  Ruan, Shaobo ^a   Cao, Xi ^a   Cun, Xingli ^a   Hu, Guanlian ^a   Zhou, Yi ^a   Zhang, Yijia ^a   Lu, Libao ^a   He, Qin ^a   Gao, Huile ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Deep penetration; Gelatin nanoparticle; Gold nanoparticle; Matrix metalloproteinase; PH release; Size shrinkable

Indexed keywords

COLLAGEN; CONTROLLED DRUG DELIVERY; GOLD NANOPARTICLES; GROWTH RATE; MAMMALS; METAL NANOPARTICLES; PARTICLE SIZE; POLYETHYLENES; SILICON COMPOUNDS; TARGETED DRUG DELIVERY; TUMORS;

DEEP PENETRATION; ENHANCED PERMEABILITY AND RETENTION EFFECTS; GELATIN NANOPARTICLES; LOADING CAPACITIES; MATRIX METALLOPROTEINASES; SIZE-SHRINKABLE; TUMOR MICROENVIRONMENT; TUMOR PENETRATION;

GOLD COMPOUNDS;

COLLAGEN GEL; DOXORUBICIN; GELATIN; GELATINASE A; GOLD NANOPARTICLE; MACROGOL; NANOCARRIER; ANTINEOPLASTIC ANTIBIOTIC; DELAYED RELEASE FORMULATION; GOLD; MACROGOL DERIVATIVE; MATRIX METALLOPROTEINASE; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RELEASE; ENDOSOME; EX VIVO STUDY; FEMALE; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; TISSUE DISTRIBUTION; TUMOR MICROENVIRONMENT; TUMOR SPHEROID; ZETA POTENTIAL; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; DELAYED RELEASE FORMULATION; METABOLISM; MULTICELLULAR SPHEROID; NEOPLASMS; PATHOLOGY; TUMOR CELL CULTURE;

MUS;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; FEMALE; GELATIN; GOLD; HYDROGEN-ION CONCENTRATION; MALE; MATRIX METALLOPROTEINASES, SECRETED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NANOPARTICLES; NEOPLASMS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

EID: 84930450037     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.05.006     Document Type: Article

References (35)

1. Bertrand N., Wu J., Xu X., Kamaly N., Farokhzad O.C. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv. Drug Deliv. Rev. 2014, 66:2-25.
2. Jain R.K. Transport of molecules across tumor vasculature. Cancer Metastasis Rev. 1987, 6(4):559-593.
3. Jain R.K. Transport of molecules in the tumor interstitium: a review. Cancer Res. 1987, 47(12):3039-3051.
4. Stylianopoulos T., Wong C., Bawendi M.G., Jain R.K., Fukumura D. Multistage nanoparticles for improved delivery into tumor tissue. Nanomedicine: cancer, diabetes, and cardiovascular, central nervous system. Pulm. Inflamm. Dis. 2012, 508:109-130.
5. Chauhan V.P., Stylianopoulos T., Boucher Y., Jain R.K. Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annu Rev. Chem. Biomol. Eng. 2011, 2:281-298.
6. Vakoc B.J., Lanning R.M., Tyrrell J.A., Padera T.P., Bartlett L.A., Stylianopoulos T., et al. Three-dimensional microscopy of the tumor microenvironment invivo using optical frequency domain imaging. Nat. Med. 2009, 15(10). 1219-U151.
7. Hobbs S.K., Monsky W.L., Yuan F., Roberts W.G., Griffith L., Torchilin V.P., et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(8):4607-4612.
8. Hashizume H., Baluk P., Morikawa S., McLean J.W., Thurston G., Roberge S., et al. Openings between defective endothelial cells explain tumor vessel leakiness. Am. J. Pathol. 2000, 156(4):1363-1380.
9. Boucher Y., Jain R.K. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors - implications for vascular collapse. Cancer Res. 1992, 52(18):5110-5114.
10. Brown E., McKee T., diTomaso E., Pluen A., Seed B., Boucher Y., et al. Dynamic imaging of collagen and its modulation in tumors invivo using second-harmonic generation. Nat. Med. 2003, 9(6):796-800.
11. Diop-Frimpong B., Chauhan V.P., Krane S., Boucher Y., Jain R.K. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(7):2909-2914.
12. Baish J.W., Stylianopoulos T., Lanning R.M., Kamoun W.S., Fukumura D., Munn L.L., et al. Scaling rules for diffusive drug delivery in tumor and normal tissues. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(5):1799-1803.
13. Popovic Z., Liu W., Chauhan V.P., Lee J., Wong C., Greytak A.B., et al. Ananoparticle size series for invivo fluorescence imaging. Angew. Chem. Int. Ed. Engl. 2010, 49(46):8649-8652.
14. Jain R.K., Stylianopoulos T. Delivering nanomedicine to solid tumors. Nat. Rev. Clin. Oncol. 2010, 7(11):653-664.
15. Perrault S.D., Walkey C., Jennings T., Fischer H.C., Chan W.C.W. Mediating tumor targeting efficiency of nanoparticles through design. Nano Lett. 2009, 9(5):1909-1915.
16. Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307(5706):58-62.
17. Baish J.W., Gazit Y., Berk D.A., Nozue M., Baxter L.T., Jain R.K. Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model. Microvasc. Res. 1996, 51(3):327-346.
18. Yuan F., Dellian M., Fukumura D., Leunig M., Berk D.A., Torchilin V.P., et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res. 1995, 55(17):3752-3756.
19. Cabral H., Matsumoto Y., Mizuno K., Chen Q., Murakami M., Kimura M., et al. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat. Nanotechnol. 2011, 6(12):815-823.
20. Shao K., Ding N., Huang S., Ren S., Zhang Y., Kuang Y., et al. Smart nanodevice combined tumor-specific vector with cellular microenvironment-triggered property for highly effective antiglioma therapy. ACS Nano 2014, 8(2):1191-1203.
21. Shao Y., Shi C., Xu G., Guo D., Luo J. Photo and redox dual responsive reversibly cross-linked nanocarrier for efficient tumor-targeted drug delivery. Acs Appl. Mater. Interf. 2014, 6(13):10381-10392.
22. Wang F., Wang Y.C., Dou S., Xiong M.H., Sun T.M., Wang J. Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells. ACS Nano 2011, 5(5):3679-3692.
23. Zhu L., Mahato R.I. Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation. Bioconjug. Chem. 2010, 21(11):2119-2127.
24. Zhu L., Kate P., Torchilin V.P. Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting. ACS Nano 2012, 6(4):3491-3498.
25. Li L.L., Xu J.H., Qi G.B., Zhao X., Yu F., Wang H. Core-shell supramolecular gelatin nanoparticles for adaptive and "on-demand" antibiotic delivery. ACS Nano 2014, 8(5):4975-4983.
26. Prabaharan M., Grailer J.J., Pilla S., Steeber D.A., Gong S. Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery. Biomaterials 2009, 30(30):6065-6075.
27. Zhu L., Wang T., Perche F., Taigind A., Torchilin V.P. Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety. Proc. Natl. Acad. Sci. U. S. A. 2013, 110(42):17047-17052.
28. Lee C.C., Cramer A.T., Szoka F.C., Frechet J.M.J. An intramolecular cyclization reaction is responsible for the invivo inefficacy and apparent pH insensitive hydrolysis kinetics of hydrazone carboxylate derivatives of doxorubicin. Bioconjug. Chem. 2006, 17(5):1364-1368.
29. Ruan S., Yuan M., Zhang L., Hu G., Chen J., Cun X., et al. Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles. Biomaterials 2015, 37:425-435.
30. Wong C., Stylianopoulos T., Cui J.A., Martin J., Chauhan V.P., Jiang W., et al. Multistage nanoparticle delivery system for deep penetration into tumor tissue. Proc. Natl. Acad. Sci. 2011, 108(6):2426-2431.
31. Fang J., Nakamura H., Maeda H. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv. Drug Deliv. Rev. 2011, 63(3):136-151.
32. Li J., Zhou Y., Li C., Wang D., Gao Y., Zhang C., et al. Poly(2-ethyl-2-oxazoline)-doxorubicin conjugate-based dual endosomal pH-sensitive micelles with enhanced antitumor efficacy. Bioconjug. Chem. 2015, 26(1):110-119.
33. Goodman T.T., Ng C.P., Pun S.H. 3-D tissue culture systems for the evaluation and optimization of nanoparticle-based drug carriers. Bioconjug. Chem. 2008, 19(10):1951-1959.
34. Gao H., Yang Z., Zhang S., Pang Z., Liu Q., Jiang X. Study and evaluation of mechanisms of dual targeting drug delivery system with tumor microenvironment assays compared with normal assays. Acta Biomater. 2014, 10(2):858-867.
35. Junttila M.R., de Sauvage F.J. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 2013, 501(7467):346-354.