Co-delivery of erlotinib and doxorubicin by pH-sensitive charge conversion nanocarrier for synergistic therapy

Journal of Controlled Release

Volumn 229, Issue , 2016, Pages 80-92

  He, Yongju ^a   Su, Zhigui ^b   Xue, Lingjing ^b   Xu, Hui ^a,b   Zhang, Can ^b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Charge conversion; DOX; Erlotinib; MSN; pH sensitive; Synergistic therapy

Indexed keywords

BIOLOGICAL ORGANS; CELL DEATH; CYTOLOGY; DISEASES; ENZYME ACTIVITY; LIPID BILAYERS; MESOPOROUS MATERIALS; NANOPARTICLES; PH SENSORS; TUMORS;

AMINO-FUNCTIONALIZED MESOPOROUS SILICAS; EPIDERMAL GROWTH FACTOR RECEPTORS; ERLOTINIB; LEWIS LUNG CARCINOMATA; PH SENSITIVE; SURFACE ZETA POTENTIAL; SYNERGISTIC THERAPY; TUMOR EXTRACELLULAR PH;

CELLS;

BENZOIC ACID DERIVATIVE; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; MESOPOROUS SILICA NANOPARTICLE; NANOCARRIER; NANOPARTICLE; OLIGOPEPTIDE; ANTINEOPLASTIC AGENT; DRUG CARRIER; PHOSPHATIDYLCHOLINE; PROTEIN KINASE INHIBITOR;

A549 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL PH; CELL TRANSPORT; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG POTENTIATION; ENDOCYTOSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; INTERNALIZATION; LEWIS CARCINOMA; LIPID BILAYER; LIPID COMPOSITION; MALE; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; ZETA POTENTIAL; A-549 CELL LINE; ANIMAL; C57BL MOUSE; CARCINOMA, LEWIS LUNG; CELL SURVIVAL; CHEMISTRY; COMBINATION DRUG THERAPY; DRUG EFFECTS; DRUG RELEASE; SPRAGUE DAWLEY RAT;

A549 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOATES; CARCINOMA, LEWIS LUNG; CELL SURVIVAL; DOXORUBICIN; DRUG CARRIERS; DRUG LIBERATION; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ERLOTINIB HYDROCHLORIDE; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MICE, INBRED C57BL; NANOPARTICLES; PHOSPHATIDYLCHOLINES; PROTEIN KINASE INHIBITORS; RATS, SPRAGUE-DAWLEY;

EID: 84961894525     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.03.001     Document Type: Article

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