-
1
-
-
79952131874
-
Impact of high-throughput screening in biomedical research
-
Macarron, R., Banks, M. N., Bojanic, D., Burns, D. J., Cirovic, D. A., Garyantes, T., Green, D. V., Hertzberg, R. P., Janzen, W. P., Paslay, J. W., Schopfer, U., and Sittampalam, G. S. (2011) Impact of high-throughput screening in biomedical research Nat. Rev. Drug Discovery 10, 188-195 10.1038/nrd3368
-
(2011)
Nat. Rev. Drug Discovery
, vol.10
, pp. 188-195
-
-
MacArron, R.1
Banks, M.N.2
Bojanic, D.3
Burns, D.J.4
Cirovic, D.A.5
Garyantes, T.6
Green, D.V.7
Hertzberg, R.P.8
Janzen, W.P.9
Paslay, J.W.10
Schopfer, U.11
Sittampalam, G.S.12
-
2
-
-
84892153139
-
Clinical development success rates for investigational drugs
-
Hay, M., Thomas, D. W., Craighead, J. L., Economides, C., and Rosenthal, J. (2014) Clinical development success rates for investigational drugs Nat. Biotechnol. 32, 40-51 10.1038/nbt.2786
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 40-51
-
-
Hay, M.1
Thomas, D.W.2
Craighead, J.L.3
Economides, C.4
Rosenthal, J.5
-
3
-
-
84928125332
-
Increasing the delivery of next generation therapeutics from high throughput screening libraries
-
Wigglesworth, M. J., Murray, D. C., Blackett, C. J., Kossenjans, M., and Nissink, J. W. (2015) Increasing the delivery of next generation therapeutics from high throughput screening libraries Curr. Opin. Chem. Biol. 26, 104-110 10.1016/j.cbpa.2015.04.006
-
(2015)
Curr. Opin. Chem. Biol.
, vol.26
, pp. 104-110
-
-
Wigglesworth, M.J.1
Murray, D.C.2
Blackett, C.J.3
Kossenjans, M.4
Nissink, J.W.5
-
4
-
-
84955216770
-
Towards a hit for every target
-
Rees, S., Gribbon, P., Birmingham, K., Janzen, W. P., and Pairaudeau, G. (2016) Towards a hit for every target Nat. Rev. Drug Discovery 15, 1-2 10.1038/nrd.2015.19
-
(2016)
Nat. Rev. Drug Discovery
, vol.15
, pp. 1-2
-
-
Rees, S.1
Gribbon, P.2
Birmingham, K.3
Janzen, W.P.4
Pairaudeau, G.5
-
5
-
-
84934439985
-
An analysis of the attrition of drug candidates from four major pharmaceutical companies
-
Waring, M. J., Arrowsmith, J., Leach, A. R., Leeson, P. D., Mandrell, S., Owen, R. M., Pairaudeau, G., Pennie, W. D., Pickett, S. D., Wang, J., Wallace, O., and Weir, A. (2015) An analysis of the attrition of drug candidates from four major pharmaceutical companies Nat. Rev. Drug Discovery 14, 475-486 10.1038/nrd4609
-
(2015)
Nat. Rev. Drug Discovery
, vol.14
, pp. 475-486
-
-
Waring, M.J.1
Arrowsmith, J.2
Leach, A.R.3
Leeson, P.D.4
Mandrell, S.5
Owen, R.M.6
Pairaudeau, G.7
Pennie, W.D.8
Pickett, S.D.9
Wang, J.10
Wallace, O.11
Weir, A.12
-
6
-
-
84962925987
-
Compound high-quality criteria: A new vision to guide the development of drugs, current situation
-
Mignani, S., Huber, S., Tomás, H., Rodrigues, J., and Majoral, J. P. (2016) Compound high-quality criteria: a new vision to guide the development of drugs, current situation Drug Discovery Today 21, 573 10.1016/j.drudis.2016.01.005
-
(2016)
Drug Discovery Today
, vol.21
, pp. 573
-
-
Mignani, S.1
Huber, S.2
Tomás, H.3
Rodrigues, J.4
Majoral, J.P.5
-
7
-
-
84860455486
-
Discovery of small molecule cancer drugs: Successes, challenges and opportunities
-
Hoelder, S., Clarke, P. A., and Workman, P. (2012) Discovery of small molecule cancer drugs: successes, challenges and opportunities Mol. Oncol. 6, 155-176 10.1016/j.molonc.2012.02.004
-
(2012)
Mol. Oncol.
, vol.6
, pp. 155-176
-
-
Hoelder, S.1
Clarke, P.A.2
Workman, P.3
-
8
-
-
84901946024
-
Lessons learned from the fate of AstraZeneca's drug pipeline: A five-dimensional framework
-
Cook, D., Brown, D., Alexander, R., March, R., Morgan, P., Satterthwaite, G., and Pangalos, M. N. (2014) Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework Nat. Rev. Drug Discovery 13, 419-431 10.1038/nrd4309
-
(2014)
Nat. Rev. Drug Discovery
, vol.13
, pp. 419-431
-
-
Cook, D.1
Brown, D.2
Alexander, R.3
March, R.4
Morgan, P.5
Satterthwaite, G.6
Pangalos, M.N.7
-
9
-
-
84896403739
-
Reducing attrition in drug development: Smart loading preclinical safety assessment
-
Roberts, R. A., Kavanagh, S. L., Mellor, H. R., Pollard, C. E., Robinson, S., and Platz, S. J. (2014) Reducing attrition in drug development: smart loading preclinical safety assessment Drug Discovery Today 19, 341-347 10.1016/j.drudis.2013.11.014
-
(2014)
Drug Discovery Today
, vol.19
, pp. 341-347
-
-
Roberts, R.A.1
Kavanagh, S.L.2
Mellor, H.R.3
Pollard, C.E.4
Robinson, S.5
Platz, S.J.6
-
10
-
-
84939986310
-
Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015
-
Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., Baehrecke, E. H., Bazan, N. G., Bertrand, M. J., Bianchi, K., Blagosklonny, M. V., Blomgren, K., Borner, C., Bredesen, D. E., Brenner, C., Campanella, M., Candi, E., Cecconi, F., Chan, F. K., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Dawson, T. M., Dawson, V. L., De Laurenzi, V., De Maria, R., Debatin, K. M., Di Daniele, N., Dixit, V. M., Dynlacht, B. D., El-Deiry, W. S., Fimia, G. M., Flavell, R. A., Fulda, S., Garrido, C., Gougeon, M. L., Green, D. R., Gronemeyer, H., Hajnoczky, G., Hardwick, J. M., Hengartner, M. O., Ichijo, H., Joseph, B., Jost, P. J., Kaufmann, T., Kepp, O., Klionsky, D. J., Knight, R. A., Kumar, S., Lemasters, J. J., Levine, B., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Lugli, E., Madeo, F., Malorni, W., Marine, J. C., Martin, S. J., Martinou, J. C., Medema, J. P., Meier, P., Melino, S., Mizushima, N., Moll, U., Muñoz-Pinedo, C., Nuñez, G., Oberst, A., Panaretakis, T., Penninger, J. M., Peter, M. E., Piacentini, M., Pinton, P., Prehn, J. H., Puthalakath, H., Rabinovich, G. A., Ravichandran, K. S., Rizzuto, R., Rodrigues, C. M., Rubinsztein, D. C., Rudel, T., Shi, Y., Simon, H. U., Stockwell, B. R., Szabadkai, G., Tait, S. W., Tang, H. L., Tavernarakis, N., Tsujimoto, Y., Vanden Berghe, T., Vandenabeele, P., Villunger, A., Wagner, E. F., Walczak, H., White, E., Wood, W. G., Yuan, J., Zakeri, Z., Zhivotovsky, B., Melino, G., and Kroemer, G. (2015) Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 Cell Death Differ. 22, 58-73 10.1038/cdd.2014.137
-
(2015)
Cell Death Differ.
, vol.22
, pp. 58-73
-
-
Galluzzi, L.1
Bravo-San Pedro, J.M.2
Vitale, I.3
Aaronson, S.A.4
Abrams, J.M.5
Adam, D.6
Alnemri, E.S.7
Altucci, L.8
Andrews, D.9
Annicchiarico-Petruzzelli, M.10
Baehrecke, E.H.11
Bazan, N.G.12
Bertrand, M.J.13
Bianchi, K.14
Blagosklonny, M.V.15
Blomgren, K.16
Borner, C.17
Bredesen, D.E.18
Brenner, C.19
Campanella, M.20
Candi, E.21
Cecconi, F.22
Chan, F.K.23
Chandel, N.S.24
Cheng, E.H.25
Chipuk, J.E.26
Cidlowski, J.A.27
Ciechanover, A.28
Dawson, T.M.29
Dawson, V.L.30
De Laurenzi, V.31
De Maria, R.32
Debatin, K.M.33
Di Daniele, N.34
Dixit, V.M.35
Dynlacht, B.D.36
El-Deiry, W.S.37
Fimia, G.M.38
Flavell, R.A.39
Fulda, S.40
Garrido, C.41
Gougeon, M.L.42
Green, D.R.43
Gronemeyer, H.44
Hajnoczky, G.45
Hardwick, J.M.46
Hengartner, M.O.47
Ichijo, H.48
Joseph, B.49
Jost, P.J.50
Kaufmann, T.51
Kepp, O.52
Klionsky, D.J.53
Knight, R.A.54
Kumar, S.55
Lemasters, J.J.56
Levine, B.57
Linkermann, A.58
Lipton, S.A.59
Lockshin, R.A.60
López-Otín, C.61
Lugli, E.62
Madeo, F.63
Malorni, W.64
Marine, J.C.65
Martin, S.J.66
Martinou, J.C.67
Medema, J.P.68
Meier, P.69
Melino, S.70
Mizushima, N.71
Moll, U.72
Muñoz-Pinedo, C.73
Nuñez, G.74
Oberst, A.75
Panaretakis, T.76
Penninger, J.M.77
Peter, M.E.78
Piacentini, M.79
Pinton, P.80
Prehn, J.H.81
Puthalakath, H.82
Rabinovich, G.A.83
Ravichandran, K.S.84
Rizzuto, R.85
Rodrigues, C.M.86
Rubinsztein, D.C.87
Rudel, T.88
Shi, Y.89
Simon, H.U.90
Stockwell, B.R.91
Szabadkai, G.92
Tait, S.W.93
Tang, H.L.94
Tavernarakis, N.95
Tsujimoto, Y.96
Vanden Berghe, T.97
Vandenabeele, P.98
Villunger, A.99
more..
-
11
-
-
84872606148
-
Autophagy, apoptosis, mitoptosis and necrosis: Interdependence between those pathways and effects on cancer
-
Chaabane, W., User, S. D., El-Gazzah, M., Jaksik, R., Sajjadi, E., Rzeszowska-Wolny, J., and Los, M. J. (2013) Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer Arch. Immunol. Ther. Exp. 61, 43-58 10.1007/s00005-012-0205-y
-
(2013)
Arch. Immunol. Ther. Exp.
, vol.61
, pp. 43-58
-
-
Chaabane, W.1
User, S.D.2
El-Gazzah, M.3
Jaksik, R.4
Sajjadi, E.5
Rzeszowska-Wolny, J.6
Los, M.J.7
-
12
-
-
84255210700
-
Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012
-
Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., Gottlieb, E., Green, D. R., Hengartner, M. O., Kepp, O., Knight, R. A., Kumar, S., Lipton, S. A., Lu, X., Madeo, F., Malorni, W., Mehlen, P., Nuñez, G., Peter, M. E., Piacentini, M., Rubinsztein, D. C., Shi, Y., Simon, H. U., Vandenabeele, P., White, E., Yuan, J., Zhivotovsky, B., Melino, G., and Kroemer, G. (2012) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 Cell Death Differ. 19, 107-120 10.1038/cdd.2011.96
-
(2012)
Cell Death Differ.
, vol.19
, pp. 107-120
-
-
Galluzzi, L.1
Vitale, I.2
Abrams, J.M.3
Alnemri, E.S.4
Baehrecke, E.H.5
Blagosklonny, M.V.6
Dawson, T.M.7
Dawson, V.L.8
El-Deiry, W.S.9
Fulda, S.10
Gottlieb, E.11
Green, D.R.12
Hengartner, M.O.13
Kepp, O.14
Knight, R.A.15
Kumar, S.16
Lipton, S.A.17
Lu, X.18
Madeo, F.19
Malorni, W.20
Mehlen, P.21
Nuñez, G.22
Peter, M.E.23
Piacentini, M.24
Rubinsztein, D.C.25
Shi, Y.26
Simon, H.U.27
Vandenabeele, P.28
White, E.29
Yuan, J.30
Zhivotovsky, B.31
Melino, G.32
Kroemer, G.33
more..
-
13
-
-
84887623828
-
Crosstalk between apoptosis, necrosis and autophagy
-
Nikoletopoulou, V., Markaki, M., Palikaras, K., and Tavernarakis, N. (2013) Crosstalk between apoptosis, necrosis and autophagy Biochim. Biophys. Acta, Mol. Cell Res. 1833, 3448-3459 10.1016/j.bbamcr.2013.06.001
-
(2013)
Biochim. Biophys. Acta, Mol. Cell Res.
, vol.1833
, pp. 3448-3459
-
-
Nikoletopoulou, V.1
Markaki, M.2
Palikaras, K.3
Tavernarakis, N.4
-
14
-
-
84894565195
-
Self-consumption: The interplay of autophagy and apoptosis
-
Mariño, G., Niso-Santano, M., Baehrecke, E. H., and Kroemer, G. (2014) Self-consumption: the interplay of autophagy and apoptosis Nat. Rev. Mol. Cell Biol. 15, 81-94 10.1038/nrm3735
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 81-94
-
-
Mariño, G.1
Niso-Santano, M.2
Baehrecke, E.H.3
Kroemer, G.4
-
15
-
-
70350451432
-
Cell death
-
Hotchkiss, R. S., Strasser, A., McDunn, J. E., and Swanson, P. E. (2009) Cell death N. Engl. J. Med. 361, 1570-1583 10.1056/NEJMra0901217
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1570-1583
-
-
Hotchkiss, R.S.1
Strasser, A.2
McDunn, J.E.3
Swanson, P.E.4
-
16
-
-
37549063419
-
Is cell death a critical end point for anticancer therapies or is cytostasis sufficient?
-
Rixe, O. and Fojo, T. (2007) Is cell death a critical end point for anticancer therapies or is cytostasis sufficient? Clin. Cancer Res. 13, 7280-7287 10.1158/1078-0432.CCR-07-2141
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 7280-7287
-
-
Rixe, O.1
Fojo, T.2
-
17
-
-
30644469760
-
Interpreting cell cycle effects of drugs: The case of melphalan
-
Lupi, M., Cappella, P., Matera, G., Natoli, C., and Ubezio, P. (2006) Interpreting cell cycle effects of drugs: the case of melphalan Cancer Chemother. Pharmacol. 57, 443-457 10.1007/s00280-005-0044-1
-
(2006)
Cancer Chemother. Pharmacol.
, vol.57
, pp. 443-457
-
-
Lupi, M.1
Cappella, P.2
Matera, G.3
Natoli, C.4
Ubezio, P.5
-
18
-
-
84987784636
-
In silico toxicology: Computational methods for the prediction of chemical toxicity
-
Raies, A. B. and Bajic, V. B. (2016) In silico toxicology: computational methods for the prediction of chemical toxicity WIREs Comput. Mol. Sci. 6, 147 10.1002/wcms.1240
-
(2016)
WIREs Comput. Mol. Sci.
, vol.6
, pp. 147
-
-
Raies, A.B.1
Bajic, V.B.2
-
19
-
-
84906303709
-
Activity cliffs in drug discovery: Dr Jekyll or Mr Hyde?
-
Cruz-Monteagudo, M., Medina-Franco, J. L., Pérez-Castillo, Y., Nicolotti, O., Cordeiro, M. N., and Borges, F. (2014) Activity cliffs in drug discovery: Dr Jekyll or Mr Hyde? Drug Discovery Today 19, 1069-1080 10.1016/j.drudis.2014.02.003
-
(2014)
Drug Discovery Today
, vol.19
, pp. 1069-1080
-
-
Cruz-Monteagudo, M.1
Medina-Franco, J.L.2
Pérez-Castillo, Y.3
Nicolotti, O.4
Cordeiro, M.N.5
Borges, F.6
-
20
-
-
84964691940
-
Current and Future Perspectives on the Development, Evaluation, and Application of in Silico Approaches for Predicting Toxicity
-
Patlewicz, G. and Fitzpatrick, J. M. (2016) Current and Future Perspectives on the Development, Evaluation, and Application of in Silico Approaches for Predicting Toxicity Chem. Res. Toxicol. 29, 438-451 10.1021/acs.chemrestox.5b00388
-
(2016)
Chem. Res. Toxicol.
, vol.29
, pp. 438-451
-
-
Patlewicz, G.1
Fitzpatrick, J.M.2
-
21
-
-
84859179256
-
Exploring activity cliffs in medicinal chemistry
-
Stumpfe, D. and Bajorath, J. (2012) Exploring activity cliffs in medicinal chemistry J. Med. Chem. 55, 2932-2942 10.1021/jm201706b
-
(2012)
J. Med. Chem.
, vol.55
, pp. 2932-2942
-
-
Stumpfe, D.1
Bajorath, J.2
-
22
-
-
84857963032
-
Evaluation of drugs with specific organ toxicities in organ-specific cell lines
-
Lin, Z. and Will, Y. (2012) Evaluation of drugs with specific organ toxicities in organ-specific cell lines Toxicol. Sci. 126, 114-127 10.1093/toxsci/kfr339
-
(2012)
Toxicol. Sci.
, vol.126
, pp. 114-127
-
-
Lin, Z.1
Will, Y.2
-
23
-
-
84954025865
-
How Consistent are Publicly Reported Cytotoxicity Data? Large-Scale Statistical Analysis of the Concordance of Public Independent Cytotoxicity Measurements
-
Cortés-Ciriano, I. and Bender, A. (2016) How Consistent are Publicly Reported Cytotoxicity Data? Large-Scale Statistical Analysis of the Concordance of Public Independent Cytotoxicity Measurements ChemMedChem 11, 57-71 10.1002/cmdc.201500424
-
(2016)
ChemMedChem
, vol.11
, pp. 57-71
-
-
Cortés-Ciriano, I.1
Bender, A.2
-
24
-
-
33846922033
-
Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays
-
Pohjala, L., Tammela, P., Samanta, S. K., Yli-Kauhaluoma, J., and Vuorela, P. (2007) Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays Anal. Biochem. 362, 221-228 10.1016/j.ab.2006.12.038
-
(2007)
Anal. Biochem.
, vol.362
, pp. 221-228
-
-
Pohjala, L.1
Tammela, P.2
Samanta, S.K.3
Yli-Kauhaluoma, J.4
Vuorela, P.5
-
25
-
-
84919784228
-
Extending in silico mechanism-of-action analysis by annotating targets with pathways: Application to cellular cytotoxicity readouts
-
Liggi, S., Drakakis, G., Koutsoukas, A., Cortes-Ciriano, I., Martínez-Alonso, P., Malliavin, T. E., Velazquez-Campoy, A., Brewerton, S. C., Bodkin, M. J., Evans, D. A., Glen, R. C., Carrodeguas, J. A., and Bender, A. (2014) Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts Future Med. Chem. 6, 2029-2056 10.4155/fmc.14.137
-
(2014)
Future Med. Chem.
, vol.6
, pp. 2029-2056
-
-
Liggi, S.1
Drakakis, G.2
Koutsoukas, A.3
Cortes-Ciriano, I.4
Martínez-Alonso, P.5
Malliavin, T.E.6
Velazquez-Campoy, A.7
Brewerton, S.C.8
Bodkin, M.J.9
Evans, D.A.10
Glen, R.C.11
Carrodeguas, J.A.12
Bender, A.13
-
26
-
-
84894539238
-
Extensions to in silico bioactivity predictions using pathway annotations and differential pharmacology analysis: Application to xenopus laevis phenotypic readouts
-
Liggi, S., Drakakis, G., Hendry, A. E., Hanson, K. M., Brewerton, S. C., Wheeler, G. N., Bodkin, M. J., Evans, D. A., and Bender, A. (2013) Extensions to in silico bioactivity predictions using pathway annotations and differential pharmacology analysis: application to xenopus laevis phenotypic readouts Mol. Inf. 32, 1009-1024 10.1002/minf.201300102
-
(2013)
Mol. Inf.
, vol.32
, pp. 1009-1024
-
-
Liggi, S.1
Drakakis, G.2
Hendry, A.E.3
Hanson, K.M.4
Brewerton, S.C.5
Wheeler, G.N.6
Bodkin, M.J.7
Evans, D.A.8
Bender, A.9
-
27
-
-
84862203775
-
WikiPathways: Building research communities on biological pathways
-
Kelder, T., van Iersel, M. P., Hanspers, K., Kutmon, M., Conklin, B. R., Evelo, C. T., and Pico, A. R. (2012) WikiPathways: building research communities on biological pathways Nucleic Acids Res. 40, D1301-1307 10.1093/nar/gkr1074
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. D1301-1307
-
-
Kelder, T.1
Van Iersel, M.P.2
Hanspers, K.3
Kutmon, M.4
Conklin, B.R.5
Evelo, C.T.6
Pico, A.R.7
-
28
-
-
84866177839
-
A chemocentric approach to the identification of cancer targets
-
Flachner, B., Lörincz, Z., Carotti, A., Nicolotti, O., Kuchipudi, P., Remez, N., Sanz, F., Tóvári, J., Szabó, M. J., Bertók, B., Cseh, S., Mestres, J., and Dormán, G. (2012) A chemocentric approach to the identification of cancer targets PLoS One 7, e35582 10.1371/journal.pone.0035582
-
(2012)
PLoS One
, vol.7
, pp. e35582
-
-
Flachner, B.1
Lörincz, Z.2
Carotti, A.3
Nicolotti, O.4
Kuchipudi, P.5
Remez, N.6
Sanz, F.7
Tóvári, J.8
Szabó, M.J.9
Bertók, B.10
Cseh, S.11
Mestres, J.12
Dormán, G.13
-
29
-
-
84919384042
-
Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression
-
Dempster, E. L., Wong, C. C., Lester, K. J., Burrage, J., Gregory, A. M., Mill, J., and Eley, T. C. (2014) Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression Biol. Psychiatry 76, 977-983 10.1016/j.biopsych.2014.04.013
-
(2014)
Biol. Psychiatry
, vol.76
, pp. 977-983
-
-
Dempster, E.L.1
Wong, C.C.2
Lester, K.J.3
Burrage, J.4
Gregory, A.M.5
Mill, J.6
Eley, T.C.7
-
30
-
-
84925960154
-
TDP1 promotes assembly of non-homologous end joining protein complexes on DNA
-
Heo, J., Li, J., Summerlin, M., Hays, A., Katyal, S., McKinnon, P. J., Nitiss, K. C., Nitiss, J. L., and Hanakahi, L. A. (2015) TDP1 promotes assembly of non-homologous end joining protein complexes on DNA DNA Repair 30, 28-37 10.1016/j.dnarep.2015.03.003
-
(2015)
DNA Repair
, vol.30
, pp. 28-37
-
-
Heo, J.1
Li, J.2
Summerlin, M.3
Hays, A.4
Katyal, S.5
McKinnon, P.J.6
Nitiss, K.C.7
Nitiss, J.L.8
Hanakahi, L.A.9
-
31
-
-
0347192782
-
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor
-
Turk, B. E., Wong, T. Y., Schwarzenbacher, R., Jarrell, E. T., Leppla, S. H., Collier, R. J., Liddington, R. C., and Cantley, L. C. (2004) The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor Nat. Struct. Mol. Biol. 11, 60-66 10.1038/nsmb708
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 60-66
-
-
Turk, B.E.1
Wong, T.Y.2
Schwarzenbacher, R.3
Jarrell, E.T.4
Leppla, S.H.5
Collier, R.J.6
Liddington, R.C.7
Cantley, L.C.8
-
32
-
-
84862540273
-
Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin
-
Wahdan-Alaswad, R. S., Bane, K. L., Song, K., Shola, D. T., Garcia, J. A., and Danielpour, D. (2012) Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin Mol. Cancer Res. 10, 821-833 10.1158/1541-7786.MCR-11-0615
-
(2012)
Mol. Cancer Res.
, vol.10
, pp. 821-833
-
-
Wahdan-Alaswad, R.S.1
Bane, K.L.2
Song, K.3
Shola, D.T.4
Garcia, J.A.5
Danielpour, D.6
-
33
-
-
84868618472
-
DeoxyArbutin and its derivatives inhibit tyrosinase activity and melanin synthesis without inducing reactive oxygen species or apoptosis
-
Chawla, S., Kvalnes, K., deLong, M. A., Wickett, R., Manga, P., and Boissy, R. E. (2012) DeoxyArbutin and its derivatives inhibit tyrosinase activity and melanin synthesis without inducing reactive oxygen species or apoptosis J. Drugs Dermatol 11, e28-34
-
(2012)
J. Drugs Dermatol
, vol.11
, pp. e28-34
-
-
Chawla, S.1
Kvalnes, K.2
DeLong, M.A.3
Wickett, R.4
Manga, P.5
Boissy, R.E.6
-
34
-
-
3543034637
-
The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK
-
Alahari, S. K., Reddig, P. J., and Juliano, R. L. (2004) The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK EMBO J. 23, 2777-2788 10.1038/sj.emboj.7600291
-
(2004)
EMBO J.
, vol.23
, pp. 2777-2788
-
-
Alahari, S.K.1
Reddig, P.J.2
Juliano, R.L.3
-
35
-
-
1842614328
-
Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro
-
Sun, S., Han, J., Ralph, W. M., Chandrasekaran, A., Liu, K., Auborn, K. J., and Carter, T. H. (2004) Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro Cell Stress Chaperones 9, 76-87 10.1379/1466-1268(2004)009<0076:ERSAAC>2.0.CO;2
-
(2004)
Cell Stress Chaperones
, vol.9
, pp. 76-87
-
-
Sun, S.1
Han, J.2
Ralph, W.M.3
Chandrasekaran, A.4
Liu, K.5
Auborn, K.J.6
Carter, T.H.7
-
36
-
-
84889581795
-
Chemical predictive modelling to improve compound quality
-
Cumming, J. G., Davis, A. M., Muresan, S., Haeberlein, M., and Chen, H. (2013) Chemical predictive modelling to improve compound quality Nat. Rev. Drug Discovery 12, 948-962 10.1038/nrd4128
-
(2013)
Nat. Rev. Drug Discovery
, vol.12
, pp. 948-962
-
-
Cumming, J.G.1
Davis, A.M.2
Muresan, S.3
Haeberlein, M.4
Chen, H.5
-
37
-
-
80555140075
-
Scikit-learn: Machine learning in Python
-
Pedregosa, F., Varoquaux, G., Gramfort, A., Michel, V., Thirion, B., Grisel, O., Blondel, M., Prettenhofer, P., Weiss, R., and Dubourg, V. (2011) Scikit-learn: Machine learning in Python Journal of Machine Learning Research 12, 2825-2830
-
(2011)
Journal of Machine Learning Research
, vol.12
, pp. 2825-2830
-
-
Pedregosa, F.1
Varoquaux, G.2
Gramfort, A.3
Michel, V.4
Thirion, B.5
Grisel, O.6
Blondel, M.7
Prettenhofer, P.8
Weiss, R.9
Dubourg, V.10
-
38
-
-
82255175505
-
Making every SAR point count: The development of Chemistry Connect for the large-scale integration of structure and bioactivity data
-
Muresan, S., Petrov, P., Southan, C., Kjellberg, M. J., Kogej, T., Tyrchan, C., Varkonyi, P., and Xie, P. H. (2011) Making every SAR point count: the development of Chemistry Connect for the large-scale integration of structure and bioactivity data Drug Discovery Today 16, 1019-1030 10.1016/j.drudis.2011.10.005
-
(2011)
Drug Discovery Today
, vol.16
, pp. 1019-1030
-
-
Muresan, S.1
Petrov, P.2
Southan, C.3
Kjellberg, M.J.4
Kogej, T.5
Tyrchan, C.6
Varkonyi, P.7
Xie, P.H.8
-
39
-
-
84944903634
-
Target prediction utilising negative bioactivity data covering large chemical space
-
Mervin, L. H., Afzal, A. M., Drakakis, G., Lewis, R., Engkvist, O., and Bender, A. (2015) Target prediction utilising negative bioactivity data covering large chemical space J. Cheminf. 7, 51 10.1186/s13321-015-0098-y
-
(2015)
J. Cheminf.
, vol.7
, pp. 51
-
-
Mervin, L.H.1
Afzal, A.M.2
Drakakis, G.3
Lewis, R.4
Engkvist, O.5
Bender, A.6
-
40
-
-
84883239935
-
In silico target predictions: Defining a benchmarking data set and comparison of performance of the multiclass Naïve Bayes and Parzen-Rosenblatt window
-
Koutsoukas, A., Lowe, R., Kalantarmotamedi, Y., Mussa, H. Y., Klaffke, W., Mitchell, J. B., Glen, R. C., and Bender, A. (2013) In silico target predictions: defining a benchmarking data set and comparison of performance of the multiclass Naïve Bayes and Parzen-Rosenblatt window J. Chem. Inf. Model. 53, 1957-1966 10.1021/ci300435j
-
(2013)
J. Chem. Inf. Model.
, vol.53
, pp. 1957-1966
-
-
Koutsoukas, A.1
Lowe, R.2
Kalantarmotamedi, Y.3
Mussa, H.Y.4
Klaffke, W.5
Mitchell, J.B.6
Glen, R.C.7
Bender, A.8
-
41
-
-
84876532610
-
Database resources of the National Center for Biotechnology Information
-
Coordinators, N. R. (2013) Database resources of the National Center for Biotechnology Information Nucleic Acids Res. 41, D8-D20 10.1093/nar/gks1189
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. D8-D20
-
-
Coordinators, N.R.1
-
42
-
-
84939488957
-
Protein homology reveals new targets for bioactive small molecules
-
Gfeller, D. and Zoete, V. (2015) Protein homology reveals new targets for bioactive small molecules Bioinformatics 31, 2721-2727 10.1093/bioinformatics/btv214
-
(2015)
Bioinformatics
, vol.31
, pp. 2721-2727
-
-
Gfeller, D.1
Zoete, V.2
-
43
-
-
84996872476
-
-
version 2.0, OpenEye Scientific Software, Santa Fe, NM
-
OEChem T, version 2.0, OpenEye Scientific Software, Santa Fe, NM.
-
OEChem T
-
-
-
44
-
-
84996990834
-
-
RDKit: Open-source cheminformatics
-
Landrum, G. (2012) RDKit: Open-source cheminformatics. http://www.rdkit.org/.
-
(2012)
-
-
Landrum, G.1
-
45
-
-
0000293407
-
The Generation of a Unique Machine Description for Chemical Structures-A Technique Developed at Chemical Abstracts Service
-
Morgan, H. L. (1965) The Generation of a Unique Machine Description for Chemical Structures-A Technique Developed at Chemical Abstracts Service J. Chem. Doc. 5, 107-113 10.1021/c160017a018
-
(1965)
J. Chem. Doc.
, vol.5
, pp. 107-113
-
-
Morgan, H.L.1
-
46
-
-
70350512851
-
Target fishing for chemical compounds using target-ligand activity data and ranking based methods
-
Wale, N. and Karypis, G. (2009) Target fishing for chemical compounds using target-ligand activity data and ranking based methods J. Chem. Inf. Model. 49, 2190-2201 10.1021/ci9000376
-
(2009)
J. Chem. Inf. Model.
, vol.49
, pp. 2190-2201
-
-
Wale, N.1
Karypis, G.2
-
47
-
-
48349105261
-
WikiPathways: Pathway editing for the people
-
Pico, A. R., Kelder, T., van Iersel, M. P., Hanspers, K., Conklin, B. R., and Evelo, C. (2008) WikiPathways: pathway editing for the people PLoS Biol. 6, e184 10.1371/journal.pbio.0060184
-
(2008)
PLoS Biol.
, vol.6
, pp. e184
-
-
Pico, A.R.1
Kelder, T.2
Van Iersel, M.P.3
Hanspers, K.4
Conklin, B.R.5
Evelo, C.6
-
48
-
-
84902201072
-
The Role of Historical Bioactivity Data in the Deconvolution of Phenotypic Screens
-
Bornot, A., Blackett, C., Engkvist, O., Murray, C., and Bendtsen, C. (2014) The Role of Historical Bioactivity Data in the Deconvolution of Phenotypic Screens J. Biomol. Screening 19, 696-706 10.1177/1087057113518966
-
(2014)
J. Biomol. Screening
, vol.19
, pp. 696-706
-
-
Bornot, A.1
Blackett, C.2
Engkvist, O.3
Murray, C.4
Bendtsen, C.5
-
49
-
-
73149111772
-
Identification of survival genes in human glioblastoma cells by small interfering RNA screening
-
Thaker, N. G., Zhang, F., McDonald, P. R., Shun, T. Y., Lewen, M. D., Pollack, I. F., and Lazo, J. S. (2009) Identification of survival genes in human glioblastoma cells by small interfering RNA screening Mol. Pharmacol. 76, 1246-1255 10.1124/mol.109.058024
-
(2009)
Mol. Pharmacol.
, vol.76
, pp. 1246-1255
-
-
Thaker, N.G.1
Zhang, F.2
McDonald, P.R.3
Shun, T.Y.4
Lewen, M.D.5
Pollack, I.F.6
Lazo, J.S.7
-
50
-
-
84868286357
-
Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of β-catenin
-
Rines, A. K., Burke, M. A., Fernandez, R. P., Volpert, O. V., and Ardehali, H. (2012) Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of β-catenin FASEB J. 26, 4685-4695 10.1096/fj.12-212282
-
(2012)
FASEB J.
, vol.26
, pp. 4685-4695
-
-
Rines, A.K.1
Burke, M.A.2
Fernandez, R.P.3
Volpert, O.V.4
Ardehali, H.5
-
51
-
-
84921020413
-
Protein deep sequencing applied to biobank samples from patients with pancreatic cancer
-
Ansari, D., Andersson, R., Bauden, M. P., Andersson, B., Connolly, J. B., Welinder, C., Sasor, A., and Marko-Varga, G. (2015) Protein deep sequencing applied to biobank samples from patients with pancreatic cancer J. Cancer Res. Clin. Oncol. 141, 369-380 10.1007/s00432-014-1817-x
-
(2015)
J. Cancer Res. Clin. Oncol.
, vol.141
, pp. 369-380
-
-
Ansari, D.1
Andersson, R.2
Bauden, M.P.3
Andersson, B.4
Connolly, J.B.5
Welinder, C.6
Sasor, A.7
Marko-Varga, G.8
-
52
-
-
2642524384
-
RIP5 is a RIP-homologous inducer of cell death
-
Zha, J., Zhou, Q., Xu, L. G., Chen, D., Li, L., Zhai, Z., and Shu, H. B. (2004) RIP5 is a RIP-homologous inducer of cell death Biochem. Biophys. Res. Commun. 319, 298-303 10.1016/j.bbrc.2004.04.194
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.319
, pp. 298-303
-
-
Zha, J.1
Zhou, Q.2
Xu, L.G.3
Chen, D.4
Li, L.5
Zhai, Z.6
Shu, H.B.7
-
53
-
-
84862309940
-
Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1
-
Wang, L. Y. and Kung, H. J. (2012) Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1 Oncogene 31, 2907-2918 10.1038/onc.2011.464
-
(2012)
Oncogene
, vol.31
, pp. 2907-2918
-
-
Wang, L.Y.1
Kung, H.J.2
-
54
-
-
84907063898
-
MKK6 is upregulated in human esophageal, stomach, and colon cancers
-
Parray, A. A., Baba, R. A., Bhat, H. F., Wani, L., Mokhdomi, T. A., Mushtaq, U., Bhat, S. S., Kirmani, D., Kuchay, S., Wani, M. M., and Khanday, F. A. (2014) MKK6 is upregulated in human esophageal, stomach, and colon cancers Cancer Invest. 32, 416-422 10.3109/07357907.2014.933236
-
(2014)
Cancer Invest.
, vol.32
, pp. 416-422
-
-
Parray, A.A.1
Baba, R.A.2
Bhat, H.F.3
Wani, L.4
Mokhdomi, T.A.5
Mushtaq, U.6
Bhat, S.S.7
Kirmani, D.8
Kuchay, S.9
Wani, M.M.10
Khanday, F.A.11
-
55
-
-
82555187810
-
Image-based genome-wide siRNA screen identifies selective autophagy factors
-
Orvedahl, A., Sumpter, R., Jr., Xiao, G., Ng, A., Zou, Z., Tang, Y., Narimatsu, M., Gilpin, C., Sun, Q., Roth, M., Forst, C. V., Wrana, J. L., Zhang, Y. E., Luby-Phelps, K., Xavier, R. J., Xie, Y., and Levine, B. (2011) Image-based genome-wide siRNA screen identifies selective autophagy factors Nature 480, 113-117 10.1038/nature10546
-
(2011)
Nature
, vol.480
, pp. 113-117
-
-
Orvedahl, A.1
Sumpter, Jr.R.2
Xiao, G.3
Ng, A.4
Zou, Z.5
Tang, Y.6
Narimatsu, M.7
Gilpin, C.8
Sun, Q.9
Roth, M.10
Forst, C.V.11
Wrana, J.L.12
Zhang, Y.E.13
Luby-Phelps, K.14
Xavier, R.J.15
Xie, Y.16
Levine, B.17
-
56
-
-
20444419344
-
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance
-
MacKeigan, J. P., Murphy, L. O., and Blenis, J. (2005) Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance Nat. Cell Biol. 7, 591-600 10.1038/ncb1258
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 591-600
-
-
MacKeigan, J.P.1
Murphy, L.O.2
Blenis, J.3
-
57
-
-
0037790592
-
Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis
-
Chawla-Sarkar, M., Lindner, D. J., Liu, Y. F., Williams, B. R., Sen, G. C., Silverman, R. H., and Borden, E. C. (2003) Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis Apoptosis 8, 237-249 10.1023/A:1023668705040
-
(2003)
Apoptosis
, vol.8
, pp. 237-249
-
-
Chawla-Sarkar, M.1
Lindner, D.J.2
Liu, Y.F.3
Williams, B.R.4
Sen, G.C.5
Silverman, R.H.6
Borden, E.C.7
-
58
-
-
0027267674
-
Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase
-
Parker, L. L., Walter, S. A., Young, P. G., and Piwnica-Worms, H. (1993) Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase Nature 363, 736-738 10.1038/363736a0
-
(1993)
Nature
, vol.363
, pp. 736-738
-
-
Parker, L.L.1
Walter, S.A.2
Young, P.G.3
Piwnica-Worms, H.4
-
59
-
-
38049161465
-
Wee1 kinase alters cyclin E/Cdk2 and promotes apoptosis during the early embryonic development of Xenopus laevis
-
Wroble, B. N., Finkielstein, C. V., and Sible, J. C. (2007) Wee1 kinase alters cyclin E/Cdk2 and promotes apoptosis during the early embryonic development of Xenopus laevis BMC Dev. Biol. 7, 119 10.1186/1471-213X-7-119
-
(2007)
BMC Dev. Biol.
, vol.7
, pp. 119
-
-
Wroble, B.N.1
Finkielstein, C.V.2
Sible, J.C.3
-
60
-
-
13444309286
-
CASK inhibits ECV304 cell growth and interacts with Id1
-
Qi, J., Su, Y., Sun, R., Zhang, F., Luo, X., Yang, Z., and Luo, X. (2005) CASK inhibits ECV304 cell growth and interacts with Id1 Biochem. Biophys. Res. Commun. 328, 517-521 10.1016/j.bbrc.2005.01.014
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.328
, pp. 517-521
-
-
Qi, J.1
Su, Y.2
Sun, R.3
Zhang, F.4
Luo, X.5
Yang, Z.6
Luo, X.7
-
61
-
-
3042781558
-
Insulin-like growth factors and neoplasia
-
Pollak, M. N., Schernhammer, E. S., and Hankinson, S. E. (2004) Insulin-like growth factors and neoplasia Nat. Rev. Cancer 4, 505-518 10.1038/nrc1387
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 505-518
-
-
Pollak, M.N.1
Schernhammer, E.S.2
Hankinson, S.E.3
-
62
-
-
84867435739
-
CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells
-
Valli, E., Trazzi, S., Fuchs, C., Erriquez, D., Bartesaghi, R., Perini, G., and Ciani, E. (2012) CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells Biochim. Biophys. Acta, Gene Regul. Mech. 1819, 1173-1185 10.1016/j.bbagrm.2012.08.001
-
(2012)
Biochim. Biophys. Acta, Gene Regul. Mech.
, vol.1819
, pp. 1173-1185
-
-
Valli, E.1
Trazzi, S.2
Fuchs, C.3
Erriquez, D.4
Bartesaghi, R.5
Perini, G.6
Ciani, E.7
-
63
-
-
0035231288
-
Initiation factor eIF2 alpha phosphorylation in stress responses and apoptosis
-
Clemens, M. J. (2001) Initiation factor eIF2 alpha phosphorylation in stress responses and apoptosis Prog. Mol. Subcell. Biol. 27, 57-89 10.1007/978-3-662-09889-9-3
-
(2001)
Prog. Mol. Subcell. Biol.
, vol.27
, pp. 57-89
-
-
Clemens, M.J.1
-
64
-
-
61349182661
-
Functionalized 3-benzylidene-indolin-2-ones: Inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity
-
Zhang, W. and Go, M. L. (2009) Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity Bioorg. Med. Chem. 17, 2077-2090 10.1016/j.bmc.2008.12.052
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 2077-2090
-
-
Zhang, W.1
Go, M.L.2
-
65
-
-
84899546008
-
NOD1, RIP2 and Caspase12 are potentially novel biomarkers for oral squamous cell carcinoma development and progression
-
Wang, X., Jiang, W., Duan, N., Qian, Y., Zhou, Q., Ye, P., Jiang, H., Bai, Y., Zhang, W., and Wang, W. (2014) NOD1, RIP2 and Caspase12 are potentially novel biomarkers for oral squamous cell carcinoma development and progression Int. J. Clin. Exp. Pathol. 7, 1677-1686
-
(2014)
Int. J. Clin. Exp. Pathol.
, vol.7
, pp. 1677-1686
-
-
Wang, X.1
Jiang, W.2
Duan, N.3
Qian, Y.4
Zhou, Q.5
Ye, P.6
Jiang, H.7
Bai, Y.8
Zhang, W.9
Wang, W.10
-
66
-
-
79955523590
-
Effect of selenocystine on gene expression profiles in human keloid fibroblasts
-
De Felice, B., Garbi, C., Wilson, R. R., Santoriello, M., and Nacca, M. (2011) Effect of selenocystine on gene expression profiles in human keloid fibroblasts Genomics 97, 265-276 10.1016/j.ygeno.2011.02.009
-
(2011)
Genomics
, vol.97
, pp. 265-276
-
-
De Felice, B.1
Garbi, C.2
Wilson, R.R.3
Santoriello, M.4
Nacca, M.5
-
67
-
-
84939856813
-
Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells
-
Mavrogonatou, E., Papadimitriou, K., Urban, J. P., Papadopoulos, V., and Kletsas, D. (2015) Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells J. Cell. Physiol. 230, 3037-3048 10.1002/jcp.25040
-
(2015)
J. Cell. Physiol.
, vol.230
, pp. 3037-3048
-
-
Mavrogonatou, E.1
Papadimitriou, K.2
Urban, J.P.3
Papadopoulos, V.4
Kletsas, D.5
|