Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression

Biological Psychiatry

Volumn 76, Issue 12, 2014, Pages 977-983

  Dempster, Emma L ^a   Wong, Chloe C Y ^b   Lester, Kathryn J ^b   Burrage, Joe ^a   Gregory, Alice M ^c   Mill, Jonathan ^a,b   Eley, Thalia C ^b  

^a UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Adolescent depression; depression; DNA methylation; epigenetic; genomics; monozygotic twins

Indexed keywords

DNA;

ADOLESCENT; ADOLESCENT DISEASE; AMPLICON; ARTICLE; AUTOPSY; BRAIN TISSUE; CHEEK; CHROMOSOME 10Q; CLINICAL ARTICLE; COMTD1 GENE; CONTROLLED STUDY; DEPDC7 GENE; DEPRESSION; DNA METHYLATION; DPYSL4 GENE; ENVIRONMENTAL FACTOR; EPIGENETICS; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME; HUMAN; HUMAN CELL; HUMAN TISSUE; KIF13B GENE; KIF5A GENE; LANCL2 GENE; MALE; MONOZYGOTIC TWINS; MYH10 GENE; POLYMERASE CHAIN REACTION; PQLC3 GENE; PYROSEQUENCING; QUALITY CONTROL; SLC35F4 GENE; TMEM106C GENE; TWIN DISCORDANCE; CEREBELLUM; CPG ISLAND; GENETICS; HUMAN GENOME; METABOLISM; PATHOLOGY; POSTMORTEM CHANGE; QUESTIONNAIRE; TWINS;

ADOLESCENT; CEREBELLUM; CPG ISLANDS; DEPRESSION; DNA METHYLATION; FEMALE; GENOME; GENOME, HUMAN; HUMANS; MALE; POSTMORTEM CHANGES; SURVEYS AND QUESTIONNAIRES; TWINS, MONOZYGOTIC;

EID: 84919384042     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2014.04.013     Document Type: Article

References (47)

1. C.J. Murray, and A.D. Lopez Mortality by cause for eight regions of the world: Global Burden of Disease Study Lancet 349 1997 1269 1276
2. P.F. Sullivan, M.C. Neale, and K.S. Kendler Genetic epidemiology of major depression: Review and meta-analysis Am J Psychiatry 157 2000 1552 1562
3. F.J. Bosker, C.A. Hartman, I.M. Nolte, B.P. Prins, P. Terpstra, and D. Posthuma Poor replication of candidate genes for major depressive disorder using genome-wide association data Mol Psychiatry 16 2011 516 532
4. J. Mill, and A. Petronis Molecular studies of major depressive disorder: The epigenetic perspective Mol Psychiatry 12 2007 799 814
5. M. Schroeder, M.O. Krebs, S. Bleich, and H. Frieling Epigenetics and depression: Current challenges and new therapeutic options Curr Opin Psychiatry 23 2010 588 592
6. T.C. Eley, H. Liang, R. Plomin, P. Sham, A. Sterne, R. Williamson, and S. Purcell Parental familial vulnerability, family environment, and their interactions as predictors of depressive symptoms in adolescents J Am Acad Child Adolesc Psychiatry 43 2004 298 306
7. S. Henikoff, and M.A. Matzke Exploring and explaining epigenetic effects Trends Genet 13 1997 293 295
8. J. Lv, Y. Xin, W. Zhou, and Z. Qiu The epigenetic switches for neural development and psychiatric disorders J Genet Genomics 40 2013 339 346
9. V. Vialou, J. Feng, A.J. Robison, and E.J. Nestler Epigenetic mechanisms of depression and antidepressant action Annu Rev Pharmacol Toxicol 53 2013 59 87
10. E. Elliott, G. Ezra-Nevo, L. Regev, A. Neufeld-Cohen, and A. Chen Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice Nat Neurosci 13 2010 1351 1353
11. T.L. Roth, P.R. Zoladz, J.D. Sweatt, and D.M. Diamond Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder J Psychiatr Res 45 2011 919 926
12. L. Sterrenburg, B. Gaszner, J. Boerrigter, L. Santbergen, M. Bramini, and E. Elliott Chronic stress induces sex-specific alterations in methylation and expression of corticotropin-releasing factor gene in the rat PLoS One 6 2011 e28128
13. I.C. Weaver, N. Cervoni, F.A. Champagne, A.C. D'Alessio, S. Sharma, and J.R. Seckl Epigenetic programming by maternal behavior Nat Neurosci 7 2004 847 854
14. E.M. Byrne, T. Carrillo-Roa, A.K. Henders, L. Bowdler, A.F. McRae, and A.C. Heath Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin Transl Psychiatry 3 2013 e269
15. R. Machado-Vieira, L. Ibrahim, and C.A. Zarate Jr Histone deacetylases and mood disorders: Epigenetic programming in gene-environment interactions CNS Neurosci Ther 17 2011 699 704
16. S. Sabunciyan, M.J. Aryee, R.A. Irizarry, M. Rongione, M.J. Webster, and W.E. Kaufman Genome-wide DNA methylation scan in major depressive disorder PLoS One 7 2012 e34451
17. M. Uddin, K.C. Koenen, A.E. Aiello, D.E. Wildman, R. de los Santos, and S. Galea Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample Psychol Med 41 2011 997 1007
18. T.A. McAdams, A.M. Gregory, R. Rowe, H.M. Zavos, N.L. Barclay, and J.Y. Lau The Genesis 12-19 (G1219) Study: A twin and sibling study of gene-environment interplay and adolescent development in the UK Twin Res Hum Genet 16 2013 134 143
19. L.D. Selemon A role for synaptic plasticity in the adolescent development of executive function Transl Psychiatry 3 2013 e238
20. J. Kim-Cohen, A. Caspi, T.E. Moffitt, H. Harrington, B.J. Milne, and R. Poulton Prior juvenile diagnoses in adults with mental disorder: Developmental follow-back of a prospective-longitudinal cohort Arch Gen Psychiatry 60 2003 709 717
21. B.L. Hankin, L.Y. Abramson, T.E. Moffitt, P.A. Silva, R. McGee, and K.E. Angell Development of depression from preadolescence to young adulthood: Emerging gender differences in a 10-year longitudinal study J Abnorm Psychol 107 1998 128 140
22. E. Fombonne, G. Wostear, V. Cooper, R. Harrington, and M. Rutter The Maudsley long-term follow-up of child and adolescent depression. 2. Suicidality, criminality and social dysfunction in adulthood Br J Psychiatry 179 2001 218 223
23. E. Fombonne, G. Wostear, V. Cooper, R. Harrington, and M. Rutter The Maudsley long-term follow-up of child and adolescent depression. 1. Psychiatric outcomes in adulthood Br J Psychiatry 179 2001 210 217
24. B.T. Heijmans, and J. Mill Commentary: The seven plagues of epigenetic epidemiology Int J Epidemiol 41 2012 74 78
25. J.T. Bell, and T.D. Spector A twin approach to unraveling epigenetics Trends Genet 27 2011 116 125
26. E.L. Dempster, R. Pidsley, L.C. Schalkwyk, S. Owens, A. Georgiades, and F. Kane Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder Hum Mol Genet 20 2011 4786 4796
27. C.C. Wong, E.L. Meaburn, A. Ronald, T.S. Price, A.R. Jeffries, and L.C. Schalkwyk Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits Mol Psychiatry 19 2014 495 503
28. V.K. Rakyan, H. Beyan, T.A. Down, M.I. Hawa, S. Maslau, and D. Aden Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis PLoS Genet 7 2011 e1002300
29. A. Angold, E.J. Costello, S.C. Messer, A. Pickles, F. Winder, and D. Silver Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents Int J Methods Psychiatric Res 5 1995 237 249
30. R. Pidsley, C.C.Y. Wong, M. Volta, K. Lunnon, J. Mill, and L.C. Schalkwyk A data-driven approach to preprocessing Illumina 450K methylation array data BMC Genomics 14 2013 293
31. D. Wang, L. Yan, Q. Hu, L.E. Sucheston, M.J. Higgins, and C.B. Ambrosone IMA: An R package for high-throughput analysis of Illumina's 450K Infinium methylation data Bioinformatics 28 2012 729 730
32. C.Y. McLean, D. Bristor, M. Hiller, S.L. Clarke, B.T. Schaar, and C.B. Lowe GREAT improves functional interpretation of cis-regulatory regions Nat Biotechnol 28 2010 495 501
33. E.F. Torrey, M. Webster, M. Knable, N. Johnston, and R.H. Yolken The Stanley Foundation Brain Collection and Neuropathology Consortium Schizophr Res 44 2000 151 155
34. Y. Dwivedi, H.S. Rizavi, R.C. Roberts, R.C. Conley, C.A. Tamminga, and G.N. Pandey Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects J Neurochem 77 2001 916 928
35. S. Narayanan, H. Arthanari, M.S. Wolfe, and G. Wagner Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly J Biol Chem 286 2011 44266 44276
36. V.L. Willour, F. Seifuddin, P.B. Mahon, D. Jancic, M. Pirooznia, and J. Steele A genome-wide association study of attempted suicide Mol Psychiatry 17 2012 433 444
37. M. Nyegaard, A.D. Borglum, T.G. Bruun, D.A. Collier, C. Russ, and O. Mors Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder Mol Psychiatry 7 2002 745 754
38. P.A. Melas, Y. Wei, C.C. Wong, L.K. Sjoholm, E. Aberg, and J. Mill Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities Int J Neuropsychopharmacol 16 2013 1513 1528
39. B.H. Miller, L.E. Schultz, B.C. Long, and M.T. Pletcher Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice Mamm Genome 21 2010 247 257
40. I. Yanai, H. Benjamin, M. Shmoish, V. Chalifa-Caspi, M. Shklar, and R. Ophir Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification Bioinformatics 21 2005 650 659
41. B.E. Bernstein, E. Birney, I. Dunham, E.D. Green, C. Gunter, and M. Snyder An integrated encyclopedia of DNA elements in the human genome Nature 489 2012 57 74
42. M. Suderman, P.O. McGowan, A. Sasaki, T.C. Huang, M.T. Hallett, and M.J. Meaney Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus Proc Natl Acad Sci U S A 109 Suppl 2 2012 17266 17272
43. V.K. Rakyan, T.A. Down, D.J. Balding, and S. Beck Epigenome-wide association studies for common human diseases Nat Rev Genet 12 2011 529 541
44. R. Lowe, C. Gemma, H. Beyan, M.I. Hawa, A. Bazeos, and R.D. Leslie Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies [published online ahead of print Mar 28] Epigenetics 8 4 2013
45. M.N. Davies, M. Volta, R. Pidsley, K. Lunnon, A. Dixit, and S. Lovestone Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood Genome Biol 13 2012 R43
46. Z. Kaminsky, M. Tochigi, P. Jia, M. Pal, J. Mill, and A. Kwan A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder Mol Psychiatry 17 2012 728 740
47. L. Gordon, J.E. Joo, J.E. Powell, M. Ollikainen, B. Novakovic, and X. Li Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence Genome Res 22 2012 1395 1406