Functionalized 3-benzylidene-indolin-2-ones: Inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 5, 2009, Pages 2077-2090

  Zhang, Wei ^a   Go, Mei Lin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Benzylideneindolinones; Induction of NADP(H): quinone oxidoreductase I, antiproliferative activity; Nitrogen linked Michael acceptor

Indexed keywords

3 BENZYLIDENE INDOLIN 2 ONE DERIVATIVE; ANTIMITOTIC AGENT; BIOLOGICAL MARKER; BRASSININ; NAD(P)H:(QUINONE ACCEPTOR) OXIDOREDUCTASE INHIBITOR; NDOLE 3 CARBINOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SUNITINIB; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; ENZYME BINDING; HUMAN; HUMAN CELL; METASTASIS INHIBITION; MOUSE; NONHUMAN; PROTEIN INDUCTION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZYLIDENE COMPOUNDS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HUMANS; INDOLES; MICE; MOLECULAR CONFORMATION; NAD; NAD(P)H DEHYDROGENASE (QUINONE); UP-REGULATION;

MURINAE;

EID: 61349182661     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.052     Document Type: Article

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