-
1
-
-
84930543167
-
Approaches to assessing drug safety in the discovery phase
-
Allen, J., Jeffrey, P., Williams, R., and Ratcliffe, A. J. (2010). Approaches to assessing drug safety in the discovery phase. Drugs Future 35, 67-75.
-
(2010)
Drugs Future
, vol.35
, pp. 67-75
-
-
Allen, J.1
Jeffrey, P.2
Williams, R.3
Ratcliffe, A.J.4
-
2
-
-
77954001438
-
The future of toxicity testing
-
Andersen, M. E., Al-Zoughool, M., Croteau, M., Westphal, M., and Krewski, D. (2010). The future of toxicity testing. J. Toxicol. Environ. Health Part B Crit. Rev. 13, 163-196.
-
(2010)
J. Toxicol. Environ. Health Part B Crit. Rev.
, vol.13
, pp. 163-196
-
-
Andersen, M.E.1
Al-Zoughool, M.2
Croteau, M.3
Westphal, M.4
Krewski, D.5
-
3
-
-
38849162370
-
Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes
-
iv4-iv15
-
Antzelevitch, C. (2007). Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes. Europace 9(Suppl. 4), iv4-iv15.
-
(2007)
Europace
, vol.9
, Issue.SUPPL. 4
-
-
Antzelevitch, C.1
-
4
-
-
68549133165
-
Exploratory drug safety: A discovery strategy to reduce attrition in development
-
Bass, A. S., Cartwright, M. E., Mahon, C., Morrison, R., Snyder, R., McNamara, P., Bradley, P., Zhou, Y. Y., and Hunter, J. (2009). Exploratory drug safety: A discovery strategy to reduce attrition in development. J. Pharmacol. Toxicol. Methods 60, 69-78.
-
(2009)
J. Pharmacol. Toxicol. Methods
, vol.60
, pp. 69-78
-
-
Bass, A.S.1
Cartwright, M.E.2
Mahon, C.3
Morrison, R.4
Snyder, R.5
McNamara, P.6
Bradley, P.7
Zhou, Y.Y.8
Hunter, J.9
-
5
-
-
0021362485
-
Torsade de pointes due to quinidine: Observations in 31 patients
-
Bauman, J. L., Bauernfeind, R. A., Hoff, J. V., Strasberg, B., Swiryn, S., and Rosen, K. M. (1984). Torsade de pointes due to quinidine: Observations in 31 patients. Am. Heart J. 107, 425-430.
-
(1984)
Am. Heart J.
, vol.107
, pp. 425-430
-
-
Bauman, J.L.1
Bauernfeind, R.A.2
Hoff, J.V.3
Strasberg, B.4
Swiryn, S.5
Rosen, K.M.6
-
6
-
-
77954954738
-
Predicting safety toleration of pharmaceutical chemical leads: Cytotoxicity correlations to exploratory toxicity studies
-
Benbow, J. W., Aubrecht, J., Banker, M. J., Nettleton, D., and Aleo, M. D. (2010). Predicting safety toleration of pharmaceutical chemical leads: Cytotoxicity correlations to exploratory toxicity studies. Toxicol. Lett. 197, 175-182.
-
(2010)
Toxicol. Lett.
, vol.197
, pp. 175-182
-
-
Benbow, J.W.1
Aubrecht, J.2
Banker, M.J.3
Nettleton, D.4
Aleo, M.D.5
-
7
-
-
79955484701
-
Toxicology in the 21st century-Working our way towards a visionary reality
-
Berg, N., De Wever, B., Fuchs, H. W., Gaca, M., Krul, C., and Roggen, E. L. (2011). Toxicology in the 21st century-Working our way towards a visionary reality. Toxicol. In Vitro 25, 874-881.
-
(2011)
Toxicol. In Vitro
, vol.25
, pp. 874-881
-
-
Berg, N.1
De Wever, B.2
Fuchs, H.W.3
Gaca, M.4
Krul, C.5
Roggen, E.L.6
-
8
-
-
34547221487
-
Antidepressant-induced liver injury
-
DeSanty, K. P., and Amabile, C. M. (2007). Antidepressant-induced liver injury. Ann. Pharmacother. 41, 1201-1211.
-
(2007)
Ann. Pharmacother.
, vol.41
, pp. 1201-1211
-
-
DeSanty, K.P.1
Amabile, C.M.2
-
9
-
-
34047154993
-
Strategies to reduce latestage compound attrition due to mitochondrial toxicity
-
Dykens, J. A., Marroquin, L. D., and Will, Y. (2007). Strategies to reduce latestage compound attrition due to mitochondrial toxicity. Expert Rev. Mol. Diagn. 7, 161-175.
-
(2007)
Expert Rev. Mol. Diagn.
, vol.7
, pp. 161-175
-
-
Dykens, J.A.1
Marroquin, L.D.2
Will, Y.3
-
10
-
-
34548379435
-
The significance of mitochondrial toxicity testing in drug development
-
Dykens, J. A., and Will, Y. (2007). The significance of mitochondrial toxicity testing in drug development. Drug Discov. Today 12, 777-785.
-
(2007)
Drug Discov. Today
, vol.12
, pp. 777-785
-
-
Dykens, J.A.1
Will, Y.2
-
11
-
-
44749083056
-
Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats
-
El-Shitany, N. A., El-Haggar, S., and El-desoky, K. (2008). Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats. Food Chem. Toxicol. 46, 2422-2428.
-
(2008)
Food Chem. Toxicol.
, vol.46
, pp. 2422-2428
-
-
El-Shitany, N.A.1
El-Haggar, S.2
El-desoky, K.3
-
12
-
-
0038471102
-
The impact of drug-induced QT interval prolongation on drug discovery and development
-
Fermini, B., and Fossa, A. A. (2003). The impact of drug-induced QT interval prolongation on drug discovery and development. Nat. Rev. Compound Discov. 2, 439-447.
-
(2003)
Nat. Rev. Compound Discov.
, vol.2
, pp. 439-447
-
-
Fermini, B.1
Fossa, A.A.2
-
13
-
-
77249175263
-
Prediction of compound-related cardiac adverse effects in humans-B: Use of QSAR programs for early detection of compound-induced cardiac toxicities
-
Frid, A. A., and Matthews, E. J. (2010). Prediction of compound-related cardiac adverse effects in humans-B: Use of QSAR programs for early detection of compound-induced cardiac toxicities. Regul. Toxicol. Pharmacol. 56, 276-289.
-
(2010)
Regul. Toxicol. Pharmacol.
, vol.56
, pp. 276-289
-
-
Frid, A.A.1
Matthews, E.J.2
-
14
-
-
77956172973
-
Enhanced toxicity and ROS generation by doxorubicin in primary cultures of cardiomyocytes from neonatal metallothionein-I/II null mice
-
Fu, Z., Guo, J., Jing, L., Li, R., Zhang, T., and Peng, S. (2010). Enhanced toxicity and ROS generation by doxorubicin in primary cultures of cardiomyocytes from neonatal metallothionein-I/II null mice. Toxicol. In Vitro 24, 1584-1591.
-
(2010)
Toxicol. In Vitro
, vol.24
, pp. 1584-1591
-
-
Fu, Z.1
Guo, J.2
Jing, L.3
Li, R.4
Zhang, T.5
Peng, S.6
-
15
-
-
77955663637
-
Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies
-
Greene, N., Aleo, M. D., Louise-May, S., Price, D. A., and Will, Y. (2010). Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies. Bioorg. Med. Chem. Lett. 20, 5308-5312.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 5308-5312
-
-
Greene, N.1
Aleo, M.D.2
Louise-May, S.3
Price, D.A.4
Will, Y.5
-
16
-
-
41849099259
-
Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening
-
Huang, R., Southall, N., Cho, M. H., Xia, M., Inglese, J., and Austin, C. P. (2008). Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chem. Res. Toxicol. 21, 659-667.
-
(2008)
Chem. Res. Toxicol.
, vol.21
, pp. 659-667
-
-
Huang, R.1
Southall, N.2
Cho, M.H.3
Xia, M.4
Inglese, J.5
Austin, C.P.6
-
17
-
-
80053527081
-
Predictive in vitro cardiotoxicity and hepatotoxicity screening system using neonatal rat heart cells and rat hepatocytes
-
21-25 August 2007. AATEX 14
-
Inoue, T., Tanaka, K., Mishima, M., and Watanabe, K. (2007). Predictive in vitro cardiotoxicity and hepatotoxicity screening system using neonatal rat heart cells and rat hepatocytes. Proceedings of 6th World Congress on Alternatives & Animal Use in the Life Sciences, 21-25 August 2007. AATEX 14, 457-462.
-
(2007)
Proceedings of 6th World Congress on Alternatives & Animal Use in the Life Sciences
, pp. 457-462
-
-
Inoue, T.1
Tanaka, K.2
Mishima, M.3
Watanabe, K.4
-
18
-
-
0021698630
-
Bioluminescence of cellular ATP: A new method for evaluating cytotoxic agents in vitro
-
Kangas, L., Grönroos, M., and Nieminen, A. L. (1984). Bioluminescence of cellular ATP: A new method for evaluating cytotoxic agents in vitro. Med. Biol. 62, 338-343.
-
(1984)
Med. Biol.
, vol.62
, pp. 338-343
-
-
Kangas, L.1
Grönroos, M.2
Nieminen, A.L.3
-
19
-
-
20844444779
-
Idiosyncratic drug hepatotoxicity
-
Kaplowitz, N. (2005). Idiosyncratic drug hepatotoxicity. Nat. Rev. Drug Discov. 4, 489-499.
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 489-499
-
-
Kaplowitz, N.1
-
20
-
-
0024596020
-
The nephrotoxic potential of drugs and chemicals. Pharmacological basis and clinical relevance
-
Koren, G. (1989). The nephrotoxic potential of drugs and chemicals. Pharmacological basis and clinical relevance. Med. Toxicol. Adverse Drug Exp. 4, 59-72.
-
(1989)
Med. Toxicol. Adverse Drug Exp.
, vol.4
, pp. 59-72
-
-
Koren, G.1
-
21
-
-
0041342015
-
Drug-induced hepatotoxicity
-
Lee, W. M. (2003). Drug-induced hepatotoxicity. N. Engl. J. Med. 349, 474-485.
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 474-485
-
-
Lee, W.M.1
-
22
-
-
80053114330
-
The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis
-
Li, Y., Li, X., Wong, Y. S., Chen, T., Zhang, H., Liu, C., and Zheng, W. (2011). The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis. Biomaterials 32, 9068-9076.
-
(2011)
Biomaterials
, vol.32
, pp. 9068-9076
-
-
Li, Y.1
Li, X.2
Wong, Y.S.3
Chen, T.4
Zhang, H.5
Liu, C.6
Zheng, W.7
-
23
-
-
72449143623
-
An expert system approach to the assessment of hepatotoxic potential
-
Marchant, C. A., Fisk, L., Note, R. R., Pate, M. L., and Suárez, D. (2009). An expert system approach to the assessment of hepatotoxic potential. Chem. Biodivers. 6, 2107-2114.
-
(2009)
Chem. Biodivers.
, vol.6
, pp. 2107-2114
-
-
Marchant, C.A.1
Fisk, L.2
Note, R.R.3
Pate, M.L.4
Suárez, D.5
-
24
-
-
77949814178
-
Building a tiered approach to in vitro predictive toxicity screening: A focus on assays with in vivo relevance
-
McKim, J. M., Jr. (2010). Building a tiered approach to in vitro predictive toxicity screening: A focus on assays with in vivo relevance. Comb. Chem. High Throughput Screen. 13, 188-206.
-
(2010)
Comb. Chem. High Throughput Screen.
, vol.13
, pp. 188-206
-
-
McKim Jr., J.M.1
-
25
-
-
33644938799
-
Comparison of in vitro assays of cellular toxicity in the human hepatic cell line HepG2
-
Miret, S., De Grone, E. M., and Klaffke, W. (2006). Comparison of in vitro assays of cellular toxicity in the human hepatic cell line HepG2. J. Biomol. Screen. 11, 184-193.
-
(2006)
J. Biomol. Screen.
, vol.11
, pp. 184-193
-
-
Miret, S.1
De Grone, E.M.2
Klaffke, W.3
-
26
-
-
16644386336
-
Comparison of the usefulness of the MTT, ATP, and calcein assays to predict the potency of cytotoxic agents in various human cancer cell lines
-
Mueller, H., Kassack, M. U., and Wiese, M. (2004). Comparison of the usefulness of the MTT, ATP, and calcein assays to predict the potency of cytotoxic agents in various human cancer cell lines. J. Biomol. Screen. 9, 506-515.
-
(2004)
J. Biomol. Screen.
, vol.9
, pp. 506-515
-
-
Mueller, H.1
Kassack, M.U.2
Wiese, M.3
-
27
-
-
78449283897
-
High-content screening for compounds that affect mtDNA-encoded protein levels in eukaryotic cells
-
Nadanaciva, S., Dillman, K., Gebhard, D. F., Shrikhande, A., and Will, Y. (2010). High-content screening for compounds that affect mtDNA-encoded protein levels in eukaryotic cells. J. Biomol. Screen. 15, 937-948.
-
(2010)
J. Biomol. Screen.
, vol.15
, pp. 937-948
-
-
Nadanaciva, S.1
Dillman, K.2
Gebhard, D.F.3
Shrikhande, A.4
Will, Y.5
-
28
-
-
33646472405
-
Molecular mechanisms underlying renal accumulation of aminoglycoside antibiotics and mechanism-based approach for developing nonnephrotoxic aminoglycoside therapy
-
Nagai, J. (2006). Molecular mechanisms underlying renal accumulation of aminoglycoside antibiotics and mechanism-based approach for developing nonnephrotoxic aminoglycoside therapy. Yakugaku Zasshi 126, 327-335.
-
(2006)
Yakugaku Zasshi
, vol.126
, pp. 327-335
-
-
Nagai, J.1
-
29
-
-
33747084103
-
High concordance of compound-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening
-
O'Brien, P. J., Irwin, W., Diaz, D., Howard-Cofield, E., Krejsa, C. M., Slaughter, M. R., Gao, B., Kaludercic, N., Angeline, A., Bernardi, P., et al. (2006). High concordance of compound-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Arch. Toxicol. 80, 580-604.
-
(2006)
Arch. Toxicol.
, vol.80
, pp. 580-604
-
-
O'Brien, P.J.1
Irwin, W.2
Diaz, D.3
Howard-Cofield, E.4
Krejsa, C.M.5
Slaughter, M.R.6
Gao, B.7
Kaludercic, N.8
Angeline, A.9
Bernardi, P.10
-
30
-
-
77955919042
-
The application of metabonomics to predict compound-induced liver injury
-
O'Connell, T. M., and Watkins, P. B. (2010). The application of metabonomics to predict compound-induced liver injury. Clin. Pharmacol. Ther. 88, 394-399.
-
(2010)
Clin. Pharmacol. Ther.
, vol.88
, pp. 394-399
-
-
O'Connell, T.M.1
Watkins, P.B.2
-
31
-
-
0029107667
-
Comparison of MTT and ATP-based assays for the measurement of viable cell number
-
Petty, R. D., Sutherland, L. A., Hunter, E. M., and Cree, I. A. (1995). Comparison of MTT and ATP-based assays for the measurement of viable cell number. J. Biolumin. Chemilumin. 10, 29-34.
-
(1995)
J. Biolumin. Chemilumin.
, vol.10
, pp. 29-34
-
-
Petty, R.D.1
Sutherland, L.A.2
Hunter, E.M.3
Cree, I.A.4
-
32
-
-
0031024931
-
"Sensitivity" and "specificity" reconsidered: The meaning of these terms in analytical and diagnostic settings
-
Saah, A. J., and Hoover, D. R. (1997). "Sensitivity" and "specificity" reconsidered: The meaning of these terms in analytical and diagnostic settings. Ann. Intern. Med. 126, 91-94.
-
(1997)
Ann. Intern. Med.
, vol.126
, pp. 91-94
-
-
Saah, A.J.1
Hoover, D.R.2
-
33
-
-
17044433346
-
Cytotoxic effects of 100 reference compounds on HepG2 and HeLa cells and of 60 compounds on ECC-1 and CHO cells. I mechanistic assays on ROS, glutathione depletion and calcein uptake
-
Schoonen, W. G., Westerink, W. M., de Roos, J. A., and Débiton, E. (2005). Cytotoxic effects of 100 reference compounds on HepG2 and HeLa cells and of 60 compounds on ECC-1 and CHO cells. I mechanistic assays on ROS, glutathione depletion and calcein uptake. Toxicol. In Vitro 19, 505-516.
-
(2005)
Toxicol. In Vitro
, vol.19
, pp. 505-516
-
-
Schoonen, W.G.1
Westerink, W.M.2
de Roos, J.A.3
Débiton, E.4
-
34
-
-
24944547571
-
Why drugs fail-A study on side effects in new chemical entities
-
Schuster, D., Laggner, C., and Langer, T. (2005). Why drugs fail-A study on side effects in new chemical entities. Curr. Pharm. Des. 11, 3545-3559.
-
(2005)
Curr. Pharm. Des.
, vol.11
, pp. 3545-3559
-
-
Schuster, D.1
Laggner, C.2
Langer, T.3
-
35
-
-
80053360260
-
Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use
-
Schutte, M., Fox, B., Baradez, M. O., Devonshire, A., Minguez, J., Bokhari, M., Przyborski, S., and Marshall, D. (2011). Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use. Assay Drug Dev. Technol. 9, 475-486.
-
(2011)
Assay Drug Dev. Technol.
, vol.9
, pp. 475-486
-
-
Schutte, M.1
Fox, B.2
Baradez, M.O.3
Devonshire, A.4
Minguez, J.5
Bokhari, M.6
Przyborski, S.7
Marshall, D.8
-
37
-
-
33847644452
-
Alternative statistical parameter for highthroughput screening assay quality assessment
-
Sui, Y., and Wu, Z. (2007). Alternative statistical parameter for highthroughput screening assay quality assessment. J. Biomol. Screen. 12, 229-234.
-
(2007)
J. Biomol. Screen.
, vol.12
, pp. 229-234
-
-
Sui, Y.1
Wu, Z.2
-
38
-
-
80053014895
-
Functional characterization of drug uptake and metabolism in the heart
-
Weiss, M. (2011). Functional characterization of drug uptake and metabolism in the heart. Expert Opin. Drug Metab. Toxicol. 7, 1295-1306.
-
(2011)
Expert Opin. Drug Metab. Toxicol.
, vol.7
, pp. 1295-1306
-
-
Weiss, M.1
-
39
-
-
36148955117
-
Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells
-
Westerink, W. M., and Schoonen, W. G. (2007a). Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicol. In Vitro 21, 1581-1591.
-
(2007)
Toxicol. In Vitro
, vol.21
, pp. 1581-1591
-
-
Westerink, W.M.1
Schoonen, W.G.2
-
40
-
-
36148949386
-
Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells
-
Westerink, W. M., and Schoonen, W. G. (2007b). Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicol. In Vitro 21, 1592-1602.
-
(2007)
Toxicol. In Vitro
, vol.21
, pp. 1592-1602
-
-
Westerink, W.M.1
Schoonen, W.G.2
-
41
-
-
69149098142
-
Cardiac magnetic resonance imaging in sunitinib malate-related cardiomyopathy: No late gadolinium enhancement
-
Wu, C. F., Chuang, W. P., Li, A. H., and Hsiao, C. H. (2009). Cardiac magnetic resonance imaging in sunitinib malate-related cardiomyopathy: No late gadolinium enhancement. J. Chin. Med. Assoc. 72, 323-327.
-
(2009)
J. Chin. Med. Assoc.
, vol.72
, pp. 323-327
-
-
Wu, C.F.1
Chuang, W.P.2
Li, A.H.3
Hsiao, C.H.4
-
42
-
-
40849137783
-
Compound cytotoxicity profiling using quantitative high-throughput screening
-
Xia, M., Huang, R., Witt, K. L., Southall, N., Fostel, J., Cho, M. H., Jadhav, A., Smith, C. S., Inglese, J., Portier, C. J., et al. (2008). Compound cytotoxicity profiling using quantitative high-throughput screening. Environ. Health Perspect. 116, 284-291.
-
(2008)
Environ. Health Perspect.
, vol.116
, pp. 284-291
-
-
Xia, M.1
Huang, R.2
Witt, K.L.3
Southall, N.4
Fostel, J.5
Cho, M.H.6
Jadhav, A.7
Smith, C.S.8
Inglese, J.9
Portier, C.J.10
-
43
-
-
49249103327
-
Cellular imaging predictions of clinical drug-induced liver injury
-
Xu, J. J., Henstock, P. V., Dunn, M. C., Smith, A. R., Chabot, J. R., and de Graaf, D. (2008). Cellular imaging predictions of clinical drug-induced liver injury. Toxicol. Sci. 105, 97-105.
-
(2008)
Toxicol. Sci.
, vol.105
, pp. 97-105
-
-
Xu, J.J.1
Henstock, P.V.2
Dunn, M.C.3
Smith, A.R.4
Chabot, J.R.5
de Graaf, D.6
-
44
-
-
34147114939
-
In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney
-
Zhang, L., Mu, X., Fu, J., and Zhou, Z. (2007). In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney. Toxicol. In Vitro 21, 734-740.
-
(2007)
Toxicol. In Vitro
, vol.21
, pp. 734-740
-
-
Zhang, L.1
Mu, X.2
Fu, J.3
Zhou, Z.4
|