Factors affecting post-stroke motor recovery: Implications on neurotherapy after brain injury

Behavioural Brain Research

Volumn 340, Issue , 2018, Pages 94-101

  Alawieh, Ali ^a   Zhao, Jing ^d   Feng, Wuwei ^b,c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d FUDAN UNIVERSITY   (China)

Author keywords

Brain injury; Brain recovery; Neurorehabilitation; Stroke recovery

Indexed keywords

ADULT; ARTICLE; BRAIN COMPUTER INTERFACE; BRAIN INJURY; CELL THERAPY; CEREBROVASCULAR ACCIDENT; DISABILITY; FEMALE; FUNCTIONAL STATUS; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MOTOR PERFORMANCE; NEUROREHABILITATION; PATHOPHYSIOLOGY; PATIENT CODING; PRIORITY JOURNAL; PROGNOSIS; REHABILITATION CARE; REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION; RISK FACTOR; STROKE PATIENT; TRANSCRANIAL DIRECT CURRENT STIMULATION; ANIMAL; BRAIN; GENETICS; STROKE REHABILITATION;

ANIMALS; BRAIN; HUMANS; STROKE; STROKE REHABILITATION;

EID: 84995961243     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2016.08.029     Document Type: Article

References (126)

1. Mozaffarian, D., Benjamin, E.J., Go, A.S., Arnett, D.K., Blaha, M.J., Cushman, M., Das, S.R., de Ferranti, S., Després, J.-P., Fullerton, H.J., Executive summary: heart disease and stroke statistics—2016 update a report from the American Heart Association. Circulation 133:4 (2016), 447–454.
2. Towfighi, A., Saver, J.L., Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead. Stroke 42:8 (2011), 2351–2355.
3. Murray, C.J., Vos, T., Lozano, R., et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:9859 (2012), 2197–2223.
4. Tissue plasminogen activator for acute ischemic stroke. the national institute of neurological disorders and stroke rt-PA Stroke Study Group. N. Engl. J. Med. 333:24 (1995), 1581–1587.
5. Langhorne, P., Coupar, F., Pollock, A., Motor recovery after stroke: a systematic review. Lancet Neurol. 8:8 (2009), 741–754.
6. Taylor, T.N., Davis, P.H., Torner, J.C., Holmes, J., Meyer, J.W., Jacobson, M.F., Lifetime cost of stroke in the United States. Stroke 27:9 (1996), 1459–1466.
7. Nakayama, H., Jorgensen, H.S., Raaschou, H.O., Olsen, T.S., The influence of age on stroke outcome. The Copenhagen Stroke Study. Stroke 25:4 (1994), 808–813.
8. Jongbloed, L., Prediction of function after stroke: a critical review. Stroke 17:4 (1986), 765–776.
9. Jorgensen, H.S., Reith, J., Nakayama, H., Kammersgaard, L.P., Raaschou, H.O., Olsen, T.S., What determines good recovery in patients with the most severe strokes? The Copenhagen Stroke Study. Stroke 30:10 (1999), 2008–2012.
10. Kelly-Hayes, M., Beiser, A., Kase, C.S., Scaramucci, A., D'Agostino, R.B., Wolf, P.A., The influence of gender and age on disability following ischemic stroke: the Framingham study. J. Stroke Cerebrovasc. Dis. 12:3 (2003), 119–126.
11. D'Amore, C., Paciaroni, M., Silvestrelli, G., Agnelli, G., Santucci, P., Lanari, A., Alberti, A., Venti, M., Acciarresi, M., Caso, V., Severity of acute intracerebral haemorrhage, elderly age and atrial fibrillation: independent predictors of poor outcome at three months. Eur. J. Intern. Med. 24:4 (2013), 310–313.
12. Bagg, S., Pombo, A.P., Hopman, W., Effect of age on functional outcomes after stroke rehabilitation. Stroke 33:1 (2002), 179–185.
13. Luk, J.K., Cheung, R.T., Ho, S.L., Li, L., Does age predict outcome in stroke rehabilitation? A study of 878 Chinese subjects. Cerebrovasc. Dis. 21:4 (2006), 229–234.
14. Umeano, O., Phillips-Bute, B., Hailey, C.E., Sun, W., Gray, M.C., Roulhac-Wilson, B., McDonagh, D.L., Kranz, P.G., Laskowitz, D.T., James, M.L., Gender and age interact to affect early outcome after intracerebral hemorrhage. PLoS One, 8(11), 2013, e81664.
15. Weimar, C., König, I., Kraywinkel, K., Ziegler, A., Diener, H., G.S.S. Collaboration, Age and national institutes of health stroke scale score within 6 hours after onset are accurate predictors of outcome after cerebral ischemia development and external validation of prognostic models. Stroke 35:1 (2004), 158–162.
16. Kwah, L.K., Harvey, L.A., Diong, J., Herbert, R.D., Models containing age and NIHSS predict recovery of ambulation and upper limb function six months after stroke: an observational study. J. Physiother. 59:3 (2013), 189–197.
17. Denti, L., Agosti, M., Franceschini, M., Outcome predictors of rehabilitation for first stroke in the elderly. Eur. J. Phys. Rehabil. Med. 44:1 (2008), 3–11.
18. Di Carlo, A., Lamassa, M., Baldereschi, M., Pracucci, G., Basile, A.M., Wolfe, C.D., Giroud, M., Rudd, A., Ghetti, A., Inzitari, D., Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: data from a multicenter multinational hospital-based registry. Stroke 34:5 (2003), 1114–1149.
19. Lai, S.M., Duncan, P.W., Dew, P., Keighley, J., Sex differences in stroke recovery. Prev. Chronic Dis., 2(3), 2005, A13.
20. Gargano, J.W., Reeves, M.J., Sex differences in stroke recovery and stroke-specific quality of life: results from a statewide stroke registry. Stroke 38:9 (2007), 2541–2548.
21. Eriksson, M., Asplund, K., Glader, E.L., Norrving, B., Stegmayr, B., Terent, A., Asberg, K.H., Wester, P.O., Self-reported depression and use of antidepressants after stroke: a national survey. Stroke 35:4 (2004), 936–941.
22. Glader, E.L., Stegmayr, B., Asplund, K., Poststroke fatigue: a 2-year follow-up study of stroke patients in Sweden. Stroke 33:5 (2002), 1327–1333.
23. Gray, L.J., Sprigg, N., Bath, P.M., Boysen, G., De Deyn, P.P., Leys, D., O'Neill, D., Ringelstein, E.B., Investigators, T., Sex differences in quality of life in stroke survivors: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Stroke 38:11 (2007), 2960–2964.
24. Feng, W., Nietert, P.J., Adams, R.J., Influence of age on racial disparities in stroke admission rates, hospital charges, and outcomes in South Carolina. Stroke 40:9 (2009), 3096–3101.
25. Johnston, S.C., Fung, L.H., Gillum, L.A., Smith, W.S., Brass, L.M., Lichtman, J.H., Brown, A.N., Utilization of intravenous tissue-type plasminogen activator for ischemic stroke at academic medical centers: the influence of ethnicity. Stroke 32:5 (2001), 1061–1068.
26. Feng, W., Hendry, R.M., Adams, R.J., Risk of recurrent stroke, myocardial infarction, or death in hospitalized stroke patients. Neurology 74:7 (2010), 588–593.
27. Jones, M.R., Horner, R.D., Edwards, L.J., Hoff, J., Armstrong, S.B., Smith-Hammond, C.A., Matchar, D.B., Oddone, E.Z., Racial variation in initial stroke severity. Stroke 31:3 (2000), 563–567.
28. Stansbury, J.P., Jia, H., Williams, L.S., Vogel, W.B., Duncan, P.W., Ethnic disparities in stroke: epidemiology, acute care, and postacute outcomes. Stroke 36:2 (2005), 374–386.
29. Horner, R.D., Matchar, D.B., Divine, G.W., Feussner, J.R., Racial variations in ischemic stroke-related physical and functional impairments. Stroke 22:12 (1991), 1497–1501.
30. Cruz-Flores, S., Rabinstein, A., Biller, J., Elkind, M.S., Griffith, P., Gorelick, P.B., Howard, G., Leira, E.C., Morgenstern, L.B., Ovbiagele, B., Peterson, E., Rosamond, W., Trimble, B., Valderrama, A.L., Racial-ethnic disparities in stroke care: the American experience: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 42:7 (2011), 2091–2116.
31. McNaughton, H., Feigin, V., Kerse, N., Barber, P.A., Weatherall, M., Bennett, D., Carter, K., Hackett, M., Anderson, C., Ethnicity and functional outcome after stroke. Stroke 42:4 (2011), 960–964.
32. Jia, H., Chumbler, N.R., Wang, X., Chuang, H.C., Damush, T.M., Cameon, R., Williams, L.S., Racial and ethnic disparities in post-stroke depression detection. Int. J. Geriatr. Psychiatry 25:3 (2010), 298–304.
33. Kirby, J.B., Hudson, J., Miller, G.E., Explaining racial and ethnic differences in antidepressant use among adolescents. Med. Care Res. Rev. 67:3 (2010), 342–363.
34. Cooper, L.A., Gonzales, J.J., Gallo, J.J., Rost, K.M., Meredith, L.S., Rubenstein, L.V., Wang, N.Y., Ford, D.E., The acceptability of treatment for depression among African-American, Hispanic, and white primary care patients. Med. Care 41:4 (2003), 479–489.
35. Horner, R.D., Swanson, J.W., Bosworth, H.B., Matchar, D.B., Effects of race and poverty on the process and outcome of inpatient rehabilitation services among stroke patients. Stroke 34:4 (2003), 1027–1031.
36. Putman, K., De Wit, L., Schoonacker, M., Baert, I., Beyens, H., Brinkmann, N., Dejaeger, E., De Meyer, A.M., De Weerdt, W., Feys, H., Jenni, W., Kaske, C., Leys, M., Lincoln, N., Schuback, B., Schupp, W., Smith, B., Louckx, F., Effect of socioeconomic status on functional and motor recovery after stroke: a European multicentre study. J. Neurol. Neurosurg. Psychiatry 78:6 (2007), 593–599.
37. Marshall, I.J., Wang, Y., Crichton, S., McKevitt, C., Rudd, A.G., Wolfe, C.D., The effects of socioeconomic status on stroke risk and outcomes. Lancet Neurol. 14:12 (2015), 1206–1218.
38. Hartman-Maeir, N., Soroker, N., Oman, S.D., Katz, N., Awareness of disabilities in stroke rehabilitation—a clinical trial. Disabil. Rehabil. 25:1 (2003), 35–44.
39. Paolucci, S., Antonucci, G., Grasso, M.G., Bragoni, M., Coiro, P., De Angelis, D., Fusco, F.R., Morelli, D., Venturiero, V., Troisi, E., Pratesi, L., Functional outcome of ischemic and hemorrhagic stroke patients after inpatient rehabilitation: a matched comparison. Stroke 34:12 (2003), 2861–2865.
40. Kelly, P.J., Furie, K.L., Shafqat, S., Rallis, N., Chang, Y., Stein, J., Functional recovery following rehabilitation after hemorrhagic and ischemic stroke. Arch. Phys. Med. Rehabil. 84:7 (2003), 968–972.
41. Bhalla, A., Wang, Y., Rudd, A., Wolfe, C.D., Differences in outcome and predictors between ischemic and intracerebral hemorrhage The South London Stroke Register. Stroke 44:8 (2013), 2174–2181.
42. Duncan, P.W., Goldstein, L.B., Matchar, D., Divine, G.W., Feussner, J., Measurement of motor recovery after stroke. Outcome assessment and sample size requirements. Stroke 23:8 (1992), 1084–1089.
43. Smania, N., Paolucci, S., Tinazzi, M., Borghero, A., Manganotti, P., Fiaschi, A., Moretto, G., Bovi, P., Gambarin, M., Active finger extension: a simple movement predicting recovery of arm function in patients with acute stroke. Stroke 38:3 (2007), 1088–1090.
44. Nijland, R.H., van Wegen, E.E., Harmeling-van der Wel, B.C., Kwakkel, G., Presence of finger extension and shoulder abduction within 72 hours after stroke predicts functional recovery: early prediction of functional outcome after stroke: the EPOS cohort study. Stroke 41:4 (2010), 745–750.
45. Feng, W., Wang, J., Chhatbar, P.Y., Doughty, C., Landsittel, D., Lioutas, V.A., Kautz, S.A., Schlaug, G., Corticospinal tract lesion load: an imaging biomarker for stroke motor outcomes. Ann. Neurol. 78:6 (2015), 860–870.
46. Krakauer, J.W., Marshall, R.S., The proportional recovery rule for stroke revisited. Ann. Neurol. 78:6 (2015), 845–847.
47. Byblow, W.D., Stinear, C.M., Barber, P.A., Petoe, M.A., Ackerley, S.J., Proportional recovery after stroke depends on corticomotor integrity. Ann. Neurol. 78:6 (2015), 848–859.
48. Prabhakaran, S., Zarahn, E., Riley, C., Speizer, A., Chong, J.Y., Lazar, R.M., Marshall, R.S., Krakauer, J.W., Inter-individual variability in the capacity for motor recovery after ischemic stroke. Neurorehabil. Neural Repair 22:1 (2008), 64–71.
49. Winters, C., van Wegen, E.E., Daffertshofer, A., Kwakkel, G., Generalizability of the proportional recovery model for the upper extremity after an ischemic stroke. Neurorehabil. Neural Repair 29:7 (2015), 614–622.
50. Murphy, T.H., Corbett, D., Plasticity during stroke recovery: from synapse to behaviour. Nat. Rev. Neurosci. 10:12 (2009), 861–872.
51. Carson, A.J., MacHale, S., Allen, K., Lawrie, S.M., Dennis, M., House, A., Sharpe, M., Depression after stroke and lesion location: a systematic review. Lancet 356:9224 (2000), 122–126.
52. Gaete, J.M., Bogousslavsky, J., Post-stroke depression. Expert Rev. Neurother. 8:1 (2008), 75–92.
53. Loubinoux, I., Kronenberg, G., Endres, M., Schumann-Bard, P., Freret, T., Filipkowski, R.K., Kaczmarek, L., Popa-Wagner, A., Post-stroke depression: mechanisms, translation and therapy. J. Cell. Mol. Med. 16:9 (2012), 1961–1969.
54. Guiraud, V., Gallarda, T., Calvet, D., Turc, G., Oppenheim, C., Rouillon, F., Mas, J.-L., Depression predictors within six months of ischemic stroke: the DEPRESS study. Int. J. Stroke 11:5 (2016), 519–525, 10.1177/1747493016632257.
55. Robinson, R.G., Jorge, R.E., Post-Stroke depression: a review. Am. J. Psychiatry 173:3 (2016), 221–231.
56. Mead, G.E., Hsieh, C.F., Lee, R., Kutlubaev, M., Claxton, A., Hankey, G.J., Hackett, M., Selective serotonin reuptake inhibitors for stroke recovery: a systematic review and meta-analysis. Stroke 44:3 (2013), 844–850.
57. Chollet, F., Tardy, J., Albucher, J.F., Thalamas, C., Berard, E., Lamy, C., Bejot, Y., Deltour, S., Jaillard, A., Niclot, P., Guillon, B., Moulin, T., Marque, P., Pariente, J., Arnaud, C., Loubinoux, I., Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol. 10:2 (2011), 123–130.
58. Dam, M., Tonin, P., De Boni, A., Pizzolato, G., Casson, S., Ermani, M., Freo, U., Piron, L., Battistin, L., Effects of fluoxetine and maprotiline on functional recovery in poststroke hemiplegic patients undergoing rehabilitation therapy. Stroke 27:7 (1996), 1211–1214.
59. Pariente, J., Loubinoux, I., Carel, C., Albucher, J.F., Leger, A., Manelfe, C., Rascol, O., Chollet, F., Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Ann. Neurol. 50:6 (2001), 718–729.
60. Desilles, J.P., Meseguer, E., Labreuche, J., Lapergue, B., Sirimarco, G., Gonzalez-Valcarcel, J., Lavallee, P., Cabrejo, L., Guidoux, C., Klein, I., Amarenco, P., Mazighi, M., Diabetes mellitus, admission glucose, and outcomes after stroke thrombolysis: a registry and systematic review. Stroke 44:7 (2013), 1915–1923.
61. Kissela, B., Lindsell, C.J., Kleindorfer, D., Alwell, K., Moomaw, C.J., Woo, D., Flaherty, M.L., Air, E., Broderick, J., Tsevat, J., Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and race. Stroke 40:2 (2009), 530–536.
62. Goldstein, L.B., Samsa, G.P., Matchar, D.B., Horner, R.D., Charlson index comorbidity adjustment for ischemic stroke outcome studies. Stroke 35:8 (2004), 1941–1945.
63. Bushnell, C.D., Lee, J., Duncan, P.W., Newby, L.K., Goldstein, L.B., Impact of comorbidities on ischemic stroke outcomes in women. Stroke 39:7 (2008), 2138–2140.
64. Poisson, S.N., Johnston, S.C., Josephson, S.A., Urinary tract infections complicating stroke: mechanisms, consequences, and possible solutions. Stroke 41:4 (2010), e180–4.
65. Cooke, E.V., Mares, K., Clark, A., Tallis, R.C., Pomeroy, V.M., The effects of increased dose of exercise-based therapies to enhance motor recovery after stroke: a systematic review and meta-analysis. BMC Med., 8, 2010, 60.
66. Kozlowski, D.A., James, D.C., Schallert, T., Use-dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions. J. Neurosci. 16:15 (1996), 4776–4786.
67. Risedal, A., Zeng, J., Johansson, B.B., Early training may exacerbate brain damage after focal brain ischemia in the rat. J. Cereb. Blood Flow Metab. 19:9 (1999), 997–1003.
68. Bland, S.T., Schallert, T., Strong, R., Aronowski, J., Grotta, J.C., Feeney, D.M., Early exclusive use of the affected forelimb after moderate transient focal ischemia in rats: functional and anatomic outcome. Stroke 31:5 (2000), 1144–1152.
69. Jones, T.A., Allred, R.P., Adkins, D.L., Hsu, J.E., O'Bryant, A., Maldonado, M.A., Remodeling the brain with behavioral experience after stroke. Stroke 40:3 Suppl (2009), S136–S138.
70. Wolf, S.L., Winstein, C.J., Miller, J.P., Taub, E., Uswatte, G., Morris, D., Giuliani, C., Light, K.E., Nichols-Larsen, D., Investigators, E., Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. JAMA 296:17 (2006), 2095–2104.
71. Taub, E., Uswatte, G., Constraint-induced movement therapy: bridging from the primate laboratory to the stroke rehabilitation laboratory. J. Rehabil. Med.(41 Suppl), 2003, 34–40.
72. Dromerick, A.W., Lang, C.E., Birkenmeier, R.L., Wagner, J.M., Miller, J.P., Videen, T.O., Powers, W.J., Wolf, S.L., Edwards, D.F., Very early constraint-induced movement during stroke rehabilitation (VECTORS): a single-center RCT. Neurology 73:3 (2009), 195–201.
73. Lele, A., Efficacy and safety of very early mobilisation within 24 hours of stroke onset (AVERT): a randomised controlled trial. Lancet 386:9988 (2015), 46–55.
74. Duncan, P.W., Sullivan, K.J., Behrman, A.L., Azen, S.P., Wu, S.S., Nadeau, S.E., Dobkin, B.H., Rose, D.K., Tilson, J.K., Cen, S., Hayden, S.K., Body-weight-supported treadmill rehabilitation after stroke. N. Engl. J. Med. 364:21 (2011), 2026–2036.
75. Ikram, M.A., Seshadri, S., Bis, J.C., Fornage, M., DeStefano, A.L., Aulchenko, Y.S., Debette, S., Lumley, T., Folsom, A.R., van den Herik, E.G., Bos, M.J., Beiser, A., Cushman, M., Launer, L.J., Shahar, E., Struchalin, M., Du, Y., Glazer, N.L., Rosamond, W.D., Rivadeneira, F., Kelly-Hayes, M., Lopez, O.L., Coresh, J., Hofman, A., DeCarli, C., Heckbert, S.R., Koudstaal, P.J., Yang, Q., Smith, N.L., Kase, C.S., Rice, K., Haritunians, T., Roks, G., de Kort, P.L., Taylor, K.D., de Lau, L.M., Oostra, B.A., Uitterlinden, A.G., Rotter, J.I., Boerwinkle, E., Psaty, B.M., Mosley, T.H., van Duijn, C.M., Breteler, M.M., Longstreth, W.T. Jr., Wolf, P.A., Genomewide association studies of stroke. N. Engl. J. Med. 360:17 (2009), 1718–1728.
76. NINDS Stroke Genetics Network and International Stroke Genetics Consortium, Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. Lancet Neurol. 15:2 (2016), 174–184.
77. Greisenegger, S., Endler, G., Haering, D., Schillinger, M., Lang, W., Lalouschek, W., Mannhalter, C., The (− 174) G/C polymorphism in the interleukin-6 gene is associated with the severity of acute cerebrovascular events. Thromb. Res. 110:4 (2003), 181–186.
78. Fritsch, B., Reis, J., Martinowich, K., Schambra, H.M., Ji, Y., Cohen, L.G., Lu, B., Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning. Neuron 66:2 (2010), 198–204.
79. Egan, M.F., Kojima, M., Callicott, J.H., Goldberg, T.E., Kolachana, B.S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., Lu, B., Weinberger, D.R., The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:2 (2003), 257–269.
80. Kleim, J.A., Chan, S., Pringle, E., Schallert, K., Procaccio, V., Jimenez, R., Cramer, S.C., BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex. Nat. Neurosci. 9:6 (2006), 735–737.
81. Jiang, Y., Wei, N., Lu, T., Zhu, J., Xu, G., Liu, X., Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience 172 (2011), 398–405.
82. Schabitz, W.R., Steigleder, T., Cooper-Kuhn, C.M., Schwab, S., Sommer, C., Schneider, A., Kuhn, H.G., Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis. Stroke 38:7 (2007), 2165–2172.
83. Siironen, J., Juvela, S., Kanarek, K., Vilkki, J., Hernesniemi, J., Lappalainen, J., The Met allele of the BDNF Val66Met polymorphism predicts poor outcome among survivors of aneurysmal subarachnoid hemorrhage. Stroke 38:10 (2007), 2858–2860.
84. Pearson-Fuhrhop, K.M., Kleim, J.A., Cramer, S.C., Brain plasticity and genetic factors. Top. Stroke Rehabil. 16:4 (2009), 282–299.
85. Chen, Z., Simmons, M.S., Perry, R.T., Wiener, H.W., Harrell, L.E., Go, R.C., Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease. Am. J. Med. Genet. Part B: Neuropsychiatr. Genet. 147:3 (2008), 363–369.
86. Hayashi, A., Nakatani, K., Nishioka, J., Sakamoto, Y., Jinda, S., Wada, H., Nobori, T., Neurotrophic receptor tyrosine kinase B induces c-fos-associated cell survival. Int. J. Mol. Med. 24:6 (2009), 807–811.
87. Chinnery, P.F., Elliott, H.R., Syed, A., Rothwell, P.M., Mitochondrial DNA haplogroups and risk of transient ischaemic attack and ischaemic stroke: a genetic association study. Lancet Neurol. 9:5 (2010), 498–503.
88. Itoh, K., Hashimoto, K., Kumakiri, C., Shimizu, E., Iyo, M., Association between brain-derived neurotrophic factor 196 G/A polymorphism and personality traits in healthy subjects. Am. J. Med. Genet. Part B: Neuropsychiatr. Genet. 124B:1 (2004), 61–63.
89. Ventriglia, M., Bocchio Chiavetto, L., Benussi, L., Binetti, G., Zanetti, O., Riva, M.A., Gennarelli, M., Association between the BDNF 196A/G polymorphism and sporadic Alzheimer's disease. Mol. Psychiatry 7:2 (2002), 136–137.
90. Chen, Z.Y., Jing, D., Bath, K.G., Ieraci, A., Khan, T., Siao, C.J., Herrera, D.G., Toth, M., Yang, C., McEwen, B.S., Hempstead, B.L., Lee, F.S., Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314:5796 (2006), 140–143.
91. Helm, E.E., Tyrell, C.M., Pohlig, R.T., Brady, L.D., Reisman, D.S., The presence of a single-nucleotide polymorphism in the BDNF gene affects the rate of locomotor adaptation after stroke. Exp. Brain Res., 2015, 1–11.
92. Kim, E.J., Park, C.H., Chang, W.H., Lee, A., Kim, S.T., Shin, Y.I., Kim, Y.H., The brain-derived neurotrophic factor Val66Met polymorphism and degeneration of the corticospinal tract after stroke: a diffusion tensor imaging study. Eur. J. Neurol. 23:1 (2016), 76–84.
93. Kim, J.M., Stewart, R., Park, M.S., Kang, H.J., Kim, S.W., Shin, I.S., Kim, H.R., Shin, M.G., Cho, K.H., Yoon, J.S., Associations of BDNF genotype and promoter methylation with acute and long-term stroke outcomes in an East Asian cohort. PLoS One, 7(12), 2012, e51280.
94. Di Pino, G., Pellegrino, G., Capone, F., Assenza, G., Florio, L., Falato, E., Lotti, F., Di Lazzaro, V., Val66Met BDNF polymorphism implies a different way to recover from stroke rather than a worse overall recoverability. Neurorehabil. Neural Repair 30:1 (2016), 3–8, 10.1177/1545968315583721.
95. Chang, W.H., Bang, O.Y., Shin, Y.I., Lee, A., Pascual-Leone, A., Kim, Y.H., BDNF polymorphism and differential rTMS effects on motor recovery of stroke patients. Brain Stimul. 7:4 (2014), 553–558.
96. Hwang, J.M., Kim, Y.H., Yoon, K.J., Uhm, K.E., Chang, W.H., Different responses to facilitatory rTMS according to BDNF genotype. Clin. Neurophysiol. 126:7 (2015), 1348–1353.
97. Uhm, K.E., Kim, Y.-H., Yoon, K.J., Hwang, J.M., Chang, W.H., BDNF genotype influence the efficacy of rTMS in stroke patients. Neurosci. Lett. 594 (2015), 117–121.
98. Cramer, S., Procaccio, V., Correlation between genetic polymorphisms and stroke recovery: analysis of the GAIN Americas and GAIN International Studies. Eur. J. Neurol. 19:5 (2012), 718–724.
99. Martinez-Gonzalez, N.A., Sudlow, C.L., Effects of apolipoprotein E genotype on outcome after ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage. J. Neurol. Neurosurg. Psychiatry 77:12 (2006), 1329–1335.
100. McCarron, M.O., Muir, K.W., Nicoll, J.A., Stewart, J., Currie, Y., Brown, K., Bone, I., Prospective study of apolipoprotein E genotype and functional outcome following ischemic stroke. Arch. Neurol. 57:10 (2000), 1480–1484.
101. Giocomo, L.M., Hasselmo, M.E., Neuromodulation by glutamate and acetylcholine can change circuit dynamics by regulating the relative influence of afferent input and excitatory feedback. Mol. Neurobiol. 36:2 (2007), 184–200.
102. Warburton, D.M., Rusted, J.M., Muller, C., Patterns of facilitation of memory by nicotine. Behav. Pharmacol. 3:4 (1992), 375–378.
103. Albert-Weissenberger, C., Siren, A.L., Kleinschnitz, C., Ischemic stroke and traumatic brain injury: the role of the kallikrein-kinin system. Prog. Neurobiol. 101–102 (2013), 65–82.
104. Nitsche, M.A., Liebetanz, D., Antal, A., Lang, N., Tergau, F., Paulus, W., Modulation of cortical excitability by weak direct current stimulation-technical, safety and functional aspects. Suppl. Clin. Neurophysiol. 56 (2003), 255–276.
105. Feng, W., a Enabore, J., Kautz, S., Adams, R.J., Chhatbar, P., Dose response relationship in transcranial direct current stimulation stroke motor recovery studies. Stroke, 46(Suppl. 1), 2015 A7–A7.
106. Cuypers, K., Leenus, D.J., Van Wijmeersch, B., Thijs, H., Levin, O., Swinnen, S.P., Meesen, R.L., Anodal tDCS increases corticospinal output and projection strength in multiple sclerosis. Neurosci. Lett. 554 (2013), 151–155.
107. Clayton, E., Kinley-Cooper, S., Weber, R., Adkins, D., Brain stimulation: neuromodulation as a potential treatment for motor recovery following traumatic brain injury. Brain Res. 1640 (2016), 30–138.
108. ® gait training. Neurosci. Lett. 620 (2016), 143–147.
109. Fregni, F., Boggio, P.S., Valle, A.C., Rocha, R.R., Duarte, J., Ferreira, M.J., Wagner, T., Fecteau, S., Rigonatti, S.P., Riberto, M., Freedman, S.D., Pascual-Leone, A., A sham-controlled trial of a 5-day course of repetitive transcranial magnetic stimulation of the unaffected hemisphere in stroke patients. Stroke 37:8 (2006), 2115–2122.
110. Hsu, W.Y., Cheng, C.H., Liao, K.K., Lee, I.H., Lin, Y.Y., Effects of repetitive transcranial magnetic stimulation on motor functions in patients with stroke: a meta-analysis. Stroke 43:7 (2012), 1849–1857.
111. Le, Q., Qu, Y., Tao, Y., Zhu, S., Effects of repetitive transcranial magnetic stimulation on hand function recovery and excitability of the motor cortex after stroke: a meta-analysis. Am. J. Phys. Med. Rehabil. Assoc. Acad. Physiatr. 93:5 (2014), 422–430.
112. Centonze, D., Koch, G., Versace, V., Mori, F., Rossi, S., Brusa, L., Grossi, K., Torelli, F., Prosperetti, C., Cervellino, A., Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis. Neurology 68:13 (2007), 1045–1050.
113. Nielson, D.M., McKnight, C.A., Patel, R.N., Kalnin, A.J., Mysiw, W.J., Preliminary guidelines for safe and effective use of repetitive transcranial magnetic stimulation in moderate to severe traumatic brain injury. Arch. Phys. Med. Rehabil. 96:4 (2015), S138–S144.
114. Levy, R., Ruland, S., Weinand, M., Lowry, D., Dafer, R., Bakay, R., Cortical stimulation for the rehabilitation of patients with hemiparetic stroke: a multicenter feasibility study of safety and efficacy. J. Neurosurg. 108:4 (2008), 707–714.
115. Miyai, I., Ito, M., Hattori, N., Mihara, M., Hatakenaka, M., Yagura, H., Sobue, G., Nishizawa, M., Cerebellar ataxia rehabilitation trial in degenerative cerebellar diseases. Neurorehabil. Neural Repair 26:5 (2012), 515–522.
116. Shin, S.S., Dixon, C.E., Okonkwo, D.O., Richardson, R.M., Neurostimulation for traumatic brain injury: a review. J. Neurosurg. 121:5 (2014), 1219–1231.
117. Hornby, T.G., Zemon, D.H., Campbell, D., Robotic-assisted, body-weight-supported treadmill training in individuals following motor incomplete spinal cord injury. Phys. Ther. 85:1 (2005), 52–66.
118. Lo, A.C., Triche, E.W., Improving gait in multiple sclerosis using robot-assisted, body weight supported treadmill training. Neurorehabil. Neural Repair 22:6 (2008), 661–671.
119. Ang, K.K., Chua, K.S., Phua, K.S., Wang, C., Chin, Z.Y., Kuah, C.W., Low, W., Guan, C., A randomized controlled trial of EEG-based motor imagery brain-computer interface robotic rehabilitation for stroke. Clin. EEG Neurosci. 46:4 (2015), 310–320.
120. Borlongan, C.V., Jolkkonen, J., Detante, O., The future of stem cell therapy for stroke rehabilitation. Future Neurol. 10:4 (2015), 313–319.
121. Steinberg, G.K., Kondziolka, D., Wechsler, L.R., Lunsford, L.D., Coburn, M.L., Billigen, J.B., Kim, A.S., Johnson, J.N., Bates, D., King, B., Case, C., McGrogan, M., Yankee, E.W., Schwartz, N.E., Clinical outcomes of transplanted modified bone marrow-derived mesenchymal stem cells in stroke: a phase 1/2a study. Stroke 47 (2016), 1817–1824.
122. Chang, J., Phelan, M., Cummings, B.J., A meta-analysis of efficacy in pre-clinical human stem cell therapies for traumatic brain injury. Exp. Neurol. 273 (2015), 225–233.
123. Rice, C.M., Marks, D.I., Ben-Shlomo, Y., Evangelou, N., Morgan, P.S., Metcalfe, C., Walsh, P., Kane, N.M., Guttridge, M.G., Miflin, G., Assessment of bone marrow-derived cellular therapy in progressive multiple sclerosis (ACTiMuS): study protocol for a randomised controlled trial. Trials 16:1 (2015), 1–8.
124. Oh, S.K., Choi, K.H., Yoo, J.Y., Kim, D.Y., Kim, S.J., Jeon, S.R., A phase III clinical trial showing limited efficacy of autologous mesenchymal stem cell therapy for spinal cord injury. Neurosurgery 78:3 (2015), 436–447.
125. McHughen, S.A., Pearson-Fuhrhop, K., Ngo, V.K., Cramer, S.C., Intense training overcomes effects of the Val66Met BDNF polymorphism on short-term plasticity. Exp. Brain Res. 213:4 (2011), 415–422.
126. Enzinger, C., Ropele, S., Fazekas, F., Loitfelder, M., Gorani, F., Seifert, T., Reiter, G., Neuper, C., Pfurtscheller, G., Müller-Putz, G., Brain motor system function in a patient with complete spinal cord injury following extensive brain–computer interface training. Exp. Brain Res. 190:2 (2008), 215–223.