The future of stem cell therapy for stroke rehabilitation

Future Neurology

Volumn 10, Issue 4, 2015, Pages 313-319

  Borlongan, Cesar V ^a   Jolkkonen, Jukka ^b   Detante, Olivier ^c,d,e  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c GRENOBLE UNIVERSITY HOSPITAL   (France)

^d INSERM   (France)

^e UNIV GRENOBLE ALPES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL FUNCTION; CELL LINEAGE; CELLS BY BODY ANATOMY; CEREBROVASCULAR ACCIDENT; CLINICAL EFFECTIVENESS; DISEASE MODEL; FUNCTIONAL ASSESSMENT; HUMAN; MEDICAL ETHICS; NERVE CELL DIFFERENTIATION; NONHUMAN; PATIENT CARE; PATIENT SAFETY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REHABILITATION CARE; REVIEW; STEM CELL; STEM CELL RESEARCH; STEM CELL TRANSPLANTATION; TRANSLATIONAL RESEARCH;

EID: 84939459537     PISSN: 14796708     EISSN: 17486971     Source Type: Journal    
DOI: 10.2217/fnl.15.27     Document Type: Review

References (43)

1. Diamandis T, Borlongan CV. One, two, three steps toward cell therapy for stroke. Stroke 46(2), 588-91 (2015).
2. Savitz SI, Cramer SC, Wechsler L. Stem cells as an emerging paradigm in stroke 3: enhancing the development of clinical trials. Stroke 45(2), 634-9 (2014).
3. Langhorne P, Bernhardt J, Kwakkel G. Stroke rehabilitation. Lancet 377(9778), 1693-702 (2011).
4. Van Praag H, Kempermann G, Gage F. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nature Neuroscience 2, 266-270 (1999).
5. Mattson MP. Neuroprotective signalling and the aging brain: take away my food and let me run. Brain Res. 886(1-2), 47-53 (2000).
6. Rodriguez JJ, Noristani HN, Olabarria M et al. Voluntary running and environmental enrichment restores impaired hippocampal neurogenesis in a triple transgenic mouse model of Alzheimer's disease. Curr. Alzheimer Res. 8(7), 707-17 (2011).
7. Zigmond MJ, Cameron JL, Leak RK et al. Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency. Parkinsonism Relat. Disord. 3, S42-S45 (2009).
8. Ploughman M, Attwood Z, White N et al. Endurance exercise facilitates relearning of forelimb motor skill after focal ischemia. Eur. J. Neurosci. 25(11), 3453-60 (2007).
9. Griesbach GS, Hovda DA, Molteni R et al. Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function. Neuroscience 125(1), 129-39 (2004).
10. Yasuhara T, Hara K, Matsukawa N et al. Lack of exercise, via hindlimb suspension, impedes endogenous neurogenesis. Neuroscience 149(1), 182-91 (2007).
11. Nomura S, Kami K, Kawano F et al. Effects of hindlimb unloading on neurogenesis in the hippocampus of newly weaned rats. Neurosci. Lett. 509(2), 76-81 (2012).
12. Veena J, Shankaranarayana Rao BS, Srikumar BN. Regulation of adult neurogenesis in the hippocampus by stress, acetylcholine and dopamine. J. Nat. Sci. Biol. Med. 2(1), 26-37 (2011).
13. Han TK, Lee JK, Leem YH. Chronic exercise prevents repeated restraint stress-provoked enhancement of immobility in forced swimming test in overiectomized mice. Metab. Brain Dis. 30(3), 711-8 (2015).
14. Barha CK, Brummelte S, Lieblich Se et al. Chronic restraint stress in adolescence differentially influences hypothalamic-pituitary-adrenal axis function and adult hippocampal neurogenesis in male and female rats. Hippocampus 21(11), 1216-27 (2011).
15. Watson N, Ji X, Yasuhara T. No pain, no gain: lack of exercise obstructs neurogenesis. Cell Transplant. 24(4), 591-7 (2015).
16. Detante O, Jaillard A, Moisan A et al. Biotherapies in stroke. Rev. Neurol. (Paris). 170(12), 779-798 (2014).
17. Kucia M, Reca R, Campbell FR et al. A population of very small embryonic-like (VSEL) CXCR4(+)SSEA-1(+)Oct-4+ stem cells identified in adult bone marrow. Leukemia 20(5), 857-69 (2006)
18. Wakao S, Kitada M, Kuroda Y et al. Multilineage-differentiating stress-enduring (MUSE) cells are a primary source of induced pluripotent stem cells in human fibroblasts. PNAS 108(24), 9875-9880 (2011).
19. Wu J, Okamura D, Li M et al. An alternative pluripotent state confers interspecies chimaeric competency. Nature 521(7552), 316-21 (2015).
20. Onteniente B. The multiple aspects of stroke and stem cell therapy. Curr. Mol. Med. 13(5), 821-831 (2013).
21. Reyes S, Tajiri N, Borlongan CV. Development in intracerebral stem cell grafts. Exp. Rev. Neurother. 15(4), 381-93 (2015).
22. Borlongan CV, Hadman M, Sanberg CD et al. Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke. Stroke 35(10), 2385-9 (2004).
23. Tajiri N, Quach DM, Kaneko Y et al. Behavioral and histopathological assessment of adult ischemic rat brains after intracerebral transplantation of NSI-556RSC cell lines. PLoS One 9(3), e9408 (2014).
24. Mitkari B, Kerkelä E, Nystedt J et al. Toward a more effective intravascular cell therapy in stroke. In: Advances in the Treatment of Ischemic Stroke. Maurizio Balestrino (Ed.). 141-160 (2012).
25. Shindo A, Liang AC, Maki T et al. Subcortical ischemic vascular disease: roles of oligodendrocyte function in experimental models of subcortical white-matter injury. J. Cereb. Blood Flow Metab. (2015).
26. Seo JH, Miyamoto N, Hayakawa K et al. Oligodendrocyte precursors induce early blood-brain barrier opening after white mater injury. J. Clin. Invest. 123(2), 782-786 (2013).
27. Lipsanen A, Jolkkonen J. Experimental approaches to study functional recovery following cerebral ischemia. Cell. Mol. Life Sci. 68(18), 3007-3017 (2011).
28. Hicks A, Schallert T, Jolkkonen J. Cell-based therapies and functional outcome in experimental stroke. Cell Stem Cell 5(2), 139-140 (2009).
29. BoltzeJ, Lukomska B, Jolkkonen J. Mesenchymal stromal cells in stroke: improvement of motor recovery or functional compensation? J. Cereb. Blood Flow Metab. 34(8), 1420-1421 (2014).
30. Stroke Therapy Academic Industry Roundtable. Recommendations for standards regarding preclinical neuroprotective and restorative drugs. Stroke 30(12), 2752-2758 (1999).
31. Stem Cell Therapies as an Emerging Paradigm in Stroke Participants. Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke. Stroke J. Cereb. Circ. 40(2), 510-515 (2009).
32. Kordower JH, Freeman TB, Vingerhoets FJ et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N. Engl. J. Med. 332(17), 1118-24 (1995).
33. Peschanski M, Defer G, N'Guyen JP et al. Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon. Brain 117(pt 3), 487-99 (1994).
34. Spencer DD, Robbins RJ, Naftolin F et al. Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's disease. N. Engl. J. Med. 327(22), 1541-8 (1992).
35. Lindvall O, Backlund EO, Farde L et al. Transplantation in Parkinson's disease: two cases of adrenal medullary grafts to the putamen. Ann. Neurol. 22(4), 457-68 (1987).
36. Backlund EO, Granberg PO, Hamberger B et al. Transplantation of adrenal medullary tissue to striatum in parkinsonism. J. Neurosurgery 62(2), 169-173 (1985).
37. Watson DJ, Longhi L, Lee EB et al. Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury. J. Neuropathol. Exp. Neurol. 62(4), 368-80 (2003).
38. Nelson PT, Kondziolka D, Wechsler L et al. Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation. Am. J. Pathol. 160(4), 1201-6 (2002).
39. Mack GS. ReNeuron and StemCells get green light for neural stem cell trials. Nat Biotechnol. 29(2), 95-7 (2011).
40. Savitz SI, Misra V, Kasam M et al. Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Ann. Neurol. 70(1), 59-69 (2011).
41. Jeong H, Yim HW, Cho YS et al. Efficacy and safety of stem cell therapies for patients with stroke: a systematic review and single arm meta-analysis. Int. J. Stem Cells 7(2), 63-69 (2014).
42. Lee JS, Hong JM, Moon GJ et al. A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells 28(6), 1099-1106 (2010).
43. Kondziolka D, Steinberg GK, Wechsler L et al. Neurotransplantation for patients with subcortical motor stroke: a Phase 2 randomized trial. J. Neurosurg. 103(1), 38-45 (2005).