Intense training overcomes effects of the val 66met BDNF polymorphism on short-term plasticity

Experimental Brain Research

Volumn 213, Issue 4, 2011, Pages 415-422

  McHughen, Stephanie A ^a   Pearson Fuhrhop, Kristin ^a   Ngo, Vivian K ^a   Cramer, Steven C ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

BDNF; Plasticity; Polymorphism; Training; Transcranial magnetic stimulation

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

ADULT; ARTICLE; BRAIN CORTEX; BRAIN MAPPING; EXERCISE INTENSITY; FEMALE; FIRST DORSAL INTEROSSEUS MUSCLE; GENOTYPE; HUMAN; HUMAN EXPERIMENT; LEARNING; LONG TERM NEUROPLASTICITY; MALE; MARBLE NAVIGATION TASK; NERVE CELL PLASTICITY; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; SHORT TERM NEUROPLASTICITY; SINGLE NUCLEOTIDE POLYMORPHISM; SKELETAL MUSCLE; TRAINING; TRANSCRANIAL MAGNETIC STIMULATION;

AMINO ACID SEQUENCE; BRAIN-DERIVED NEUROTROPHIC FACTOR; FEMALE; GENETIC TESTING; HUMANS; LONGITUDINAL STUDIES; MALE; METHIONINE; MOTOR CORTEX; MOVEMENT DISORDERS; NEURONAL PLASTICITY; PHYSICAL EDUCATION AND TRAINING; POLYMORPHISM, SINGLE NUCLEOTIDE; VALINE; YOUNG ADULT;

EID: 80053913676     PISSN: 00144819     EISSN: 14321106     Source Type: Journal    
DOI: 10.1007/s00221-011-2791-z     Document Type: Article

References (35)

1. Bath KG, Lee FS (2006) Variant BDNF (Val66Met) impact on brain structure and function. Cogn Affect Behav Neurosci 6:79-85
2. Berchtold NC, Castello N, Cotman CW (2010) Exercise and timedependent benefits to learning and memory. Neuroscience 167:588-597
3. Cheeran B, Talelli P, Mori F, Koch G, Suppa A, Edwards M, Houlden H, Bhatia K, Greenwood R, Rothwell JC (2008) A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS. J Physiol 586:5717-5725
4. Chen J, Zhang C, Jiang H, Li Y, Zhang L, Robin A, Katakowski M, Lu M, Chopp M (2005) Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice. J Cereb Blood Flow Metab 25:281-290 (Pubitemid 40171209)
5. Costa RM, Cohen D, Nicolelis MA (2004) Differential corticostriatal plasticity during fast and slow motor skill learning in mice. Curr Biol 14:1124-1134 (Pubitemid 38893975)
6. Cramer SC, Sampat A, Haske-Palomino M, Nguyen S, Procaccio V, Hermanowicz N (2010) Increased prevalence of val(66)met BDNF genotype among subjects with cervical dystonia. Neurosci Lett 468:42-45
7. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257-269 (Pubitemid 36144114)
8. Floyer-Lea A, Matthews PM (2005) Distinguishable brain activation networks for short- and long-term motor skill learning. J Neurophysiol 94:512-518 (Pubitemid 40923266)
9. Fritsch B, Reis J, Martinowich K, Schambra HM, Ji Y, Cohen LG, Lu B (2010) Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning. Neuron 66:198-204
10. Gines S, Bosch M, Marco S, Gavalda N, Diaz-Hernandez M, Lucas JJ, Canals JM, Alberch J (2006) Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain. Eur J Neurosci 23:649-658
11. Gomez-Pinilla F, Ying Z, Roy RR, Molteni R, Edgerton VR (2002) Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. J Neurophysiol 88:2187-2195 (Pubitemid 35346024)
12. Hashimoto K (2007) BDNF variant linked to anxiety-related behaviors. Bioessays 29:116-119 (Pubitemid 46340246)
13. Ho BC, Milev P, O'Leary DS, Librant A, Andreasen NC, Wassink TH (2006) Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Arch Gen Psychiatry 63:731-740
14. Ji Y, Lu Y, Yang F, Shen W, Tang TT, Feng L, Duan S, Lu B (2010) Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nat Neurosci 13:302-309
15. Kang H, Schuman EM (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267:1658-1662
16. Karni A, Meyer G, Jezzard P, Adams MM, Turner R, Ungerleider LG (1995) Functional MRI evidence for adult motor cortex plasticity during motor skill learning. Nature 377:155-158
17. Kleim JA, Cooper NR, VandenBerg PM (2002) Exercise induces angiogenesis but does not alter movement representations within rat motor cortex. Brain Res 934:1-6 (Pubitemid 34286562)
18. Kleim JA, Hogg TM, VandenBerg PM, Cooper NR, Bruneau R, Remple M (2004) Cortical synaptogenesis and motor map reorganization occur during late, but not early, phase of motor skill learning. J Neurosci 24:628-633 (Pubitemid 38166488)
19. Kleim JA, Chan S, Pringle E, Schallert K, Procaccio V, Jimenez R, Cramer SC (2006) BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex. Nat Neurosci 9:735-737
20. Kleim JA, Kleim ED, Cramer SC (2007) Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulation. Nat Protoc 2:1675-1684
21. Li J, Ding YH, Rafols JA, Lai Q, McAllister JP 2nd, Ding Y (2005) Increased astrocyte proliferation in rats after running exercise. Neurosci Lett 386:160-164 (Pubitemid 41112306)
22. McHughen SA, Rodriguez PF, Kleim JA, Kleim ED, Crespo LM, Procaccio V, Cramer SC (2010) BDNF val66met polymorphisminfluences motor system function in the human brain. Cereb Cortex 20:1254-1262
23. Nagappan G, Lu B (2005) Activity-dependent modulation of the BDNF receptor TrkB: Mechanisms and implications. Trends Neurosci 28:464-471 (Pubitemid 41187795)
24. Neeper SA, Gomez-Pinilla F, Choi J, Cotman C (1995) Exercise and brain neurotrophins. Nature 373:109
25. Pascual-Leone A, Nguyet D, Cohen L, Brasil-Neto J, Cammarota A, Hallett M (1995) Modulation of muscle responses evoked by transcranial magnetic stimulation during the acquisition of new fine motor skills. J Neurophysiol 74:1037-1045
26. Pezawas L, Verchinski BA, Mattay VS, Callicott JH, Kolachana BS, Straub RE, Egan MF, Meyer-Lindenberg A, Weinberger DR (2004) The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 24:10099-10102 (Pubitemid 39492034)
27. Pezet S, Malcangio M, McMahon SB (2002) BDNF: A neuromodulator in nociceptive pathways? Brain Res Brain Res Rev 40:240-249 (Pubitemid 36183173)
28. Rossini PM, Barker AT, Berardelli A, Caramia MD, Caruso G, Cracco RQ, Dimitrijevic MR, Hallett M, Katayama Y, Lucking CH et al (1994) Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: Basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr Clin Neurophysiol 91:79-92 (Pubitemid 24246462)
29. Rybakowski JK (2008) BDNF gene: Functional Val66Met polymorphism in mood disorders and schizophrenia. Pharmacogenomics 9:1589-1593
30. Shimizu E, Hashimoto K, Iyo M (2004) Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: The possibility to explain ethnic mental traits. Am J Med Genet B Neuropsychiatr Genet 126:122-123 (Pubitemid 38420134)
31. Siironen J, Juvela S, Kanarek K, Vilkki J, Hernesniemi J, Lappalainen J (2007) The Met allele of the BDNF Val66Met polymorphism predicts poor outcome among survivors of aneurysmal subarachnoid hemorrhage. Stroke 38:2858-2860 (Pubitemid 47494031)
32. Simmons DA, Rex CS, Palmer L, Pandyarajan V, Fedulov V, Gall CM, Lynch G (2009) Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice. Proc Natl Acad Sci U S A 106:4906-4911
33. Swain RA, Harris AB, Wiener EC, Dutka MV, Morris HD, Theien BE, Konda S, Engberg K, Lauterbur PC, Greenough WT (2003) Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat. Neuroscience 117:1037-1046 (Pubitemid 36332321)
34. Wu D (2005) Neuroprotection in experimental stroke with targeted neurotrophins. Neurorx 2:120-128 (Pubitemid 40128032)
35. Zuccato C, Cattaneo E (2009) Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 5:311-322