메뉴 건너뛰기




Volumn 16, Issue 12, 2016, Pages 1541-1548

Peroxisome proliferator-activated receptors and their ligands in cancer drug-resistance: opportunity or challenge

Author keywords

Cancer; Chemotherapy; Drug resistance; P glycoprotein; PPARs; Thiazolidinedione

Indexed keywords

BEZAFIBRATE; CARBACYCLIN; CLOFIBRATE; DRUG METABOLIZING ENZYME; FENOFIBRATE; GEMFIBROZIL; ICOSAPENTAENOIC ACID; LIGAND; LINOLEIC ACID; NAFENOPIN; OLEIC ACID; PALMITIC ACID; PALMITOLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEARIC ACID; ANTINEOPLASTIC AGENT;

EID: 84995932441     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520616666160204112941     Document Type: Review
Times cited : (43)

References (102)
  • 2
    • 84863652136 scopus 로고    scopus 로고
    • Circumventing cancer drug resistance in the era of personalized medicine
    • Garraway, L.A.; Janne, P.A. Circumventing cancer drug resistance in the era of personalized medicine. Cancer Discov., 2012, 2(3), 214-226.
    • (2012) Cancer Discov. , vol.2 , Issue.3 , pp. 214-226
    • Garraway, L.A.1    Janne, P.A.2
  • 5
    • 84995959311 scopus 로고    scopus 로고
    • Principles of cytotoxic chemotherapy
    • Lind, M. Principles of cytotoxic chemotherapy. Medicine, 2004, 32(3), 20-25.
    • (2004) Medicine , vol.32 , Issue.3 , pp. 20-25
    • Lind, M.1
  • 6
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • Nahta, R.; Yu, D.; Hung, M.C.; Hortobagyi, G.N.; Esteva, F.J. Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer. Nat. Clin. Practice Oncol., 2006, 3(5), 269-280.
    • (2006) Nat. Clin. Practice Oncol. , vol.3 , Issue.5 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.C.3    Hortobagyi, G.N.4    Esteva, F.J.5
  • 7
    • 84887992978 scopus 로고    scopus 로고
    • Different strategies to overcome multidrug resistance in cancer
    • Saraswathy, M.; Gong, S. Different strategies to overcome multidrug resistance in cancer. Biotechnol. Adv., 2013, 31(8), 1397-1407.
    • (2013) Biotechnol. Adv. , vol.31 , Issue.8 , pp. 1397-1407
    • Saraswathy, M.1    Gong, S.2
  • 8
    • 13644254794 scopus 로고    scopus 로고
    • Molecular mechanisms of drug resistance
    • Longley, D.; Johnston, P. Molecular mechanisms of drug resistance. J. Pathol., 2005, 205(2), 275-292.
    • (2005) J. Pathol. , vol.205 , Issue.2 , pp. 275-292
    • Longley, D.1    Johnston, P.2
  • 9
    • 0344393732 scopus 로고    scopus 로고
    • Strategies for reversing drug resistance
    • Fojo, T.; Bates, S. Strategies for reversing drug resistance. Oncogene. 2003, 22(47), 7512-7523.
    • (2003) Oncogene , vol.22 , Issue.47 , pp. 7512-7523
    • Fojo, T.1    Bates, S.2
  • 10
    • 84905283334 scopus 로고    scopus 로고
    • Akt and p53R2, partners that dictate the progression and invasiveness of cancer
    • Yousefi, B.; Samadi, N.; Ahmadi, Y. Akt and p53R2, partners that dictate the progression and invasiveness of cancer. DNA Repair, 2014, 22, 24-29.
    • (2014) DNA Repair , vol.22 , pp. 24-29
    • Yousefi, B.1    Samadi, N.2    Ahmadi, Y.3
  • 11
    • 34247349605 scopus 로고    scopus 로고
    • Nuclear receptors and the regulation of drug_metabolizing Enzymes and drug transporters: Implications for Interindividual variability in response to drugs
    • Urquhart, B.L.; Tirona, R.G.; Kim, R.B. Nuclear receptors and the regulation of drug_metabolizing Enzymes and drug transporters: Implications for Interindividual variability in response to drugs. J. Clin. Pharmacol., 2007, 47(5), 566-578.
    • (2007) J. Clin. Pharmacol. , vol.47 , Issue.5 , pp. 566-578
    • Urquhart, B.L.1    Tirona, R.G.2    Kim, R.B.3
  • 12
    • 84899070293 scopus 로고    scopus 로고
    • Mechanisms of drug resistance in cancer chemotherapy: Coordinated role and regulation of efflux transporters and metabolizing enzymes
    • Krishna Vadlapatla, R.; Dutt Vadlapudi, A.; Pal, D.K.; Mitra, A. Mechanisms of drug resistance in cancer chemotherapy: Coordinated role and regulation of efflux transporters and metabolizing enzymes. Curr. Pharmaceut. Desig., 2013, 19(40), 7126-7140.
    • (2013) Curr. Pharmaceut. Desig. , vol.19 , Issue.40 , pp. 7126-7140
    • Krishna Vadlapatla, R.1    Dutt Vadlapudi, A.2    Pal, D.K.3    Mitra, A.4
  • 13
    • 84876817977 scopus 로고    scopus 로고
    • P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: Current status and future perspectives
    • Binkhathlan, Z.; Lavasanifar, A. P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: Current status and future perspectives. Curr. Cancer Drug Targ., 2013, 13(3), 326-346.
    • (2013) Curr. Cancer Drug Targ. , vol.13 , Issue.3 , pp. 326-346
    • Binkhathlan, Z.1    Lavasanifar, A.2
  • 14
    • 27644577664 scopus 로고    scopus 로고
    • ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal
    • Choi, C.H. ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal. Cancer Cell Int., 2005, 5(1), 30.
    • (2005) Cancer Cell Int. , vol.5 , Issue.1 , pp. 30
    • Choi, C.H.1
  • 15
    • 39749097290 scopus 로고    scopus 로고
    • Role of the MRP1/ABCC1 multidrug transporter protein in cancer
    • Munoz, M.; Henderson, M.; Haber, M.; Norris, M. Role of the MRP1/ABCC1 multidrug transporter protein in cancer. IUBMB Life, 2007, 59(12), 752.
    • (2007) IUBMB Life , vol.59 , Issue.12 , pp. 752
    • Munoz, M.1    Henderson, M.2    Haber, M.3    Norris, M.4
  • 16
    • 84949458087 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade
    • Chen, Z.; Shi, T.; Zhang, L.; Zhu, P.; Deng, M.; Huang, C.; Hu, T.; Jiang, L.; Li, J. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett., 2016, 370(1), 153-164.
    • (2016) Cancer Lett. , vol.370 , Issue.1 , pp. 153-164
    • Chen, Z.1    Shi, T.2    Zhang, L.3    Zhu, P.4    Deng, M.5    Huang, C.6    Hu, T.7    Jiang, L.8    Li, J.9
  • 17
    • 84860282454 scopus 로고    scopus 로고
    • Genetic variants in genes involved in mechanisms of chemoresistance to anticancer drugs
    • Marin, J.G.J.; Briz, O.J.; Monte, M.G.; Blazquez, A.I.R.; Macias, R. Genetic variants in genes involved in mechanisms of chemoresistance to anticancer drugs. Curr. Cancer Drug Targ., 2012, 12(4), 402-438.
    • (2012) Curr. Cancer Drug Targ. , vol.12 , Issue.4 , pp. 402-438
    • Marin, J.G.J.1    Briz, O.J.2    Monte, M.G.3    Blazquez, A.I.R.4    Macias, R.5
  • 18
    • 84949314485 scopus 로고    scopus 로고
    • Genetic and/or nongenetic causes for inter-individual and inter-cellular variability in transporter protein expression: Implications for understanding drug efficacy and toxicity
    • Koo, S.H.; Lo, Y.L.; Yee, J.Y.; Lee, E.J.D. Genetic and/or nongenetic causes for inter-individual and inter-cellular variability in transporter protein expression: implications for understanding drug efficacy and toxicity. Exp. Opin. Drug Metabol. Toxicol., 2015, 1-17.
    • (2015) Exp. Opin. Drug Metabol. Toxicol. , pp. 1-17
    • Koo, S.H.1    Lo, Y.L.2    Yee, J.Y.3    Lee, E.J.D.4
  • 21
    • 84896696388 scopus 로고    scopus 로고
    • The roles of p53R2 in cancer progression based on the new function of mutant p53 and cytoplasmic p21
    • Yousefi, B.; Rahmati, M.; Ahmadi, Y. The roles of p53R2 in cancer progression based on the new function of mutant p53 and cytoplasmic p21. Life Sci., 2014, 99(1), 14-17.
    • (2014) Life Sci. , vol.99 , Issue.1 , pp. 14-17
    • Yousefi, B.1    Rahmati, M.2    Ahmadi, Y.3
  • 23
    • 84856019858 scopus 로고    scopus 로고
    • The DNA damage response and cancer therapy
    • Lord, C.J.; Ashworth, A. The DNA damage response and cancer therapy. Nature, 2012, 481(7381), 287-294.
    • (2012) Nature , vol.481 , Issue.7381 , pp. 287-294
    • Lord, C.J.1    Ashworth, A.2
  • 24
    • 84878115770 scopus 로고    scopus 로고
    • Estrogen receptor-α36 is involved in development of acquired tamoxifen resistance via regulating the growth status switch in breast cancer cells
    • Li, G.; Zhang, J.; Jin, K.; He, K.; Zheng, Y.; Xu, X.; Wang, H.; Li, Z.; Yu, X. Estrogen receptor-α36 is involved in development of acquired tamoxifen resistance via regulating the growth status switch in breast cancer cells. Molecular Oncol., 2013, 7(3), 611-624.
    • (2013) Molecular Oncol. , vol.7 , Issue.3 , pp. 611-624
    • Li, G.1    Zhang, J.2    Jin, K.3    He, K.4    Zheng, Y.5    Xu, X.6    Wang, H.7    Li, Z.8    Yu, X.9
  • 27
    • 84856740319 scopus 로고    scopus 로고
    • Intratumor heterogeneity and chemotherapy-induced changes in EGFR status in non-small cell lung cancer
    • Jakobsen, J.N.; Sorensen J.B. Intratumor heterogeneity and chemotherapy-induced changes in EGFR status in non-small cell lung cancer. Cancer Chemo. Pharmacol., 2012, 69(2), 289-299.
    • (2012) Cancer Chemo. Pharmacol. , vol.69 , Issue.2 , pp. 289-299
    • Jakobsen, J.N.1    Sorensen, J.B.2
  • 28
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism 1
    • Desvergne, B.; Wahli, W. Peroxisome proliferator-activated receptors: Nuclear control of metabolism 1. Endocrine Rev., 1999, 20(5), 649-688.
    • (1999) Endocrine Rev. , vol.20 , Issue.5 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 29
    • 84857641358 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention
    • Peters, J.M.; Shah, Y.M.; Gonzalez, F.J. The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention. Nat. Rev. Cancer, 2012, 12(3), 181-195.
    • (2012) Nat. Rev. Cancer , vol.12 , Issue.3 , pp. 181-195
    • Peters, J.M.1    Shah, Y.M.2    Gonzalez, F.J.3
  • 30
    • 0842263981 scopus 로고    scopus 로고
    • The biology of peroxisome proliferator-activated receptors relationship with lipid metabolism and insulin sensitivity
    • Ferre, P. The biology of peroxisome proliferator-activated receptors relationship with lipid metabolism and insulin sensitivity. Diabetes, 2004, 53(suppl 1), S43-S50.
    • (2004) Diabetes , vol.53 , pp. S43-S50
    • Ferre, P.1
  • 32
    • 84903641323 scopus 로고    scopus 로고
    • Physiological functions of peroxisome proliferator-activated receptor β
    • Neels, J.G.; Grimaldi, P.A. Physiological functions of peroxisome proliferator-activated receptor β. Physiol. Rev., 2014, 94(3), 795-858.
    • (2014) Physiol. Rev. , vol.94 , Issue.3 , pp. 795-858
    • Neels, J.G.1    Grimaldi, P.A.2
  • 33
    • 32644460092 scopus 로고    scopus 로고
    • From molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
    • Feige, J.N.; Gelman, L.; Michalik, L.; Desvergne, B.; Wahli, W. From molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog. lipid Res., 2006, 45(2), 120-159.
    • (2006) Prog. Lipid Res. , vol.45 , Issue.2 , pp. 120-159
    • Feige, J.N.1    Gelman, L.2    Michalik, L.3    Desvergne, B.4    Wahli, W.5
  • 35
    • 84893794489 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and their ligands: Nutritional and clinical implications–a review
    • Grygiel-Górniak, B. Peroxisome proliferator-activated receptors and their ligands: Nutritional and clinical implications–a review. Nutr. J., 2014, 13(1), 1-17.
    • (2014) Nutr. J. , vol.13 , Issue.1 , pp. 1-17
    • Grygiel-Górniak, B.1
  • 36
    • 58149466606 scopus 로고    scopus 로고
    • PPARs mediate lipid signaling in inflammation and cancer
    • Michalik, L.; Wahli, W. PPARs mediate lipid signaling in inflammation and cancer. PPAR Res., 2008, 2008.
    • (2008) PPAR Res , pp. 2008
    • Michalik, L.1    Wahli, W.2
  • 37
    • 67449108376 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha (PPARα): At the crossroads of obesity, diabetes and cardiovascular disease
    • Fruchart, J.C. Peroxisome proliferator-activated receptor-alpha (PPARα): At the crossroads of obesity, diabetes and cardiovascular disease. Atherosclerosis, 2009, 205(1), 1-8.
    • (2009) Atherosclerosis , vol.205 , Issue.1 , pp. 1-8
    • Fruchart, J.C.1
  • 39
    • 33645828659 scopus 로고    scopus 로고
    • Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation
    • Reddy, J.K.; Rao, M.S. Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am. J. Physiol. Gastrointestinal a Liver Physiol., 2006, 290(5), G852-G858.
    • (2006) Am. J. Physiol. Gastrointestinal a Liver Physiol. , vol.290 , Issue.5 , pp. G852-G858
    • Reddy, J.K.1    Rao, M.S.2
  • 40
    • 33845326985 scopus 로고    scopus 로고
    • Peroxisomal β-oxidation-a metabolic pathway with multiple functions
    • Poirier, Y.; Antonenkov, V.D.; Glumoff, T.; Hiltunen J.K. Peroxisomal β-oxidation-a metabolic pathway with multiple functions. BBA. Mol. Cell Res., 2006, 1763(12), 1413-1426.
    • (2006) BBA. Mol. Cell Res. , vol.1763 , Issue.12 , pp. 1413-1426
    • Poirier, Y.1    Antonenkov, V.D.2    Glumoff, T.3    Hiltunen, J.K.4
  • 41
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
    • Wang, Y.X.; Lee, C.H.; Tiep, S.; Ruth, T.Y.; Ham, J.; Kang, H.; Evans, R.M. Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell, 2003, 113(2), 159-170.
    • (2003) Cell , vol.113 , Issue.2 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3    Ruth, T.Y.4    Ham, J.5    Kang, H.6    Evans, R.M.7
  • 42
    • 77449117735 scopus 로고    scopus 로고
    • Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
    • Huang, W.; Metlakunta, A.; Dedousis, N.; Zhang, P.; Sipula, I.; Dube, J.J.; Scott, D.K.; O'Doherty, R.M. Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes, 2010, 59(2), 347-357.
    • (2010) Diabetes , vol.59 , Issue.2 , pp. 347-357
    • Huang, W.1    Metlakunta, A.2    Dedousis, N.3    Zhang, P.4    Sipula, I.5    Dube, J.J.6    Scott, D.K.7    O'doherty, R.M.8
  • 44
  • 45
    • 79953061638 scopus 로고    scopus 로고
    • A new, highly selective murine peroxisome proliferator_activated receptor δ agonist increases responsiveness to thermogenic stimuli and glucose uptake in skeletal muscle in obese mice
    • Ngala, R.; Stocker, C.; Roy, A.; Hislop, D.; Wargent, E.; Bell, R.; Hassall, D.; Harling, J.; Billin, A.; Willson, T. A new, highly selective murine peroxisome proliferator_activated receptor δ agonist increases responsiveness to thermogenic stimuli and glucose uptake in skeletal muscle in obese mice. Diabetes Obes. Metab., 2011, 13(5), 455-464.
    • (2011) Diabetes Obes. Metab. , vol.13 , Issue.5 , pp. 455-464
    • Ngala, R.1    Stocker, C.2    Roy, A.3    Hislop, D.4    Wargent, E.5    Bell, R.6    Hassall, D.7    Harling, J.8    Billin, A.9    Willson, T.10
  • 47
    • 51749114921 scopus 로고    scopus 로고
    • Decrease of peroxisome proliferator-activated receptor delta expression in cardiomyopathy of streptozotocin-induced diabetic rats
    • Yu, B.C.; Chang, C.K.; Ou, H.Y.; Cheng, K.C.; Cheng, J.T. Decrease of peroxisome proliferator-activated receptor delta expression in cardiomyopathy of streptozotocin-induced diabetic rats. Cardiovascular Res., 2008
    • (2008) Cardiovascular Res
    • Yu, B.C.1    Chang, C.K.2    Ou, H.Y.3    Cheng, K.C.4    Cheng, J.T.5
  • 48
    • 84876007745 scopus 로고    scopus 로고
    • Knockdown of PPAR δ gene promotes the growth of colon cancer and reduces the sensitivity to bevacizumab in nude mice model
    • Yang, L.; Zhou, J.; Ma, Q.; Wang, C.; Chen, K.; Meng, W.; Yu, Y.; Zhou, Z.; Sun, X. Knockdown of PPAR δ gene promotes the growth of colon cancer and reduces the sensitivity to bevacizumab in nude mice model. PloSone, 2013, 8, e60715.
    • (2013) Plosone , vol.8
    • Yang, L.1    Zhou, J.2    Ma, Q.3    Wang, C.4    Chen, K.5    Meng, W.6    Yu, Y.7    Zhou, Z.8    Sun, X.9
  • 49
    • 84961713453 scopus 로고    scopus 로고
    • PPAR gamma at the crossroads of health and disease: A masterchef in metabolic homeostasis
    • 2161-1017.1000126
    • El Akoum, S. PPAR gamma at the crossroads of health and disease: A masterchef in metabolic homeostasis. Endocrinol. Metab. Synd., 2014, 3(126), 2161-1017.1000126.
    • (2014) Endocrinol. Metab. Synd , vol.3 , Issue.126
    • El Akoum, S.1
  • 50
    • 13744249406 scopus 로고    scopus 로고
    • PPAR 2 γ -mediated insulin sensitization: The importance of fat versus muscle
    • Kintscher, U.; Law, R.E. PPAR 2 γ -mediated insulin sensitization: the importance of fat versus muscle. Am. J. Physiol. Endocrinol. Metab., 2005, 288(2), E287-E291.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.288 , Issue.2 , pp. E287-E291
    • Kintscher, U.1    Law, R.E.2
  • 51
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of PPARs
    • Berger, J.; Moller, D.E. The mechanisms of action of PPARs. Annu. Rev. Med., 2002, 53(1), 409-435.
    • (2002) Annu. Rev. Med. , vol.53 , Issue.1 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 52
    • 1942471942 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor-γ (PPAR-γ) ligands and angiogenesis
    • Margeli, A.; Kouraklis, G.; Theocharis, S. Peroxisome proliferator activated receptor-γ (PPAR-γ) ligands and angiogenesis. Angiogenesis, 2003, 6(3), 165-169.
    • (2003) Angiogenesis , vol.6 , Issue.3 , pp. 165-169
    • Margeli, A.1    Kouraklis, G.2    Theocharis, S.3
  • 53
    • 25144475465 scopus 로고    scopus 로고
    • PPARγ as a therapeutic target for tumor angiogenesis and metastasis
    • Panigraphy, D.; Huang, S.; Kieran, M.W.; Kaipainen, A. PPARγ as a therapeutic target for tumor angiogenesis and metastasis. Cancer Biol. Ther., 2005, 4(7), 687-693.
    • (2005) Cancer Biol. Ther. , vol.4 , Issue.7 , pp. 687-693
    • Panigraphy, D.1    Huang, S.2    Kieran, M.W.3    Kaipainen, A.4
  • 54
    • 56749130032 scopus 로고    scopus 로고
    • Structure of the intact PPARγ-RXRα nuclear receptor complex on DNA (J)
    • Chandrav, H. Structure of the intact PPARγ-RXRα nuclear receptor complex on DNA (J). Nature, 2008, 456(7220), 350.
    • (2008) Nature , vol.456 , Issue.7220 , pp. 350
    • Chandrav, H.1
  • 55
    • 34547909260 scopus 로고    scopus 로고
    • HDAC3: Taking the SMRT-N-CoRrect road to repression
    • Karagianni, P.; Wong, J. HDAC3: Taking the SMRT-N-CoRrect road to repression. Oncogene, 2007, 26(37), 5439-5449.
    • (2007) Oncogene , vol.26 , Issue.37 , pp. 5439-5449
    • Karagianni, P.1    Wong, J.2
  • 56
    • 0030953186 scopus 로고    scopus 로고
    • Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
    • Nagy, L.; Kao, H.Y.; Chakravarti, D.; Lin, R.J.; Hassig, C.A.; Ayer, D.E.; Schreiber, S.L.; Evans, R.M. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell, 1997, 89(3), 373-380.
    • (1997) Cell , vol.89 , Issue.3 , pp. 373-380
    • Nagy, L.1    Kao, H.Y.2    Chakravarti, D.3    Lin, R.J.4    Hassig, C.A.5    Ayer, D.E.6    Schreiber, S.L.7    Evans, R.M.8
  • 57
    • 0032567204 scopus 로고    scopus 로고
    • Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor α and liver-X-receptor α
    • Miyata, K.S.; McCaw, S.E.; Meertens, L.M.; Patel, H.V.; Rachubinski, R.A.; Capone, J.P. Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor α and liver-X-receptor α. Mol. Cell Endocrinol., 1998, 146(1), 69-76.
    • (1998) Mol. Cell Endocrinol. , vol.146 , Issue.1 , pp. 69-76
    • Miyata, K.S.1    McCaw, S.E.2    Meertens, L.M.3    Patel, H.V.4    Rachubinski, R.A.5    Capone, J.P.6
  • 58
    • 34347261400 scopus 로고    scopus 로고
    • Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogenrelated receptor α
    • Debevec, D.; Christian, M.; Morganstein, D.; Seth, A.; Herzog, B.; Parker, M.; White, R. Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogenrelated receptor α. Mol. Endocrinol., 2007, 21(7), 1581-1592.
    • (2007) Mol. Endocrinol. , vol.21 , Issue.7 , pp. 1581-1592
    • Debevec, D.1    Christian, M.2    Morganstein, D.3    Seth, A.4    Herzog, B.5    Parker, M.6    White, R.7
  • 59
    • 84879552015 scopus 로고    scopus 로고
    • Structural and functional analysis of the human nuclear xenobiotic receptor pxr in complex with RXRα
    • Wallace, B.D.; Betts, L.; Talmage, G.; Pollet, R.M.; Holman, N.S.; Redinbo, M.R. Structural and functional analysis of the human nuclear xenobiotic receptor pxr in complex with RXRα. J. Mol. Biol., 2013, 425(14), 2561-2577.
    • (2013) J. Mol. Biol. , vol.425 , Issue.14 , pp. 2561-2577
    • Wallace, B.D.1    Betts, L.2    Talmage, G.3    Pollet, R.M.4    Holman, N.S.5    Redinbo, M.R.6
  • 60
    • 14544280757 scopus 로고    scopus 로고
    • Transcriptional regulation and the role of diverse coactivators in animal cells
    • Roeder, R.G. Transcriptional regulation and the role of diverse coactivators in animal cells. FEBS Lett., 2005, 579(4), 909-915.
    • (2005) FEBS Lett. , vol.579 , Issue.4 , pp. 909-915
    • Roeder, R.G.1
  • 61
    • 33750908077 scopus 로고    scopus 로고
    • Nuclear receptor transcriptional coactivators in development and metabolism
    • Reddy, J. K.; Guo D.; Jia Y.; Yu S.; Rao M. S., Nuclear receptor transcriptional coactivators in development and metabolism. Adv. Develop. Biol., 2006, 16, 389-420.
    • (2006) Adv. Develop. Biol. , vol.16 , pp. 389-420
    • Reddy, J.K.1    Guo, D.2    Jia, Y.3    Yu, S.4    Rao, M.S.5
  • 62
    • 84869025959 scopus 로고    scopus 로고
    • Gemfibrozil and fenofibrate, Food and drug administration-approved lipidlowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α implications for late infantile batten disease therapy
    • Ghosh, A.; Corbett, G.T.; Gonzalez, F.J.; Pahan, K. Gemfibrozil and fenofibrate, Food and drug administration-approved lipidlowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α implications for late infantile batten disease therapy. J. Biol. Chem., 2012, 287(46), 38922-38935.
    • (2012) J. Biol. Chem. , vol.287 , Issue.46 , pp. 38922-38935
    • Ghosh, A.1    Corbett, G.T.2    Gonzalez, F.J.3    Pahan, K.4
  • 63
    • 84864290671 scopus 로고    scopus 로고
    • Lipid-lowering agents in nonalcoholic fatty liver disease and steatohepatitis: Human studies
    • Nseir, W.; Mograbi, J.; Ghali, M. Lipid-lowering agents in nonalcoholic fatty liver disease and steatohepatitis: Human studies. Dig. Dis. Sci., 2012, 57(7), 1773-1781.
    • (2012) Dig. Dis. Sci. , vol.57 , Issue.7 , pp. 1773-1781
    • Nseir, W.1    Mograbi, J.2    Ghali, M.3
  • 66
    • 84859113048 scopus 로고    scopus 로고
    • Genetic heterogeneity and cancer drug resistance
    • Turner, N.C.; Reis-Filho, J.S. Genetic heterogeneity and cancer drug resistance. Lancet Oncol., 2012, 13(4), e178-e185.
    • (2012) Lancet Oncol. , vol.13 , Issue.4 , pp. e178-e185
    • Turner, N.C.1    Reis-Filho, J.S.2
  • 67
    • 84875722622 scopus 로고    scopus 로고
    • Molecular aspects of cancer cell resistance to chemotherapy
    • Rebucci, M.; Michiels, C. Molecular aspects of cancer cell resistance to chemotherapy. Biochem. Pharmacol., 2013, 85(9), 1219-1226.
    • (2013) Biochem. Pharmacol. , vol.85 , Issue.9 , pp. 1219-1226
    • Rebucci, M.1    Michiels, C.2
  • 68
    • 0037184821 scopus 로고    scopus 로고
    • Regulation of P450 4A expression by peroxisome proliferator activated receptors
    • Johnson, E.F.; Hsu, M.H.; Savas, U.; Griffin, K.J. Regulation of P450 4A expression by peroxisome proliferator activated receptors. Toxicology, 2002, 181, 203-206.
    • (2002) Toxicology , vol.181 , pp. 203-206
    • Johnson, E.F.1    Hsu, M.H.2    Savas, U.3    Griffin, K.J.4
  • 70
    • 84872335543 scopus 로고    scopus 로고
    • An overview of transcriptional regulation in response to toxicological insult
    • Jennings, P.; Limonciel, A.; Felice, L.; Leonard, M.O. An overview of transcriptional regulation in response to toxicological insult. Arch. Toxicol., 2013, 87(1), 49-72.
    • (2013) Arch. Toxicol. , vol.87 , Issue.1 , pp. 49-72
    • Jennings, P.1    Limonciel, A.2    Felice, L.3    Leonard, M.O.4
  • 71
    • 63849258680 scopus 로고    scopus 로고
    • Induction of mouse UDPglucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor α, and nuclear factor erythroid 2-related factor 2
    • Buckley, D.B.; Klaassen, C.D. Induction of mouse UDPglucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor α, and nuclear factor erythroid 2-related factor 2. Drug Metab. Dispos., 2009, 37(4), 847-856.
    • (2009) Drug Metab. Dispos. , vol.37 , Issue.4 , pp. 847-856
    • Buckley, D.B.1    Klaassen, C.D.2
  • 73
    • 0142074253 scopus 로고    scopus 로고
    • Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases
    • Turgeon, D.; Chouinard, S.; Belanger, P.; Picard, S.; Labbe, J.F.; Borgeat, P.; Belanger, A. Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases. J. Lipid Res., 2003, 44(6), 1182-1191.
    • (2003) J. Lipid Res. , vol.44 , Issue.6 , pp. 1182-1191
    • Turgeon, D.1    Chouinard, S.2    Belanger, P.3    Picard, S.4    Labbe, J.F.5    Borgeat, P.6    Belanger, A.7
  • 74
    • 15744395646 scopus 로고    scopus 로고
    • Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferatoractivated receptor α transcription factor
    • Fang, H.L.; Strom, S.C.; Cai, H.; Falany, C.N.; Kocarek, T.A.; Runge-Morris, M. Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferatoractivated receptor α transcription factor. Mol. Pharmacol., 2005, 67(4), 1257-1267.
    • (2005) Mol. Pharmacol. , vol.67 , Issue.4 , pp. 1257-1267
    • Fang, H.L.1    Strom, S.C.2    Cai, H.3    Falany, C.N.4    Kocarek, T.A.5    Runge-Morris, M.6
  • 75
    • 74549116096 scopus 로고    scopus 로고
    • Use of transgenic mice in UDP-glucuronosyltransferase (UGT) studies
    • Ou, Z.; Huang, M.; Zhao, L.; Xie, W. Use of transgenic mice in UDP-glucuronosyltransferase (UGT) studies. Drug Metab. Rev., 2010, 42(1), 123-131.
    • (2010) Drug Metab. Rev. , vol.42 , Issue.1 , pp. 123-131
    • Ou, Z.1    Huang, M.2    Zhao, L.3    Xie, W.4
  • 76
    • 0042858402 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme
    • Barbier, O.; Duran-Sandoval, D.; Pineda-Torra, I.; Kosykh, V.; Fruchart, J.C.; Staels, B. Peroxisome proliferator-activated receptor α induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme. J. Biol. Chem., 2003, 278(35), 32852-32860.
    • (2003) J. Biol. Chem. , vol.278 , Issue.35 , pp. 32852-32860
    • Barbier, O.1    Duran-Sandoval, D.2    Pineda-Torra, I.3    Kosykh, V.4    Fruchart, J.C.5    Staels, B.6
  • 77
    • 84862813487 scopus 로고    scopus 로고
    • Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters
    • Chen, Y.; Tang, Y.; Guo, C.; Wang, J.; Boral, D.; Nie, D. Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters. Biochem. Pharmacol., 2012, 83(8), 1112-1126.
    • (2012) Biochem. Pharmacol. , vol.83 , Issue.8 , pp. 1112-1126
    • Chen, Y.1    Tang, Y.2    Guo, C.3    Wang, J.4    Boral, D.5    Nie, D.6
  • 79
    • 4444344438 scopus 로고    scopus 로고
    • Genomic and non-genomic interactions of PPARα with xenobiotic-metabolizing enzymes
    • Barbier, O.; Fontaine, C.; Fruchart, J.C.; Staels, B. Genomic and non-genomic interactions of PPARα with xenobiotic-metabolizing enzymes. Trends Endocrinol. Metab., 2004, 15(7), 324-330.
    • (2004) Trends Endocrinol. Metab. , vol.15 , Issue.7 , pp. 324-330
    • Barbier, O.1    Fontaine, C.2    Fruchart, J.C.3    Staels, B.4
  • 80
    • 0141960451 scopus 로고    scopus 로고
    • Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling
    • She, Q.B.; Solit, D.; Basso, A.; Moasser, M.M. Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling. Clin. Cancer Res., 2003, 9(12), 4340-4346.
    • (2003) Clin. Cancer Res. , vol.9 , Issue.12 , pp. 4340-4346
    • She, Q.B.1    Solit, D.2    Basso, A.3    Moasser, M.M.4
  • 81
    • 84860217431 scopus 로고    scopus 로고
    • The functions and regulation of the PTEN tumour suppressor
    • Song, M.S.; Salmena, L.; Pandolfi, P.P. The functions and regulation of the PTEN tumour suppressor. Nat. Rev. Mol. Cell Biol., 2012, 13(5), 283-296.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , Issue.5 , pp. 283-296
    • Song, M.S.1    Salmena, L.2    Pandolfi, P.P.3
  • 82
    • 84894593093 scopus 로고    scopus 로고
    • PTEN overexpression improves cisplatin-resistance of human ovarian cancer cells through upregulating KRT10 expression
    • Wu, H.; Wang, K.; Liu, W.; Hao, Q. PTEN overexpression improves cisplatin-resistance of human ovarian cancer cells through upregulating KRT10 expression. Biochem. Biophys. Res. Commun., 2014, 444(2), 141-146.
    • (2014) Biochem. Biophys. Res. Commun. , vol.444 , Issue.2 , pp. 141-146
    • Wu, H.1    Wang, K.2    Liu, W.3    Hao, Q.4
  • 83
    • 84940562156 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN
    • Li, Y.; Zhang, D.W.; Lin, D.Q.; Cao, L.Q. Peroxisome proliferator-activated receptor-γ inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN. Mol. Med. Rep., 2015, 12(4), 6255-6260.
    • (2015) Mol. Med. Rep , vol.12 , Issue.4 , pp. 6255-6260
    • Li, Y.1    Zhang, D.W.2    Lin, D.Q.3    Cao, L.Q.4
  • 84
    • 84885077970 scopus 로고    scopus 로고
    • Troglitazone upregulates PTEN expression and induces the apoptosis of pulmonary artery smooth muscle cells under hypoxic conditions
    • Pi, W.F.; Guo, X.J.; Su, L.P.; Xu, W.G. Troglitazone upregulates PTEN expression and induces the apoptosis of pulmonary artery smooth muscle cells under hypoxic conditions. Int. J. Mol. Med., 2013, 32(5), 1101-1109.
    • (2013) Int. J. Mol. Med , vol.32 , Issue.5 , pp. 1101-1109
    • Pi, W.F.1    Guo, X.J.2    Su, L.P.3    Xu, W.G.4
  • 87
    • 84907028231 scopus 로고    scopus 로고
    • Proteomic-based analysis for identification of proteins involved in 5-fluorouracil resistance in hepatocellular carcinoma
    • Tan, Y.; Qin, S.; Hou, X.; Qian, X.; Xia, J.; Li, Y.; Wang, R.; Chen, C.; Yang, Q.; Miele, L. Proteomic-based analysis for identification of proteins involved in 5-fluorouracil resistance in hepatocellular carcinoma. Curr. Pharmaceut. Desig., 2014, 20(1), 81-87.
    • (2014) Curr. Pharmaceut. Desig. , vol.20 , Issue.1 , pp. 81-87
    • Tan, Y.1    Qin, S.2    Hou, X.3    Qian, X.4    Xia, J.5    Li, Y.6    Wang, R.7    Chen, C.8    Yang, Q.9    Miele, L.10
  • 88
    • 70349139683 scopus 로고    scopus 로고
    • Rosiglitazone sensitizes hepatocellular carcinoma cell lines to 5-fluorouracil antitumor activity through activation of the PPARγ signaling pathway
    • Cao, L.Q.; Wang, X.l.; Wang, Q.; Xue, P.; Jiao, X.Y.; Peng, H.P.; Lu, H.W.; Zheng, Q.; Chen, X.l.; Huang, X.H. Rosiglitazone sensitizes hepatocellular carcinoma cell lines to 5-fluorouracil antitumor activity through activation of the PPARγ signaling pathway. Acta Pharmacol. Sinica, 2009, 30(9), 1316-1322.
    • (2009) Acta Pharmacol. Sinica , vol.30 , Issue.9 , pp. 1316-1322
    • Cao, L.Q.1    Wang, X.L.2    Wang, Q.3    Xue, P.4    Jiao, X.Y.5    Peng, H.P.6    Lu, H.W.7    Zheng, Q.8    Chen, X.L.9    Huang, X.H.10
  • 89
    • 84873660557 scopus 로고    scopus 로고
    • A novel mechanism of PPAR gamma induction via EGFR signalling constitutes rational for combination therapy in bladder cancer
    • Mansure, J.J.; Nassim, R.; Chevalier, S.; Szymanski, K.; Rocha, J.; Aldousari, S.; Kassouf, W. A novel mechanism of PPAR gamma induction via EGFR signalling constitutes rational for combination therapy in bladder cancer. PloSone 2013, 8(2), e55997.
    • (2013) Plosone , vol.8 , Issue.2
    • Mansure, J.J.1    Nassim, R.2    Chevalier, S.3    Szymanski, K.4    Rocha, J.5    Aldousari, S.6    Kassouf, W.7
  • 91
    • 84885590951 scopus 로고    scopus 로고
    • Targeting the ABCG2_overexpressing multidrug resistant (MDR) cancer cells by PPARγ agonists
    • To, K.K.; Tomlinson, B. Targeting the ABCG2_overexpressing multidrug resistant (MDR) cancer cells by PPARγ agonists. Bri. J. Pharmacol., 2013, 170(5), 1137-1151.
    • (2013) Bri. J. Pharmacol. , vol.170 , Issue.5 , pp. 1137-1151
    • To, K.K.1    Tomlinson, B.2
  • 93
    • 23144454291 scopus 로고    scopus 로고
    • Troglitazone overcomes doxorubicin-resistance in resistant K562 leukemia cells
    • Harkness, T.A. Troglitazone overcomes doxorubicin-resistance in resistant K562 leukemia cells. Leukemia Lymphoma, 2005, 46(8), 1199-1206.
    • (2005) Leukemia Lymphoma , vol.46 , Issue.8 , pp. 1199-1206
    • Harkness, T.A.1
  • 94
    • 74849116490 scopus 로고    scopus 로고
    • Troglitazone reverses the multiple drug resistance phenotype in cancer cells
    • Davies, G.F.; Juurlink, B.H.; Harkness, T.A. Troglitazone reverses the multiple drug resistance phenotype in cancer cells. Drug Desig. Develop. Ther., 2009, 3, 79.
    • (2009) Drug Desig. Develop. Ther. , vol.3 , pp. 79
    • Davies, G.F.1    Juurlink, B.H.2    Harkness, T.A.3
  • 97
    • 39649120375 scopus 로고    scopus 로고
    • Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARγ cross talk with NF-κB and C/EBPβ
    • Wang, L.H.; Yang, X.Y.; Zhang, X.; Farrar, W.L. Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARγ cross talk with NF-κB and C/EBPβ. Blood, 2007, 110(13), 4373-4384.
    • (2007) Blood , vol.110 , Issue.13 , pp. 4373-4384
    • Wang, L.H.1    Yang, X.Y.2    Zhang, X.3    Farrar, W.L.4
  • 98
    • 0035045084 scopus 로고    scopus 로고
    • Suppression of nuclear factor-κB and stimulation of inhibitor κB by troglitazone: Evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese
    • Ghanim, H.; Garg, R.; Aljada, A.; Mohanty, P.; Kumbkarni, Y.; Assian, E.; Hamouda, W.; Dandona, P. Suppression of nuclear factor-κB and stimulation of inhibitor κB by troglitazone: Evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese. J. Clin. Endocrinol. Metab., 2001, 86(3), 1306-1312.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , Issue.3 , pp. 1306-1312
    • Ghanim, H.1    Garg, R.2    Aljada, A.3    Mohanty, P.4    Kumbkarni, Y.5    Assian, E.6    Hamouda, W.7    Dandona, P.8
  • 99
    • 84864409678 scopus 로고    scopus 로고
    • Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells
    • Zhan, L.; Zhang, H.; Zhang, Q.; Woods, C.G.; Chen, Y.; Xue, P.; Dong, J.; Tokar, E.J.; Xu, Y.; Hou, Y. Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic. Biol. Med., 2012, 53(4), 758-768.
    • (2012) Free Radic. Biol. Med. , vol.53 , Issue.4 , pp. 758-768
    • Zhan, L.1    Zhang, H.2    Zhang, Q.3    Woods, C.G.4    Chen, Y.5    Xue, P.6    Dong, J.7    Tokar, E.J.8    Xu, Y.9    Hou, Y.10
  • 101
    • 42549124085 scopus 로고    scopus 로고
    • Rosiglitazone induces caveolin-1 by PPARγ-dependent and PPREindependent mechanisms: The role of EGF receptor signaling and its effect on cancer cell drug resistance
    • Tencer, L.; Burgermeister, E.; Ebert, M.P.; Liscovitch, M. Rosiglitazone induces caveolin-1 by PPARγ-dependent and PPREindependent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance. Anticancer Res., 2008, 28(2A), 895-906.
    • (2008) Anticancer Res. , vol.28 , Issue.2A , pp. 895-906
    • Tencer, L.1    Burgermeister, E.2    Ebert, M.P.3    Liscovitch, M.4
  • 102
    • 2942593991 scopus 로고    scopus 로고
    • Huang, P. ROS stress in cancer cells and therapeutic implications
    • Pelicano, H.; Carney, D.; Huang, P. ROS stress in cancer cells and therapeutic implications. Drug Resist. Updates, 2004, 7(2), 97-110.
    • (2004) Drug Resist. Updates , vol.7 , Issue.2 , pp. 97-110
    • Pelicano, H.1    Carney, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.