PPARγ agonist-induced alterations in δ6-desaturase and stearoyl-CoA desaturase 1: Role of MEK/ERK1/2 pathway

World Journal of Hepatology

Volumn 5, Issue 4, 2013, Pages 220-225

  Saliani, Negar ^a   Darabi, Masoud ^a,b   Yousefi, Bahman ^b   Baradaran, Behzad ^b   Khaniani, Mahmoud Shekari ^b   Darabi, Maryam ^b   Shaaker, Maghsod ^b   Mehdizadeh, Amir ^b   Naji, Tahereh ^c   Hashemi, Mehrdad ^d  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

^d ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

6 desaturase; Hepg2 cells; Pd98059; Pioglitazone; Stearoyl coa desaturase

Indexed keywords

EID: 84879180816     PISSN: None     EISSN: 19485182     Source Type: Journal    
DOI: 10.4254/wjh.v5.i4.220     Document Type: Article

References (36)

1. Jump DB. Fatty acid regulation of hepatic lipid metabolism. Curr Opin Clin Nutr Metab Care 2011; 14: 115-120 [PMID: 21178610 DOI: 10.1097/MCO.0b013e328342991c]
2. Liu X, Strable MS, Ntambi JM. Stearoyl CoA desaturase 1: role in cellular inflammation and stress. Adv Nutr 2011; 2: 15-22 [PMID: 22211186 DOI: 10.3945/an.110.000125]
3. Fèvre C, Bellenger S, Pierre AS, Minville M, Bellenger J, Gresti J, Rialland M, Narce M, Tessier C. The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats. Biochim Biophys Acta 2011; 1811: 409-417 [PMID: 21172452 DOI: 10.1016/j.bbalip.2010.12.004]
4. Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One 2011; 6: e24777 [PMID: 22046234 DOI: 10.1371/journal.pone.0024777]
5. Gutiérrez-Juárez R, Pocai A, Mulas C, Ono H, Bhanot S, Monia BP, Rossetti L. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J Clin Invest 2006; 116: 1686-1695 [PMID: 16741579 DOI: 10.1172/JCI26991]
6. MacDonald ML, van Eck M, Hildebrand RB, Wong BW, Bissada N, Ruddle P, Kontush A, Hussein H, Pouladi MA, Chapman MJ, Fievet C, van Berkel TJ, Staels B, McManus BM, Hayden MR. Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol 2009; 29: 341-347 [PMID: 19095997 DOI: 10.1161/ATVBAHA.108.181099]
7. Liu Y, McNamara RK. Elevated Delta-6 desaturase (FADS2) gene expression in the prefrontal cortex of patients with bipolar disorder. J Psychiatr Res 2011; 45: 269-272 [PMID: 20615514 DOI: 10.1016/j.jpsychires.2010.06.010]
8. Tang C, Cho HP, Nakamura MT, Clarke SD. Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element. J Lipid Res 2003; 44: 686-695 [PMID: 12562861 DOI: 10.1194/jlr.M200195-JLR200]
9. Miller CW, Ntambi JM. Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression. Proc Natl Acad Sci USA 1996; 93: 9443-9448 [PMID: 8790349 DOI: 10.1073/pnas.93.18.9443]
10. Friedland SN, Leong A, Filion KB, Genest J, Lega IC, Mottillo S, Poirier P, Reoch J, Eisenberg MJ. The cardiovascular effects of peroxisome proliferator-activated receptor agonists. Am J Med 2012; 125: 126-133 [PMID: 22269613 DOI: 10.1016/ j.amjmed.2011.08.025]
11. Yousefi B, Darabi M, Baradaran B, Khaniani M, Rahbani M, Darabi M, Fayezi S, Mehdizadeh A, Saliani N, Shaaker M. Inhibition of MEK/ERK1/2 signaling affects the fatty acid composition of HepG2 human hepatic cell line. BioImpacts 2012; 2: 145-150 [DOI: 10.5681/bi.2012.019]
12. Mauvoisin D, Prévost M, Ducheix S, Arnaud MP, Mounier C. Key role of the ERK1/2 MAPK pathway in the transcriptional regulation of the Stearoyl-CoA Desaturase (SCD1) gene expression in response to leptin. Mol Cell Endocrinol 2010; 319: 116-128 [PMID: 20109524 DOI: 10.1016/j.mce.2010.01.027]
13. Kempná P, Hofer G, Mullis PE, Flück CE. Pioglitazone inhibits androgen production in NCI-H295R cells by regulating gene expression of CYP17 and HSD3B2. Mol Pharmacol 2007; 71: 787-798 [PMID: 17138841 DOI: 10.1124/mol.106.028902]
14. Camp HS, Tafuri SR. Regulation of peroxisome proliferatoractivated receptor gamma activity by mitogen-activated protein kinase. J Biol Chem 1997; 272: 10811-10816 [PMID: 9099735 DOI: 10.1074/jbc.272.16.10811]
15. Liu Y, Jandacek R, Rider T, Tso P, McNamara RK. Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition. Schizophr Res 2009; 109: 113-120 [PMID: 19195843 DOI: 10.1016/j.schres.2008.12.027]
16. Noori M, Darabi M, Rahimipour A, Rahbani M, Abadi NA, Darabi M, Ghatrehsamani K. Fatty acid composition of HDL phospholipids and coronary artery disease. J Clin Lipidol 2009; 3: 39-44 [PMID: 21291787 DOI: 10.1016/j.jacl.2008.11.010]
17. Guillou H, Martin PG, Pineau T. Transcriptional regulation of hepatic fatty acid metabolism. Subcell Biochem 2008; 49: 3-47 [PMID: 18751906 DOI: 10.1007/978-1-4020-8831-5_1]
18. Ntambi JM, Miyazaki M. Regulation of stearoyl-CoA desaturases and role in metabolism. Prog Lipid Res 2004; 43: 91-104 [PMID: 14654089 DOI: 10.1016/S0163-7827(03)00039-0]
19. Pachikian BD, Essaghir A, Demoulin JB, Neyrinck AM, Catry E, De Backer FC, Dejeans N, Dewulf EM, Sohet FM, Portois L, Deldicque L, Molendi-Coste O, Leclercq IA, Francaux M, Carpentier YA, Foufelle F, Muccioli GG, Cani PD, Delzenne NM. Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. PLoS One 2011; 6: e23365 [PMID: 21853118 DOI: 10.1371/journal.pone.0023365]
20. Bjermo H, Risérus U. Role of hepatic desaturases in obesityrelated metabolic disorders. Curr Opin Clin Nutr Metab Care 2010; 13: 703-708 [PMID: 20823776 DOI: 10.1097/ MCO.0b013e32833ec41b]
21. Hein GJ, Bernasconi AM, Montanaro MA, Pellon-Maison M, Finarelli G, Chicco A, Lombardo YB, Brenner RR. Nuclear receptors and hepatic lipidogenic enzyme response to a dyslipidemic sucrose-rich diet and its reversal by fish oil n-3 polyunsaturated fatty acids. Am J Physiol Endocrinol Metab 2010; 298: E429-E439 [PMID: 19952344 DOI: 10.1152/ajpendo. 00513.2009]
22. Kotronen A, Seppänen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepää AL, Oresic M, Yki-Järvinen H. Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. Diabetes 2009; 58: 203-208 [PMID: 18952834 DOI: 10.2337/db08-1074]
23. Hu S, Xie Z, Onishi A, Yu X, Jiang L, Lin J, Rho HS, Woodard C, Wang H, Jeong JS, Long S, He X, Wade H, Blackshaw S, Qian J, Zhu H. Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell 2009; 139: 610-622 [PMID: 19879846 DOI: 10.1016/ j.cell.2009.08.037]
24. Wang Y, Botolin D, Xu J, Christian B, Mitchell E, Jayaprakasam B, Nair MG, Peters JM, Busik JV, Olson LK, Jump DB. Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. J Lipid Res 2006; 47: 2028-2041 [PMID: 16790840 DOI: 10.1194/jlr.M600177-JLR200]
25. Adams M, Reginato MJ, Shao D, Lazar MA, Chatterjee VK. Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. J Biol Chem 1997; 272: 5128-5132 [PMID: 9030579 DOI: 10.1074/jbc.272.8.5128]
26. Sahmani M, Sakhinia E, Farzadi L, Najafipour R, Darabi M, Mehdizadeh A, Shahnazi V, Shaaker M, Noori M. Two common polymorphisms in the peroxisome proliferatoractivated receptor ? gene may improve fertilization in IVF. Reprod Biomed Online 2011; 23: 355-360 [PMID: 21764381 DOI: 10.1016/j.rbmo.2011.05.005]
27. Cheatham WW. Peroxisome proliferator-activated receptor translational research and clinical experience. Am J Clin Nutr 2010; 91: 262S-266S [PMID: 19923366 DOI: 10.3945/ ajcn.2009.28449D]
28. Lennon AM, Ramaugé M, Dessouroux A, Pierre M. MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species. J Biol Chem 2002; 277: 29681-29685 [PMID: 12052825 DOI: 10.1074/jbc.M201517200]
29. Toyama T, Kudo N, Hibino Y, Mitsumoto A, Nishikawa M, Kawashima Y. Effects of pioglitazone on stearoyl-CoA desaturase in obese Zucker fa/fa rats. J Pharmacol Sci 2007; 104: 137-145 [PMID: 17538229 DOI: 10.1254/jphs.FP0060997]
30. Montanaro MA, Lombardo YB, González MS, Bernasconi AM, Chicco A, Rimoldi OJ, Basabe JC, Brenner RR. Effect of troglitazone on the desaturases in a rat model of insulinresistance induced by a sucrose-rich diet. Prostaglandins Leukot Essent Fatty Acids 2005; 72: 241-250 [PMID: 15763435 DOI: 10.1016/j.plefa.2004.11.003]
31. Wahl HG, Kausch C, Machicao F, Rett K, Stumvoll M, Häring HU. Troglitazone downregulates delta-6 desaturase gene expression in human skeletal muscle cell cultures. Diabetes 2002; 51: 1060-1065 [PMID: 11916926 DOI: 10.2337/diabetes. 51.4.1060]
32. Deehan R, Maerz-Weiss P, Catlett NL, Steiner G, Wong B, Wright MB, Blander G, Elliston KO, Ladd W, Bobadilla M, Mizrahi J, Haefliger C, Edgar A. Comparative transcriptional network modeling of three PPAR-a/? co-agonists reveals distinct metabolic gene signatures in primary human hepatocytes. PLoS One 2012; 7: e35012 [PMID: 22514701 DOI: 10.1371/journal.pone.0035012]
33. Kahn CR, Chen L, Cohen SE. Unraveling the mechanism of action of thiazolidinediones. J Clin Invest 2000; 106: 1305-1307 [PMID: 11104782 DOI: 10.1172/JCI11705]
34. Li Y, Lazar MA. Differential gene regulation by PPARgamma agonist and constitutively active PPARgamma2. Mol Endocrinol 2002; 16: 1040-1048 [PMID: 11981038 DOI: 10.1210/ me.16.5.1040]
35. Risérus U, Tan GD, Fielding BA, Neville MJ, Currie J, Savage DB, Chatterjee VK, Frayn KN, O'Rahilly S, Karpe F. Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferatoractivated receptor-gamma. Diabetes 2005; 54: 1379-1384 [PMID: 15855323 DOI: 10.2337/diabetes.54.5.1379]
36. Stefan N, Peter A, Cegan A, Staiger H, Machann J, Schick F, Claussen CD, Fritsche A, Häring HU, Schleicher E. Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans. Diabetologia 2008; 51: 648-656 [PMID: 18286258 DOI: 10.1007/ s00125-008-0938-7]