-
1
-
-
33746015638
-
The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha, 25-dihydroxyvitamin D(3) in human intestinal cell lines, caco-2 and LS180
-
Aiba T, Susa M, Fukumori S., Hashimoto Y. (2005) The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha, 25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180. Drug Metab Pharmacokinet 20:268-274.
-
(2005)
Drug Metab Pharmacokinet
, vol.20
, pp. 268-274
-
-
Aiba, T.1
Susa, M.2
Fukumori, S.3
Hashimoto, Y.4
-
2
-
-
63449139456
-
Structure of P-glycoprotein reveals a molecular basis for polyspecific drug binding
-
Aller SG, Yu J, Ward A., Weng Y, Chittaboina S, Zhuo R., Harrell PM, Trinh YT, Zhang Q, and Urbatsch IL, et al. (2009) Structure of P-glycoprotein reveals a molecular basis for polyspecific drug binding. Science 323:1718-1722.
-
(2009)
Science
, vol.323
, pp. 1718-1722
-
-
Aller, S.G.1
Yu, J.2
Ward, A.3
Weng, Y.4
Chittaboina, S.5
Zhuo, R.6
Harrell, P.M.7
Trinh, Y.T.8
Zhang, Q.9
Urbatsch, I.L.10
-
3
-
-
48749106993
-
Tariquidar-induced P-glycoprotein inhibition at the rat bloodbrain Barrier studied with (R)-11C-verapamil and PET
-
Bankstahl JP, Kuntner C, Abrahim A., Karch R, Stanek J, Wanek T., Wadsak W, Kletter K, Müller M, and Löscher W, et al. (2008) Tariquidar-induced P-glycoprotein inhibition at the rat bloodbrain barrier studied with (R)-11C-verapamil and PET. J Nucl Med 49:1328-1335.
-
(2008)
J Nucl Med
, vol.49
, pp. 1328-1335
-
-
Bankstahl, J.P.1
Kuntner, C.2
Abrahim, A.3
Karch, R.4
Stanek, J.5
Wanek, T.6
Wadsak, W.7
Kletter, K.8
Müller, M.9
Löscher, W.10
-
4
-
-
33748950454
-
In vivo activation of human pregnane X receptor tightens the blood-brain Barrier to methadone through P-glycoprotein up-regulation
-
Bauer B, Yang X, Hartz A.M., Olson ER, Zhao R, Kalvass JC, Pollack G.M., Miller D.S. (2006) In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation. Mol Pharmacol 70:1212-1219.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1212-1219
-
-
Bauer, B.1
Yang, X.2
Hartz, A.M.3
Olson, E.R.4
Zhao, R.5
Kalvass, J.C.6
Pollack, G.M.7
Miller, D.S.8
-
5
-
-
84921966208
-
In vivo P-glycoprotein function before and after epilepsy surgery
-
Bauer M, Karch R, Zeitlinger M. (2014) In vivo P-glycoprotein function before and after epilepsy surgery. Neurology 83:1326-1331.
-
(2014)
Neurology
, vol.83
, pp. 1326-1331
-
-
Bauer, M.1
Karch, R.2
Zeitlinger, M.3
-
6
-
-
84855960602
-
Pgp-mediated interaction between (R)-[11C] verapamil and tariquidar at the human blood-brain Barrier: A comparison with rat data
-
Bauer M, Zeitlinger M, Karch R., Matzneller P, Stanek J, Jäger W, Böhmdorfer M, Wadsak W., Mitterhauser M, and Bankstahl JP, et al. (2012) Pgp-mediated interaction between (R)-[11C] verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data. Clin Pharmacol Ther 91:227-233.
-
(2012)
Clin Pharmacol Ther
, vol.91
, pp. 227-233
-
-
Bauer, M.1
Zeitlinger, M.2
Karch, R.3
Matzneller, P.4
Stanek, J.5
Jäger, W.6
Böhmdorfer, M.7
Wadsak, W.8
Mitterhauser, M.9
Bankstahl, J.P.10
-
7
-
-
84885051199
-
P-glycoprotein ABCB1: A major player in drug handling by mammals
-
Borst P and Schinkel AH (2013) P-glycoprotein ABCB1: a major player in drug handling by mammals. J Clin Invest 123:4131-4133.
-
(2013)
J Clin Invest
, vol.123
, pp. 4131-4133
-
-
Borst, P.1
Schinkel, A.H.2
-
8
-
-
34250827959
-
-
12th ed, McGraw-Hill, New York
-
Brunton LL, Blumenthal DK, Murri N, Dandan R.H., and Knollmann BC (2011) Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th ed, McGraw-Hill, New York, p 855.
-
(2011)
Goodman & Gilman's the Pharmacological Basis of Therapeutics
, pp. 855
-
-
Brunton, L.L.1
Blumenthal, D.K.2
Murri, N.3
Dandan, R.H.4
Knollmann, B.C.5
-
9
-
-
84886087870
-
In vivo induction of P-glycoprotein expression at the mouse blood-brain Barrier: An intracerebral microdialysis study
-
Chan G, Saldivia V, Yang Y., Pang H, de Lannoy I, Bendayan R. (2013) In vivo induction of P-glycoprotein expression at the mouse blood-brain barrier: an intracerebral microdialysis study. J Neurochem 127:342-352.
-
(2013)
J Neurochem
, vol.127
, pp. 342-352
-
-
Chan, G.1
Saldivia, V.2
Yang, Y.3
Pang, H.4
De Lannoy, I.5
Bendayan, R.6
-
10
-
-
27644489474
-
P-glycoprotein deficiency at the blood-brain Barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
-
Cirrito J.R, Deane R, Fagan A.M., Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior J.L., Sagare A., Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman D.M. (2005) P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest 115:3285-3290.
-
(2005)
J Clin Invest
, vol.115
, pp. 3285-3290
-
-
Cirrito, J.R.1
Deane, R.2
Fagan, A.M.3
Spinner, M.L.4
Parsadanian, M.5
Finn, M.B.6
Jiang, H.7
Prior, J.L.8
Sagare, A.9
Bales, K.R.10
Paul, S.M.11
Zlokovic, B.V.12
Piwnica-Worms, D.13
Holtzman, D.M.14
-
11
-
-
56749151204
-
ABC transporters, cytochromes P450 and their main transcription factors: Expression at the human blood-brain Barrier
-
Dauchy S, Dutheil F, Weaver R.J., Chassoux F., Daumas-Duport C, Couraud PO, Scherrmann J.M, De Waziers I, Declèves X (2008) ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier. J Neurochem 107:1518-1528.
-
(2008)
J Neurochem
, vol.107
, pp. 1518-1528
-
-
Dauchy, S.1
Dutheil, F.2
Weaver, R.J.3
Chassoux, F.4
Daumas-Duport, C.5
Couraud, P.O.6
Scherrmann, J.M.7
De Waziers, I.8
Declèves, X.9
-
12
-
-
84904100818
-
Activity of p-glycoprotein, a β-amyloid transporter at the blood-brain Barrier, is compromised in patients with mild Alzheimer disease
-
Deo AK, Borson S, Link J.M., Domino K., Eary JF, Ke B, Richards TL, Mankoff D.A., Minoshima S., O'Sullivan F, Eyal S, Hsiao P., Maravilla K, Unadkat J.D. (2014) Activity of p-glycoprotein, a β-amyloid transporter at the blood-brain barrier, is compromised in patients with mild alzheimer disease. J Nucl Med 55:1106-1111.
-
(2014)
J Nucl Med
, vol.55
, pp. 1106-1111
-
-
Deo, A.K.1
Borson, S.2
Link, J.M.3
Domino, K.4
Eary, J.F.5
Ke, B.6
Richards, T.L.7
Mankoff, D.A.8
Minoshima, S.9
O'Sullivan, F.10
Eyal, S.11
Hsiao, P.12
Maravilla, K.13
Unadkat, J.D.14
-
13
-
-
65749088027
-
Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate
-
Eyal S, Chung FS, Muzi M, Link J.M., Mankoff DA, Kaddoumi A, O'Sullivan F, Hebert MF, and Unadkat JD (2009) Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate. J Nucl Med 50:798-806.
-
(2009)
J Nucl Med
, vol.50
, pp. 798-806
-
-
Eyal, S.1
Chung, F.S.2
Muzi, M.3
Link, J.M.4
Mankoff, D.A.5
Kaddoumi, A.6
O'Sullivan, F.7
Hebert, M.F.8
Unadkat, J.D.9
-
14
-
-
77951498281
-
Regional P-glycoprotein activity and inhibition at the human blood-brain Barrier as imaged by positron emission tomography
-
Eyal S, Ke B, Muzi M., Link JM, Mankoff DA, Collier AC, and Unadkat JD (2010) Regional P-glycoprotein activity and inhibition at the human blood-brain barrier as imaged by positron emission tomography. Clin Pharmacol Ther 87:579-585.
-
(2010)
Clin Pharmacol Ther
, vol.87
, pp. 579-585
-
-
Eyal, S.1
Ke, B.2
Muzi, M.3
Link, J.M.4
Mankoff, D.A.5
Collier, A.C.6
Unadkat, J.D.7
-
15
-
-
0017725064
-
Comparison of quinidine plasma concentration curves following oral administration of some short- and longacting formulations
-
Frigo GM, Perucca E, Teggia-Droghi M, Gatti G., Mussini A, and Salerno J (1977) Comparison of quinidine plasma concentration curves following oral administration of some short- and longacting formulations. Br J Clin Pharmacol 4:449-454.
-
(1977)
Br J Clin Pharmacol
, vol.4
, pp. 449-454
-
-
Frigo, G.M.1
Perucca, E.2
Teggia-Droghi, M.3
Gatti, G.4
Mussini, A.5
Salerno, J.6
-
16
-
-
53249094298
-
Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: Comparative effects of st. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics
-
Gurley BJ, Swain A, Williams D.K., Barone G., Battu S.K. (2008) Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics. Mol Nutr Food Res 52: 772-779.
-
(2008)
Mol Nutr Food Res
, vol.52
, pp. 772-779
-
-
Gurley, B.J.1
Swain, A.2
Williams, D.K.3
Barone, G.4
Battu, S.K.5
-
18
-
-
77951078680
-
Restoring blood-brain Barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease
-
Hartz AM, Miller DS, Bauer B. (2010) Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease. Mol Pharmacol 77:715-723.
-
(2010)
Mol Pharmacol
, vol.77
, pp. 715-723
-
-
Hartz, A.M.1
Miller, D.S.2
Bauer, B.3
-
19
-
-
0031874816
-
Complete in vivo reversal of P-glycoprotein pump function in the bloodbrain Barrier visualized with positron emission tomography
-
Hendrikse NH, Schinkel AH, de Vries EG, Fluks E, Van der Graaf WT, Willemsen A, Vaalburg W, Franssen EJ (1998) Complete in vivo reversal of P-glycoprotein pump function in the bloodbrain barrier visualized with positron emission tomography. Br J Pharmacol 124:1413-1418.
-
(1998)
Br J Pharmacol
, vol.124
, pp. 1413-1418
-
-
Hendrikse, N.H.1
Schinkel, A.H.2
De Vries, E.G.3
Fluks, E.4
Van Der Graaf, W.T.5
Willemsen, A.6
Vaalburg, W.7
Franssen, E.J.8
-
20
-
-
40849145621
-
In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain Barrier
-
Hsiao P, Bui T, Ho R.J., and Unadkat JD (2008) In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier. Drug Metab Dispos 36: 481-484.
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 481-484
-
-
Hsiao, P.1
Bui, T.2
Ho, R.J.3
Unadkat, J.D.4
-
21
-
-
33645881089
-
Verapamil P-glycoprotein transport across the rat blood-brain Barrier: Cyclosporine, a concentration inhibition analysis, and comparison with human data
-
Hsiao P, Sasongko L, Link J.M., Mankoff DA, Muzi M, Collier AC, and Unadkat JD (2006) Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a concentration inhibition analysis, and comparison with human data. J Pharmacol Exp Ther 317:704-710.
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 704-710
-
-
Hsiao, P.1
Sasongko, L.2
Link, J.M.3
Mankoff, D.A.4
Muzi, M.5
Collier, A.C.6
Unadkat, J.D.7
-
22
-
-
84893312014
-
Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain Barrier based on rat studies
-
Hsiao P and Unadkat JD (2014) Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain barrier based on rat studies. Mol Pharm 11: 436-444.
-
(2014)
Mol Pharm
, vol.11
, pp. 436-444
-
-
Hsiao, P.1
Unadkat, J.D.2
-
23
-
-
79953718797
-
Quantitative membrane protein expression at the blood-brain Barrier of adult and younger cynomolgus monkeys
-
Ito K, Uchida Y, Ohtsuki S., Aizawa S, Kawakami H, Katsukura Y., Kamiie J, and Terasaki T (2011) Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys. J Pharm Sci 100:3939-3950.
-
(2011)
J Pharm Sci
, vol.100
, pp. 3939-3950
-
-
Ito, K.1
Uchida, Y.2
Ohtsuki, S.3
Aizawa, S.4
Kawakami, H.5
Katsukura, Y.6
Kamiie, J.7
Terasaki, T.8
-
24
-
-
34548106741
-
Inhibition of P-glycoprotein activity at the primate blood-brain Barrier increases the distribution of nelfinavir into the brain but not into the cerebrospinal fluid
-
Kaddoumi A, Choi SU, Kinman L, Whittington D., Tsai CC, Ho RJ, Anderson BD, and Unadkat JD (2007) Inhibition of P-glycoprotein activity at the primate blood-brain barrier increases the distribution of nelfinavir into the brain but not into the cerebrospinal fluid. Drug Metab Dispos 35:1459-1462.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1459-1462
-
-
Kaddoumi, A.1
Choi, S.U.2
Kinman, L.3
Whittington, D.4
Tsai, C.C.5
Ho, R.J.6
Anderson, B.D.7
Unadkat, J.D.8
-
25
-
-
84879415192
-
Why clinical modulation of efflux transport at the human blood-brain Barrier is unlikely: The ITC evidence-based position
-
Kalvass JC, Polli JW, Bourdet D.L., Feng B., Huang SM, Liu X, Smith QR, Zhang L.K., and Zamek-Gliszczynski MJ; International Transporter Consortium (2013) Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position. Clin Pharmacol Ther 94:80-94.
-
(2013)
Clin Pharmacol Ther
, vol.94
, pp. 80-94
-
-
Kalvass, J.C.1
Polli, J.W.2
Bourdet, D.L.3
Feng, B.4
Huang, S.M.5
Liu, X.6
Smith, Q.R.7
Zhang, L.K.8
Zamek-Gliszczynski, M.J.9
-
26
-
-
0036229852
-
Drugs As P-glycoprotein substrates, inhibitors, and inducers
-
Kim, RB (2002) Drugs as P-glycoprotein substrates, inhibitors, and inducers. Drug Metab Rev 34: 47-54.
-
(2002)
Drug Metab Rev
, vol.34
, pp. 47-54
-
-
Kim, R.B.1
-
27
-
-
77950952797
-
P-glycoprotein function at the blood-brain Barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide
-
Kreisl WC, Liow JS, Kimura N, Seneca N., Zoghbi SS, Morse CL, Herscovitch P, Pike V.W., and Innis RB (2010) P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide. J Nucl Med 51:559-566.
-
(2010)
J Nucl Med
, vol.51
, pp. 559-566
-
-
Kreisl, W.C.1
Liow, J.S.2
Kimura, N.3
Seneca, N.4
Zoghbi, S.S.5
Morse, C.L.6
Herscovitch, P.7
Pike, V.W.8
Innis, R.B.9
-
28
-
-
34548413773
-
Pharmacoresistance in epilepsy: A pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil
-
Langer O, Bauer M, Hammers A., Karch R, Pataraia E, Koepp M.J., Abrahim A., Luurtsema G, Brunner M, Sunder-Plassmann R, Zimprich F., Joukhadar C, Gentzsch S, Dudczak R., Kletter K, Müller M, Baumgartner C (2007) Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. Epilepsia 48:1774-1784.
-
(2007)
Epilepsia
, vol.48
, pp. 1774-1784
-
-
Langer, O.1
Bauer, M.2
Hammers, A.3
Karch, R.4
Pataraia, E.5
Koepp, M.J.6
Abrahim, A.7
Luurtsema, G.8
Brunner, M.9
Sunder-Plassmann, R.10
Zimprich, F.11
Joukhadar, C.12
Gentzsch, S.13
Dudczak, R.14
Kletter, K.15
Müller, M.16
Baumgartner, C.17
-
29
-
-
58249113831
-
P-glycoprotein function at the blood-brain Barrier imaged using 11C-N-desmethyl-loperamide in monkeys
-
Liow JS, Kreisl W, Zoghbi S.S., Lazarova N., Seneca N, Gladding RL, Taku A, Herscovitch P., Pike VW, and Innis RB (2009) P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys. J Nucl Med 50:108-115.
-
(2009)
J Nucl Med
, vol.50
, pp. 108-115
-
-
Liow, J.S.1
Kreisl, W.2
Zoghbi, S.S.3
Lazarova, N.4
Seneca, N.5
Gladding, R.L.6
Taku, A.7
Herscovitch, P.8
Pike, V.W.9
Innis, R.B.10
-
30
-
-
0033862765
-
Communication between multiple drug binding sites on P-glycoprotein
-
Martin C, Berridge G, Higgins C.F., Mistry P., Charlton P, and Callaghan R (2000) Communication between multiple drug binding sites on P-glycoprotein. Mol Pharmacol 58:624-632.
-
(2000)
Mol Pharmacol
, vol.58
, pp. 624-632
-
-
Martin, C.1
Berridge, G.2
Higgins, C.F.3
Mistry, P.4
Charlton, P.5
Callaghan, R.6
-
31
-
-
39449119289
-
Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells
-
Martin P, Riley R, Back D.J., Owen A. (2008) Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells. Br J Pharmacol 153:805-819.
-
(2008)
Br J Pharmacol
, vol.153
, pp. 805-819
-
-
Martin, P.1
Riley, R.2
Back, D.J.3
Owen, A.4
-
32
-
-
77953687856
-
Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain Barrier
-
Miller DS (2010) Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier. Trends Pharmacol Sci 31:246-254.
-
(2010)
Trends Pharmacol Sci
, vol.31
, pp. 246-254
-
-
Miller, D.S.1
-
33
-
-
68249161945
-
Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: Studies of healthy humans
-
Muzi M, Mankoff DA, Link J.M., Shoner S., Collier AC, Sasongko L, and Unadkat JD (2009) Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: studies of healthy humans. J Nucl Med 50:1267-1275.
-
(2009)
J Nucl Med
, vol.50
, pp. 1267-1275
-
-
Muzi, M.1
Mankoff, D.A.2
Link, J.M.3
Shoner, S.4
Collier, A.C.5
Sasongko, L.6
Unadkat, J.D.7
-
34
-
-
55949099344
-
Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain Barrier
-
Narang VS, Fraga C, Kumar N., Shen J, Throm S, Stewart C.F., Waters C.M. (2008) Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. Am J Physiol Cell Physiol 295:C440-450.
-
(2008)
Am J Physiol Cell Physiol
, vol.295
, pp. C440-450
-
-
Narang, V.S.1
Fraga, C.2
Kumar, N.3
Shen, J.4
Throm, S.5
Stewart, C.F.6
Waters, C.M.7
-
35
-
-
0042163137
-
Pharmacokinetic interactions with rifampicin: Clinical relevance
-
Niemi M, Backman JT, Fromm M.F., Neuvonen PJ, Kivistö KT (2003) Pharmacokinetic interactions with rifampicin: clinical relevance. Clin Pharmacokinet 42:819-850.
-
(2003)
Clin Pharmacokinet
, vol.42
, pp. 819-850
-
-
Niemi, M.1
Backman, J.T.2
Fromm, M.F.3
Neuvonen, P.J.4
Kivistö, K.T.5
-
37
-
-
63849146957
-
Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain Barrier: Functional similarities between pig and human PXR
-
Ott M, Fricker G, Bauer B. (2009) Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. J Pharmacol Exp Ther 329:141-149.
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 141-149
-
-
Ott, M.1
Fricker, G.2
Bauer, B.3
-
38
-
-
84855961898
-
Blood brain Barrier permeability of [11C]loperamide in humans under normal and impaired P-glycoprotein function
-
Passchier J, Comley R, Salinas C., Rabiner E, Gunn R, Cunningham V., Wilson A, Houle S, Gee A., and Laruelle M, (2008) Blood brain barrier permeability of [11C]loperamide in humans under normal and impaired P-glycoprotein function. J Nucl Med 49:211P.
-
(2008)
J Nucl Med
, vol.49
-
-
Passchier, J.1
Comley, R.2
Salinas, C.3
Rabiner, E.4
Gunn, R.5
Cunningham, V.6
Wilson, A.7
Houle, S.8
Gee, A.9
Laruelle, M.10
-
39
-
-
0034058897
-
Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein
-
Pauli-Magnus C., von Richter O, Burk O, Ziegler A., Mettang T, Eichelbaum M, and Fromm MF (2000) Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther 293:376-382.
-
(2000)
J Pharmacol Exp Ther
, vol.293
, pp. 376-382
-
-
Pauli-Magnus, C.1
Von Richter, O.2
Burk, O.3
Ziegler, A.4
Mettang, T.5
Eichelbaum, M.6
Fromm, M.F.7
-
40
-
-
0018821640
-
Simple and selective high-performance liquid chromatographic method for estimating plasma quinidine levels
-
Reece PA and Peikert M (1980) Simple and selective high-performance liquid chromatographic method for estimating plasma quinidine levels. J Chromatogr A 181:207-217.
-
(1980)
J Chromatogr A
, vol.181
, pp. 207-217
-
-
Reece, P.A.1
Peikert, M.2
-
41
-
-
0024509598
-
Cerebral cortical and white matter reactivity to carbon dioxide
-
Reich T and Rusinek H (1989) Cerebral cortical and white matter reactivity to carbon dioxide. Stroke 20:453-457.
-
(1989)
Stroke
, vol.20
, pp. 453-457
-
-
Reich, T.1
Rusinek, H.2
-
42
-
-
33646513294
-
Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds
-
Reschly EJ and Krasowski MD (2006) Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds. Curr Drug Metab 7:349-365.
-
(2006)
Curr Drug Metab
, vol.7
, pp. 349-365
-
-
Reschly, E.J.1
Krasowski, M.D.2
-
43
-
-
0033833430
-
Increased drug delivery to the brain by P-glycoprotein inhibition
-
Sadeque AJ, Wandel C, He H., Shah S, and Wood AJ (2000) Increased drug delivery to the brain by P-glycoprotein inhibition. Clin Pharmacol Ther 68:231-237.
-
(2000)
Clin Pharmacol Ther
, vol.68
, pp. 231-237
-
-
Sadeque, A.J.1
Wandel, C.2
He, H.3
Shah, S.4
Wood, A.J.5
-
44
-
-
20444480695
-
Imaging P-glycoprotein transport activity at the human blood-brain Barrier with positron emission tomography
-
Sasongko L, Link JM, Muzi M, Mankoff D.A., Yang X., Collier AC, Shoner SC, and Unadkat JD (2005) Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography. Clin Pharmacol Ther 77:503-514.
-
(2005)
Clin Pharmacol Ther
, vol.77
, pp. 503-514
-
-
Sasongko, L.1
Link, J.M.2
Muzi, M.3
Mankoff, D.A.4
Yang, X.5
Collier, A.C.6
Shoner, S.C.7
Unadkat, J.D.8
-
45
-
-
0028229150
-
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain Barrier and to increased sensitivity to drugs
-
Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, and te Riele HP, et al. (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502.
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Smit, J.J.2
Van Tellingen, O.3
Beijnen, J.H.4
Wagenaar, E.5
Van Deemter, L.6
Mol, C.A.7
Van Der Valk, M.A.8
Robanus-Maandag, E.C.9
Te Riele, H.P.10
-
46
-
-
66149123753
-
Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein
-
Seneca N, Zoghbi SS, Liow J.S., Kreisl W., Herscovitch P, Jenko K, Gladding R.L., Taku A., Pike VW, and Innis RB (2009) Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein. J Nucl Med 50:807-813.
-
(2009)
J Nucl Med
, vol.50
, pp. 807-813
-
-
Seneca, N.1
Zoghbi, S.S.2
Liow, J.S.3
Kreisl, W.4
Herscovitch, P.5
Jenko, K.6
Gladding, R.L.7
Taku, A.8
Pike, V.W.9
Innis, R.B.10
-
47
-
-
79961096875
-
Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels
-
Shawahna R, Uchida Y, Declèves X, Ohtsuki S., Yousif S, Dauchy S, Jacob A., Chassoux F, Daumas-Duport C, and Couraud PO, et al. (2011) Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol Pharm 8:1332-1341.
-
(2011)
Mol Pharm
, vol.8
, pp. 1332-1341
-
-
Shawahna, R.1
Uchida, Y.2
Declèves, X.3
Ohtsuki, S.4
Yousif, S.5
Dauchy, S.6
Jacob, A.7
Chassoux, F.8
Daumas-Duport, C.9
Couraud, P.O.10
-
49
-
-
0032897280
-
Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil
-
Tracy TS, Korzekwa KR, Gonzalez F.J., and Wainer IW (1999) Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil. Br J Clin Pharmacol 47:545-552.
-
(1999)
Br J Clin Pharmacol
, vol.47
, pp. 545-552
-
-
Tracy, T.S.1
Korzekwa, K.R.2
Gonzalez, F.J.3
Wainer, I.W.4
-
50
-
-
79953686193
-
Quantitative targeted absolute proteomics of human blood-brain Barrier transporters and receptors
-
Uchida Y, Ohtsuki S, Katsukura Y., Ikeda C, Suzuki T, Kamiie J., and Terasaki T (2011) Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors. J Neurochem 117:333-345.
-
(2011)
J Neurochem
, vol.117
, pp. 333-345
-
-
Uchida, Y.1
Ohtsuki, S.2
Katsukura, Y.3
Ikeda, C.4
Suzuki, T.5
Kamiie, J.6
Terasaki, T.7
-
51
-
-
56249119836
-
Rapid solid-phase extraction method to quantify [(11)C]-verapamil, and its [(11)C]-metabolites, in human and macaque plasma
-
Unadkat JD, Chung F, Sasongko L., Whittington D, Eyal S, Mankoff D., Collier AC, Muzi M, and Link J (2008) Rapid solid-phase extraction method to quantify [(11)C]-verapamil, and its [(11)C]-metabolites, in human and macaque plasma. Nucl Med Biol 35:911-917.
-
(2008)
Nucl Med Biol
, vol.35
, pp. 911-917
-
-
Unadkat, J.D.1
Chung, F.2
Sasongko, L.3
Whittington, D.4
Eyal, S.5
Mankoff, D.6
Collier, A.C.7
Muzi, M.8
Link, J.9
-
52
-
-
0036797713
-
Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
-
Vogelgesang S, Cascorbi I, Schroeder E., Pahnke J, Kroemer HK, Siegmund W, Kunert-Keil C, Walker L.C., Warzok R.W. (2002) Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics 12:535-541.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 535-541
-
-
Vogelgesang, S.1
Cascorbi, I.2
Schroeder, E.3
Pahnke, J.4
Kroemer, H.K.5
Siegmund, W.6
Kunert-Keil, C.7
Walker, L.C.8
Warzok, R.W.9
-
53
-
-
58149346070
-
Cerebral blood flow and cerebral edema in rats with diabetic ketoacidosis
-
Yuen N, Anderson SE, Glaser N, Tancredi D.J., and O'Donnell ME (2008) Cerebral blood flow and cerebral edema in rats with diabetic ketoacidosis. Diabetes 57:2588-2594.
-
(2008)
Diabetes
, vol.57
, pp. 2588-2594
-
-
Yuen, N.1
Anderson, S.E.2
Glaser, N.3
Tancredi, D.J.4
O'Donnell, M.E.5
-
54
-
-
79958829984
-
Substrate- and species-dependent inhibition of P-glycoprotein-mediated transport: Implications for predicting in vivo drug interactions
-
Zolnerciks JK, Booth-Genthe CL, Gupta A., Harris J, and Unadkat JD (2011) Substrate- and species-dependent inhibition of P-glycoprotein-mediated transport: implications for predicting in vivo drug interactions. J Pharm Sci 100:3055-3061.
-
(2011)
J Pharm Sci
, vol.100
, pp. 3055-3061
-
-
Zolnerciks, J.K.1
Booth-Genthe, C.L.2
Gupta, A.3
Harris, J.4
Unadkat, J.D.5
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