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Volumn 7, Issue 3, 2013, Pages 611-624

Estrogen receptor-α36 is involved in development of acquired tamoxifen resistance via regulating the growth status switch in breast cancer cells

Author keywords

Acquired tamoxifen resistance; Breast cancer; ER 36; ER 66 and EGFR

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR ALPHA 36; ESTROGEN RECEPTOR ALPHA 66; MESSENGER RNA; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 84878115770     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2013.02.001     Document Type: Article
Times cited : (66)

References (56)
  • 2
    • 0028884033 scopus 로고
    • PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo
    • Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel A.R. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo. Journal of Biological Chemistry 1995, 270:27489-27494.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 27489-27494
    • Alessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4    Saltiel, A.R.5
  • 3
    • 0036488531 scopus 로고    scopus 로고
    • Endocrine-responsive breast cancer and strategies for combating resistance
    • Ali S., Coombes R.C. Endocrine-responsive breast cancer and strategies for combating resistance. Nature Reviews Cancer 2002, 2:101-112.
    • (2002) Nature Reviews Cancer , vol.2 , pp. 101-112
    • Ali, S.1    Coombes, R.C.2
  • 4
    • 4444278403 scopus 로고    scopus 로고
    • HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a Southwest oncology group study
    • Arpino G. HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a Southwest oncology group study. Clinical Cancer Research 2004, 10:5670-5676.
    • (2004) Clinical Cancer Research , vol.10 , pp. 5670-5676
    • Arpino, G.1
  • 5
    • 42049121934 scopus 로고    scopus 로고
    • Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance
    • Arpino G., Wiechmann L., Osborne C.K., Schiff R. Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance. Endocrine Reviews 2008, 29:217-233.
    • (2008) Endocrine Reviews , vol.29 , pp. 217-233
    • Arpino, G.1    Wiechmann, L.2    Osborne, C.K.3    Schiff, R.4
  • 6
    • 37249069903 scopus 로고    scopus 로고
    • Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response
    • Bayliss J., Hilger A., Vishnu P., Diehl K., El-Ashry D. Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response. Clinical Cancer Research 2007, 13:7029-7036.
    • (2007) Clinical Cancer Research , vol.13 , pp. 7029-7036
    • Bayliss, J.1    Hilger, A.2    Vishnu, P.3    Diehl, K.4    El-Ashry, D.5
  • 7
    • 84857756831 scopus 로고    scopus 로고
    • Membrane estrogen signaling enhances tumorigenesis and metastatic potential of breast cancer cells via estrogen receptor-alpha36 (ERalpha36)
    • Chaudhri R.A., Olivares-Navarrete R., Cuenca N., Hadadi A., Boyan B.D., Schwartz Z. Membrane estrogen signaling enhances tumorigenesis and metastatic potential of breast cancer cells via estrogen receptor-alpha36 (ERalpha36). The Journal of Biological Chemistry 2012, 287:7169-7181.
    • (2012) The Journal of Biological Chemistry , vol.287 , pp. 7169-7181
    • Chaudhri, R.A.1    Olivares-Navarrete, R.2    Cuenca, N.3    Hadadi, A.4    Boyan, B.D.5    Schwartz, Z.6
  • 9
    • 33645730357 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors
    • Creighton C.J., Hilger A.M., Murthy S., Rae J.M., Chinnaiyan A.M., El-Ashry D. Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors. Cancer Research 2006, 66:3903-3911.
    • (2006) Cancer Research , vol.66 , pp. 3903-3911
    • Creighton, C.J.1    Hilger, A.M.2    Murthy, S.3    Rae, J.M.4    Chinnaiyan, A.M.5    El-Ashry, D.6
  • 12
    • 33847023585 scopus 로고    scopus 로고
    • Long-term treatment with tamoxifen facilitates translocation of estrogen receptor alpha out of the nucleus and enhances its interaction with EGFR in MCF-7 breast cancer cells
    • Fan P., Wang J., Santen R.J., Yue W. Long-term treatment with tamoxifen facilitates translocation of estrogen receptor alpha out of the nucleus and enhances its interaction with EGFR in MCF-7 breast cancer cells. Cancer Research 2007, 67:1352-1360.
    • (2007) Cancer Research , vol.67 , pp. 1352-1360
    • Fan, P.1    Wang, J.2    Santen, R.J.3    Yue, W.4
  • 13
    • 0036127836 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
    • Filardo E.J. Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. The Journal of Steroid Biochemistry and Molecular Biology 2002, 80:231-238.
    • (2002) The Journal of Steroid Biochemistry and Molecular Biology , vol.80 , pp. 231-238
    • Filardo, E.J.1
  • 14
    • 48249132499 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells
    • Fox E.M., Bernaciak T.M., Wen J., Weaver A.M., Shupnik M.A., Silva C.M. Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells. Molecular Endocrinology 2008, 22:1781-1796.
    • (2008) Molecular Endocrinology , vol.22 , pp. 1781-1796
    • Fox, E.M.1    Bernaciak, T.M.2    Wen, J.3    Weaver, A.M.4    Shupnik, M.A.5    Silva, C.M.6
  • 16
    • 4344705051 scopus 로고    scopus 로고
    • Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: inhibition by gefitinib (Iressa', ZD1839)
    • Hiscox S., Morgan L., Barrow D., Dutkowski C., Wakeling A., Nicholson R.I. Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: inhibition by gefitinib (Iressa', ZD1839). Clinical and Experimental Metastasis 2004, 21:201-212.
    • (2004) Clinical and Experimental Metastasis , vol.21 , pp. 201-212
    • Hiscox, S.1    Morgan, L.2    Barrow, D.3    Dutkowski, C.4    Wakeling, A.5    Nicholson, R.I.6
  • 18
    • 2542454563 scopus 로고    scopus 로고
    • A cytoplasmic substrate of mitogen-activated protein kinase is responsible for estrogen receptor-alpha down-regulation in breast cancer cells: the role of nuclear factor-kappaB
    • Holloway J.N., Murthy S., El-Ashry D. A cytoplasmic substrate of mitogen-activated protein kinase is responsible for estrogen receptor-alpha down-regulation in breast cancer cells: the role of nuclear factor-kappaB. Molecular Endocrinology 2004, 18:1396-1410.
    • (2004) Molecular Endocrinology , vol.18 , pp. 1396-1410
    • Holloway, J.N.1    Murthy, S.2    El-Ashry, D.3
  • 21
    • 0029113686 scopus 로고
    • Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer
    • Johnston S., Saccani-Jotti G., Smith I., Salter J., Newby J., Coppen M., Ebbs S., Dowsett M. Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer. Cancer Research 1995, 55:3331-3338.
    • (1995) Cancer Research , vol.55 , pp. 3331-3338
    • Johnston, S.1    Saccani-Jotti, G.2    Smith, I.3    Salter, J.4    Newby, J.5    Coppen, M.6    Ebbs, S.7    Dowsett, M.8
  • 22
    • 0037429737 scopus 로고    scopus 로고
    • Epidermal growth factor receptor: mechanisms of activation and signalling
    • Jorissen R. Epidermal growth factor receptor: mechanisms of activation and signalling. Experimental Cell Research 2003, 284:31-53.
    • (2003) Experimental Cell Research , vol.284 , pp. 31-53
    • Jorissen, R.1
  • 23
    • 77950407928 scopus 로고    scopus 로고
    • Involvement of estrogen receptor variant ER-alpha36, not GPR30, in nongenomic estrogen signaling
    • Kang L., Zhang X., Xie Y., Tu Y., Wang D., Liu Z., Wang Z.Y. Involvement of estrogen receptor variant ER-alpha36, not GPR30, in nongenomic estrogen signaling. Molecular Endocrinology 2010, 24:709-721.
    • (2010) Molecular Endocrinology , vol.24 , pp. 709-721
    • Kang, L.1    Zhang, X.2    Xie, Y.3    Tu, Y.4    Wang, D.5    Liu, Z.6    Wang, Z.Y.7
  • 25
    • 0037373326 scopus 로고    scopus 로고
    • Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
    • Knowlden J.M., Hutcheson I.R., Jones H.E., Madden T., Gee J.M.W., Harper M.E., Barrow D., Wakeling A.E., Nicholson R.I. Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 2003, 144:1032-1044.
    • (2003) Endocrinology , vol.144 , pp. 1032-1044
    • Knowlden, J.M.1    Hutcheson, I.R.2    Jones, H.E.3    Madden, T.4    Gee, J.M.W.5    Harper, M.E.6    Barrow, D.7    Wakeling, A.E.8    Nicholson, R.I.9
  • 26
    • 0025651504 scopus 로고
    • Inverse relationship between estrogen receptor and epidermal growth factor receptor mRNA levels in human breast cancer cell lines
    • Lee C.S.L., Hall R.E., Alexander I.E., Koga M., Shine J., Sutherland R.L. Inverse relationship between estrogen receptor and epidermal growth factor receptor mRNA levels in human breast cancer cell lines. Growth Factors 1990, 3:97-103.
    • (1990) Growth Factors , vol.3 , pp. 97-103
    • Lee, C.S.L.1    Hall, R.E.2    Alexander, I.E.3    Koga, M.4    Shine, J.5    Sutherland, R.L.6
  • 27
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: an approach to drug development
    • Levitzki A., Gazit A. Tyrosine kinase inhibition: an approach to drug development. Science 1995, 267:1782.
    • (1995) Science , vol.267 , pp. 1782
    • Levitzki, A.1    Gazit, A.2
  • 29
    • 77749252827 scopus 로고    scopus 로고
    • ER-α36, a variant of ER-α, promotes tamoxifen agonist action in endometrial cancer cells via the MAPK/ERK and PI3K/Akt pathways
    • Lin S.L., Yan L.Y., Zhang X.T., Yuan J., Li M., Qiao J., Wang Z.Y., Sun Q.Y. ER-α36, a variant of ER-α, promotes tamoxifen agonist action in endometrial cancer cells via the MAPK/ERK and PI3K/Akt pathways. PloS One 2010, 5:e9013.
    • (2010) PloS One , vol.5
    • Lin, S.L.1    Yan, L.Y.2    Zhang, X.T.3    Yuan, J.4    Li, M.5    Qiao, J.6    Wang, Z.Y.7    Sun, Q.Y.8
  • 31
    • 33846869263 scopus 로고    scopus 로고
    • Resistance to endocrine therapy in breast cancer: exploiting estrogen receptor/growth factor signaling crosstalk
    • Massarweh S., Schiff R. Resistance to endocrine therapy in breast cancer: exploiting estrogen receptor/growth factor signaling crosstalk. Endocrine Related Cancer 2006, 13(Suppl. 1):S15-S24.
    • (2006) Endocrine Related Cancer , vol.13 , Issue.SUPPL. 1
    • Massarweh, S.1    Schiff, R.2
  • 32
    • 38849091433 scopus 로고    scopus 로고
    • Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function
    • Massarweh S., Osborne C.K., Creighton C.J., Qin L., Tsimelzon A., Huang S., Weiss H., Rimawi M., Schiff R. Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function. Cancer Research 2008, 68:826-833.
    • (2008) Cancer Research , vol.68 , pp. 826-833
    • Massarweh, S.1    Osborne, C.K.2    Creighton, C.J.3    Qin, L.4    Tsimelzon, A.5    Huang, S.6    Weiss, H.7    Rimawi, M.8    Schiff, R.9
  • 33
    • 0035423119 scopus 로고    scopus 로고
    • Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth
    • Oesterreich S., Zhang P., Guler R.L., Sun X., Curran E.M., Welshons W.V., Osborne C.K., Lee A.V. Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth. Cancer Research 2001, 61:5771-5777.
    • (2001) Cancer Research , vol.61 , pp. 5771-5777
    • Oesterreich, S.1    Zhang, P.2    Guler, R.L.3    Sun, X.4    Curran, E.M.5    Welshons, W.V.6    Osborne, C.K.7    Lee, A.V.8
  • 35
    • 79551576468 scopus 로고    scopus 로고
    • Mechanisms of endocrine resistance in breast cancer
    • Osborne C.K., Schiff R. Mechanisms of endocrine resistance in breast cancer. Annual Review of Medicine 2011, 62:233-247.
    • (2011) Annual Review of Medicine , vol.62 , pp. 233-247
    • Osborne, C.K.1    Schiff, R.2
  • 36
    • 58249105933 scopus 로고    scopus 로고
    • ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2
    • Pancholi S., Lykkesfeldt A.E., Hilmi C., Banerjee S., Leary A., Drury S., Johnston S., Dowsett M., Martin L.A. ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2. Endocrine Related Cancer 2008, 15:985-1002.
    • (2008) Endocrine Related Cancer , vol.15 , pp. 985-1002
    • Pancholi, S.1    Lykkesfeldt, A.E.2    Hilmi, C.3    Banerjee, S.4    Leary, A.5    Drury, S.6    Johnston, S.7    Dowsett, M.8    Martin, L.A.9
  • 38
    • 63649117164 scopus 로고    scopus 로고
    • Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells
    • Santen R.J., Fan P., Zhang Z., Bao Y., Song R.X.D., Yue W. Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells. Steroids 2009, 74:586-594.
    • (2009) Steroids , vol.74 , pp. 586-594
    • Santen, R.J.1    Fan, P.2    Zhang, Z.3    Bao, Y.4    Song, R.X.D.5    Yue, W.6
  • 40
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R., Ward E., Brawley O., Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer Journal of Clinicians 2011, 61:212-236.
    • (2011) CA Cancer Journal of Clinicians , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 42
    • 84860406451 scopus 로고    scopus 로고
    • Macrophage-elicited loss of estrogen receptor-alpha in breast cancer cells via involvement of MAPK and c-Jun at the ESR1 genomic locus
    • Stossi F., Madak-Erdogan Z., Katzenellenbogen B.S. Macrophage-elicited loss of estrogen receptor-alpha in breast cancer cells via involvement of MAPK and c-Jun at the ESR1 genomic locus. Oncogene 2012, 31:1825-1834.
    • (2012) Oncogene , vol.31 , pp. 1825-1834
    • Stossi, F.1    Madak-Erdogan, Z.2    Katzenellenbogen, B.S.3
  • 43
    • 78149476449 scopus 로고    scopus 로고
    • ER-α36, a novel variant of ER-α, mediates estrogen-stimulated proliferation of endometrial carcinoma cells via the PKCδ/ERK pathway
    • Tong J.S., Zhang Q.H., Wang Z.B., Li S., Yang C.R., Fu X.Q., Hou Y., Wang Z.Y., Sheng J., Sun Q.Y. ER-α36, a novel variant of ER-α, mediates estrogen-stimulated proliferation of endometrial carcinoma cells via the PKCδ/ERK pathway. PloS One 2010, 5:e15408.
    • (2010) PloS One , vol.5
    • Tong, J.S.1    Zhang, Q.H.2    Wang, Z.B.3    Li, S.4    Yang, C.R.5    Fu, X.Q.6    Hou, Y.7    Wang, Z.Y.8    Sheng, J.9    Sun, Q.Y.10
  • 44
    • 80052265968 scopus 로고    scopus 로고
    • ER-alpha36, a novel variant of estrogen receptor alpha, is involved in EGFR-related carcinogenesis in endometrial cancer
    • Tu B.B., Lin S.L., Yan L.Y., Wang Z.Y., Sun Q.Y., Qiao J. ER-alpha36, a novel variant of estrogen receptor alpha, is involved in EGFR-related carcinogenesis in endometrial cancer. American Journal of Obstetrics and Gynecology 2011, 205(227):e221-226.
    • (2011) American Journal of Obstetrics and Gynecology , vol.205 , Issue.227
    • Tu, B.B.1    Lin, S.L.2    Yan, L.Y.3    Wang, Z.Y.4    Sun, Q.Y.5    Qiao, J.6
  • 45
    • 0024514882 scopus 로고
    • Characterisation of a tamoxifen-resistant variant of the ZR-75-1 human breast cancer cell line (ZR-75-9a1) and ability of the resistant phenotype
    • Van den Berg H., Lynch M., Martin J., Nelson J., Dickson G., Crockard A. Characterisation of a tamoxifen-resistant variant of the ZR-75-1 human breast cancer cell line (ZR-75-9a1) and ability of the resistant phenotype. British Journal of Cancer 1989, 59:522.
    • (1989) British Journal of Cancer , vol.59 , pp. 522
    • Van den Berg, H.1    Lynch, M.2    Martin, J.3    Nelson, J.4    Dickson, G.5    Crockard, A.6
  • 46
    • 25644437706 scopus 로고    scopus 로고
    • Identification, cloning, and expression of human estrogen receptor-alpha36, a novel variant of human estrogen receptor-alpha66
    • Wang Z., Zhang X., Shen P., Loggie B.W., Chang Y., Deuel T.F. Identification, cloning, and expression of human estrogen receptor-alpha36, a novel variant of human estrogen receptor-alpha66. Biochemical and Biophysical Research Communications 2005, 336:1023-1027.
    • (2005) Biochemical and Biophysical Research Communications , vol.336 , pp. 1023-1027
    • Wang, Z.1    Zhang, X.2    Shen, P.3    Loggie, B.W.4    Chang, Y.5    Deuel, T.F.6
  • 47
    • 33745160700 scopus 로고    scopus 로고
    • A variant of estrogen receptor-{alpha}, hER-{alpha}36: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling
    • Wang Z., Zhang X., Shen P., Loggie B.W., Chang Y., Deuel T.F. A variant of estrogen receptor-{alpha}, hER-{alpha}36: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling. Proceedings of the National Academy of Sciences USA 2006, 103:9063-9068.
    • (2006) Proceedings of the National Academy of Sciences USA , vol.103 , pp. 9063-9068
    • Wang, Z.1    Zhang, X.2    Shen, P.3    Loggie, B.W.4    Chang, Y.5    Deuel, T.F.6
  • 48
    • 0030010812 scopus 로고    scopus 로고
    • Bimodal regulation of epidermal growth factor receptor by estrogen in breast cancer cells
    • Yarden R.I., Lauber A., El-Ashry D., Chrysogelos S. Bimodal regulation of epidermal growth factor receptor by estrogen in breast cancer cells. Endocrinology 1996, 137:2739-2747.
    • (1996) Endocrinology , vol.137 , pp. 2739-2747
    • Yarden, R.I.1    Lauber, A.2    El-Ashry, D.3    Chrysogelos, S.4
  • 49
    • 0035036735 scopus 로고    scopus 로고
    • Estrogen suppression of EGFR expression in breast cancer cells: a possible mechanism to modulate growth
    • Yarden R.I., Wilson M.A., Chrysogelos S.A. Estrogen suppression of EGFR expression in breast cancer cells: a possible mechanism to modulate growth. Journal of Cellular Biochemistry 2001, 81:232-246.
    • (2001) Journal of Cellular Biochemistry , vol.81 , pp. 232-246
    • Yarden, R.I.1    Wilson, M.A.2    Chrysogelos, S.A.3
  • 50
    • 70249145117 scopus 로고    scopus 로고
    • EGFRvIII-induced estrogen-independence, tamoxifen-resistance phenotype correlates with PgR expression and modulation of apoptotic molecules in breast cancer
    • Zhang Y., Su H., Rahimi M., Tochihara R., Tang C. EGFRvIII-induced estrogen-independence, tamoxifen-resistance phenotype correlates with PgR expression and modulation of apoptotic molecules in breast cancer. International Journal of Cancer 2009, 125:2021-2028.
    • (2009) International Journal of Cancer , vol.125 , pp. 2021-2028
    • Zhang, Y.1    Su, H.2    Rahimi, M.3    Tochihara, R.4    Tang, C.5
  • 51
    • 79951809981 scopus 로고    scopus 로고
    • A positive feedback loop of ER-alpha36/EGFR promotes malignant growth of ER-negative breast cancer cells
    • Zhang X.T., Kang L.G., Ding L., Vranic S., Gatalica Z., Wang Z.Y. A positive feedback loop of ER-alpha36/EGFR promotes malignant growth of ER-negative breast cancer cells. Oncogene 2011, 30:770-780.
    • (2011) Oncogene , vol.30 , pp. 770-780
    • Zhang, X.T.1    Kang, L.G.2    Ding, L.3    Vranic, S.4    Gatalica, Z.5    Wang, Z.Y.6
  • 53
    • 84856024073 scopus 로고    scopus 로고
    • Estrogen receptor-alpha 36 mediates mitogenic antiestrogen signaling in ER-negative breast cancer cells
    • Zhang X., Ding L., Kang L., Wang Z.Y. Estrogen receptor-alpha 36 mediates mitogenic antiestrogen signaling in ER-negative breast cancer cells. PLoS One 2012, 7:e30174.
    • (2012) PLoS One , vol.7
    • Zhang, X.1    Ding, L.2    Kang, L.3    Wang, Z.Y.4
  • 55
    • 0035839317 scopus 로고    scopus 로고
    • EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells
    • Zhu X.F., Liu Z.C., Xie B.F., Li Z.M., Feng G.K., Yang D., Zeng Y.X. EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells. Cancer Letters 2001, 169:27-32.
    • (2001) Cancer Letters , vol.169 , pp. 27-32
    • Zhu, X.F.1    Liu, Z.C.2    Xie, B.F.3    Li, Z.M.4    Feng, G.K.5    Yang, D.6    Zeng, Y.X.7
  • 56
    • 64049115275 scopus 로고    scopus 로고
    • Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36
    • Zou Y., Ding L., Coleman M., Wang Z. Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36. FEBS Letters 2009, 583:1368-1374.
    • (2009) FEBS Letters , vol.583 , pp. 1368-1374
    • Zou, Y.1    Ding, L.2    Coleman, M.3    Wang, Z.4


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