The Gut Microbiota: The Gateway to Improved Metabolism

Gastroenterology Clinics of North America

Volumn 45, Issue 4, 2016, Pages 601-614

  Martinez, Kristina B ^a   Pierre, Joseph F ^a   Chang, Eugene B ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Bariatric surgery; Enteroendocrine hormones; Lipid absorption; Metabolism; Microbiota; Prebiotics; Probiotics; Synbiotics

Indexed keywords

MICROBIAL PRODUCTS NOT CLASSIFIED ELSEWHERE; POSTBIOTIC AGENT; PREBIOTIC AGENT; PROBIOTIC AGENT; UNCLASSIFIED DRUG;

BARIATRIC SURGERY; COMORBIDITY; DIET; DISEASE ASSOCIATION; FECAL MICROBIOTA TRANSPLANTATION; HOST MICROBE INTERACTION; HUMAN; INTESTINE FLORA; METABOLIC PARAMETERS; METABOLIC REGULATION; METABOLISM; METABOLOMICS; METAGENOMICS; MICROBIAL COMMUNITY; MORBID OBESITY; NONHUMAN; OBESITY; ORGANISMAL INTERACTION; REVIEW; MICROBIOLOGY; PHYSIOLOGY; RISK FACTOR;

BARIATRIC SURGERY; DIET; FECAL MICROBIOTA TRANSPLANTATION; GASTROINTESTINAL MICROBIOME; HUMANS; OBESITY; PREBIOTICS; PROBIOTICS; RISK FACTORS;

EID: 84995489045     PISSN: 08898553     EISSN: 15581942     Source Type: Journal    
DOI: 10.1016/j.gtc.2016.07.001     Document Type: Review

References (75)

1. 1 Flegal, K.M., Epidemiologic aspects of overweight and obesity in the United States. Physiol Behav 86:5 (2005), 599-602.
2. 2 Sturm, R., Hattori, A., Morbid obesity rates continue to rise rapidly in the United States. Int J Obes (Lond) 37:6 (2013), 889-891.
3. 3 Bray, G.A., Obesity: a time bomb to be defused. Lancet 352:9123 (1998), 160-161.
4. 4 de Onis, M., Blossner, M., Borghi, E., Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr 92:5 (2010), 1257-1264.
5. 5 Ogden, C.L., Carroll, M.D., Curtin, L.R., et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 295:13 (2006), 1549-1555.
6. 6 Turnbaugh, P.J., Ridaura, V.K., Faith, J.J., et al. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med, 1(6), 2009, 6ra14.
7. 7 Liou, A.P., Paziuk, M., Luevano, J.-M., et al. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci Transl Med, 5(178), 2013, 178ra41.
8. 8 Amar, J., Serino, M., Lange, C., et al. Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept. Diabetologia 54:12 (2011), 3055-3061.
9. 9 Ley, R.E., Bäckhed, F., Turnbaugh, P., et al. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 102:31 (2005), 11070-11075.
10. 10 Shen, W., Gaskins, H.R., McIntosh, M.K., Influence of dietary fat on intestinal microbes, inflammation, barrier function and metabolic outcomes. J Nutr Biochem 25:3 (2014), 270-280.
11. 11 Ley, R.E., Turnbaugh, P.J., Klein, S., et al. Microbial ecology: human gut microbes associated with obesity. Nature 444:7122 (2006), 1022-1023.
12. 12 Gill, S.R., Pop, M., Deboy, R.T., et al. Metagenomic analysis of the human distal gut microbiome. Science 312:5778 (2006), 1355-1359.
13. 13 Ojeda, P., Bobe, A., Dolan, K., et al. Nutritional modulation of gut microbiota - the impact on metabolic disease pathophysiology. J Nutr Biochem 28 (2016), 191-200.
14. 14 Hoffmann, C., Dollive, S., Grunberg, S., et al. Archaea and fungi of the human gut microbiome: correlations with diet and bacterial residents. PLoS One, 8(6), 2013, e66019.
15. 15 Borgo, F., Verduci, E., Riva, A., et al. Relative abundance in bacterial and fungal gut microbes in obese children: a case control study. Child Obes, 2016 [Epub ahead of print].
16. 16 de Araújo, T.V., Andrade, E.F., Lobato, R.V., et al. Effects of beta-glucans ingestion (Saccharomyces cerevisiae) on metabolism of rats receiving high-fat diet. J Anim Physiol Anim Nutr (Berl), 2016, 10.1111/jpn.12452.
17. 17 Everard, A., Matamoros, S., Geurts, L., et al. Saccharomyces boulardii administration changes gut microbiota and reduces hepatic steatosis, low-grade inflammation, and fat mass in obese and type 2 diabetic db/db mice. MBio 5:3 (2014), e01011-e01014.
18. 18 Schneeberger, M., Everard, A., Gómez-Valadés, A.G., et al. Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice. Sci Rep, 5, 2015, 16643.
19. 19 Everard, A., Belzer, C., Geurts, L., et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A 110:22 (2013), 9066-9071.
20. 20 Devkota, S., Wang, Y., Musch, M.W., et al. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature 487:7405 (2012), 104-108.
21. 21 Subramanian, S., Huq, S., Yatsunenko, T., et al. Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature 510:7505 (2014), 417-421.
22. 22 David, L.A., Maurice, C.F., Carmody, R.N., et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505:7484 (2014), 559-563.
23. 23 Carmody, R.N., Gerber, G.K., Luevano, J.M. Jr., et al. Diet dominates host genotype in shaping the murine gut microbiota. Cell Host Microbe 17:1 (2015), 72-84.
24. 24 Sonnenburg, E.D., Smits, S.A., Tikhonov, M., et al. Diet-induced extinctions in the gut microbiota compound over generations. Nature 529:7585 (2016), 212-215.
25. 25 Howe, A., Ringus, D.L., Williams, R.J., et al. Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice. ISME J 10:5 (2016), 1217-1227.
26. 26 Tadross, J.A., le Roux, C.W., The mechanisms of weight loss after bariatric surgery. Int J Obes (Lond) 33:Suppl 1 (2009), S28-S32.
27. 27 Islam, K.B., Fukiya, S., Hagio, M., et al. Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology 141:5 (2011), 1773-1781.
28. 28 Begley, M., Gahan, C.G., Hill, C., The interaction between bacteria and bile. FEMS Microbiol Rev 29:4 (2005), 625-651.
29. 29 Kashyap, S.R., Daud, S., Kelly, K.R., et al. Acute effects of gastric bypass versus gastric restrictive surgery on beta-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes. Int J Obes (Lond) 34:3 (2010), 462-471.
30. 30 Yan, M., Song, M.M., Bai, R.X., et al. Effect of Roux-en-Y gastric bypass surgery on intestinal Akkermansia muciniphila. World J Gastrointest Surg 8:4 (2016), 301-307.
31. 31 Furet, J.P., Kong, L.C., Tap, J., et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes 59:12 (2010), 3049-3057.
32. 32 Zhang, H., DiBaise, J.K., Zuccolo, A., et al. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci U S A 106:7 (2009), 2365-2370.
33. 33 Carvalho, B.M., Guadagnini, D., Tsukumo, D.M., et al. Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice. Diabetologia 55:10 (2012), 2823-2834.
34. 34 Everard, A., Lazarevic, V., Gaïa, N., et al. Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity. ISME J 8:10 (2014), 2116-2130.
35. 35 Baptissart, M., Vega, A., Maqdasy, S., et al. Bile acids: from digestion to cancers. Biochimie 95:3 (2013), 504-517.
36. 36 Watanabe, M., Houten, S.M., Mataki, C., et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439:7075 (2006), 484-489.
37. 37 Swann, J.R., Want, E.J., Geier, F.M., et al. Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc Natl Acad Sci U S A 108:Suppl 1 (2011), 4523-4530.
38. 38 Inagaki, T., Moschetta, A., Lee, Y.K., et al. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A 103:10 (2006), 3920-3925.
39. 39 Palazzo, M., Balsari, A., Rossini, A., et al. Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion. J Immunol 178:7 (2007), 4296-4303 Available at: http://www.ncbi.nlm.nih.gov/pubmed/17371986 Accessed May 26, 2016.
40. 40 Dirksen, C., Jørgensen, N.B., Bojsen-Møller, K.N., et al. Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. Int J Obes (Lond) 37:11 (2013), 1452-1459.
41. 41 le Roux, C.W., Borg, C., Wallis, K., et al. Gut hypertrophy after gastric bypass is associated with increased glucagon-like peptide 2 and intestinal crypt cell proliferation. Ann Surg 252:1 (2010), 50-56.
42. 42 Batterham, R.L., Cowley, M.A., Small, C.J., et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418:6898 (2002), 650-654.
43. 43 Semova, I., Carten, J.D., Stombaugh, J., et al. Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish. Cell Host Microbe 12:3 (2012), 277-288.
44. 44 Leone, V., Gibbons, S.M., Martinez, K., et al. Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell Host Microbe 17:5 (2015), 681-689.
45. 45 Schwiertz, A., Taras, D., Schäfer, K., et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity 18:1 (2010), 190-195.
46. 46 De Vadder, F., Kovatcheva-Datchary, P., Goncalves, D., et al. Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell 156:1-2 (2014), 84-96.
47. 47 Karlsson, F.H., Tremaroli, V., Nookaew, I., et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498:7452 (2013), 99-103.
48. 48 Karastergiou, K., Fried, S.K., Xie, H., et al. Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots. J Clin Endocrinol Metab 98:1 (2013), 362-371.
49. 49 Cani, P.D., Delzenne, N.M., Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care 10:6 (2007), 729-734.
50. 50 Caesar, R., Tremaroli, V., Kovatcheva-Datchary, P., et al. Crosstalk between gut microbiota and dietary lipids aggravates wat inflammation through TLR signaling. Cell Metab 22:4 (2015), 658-668.
51. 51 Anhê, F.F., Roy, D., Pilon, G., et al. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut 64:6 (2015), 872-883.
52. 52 Collins, B., Hoffman, J., Martinez, K., et al. A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice. J Nutr Biochem 31 (2016), 150-165.
53. 53 Swartz, T.D., Duca, F.A., de Wouters, T., et al. Up-regulation of intestinal type 1 taste receptor 3 and sodium glucose luminal transporter-1 expression and increased sucrose intake in mice lacking gut microbiota. Br J Nutr 107:5 (2012), 621-630.
54. 54 Duca, F.A., Swartz, T.D., Sakar, Y., et al. Increased oral detection, but decreased intestinal signaling for fats in mice lacking gut microbiota. PLoS One, 7(6), 2012, e39748.
55. 55 Wichmann, A., Allahyar, A., Greiner, T.U., et al. Microbial modulation of energy availability in the colon regulates intestinal transit. Cell Host Microbe 14:5 (2013), 582-590.
56. 56 Rabot, S., Membrez, M., Bruneau, A., et al. Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism. FASEB J 24:12 (2010), 4948-4959.
57. 57 Sayin, S.I., Wahlström, A., Felin, J., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 17:2 (2013), 225-235.
58. 58 Björkholm, B., Bok, C.M., Lundin, A., et al. Intestinal microbiota regulate xenobiotic metabolism in the liver. PLoS One, 4(9), 2009, e6958.
59. 59 Gao, J., He, J., Zhai, Y., et al. The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity. J Biol Chem 284:38 (2009), 25984-25992.
60. 60 Dong, B., Saha, P.K., Huang, W., et al. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A 106:44 (2009), 18831-18836.
61. 61 Moore, D.D., Physiology: a metabolic minuet. Nature 502:7472 (2013), 454-455.
62. 62 Kohsaka, A., Laposky, A.D., Ramsey, K.M., et al. High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab 6:5 (2007), 414-421.
63. 63 Mukherji, A., Kobiita, A., Ye, T., et al. Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs. Cell 153:4 (2013), 812-827.
64. 64 Mennigen, R., Nolte, K., Rijcken, E., et al. Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol 296:5 (2009), G1140-G1149.
65. 65 Wang, J., Tang, H., Zhang, C., et al. Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. ISME J 9:1 (2015), 1-15.
66. 66 Nilsson, A., Johansson, E., Ekström, L., et al. Effects of a brown beans evening meal on metabolic risk markers and appetite regulating hormones at a subsequent standardized breakfast: a randomized cross-over study. PLoS One, 8(4), 2013, e59985.
67. 67 Xiao, S., Fei, N., Pang, X., et al. A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome. FEMS Microbiol Ecol 87:2 (2014), 357-367.
68. 68 Ettinger, G., MacDonald, K., Reid, G., et al. The influence of the human microbiome and probiotics on cardiovascular health. Gut Microbes 5:6 (2014), 719-728.
69. 69 Alisi, A., Bedogni, G., Baviera, G., et al. Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non-alcoholic steatohepatitis. Aliment Pharmacol Ther 39:11 (2014), 1276-1285.
70. 70 Dhiman, R.K., Rana, B., Agrawal, S., et al. Probiotic VSL#3 reduces liver disease severity and hospitalization in patients with cirrhosis: a randomized, controlled trial. Gastroenterology 147:6 (2014), 1327-1337.e3.
71. 71 Bakken, J.S., Fecal bacteriotherapy for recurrent Clostridium difficile infection. Anaerobe 15:6 (2009), 285-289.
72. 72 Tremaroli, V., Karlsson, F., Werling, M., et al. Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation. Cell Metab 22:2 (2015), 228-238.
73. 73 Vrieze, A., Van Nood, E., Holleman, F., et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143:4 (2012), 913-916.e7.
74. 74 Bakken, J.S., Borody, T., Brandt, L.J., et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol 9:12 (2011), 1044-1049.
75. 75 Tsilingiri, K., Barbosa, T., Penna, G., et al. Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model. Gut 61:7 (2012), 1007-1015.