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Volumn 147, Issue 6, 2014, Pages 1327-1337.e3

Probiotic VSL#3 reduces liver disease severity and hospitalization in patients with cirrhosis: A randomized, controlled trial

Author keywords

CTP; Gut Microbiome; Inflammation; MELD

Indexed keywords

ALDOSTERONE; AMMONIA; CREATININE; INDOLE; INTERLEUKIN 1BETA; INTERLEUKIN 6; PLACEBO; RENIN; TUMOR NECROSIS FACTOR ALPHA; UREA; VSL3; BIOLOGICAL MARKER; PROBIOTIC AGENT;

EID: 84913553798     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.08.031     Document Type: Article
Times cited : (278)

References (40)
  • 1
    • 0033034892 scopus 로고    scopus 로고
    • Prognostic significance of hepatic encephalopathy in patients with cirrhosis
    • J. Bustamante, A. Rimola, and P.J. Ventura Prognostic significance of hepatic encephalopathy in patients with cirrhosis J Hepatol 30 1999 890 895
    • (1999) J Hepatol , vol.30 , pp. 890-895
    • Bustamante, J.1    Rimola, A.2    Ventura, P.J.3
  • 2
    • 35449004862 scopus 로고    scopus 로고
    • Hepatic encephalopathy as a predictor of survival in patients with end-stage liver disease
    • C.A. Stewart, M. Malinchoc, and W.R. Kim Hepatic encephalopathy as a predictor of survival in patients with end-stage liver disease Liver Transpl 13 2007 1366 1371
    • (2007) Liver Transpl , vol.13 , pp. 1366-1371
    • Stewart, C.A.1    Malinchoc, M.2    Kim, W.R.3
  • 3
    • 33846446011 scopus 로고    scopus 로고
    • Review article: The burden of hepatic encephalopathy
    • F.F. Poordad Review article: the burden of hepatic encephalopathy Aliment Pharmacol Ther 25 Suppl 1 2007 3 9
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 3-9
    • Poordad, F.F.1
  • 4
    • 0043202662 scopus 로고    scopus 로고
    • Influence of hepatic encephalopathy on health-related quality of life in patients with cirrhosis
    • M.R. Arguedas, T.G. DeLawrence, and B.M. McGuire Influence of hepatic encephalopathy on health-related quality of life in patients with cirrhosis Dig Dis Sci 48 2003 1622 1626
    • (2003) Dig Dis Sci , vol.48 , pp. 1622-1626
    • Arguedas, M.R.1    Delawrence, T.G.2    McGuire, B.M.3
  • 5
    • 77951730306 scopus 로고    scopus 로고
    • Factors affecting compliance and persistence with treatment for hepatic encephalopathy
    • G. Neff Factors affecting compliance and persistence with treatment for hepatic encephalopathy Pharmacotherapy 30 2010 22S 27S
    • (2010) Pharmacotherapy , vol.30 , pp. 22S-27S
    • Neff, G.1
  • 6
    • 77950246404 scopus 로고    scopus 로고
    • Rifaximin treatment in hepatic encephalopathy
    • N.M. Bass, K.D. Mullen, and A. Sanyal Rifaximin treatment in hepatic encephalopathy N Engl J Med 362 2010 1071 1081
    • (2010) N Engl J Med , vol.362 , pp. 1071-1081
    • Bass, N.M.1    Mullen, K.D.2    Sanyal, A.3
  • 7
    • 69249166158 scopus 로고    scopus 로고
    • Secondary prophylaxis of hepatic encephalopathy: An open-label randomized controlled trial of lactulose versus placebo
    • 891 e1
    • B.C. Sharma, P. Sharma, and A. Agrawal Secondary prophylaxis of hepatic encephalopathy: an open-label randomized controlled trial of lactulose versus placebo Gastroenterology 137 2009 885 891 891 e1
    • (2009) Gastroenterology , vol.137 , pp. 885-891
    • Sharma, B.C.1    Sharma, P.2    Agrawal, A.3
  • 8
    • 84878012874 scopus 로고    scopus 로고
    • Gut microbiota and hepatic encephalopathy
    • R.K. Dhiman Gut microbiota and hepatic encephalopathy Metab Brain Dis 28 2013 321 326
    • (2013) Metab Brain Dis , vol.28 , pp. 321-326
    • Dhiman, R.K.1
  • 10
    • 79952695979 scopus 로고    scopus 로고
    • Infection and systemic inflammation, not ammonia, are associated with grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis
    • D.L. Shawcross, Y. Sharifi, and J.B. Canavan Infection and systemic inflammation, not ammonia, are associated with grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis J Hepatol 54 2011 640 649
    • (2011) J Hepatol , vol.54 , pp. 640-649
    • Shawcross, D.L.1    Sharifi, Y.2    Canavan, J.B.3
  • 11
    • 1642491776 scopus 로고    scopus 로고
    • Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis
    • D.L. Shawcross, N.A. Davies, and R. Williams Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis J Hepatol 40 2004 247 254
    • (2004) J Hepatol , vol.40 , pp. 247-254
    • Shawcross, D.L.1    Davies, N.A.2    Williams, R.3
  • 12
    • 2342580955 scopus 로고    scopus 로고
    • Synbiotic modulation of gut flora: Effect on minimal hepatic encephalopathy in patients with cirrhosis
    • Q. Liu, Z.P. Duan, and D.K. Ha Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis Hepatology 39 2004 1441 1449
    • (2004) Hepatology , vol.39 , pp. 1441-1449
    • Liu, Q.1    Duan, Z.P.2    Ha, D.K.3
  • 13
    • 33646011734 scopus 로고    scopus 로고
    • Effect of administration of Escherichia coli Nissle (Mutaflor) on intestinal colonisation, endo-toxemia, liver function and minimal hepatic encephalopathy in patients with liver cirrhosis
    • J. Lata, J. Jurankova, and V. Pribramska [Effect of administration of Escherichia coli Nissle (Mutaflor) on intestinal colonisation, endo-toxemia, liver function and minimal hepatic encephalopathy in patients with liver cirrhosis] Vnitr Lek 52 2006 215 219
    • (2006) Vnitr Lek , vol.52 , pp. 215-219
    • Lata, J.1    Jurankova, J.2    Pribramska, V.3
  • 14
    • 50649088399 scopus 로고    scopus 로고
    • Probiotic yogurt for the treatment of minimal hepatic encephalopathy
    • J.S. Bajaj, K. Saeian, and K.M. Christensen Probiotic yogurt for the treatment of minimal hepatic encephalopathy Am J Gastroenterol 103 2008 1707 1715
    • (2008) Am J Gastroenterol , vol.103 , pp. 1707-1715
    • Bajaj, J.S.1    Saeian, K.2    Christensen, K.M.3
  • 15
    • 84860810938 scopus 로고    scopus 로고
    • Probiotics for patients with hepatic encephalopathy
    • R.G. McGee, A. Bakens, and K. Wiley Probiotics for patients with hepatic encephalopathy Cochrane Database Syst Rev 11 2011 CD008716
    • (2011) Cochrane Database Syst Rev , vol.11 , pp. 008716
    • McGee, R.G.1    Bakens, A.2    Wiley, K.3
  • 16
    • 0036191173 scopus 로고    scopus 로고
    • Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: Final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998
    • P. Ferenci, A. Lockwood, and K. Mullen Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998 Hepatology 35 2002 716 721
    • (2002) Hepatology , vol.35 , pp. 716-721
    • Ferenci, P.1    Lockwood, A.2    Mullen, K.3
  • 17
    • 83455181716 scopus 로고    scopus 로고
    • Pathogenesis, diagnosis, and treatment of hepatic encephalopathy
    • D.K. Atluri, R. Prakash, and K. Mullen Pathogenesis, diagnosis, and treatment of hepatic encephalopathy J Clin Exp Hepatol 1 2011 77 86
    • (2011) J Clin Exp Hepatol , vol.1 , pp. 77-86
    • Atluri, D.K.1    Prakash, R.2    Mullen, K.3
  • 18
    • 84879601583 scopus 로고    scopus 로고
    • The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus
    • P. Amodio, C. Bemeur, and R. Butterworth The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus Hepatology 58 2013 325 336
    • (2013) Hepatology , vol.58 , pp. 325-336
    • Amodio, P.1    Bemeur, C.2    Butterworth, R.3
  • 19
    • 77954426505 scopus 로고    scopus 로고
    • Diagnosis and prognostic significance of minimal hepatic encephalopathy in patients with cirrhosis of liver
    • R.K. Dhiman, R. Kurmi, and K.K. Thumburu Diagnosis and prognostic significance of minimal hepatic encephalopathy in patients with cirrhosis of liver Dig Dis Sci 55 2010 2381 2390
    • (2010) Dig Dis Sci , vol.55 , pp. 2381-2390
    • Dhiman, R.K.1    Kurmi, R.2    Thumburu, K.K.3
  • 20
    • 0028901141 scopus 로고
    • Figure connection test: A universal test for assessment of mental state
    • R.K. Dhiman, V.A. Saraswat, and M. Verma Figure connection test: a universal test for assessment of mental state J Gastroenterol Hepatol 10 1995 14 23
    • (1995) J Gastroenterol Hepatol , vol.10 , pp. 14-23
    • Dhiman, R.K.1    Saraswat, V.A.2    Verma, M.3
  • 21
    • 84878016122 scopus 로고    scopus 로고
    • Correlation between degree and quality of sleep disturbance and the level of neuropsychiatric impairment in patients with liver cirrhosis
    • J. Samanta, R.K. Dhiman, and A. Khatri Correlation between degree and quality of sleep disturbance and the level of neuropsychiatric impairment in patients with liver cirrhosis Metab Brain Dis 28 2013 249 259
    • (2013) Metab Brain Dis , vol.28 , pp. 249-259
    • Samanta, J.1    Dhiman, R.K.2    Khatri, A.3
  • 22
    • 0024389366 scopus 로고
    • The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research
    • D.J. Buysse, C.F. Reynolds 3rd, and T.H. Monk The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research Psychiatry Res 28 1989 193 213
    • (1989) Psychiatry Res , vol.28 , pp. 193-213
    • Buysse, D.J.1    Reynolds, C.F.2    Monk, T.H.3
  • 23
    • 0026333617 scopus 로고
    • A new method for measuring daytime sleepiness: The Epworth sleepiness scale
    • M.W. Johns A new method for measuring daytime sleepiness: the Epworth sleepiness scale Sleep 14 1991 540 545
    • (1991) Sleep , vol.14 , pp. 540-545
    • Johns, M.W.1
  • 25
    • 0023801160 scopus 로고
    • Serum indole and skatole in patients with various liver diseases
    • Y. Suyama, and C. Hirayama Serum indole and skatole in patients with various liver diseases Clin Chim Acta 176 1988 203 206
    • (1988) Clin Chim Acta , vol.176 , pp. 203-206
    • Suyama, Y.1    Hirayama, C.2
  • 26
    • 68949093815 scopus 로고    scopus 로고
    • Management of adult patients with ascites due to cirrhosis: An update
    • B.A. Runyon Management of adult patients with ascites due to cirrhosis: an update Hepatology 49 2009 2087 2107
    • (2009) Hepatology , vol.49 , pp. 2087-2107
    • Runyon, B.A.1
  • 27
    • 34548802928 scopus 로고    scopus 로고
    • Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis
    • G. Garcia-Tsao, A.J. Sanyal, and N.D. Grace Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis Hepatology 46 2007 922 938
    • (2007) Hepatology , vol.46 , pp. 922-938
    • Garcia-Tsao, G.1    Sanyal, A.J.2    Grace, N.D.3
  • 28
    • 77951485993 scopus 로고    scopus 로고
    • Clinical course of alcoholic liver cirrhosis: A Danish population-based cohort study
    • P. Jepsen, P. Ott, and P.K. Andersen Clinical course of alcoholic liver cirrhosis: a Danish population-based cohort study Hepatology 51 2010 1675 1682
    • (2010) Hepatology , vol.51 , pp. 1675-1682
    • Jepsen, P.1    Ott, P.2    Andersen, P.K.3
  • 29
    • 84863722812 scopus 로고    scopus 로고
    • Secondary prophylaxis of hepatic encephalopathy in cirrhosis: An open-label, randomized controlled trial of lactulose, probiotics, and no therapy
    • A. Agrawal, B.C. Sharma, and P. Sharma Secondary prophylaxis of hepatic encephalopathy in cirrhosis: an open-label, randomized controlled trial of lactulose, probiotics, and no therapy Am J Gastroenterol 107 2012 1043 1050
    • (2012) Am J Gastroenterol , vol.107 , pp. 1043-1050
    • Agrawal, A.1    Sharma, B.C.2    Sharma, P.3
  • 30
    • 2342487336 scopus 로고    scopus 로고
    • Non-absorbable disaccharides for hepatic encephalopathy: Systematic review of randomised trials
    • B. Als-Nielsen, L.L. Gluud, and C. Gluud Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trials BMJ 328 2004 1046
    • (2004) BMJ , vol.328 , pp. 1046
    • Als-Nielsen, B.1    Gluud, L.L.2    Gluud, C.3
  • 31
    • 33645082248 scopus 로고    scopus 로고
    • Effect of lactulose and Saccharomyces boulardii administration on the colonic urea-nitrogen metabolism and the bifidobacteria concentration in healthy human subjects
    • V. De Preter, T. Vanhoutte, and G. Huys Effect of lactulose and Saccharomyces boulardii administration on the colonic urea-nitrogen metabolism and the bifidobacteria concentration in healthy human subjects Aliment Pharmacol Ther 23 2006 963 974
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 963-974
    • De Preter, V.1    Vanhoutte, T.2    Huys, G.3
  • 32
    • 79959861780 scopus 로고    scopus 로고
    • Gut microbiota and inflammation
    • A. Hakansson, and G. Molin Gut microbiota and inflammation Nutrients 3 2011 637 682
    • (2011) Nutrients , vol.3 , pp. 637-682
    • Hakansson, A.1    Molin, G.2
  • 33
    • 77957345947 scopus 로고    scopus 로고
    • Role of small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhotic patients with minimal hepatic encephalopathy
    • A. Gupta, R.K. Dhiman, and S. Kumari Role of small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhotic patients with minimal hepatic encephalopathy J Hepatol 53 2010 849 855
    • (2010) J Hepatol , vol.53 , pp. 849-855
    • Gupta, A.1    Dhiman, R.K.2    Kumari, S.3
  • 34
    • 84873406452 scopus 로고    scopus 로고
    • Systemic inflammation and ammonia in hepatic encephalopathy
    • T.H. Tranah, G.K. Vijay, and J.M. Ryan Systemic inflammation and ammonia in hepatic encephalopathy Metab Brain Dis 28 2013 1 5
    • (2013) Metab Brain Dis , vol.28 , pp. 1-5
    • Tranah, T.H.1    Vijay, G.K.2    Ryan, J.M.3
  • 35
    • 84864336737 scopus 로고    scopus 로고
    • Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism
    • D. Corridoni, L. Pastorelli, and B. Mattioli Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism PLoS One 7 2012 e42067
    • (2012) PLoS One , vol.7 , pp. 42067
    • Corridoni, D.1    Pastorelli, L.2    Mattioli, B.3
  • 36
    • 76249094155 scopus 로고    scopus 로고
    • Probiotics promote gut health through stimulation of epithelial innate immunity
    • C. Pagnini, R. Saeed, and G. Bamias Probiotics promote gut health through stimulation of epithelial innate immunity Proc Natl Acad Sci U S A 107 2010 454 459
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 454-459
    • Pagnini, C.1    Saeed, R.2    Bamias, G.3
  • 37
    • 84899046306 scopus 로고    scopus 로고
    • Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis
    • J.S. Bajaj, D.M. Heuman, and P.B. Hylemon Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis Aliment Pharmacol Ther 39 2014 1113 1125
    • (2014) Aliment Pharmacol Ther , vol.39 , pp. 1113-1125
    • Bajaj, J.S.1    Heuman, D.M.2    Hylemon, P.B.3
  • 38
    • 0141757412 scopus 로고    scopus 로고
    • Increased circulating pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP) in patients with cirrhosis: Relation to cardiovascular dysfunction and severity of disease
    • J.H. Henriksen, J.P. Gotze, and S. Fuglsang Increased circulating pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP) in patients with cirrhosis: relation to cardiovascular dysfunction and severity of disease Gut 52 2003 1511 1517
    • (2003) Gut , vol.52 , pp. 1511-1517
    • Henriksen, J.H.1    Gotze, J.P.2    Fuglsang, S.3
  • 39
    • 64949118102 scopus 로고    scopus 로고
    • Brain natriuretic peptide in decompensation of liver cirrhosis in non-cardiac patients
    • M. Radvan, P. Svoboda, and J. Radvanova Brain natriuretic peptide in decompensation of liver cirrhosis in non-cardiac patients Hepatogastroenterology 56 2009 181 185
    • (2009) Hepatogastroenterology , vol.56 , pp. 181-185
    • Radvan, M.1    Svoboda, P.2    Radvanova, J.3
  • 40
    • 84881542388 scopus 로고    scopus 로고
    • Effects of the adjunctive probiotic VSL#3 on portal haemodynamics in patients with cirrhosis and large varices: A randomized trial
    • N. Gupta, A. Kumar, and P. Sharma Effects of the adjunctive probiotic VSL#3 on portal haemodynamics in patients with cirrhosis and large varices: a randomized trial Liver Int 33 2013 1148 1157
    • (2013) Liver Int , vol.33 , pp. 1148-1157
    • Gupta, N.1    Kumar, A.2    Sharma, P.3


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