Activation of GLP-1 receptor enhances neuronal base excision repair via PI3K-AKT-induced expression of apurinic/apyrimidinic endonuclease 1

Theranostics

Volumn 6, Issue 12, 2016, Pages 2015-2027

  Yang, Jenq Lin ^a   Chen, Wei Yu ^a   Chen, Yin Ping ^a   Kuo, Chao Ying ^a   Chen, Shang Der ^a,b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Apurinic apyrimidinic endonuclease 1 (APE1); Base excision repair (BER); Exendin 4; Glucagon like peptide 1(GLP 1); Oxidative DNA damage

Indexed keywords

APURINIC APYRIMIDINIC ENDONUCLEASE 1; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEOXYRIBONUCLEASE I; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; APEX1 PROTEIN, RAT; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; MENADIONE; MUTAGENIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN ISCHEMIA; CONTROLLED STUDY; DISEASE ACTIVITY; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EXCISION REPAIR; MALE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL CULTURE; DNA REPAIR; DRUG EFFECTS; METABOLISM; NERVE CELL; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; MUTAGENS; NEURONS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; VITAMIN K 3;

EID: 84995467718     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.15993     Document Type: Article

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