Iron overload induced death of osteoblasts in vitro: Involvement of the mitochondrial apoptotic pathway

PeerJ

Volumn 2016, Issue 11, 2016, Pages

  Tian, Qing ^a   Wu, Shilei ^a   Dai, Zhipeng ^b   Yang, Jingjing ^c   Zheng, Jin ^a   Zheng, Qixin ^a   Liu, Yong ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c Nanjing Medical University   (China)

Author keywords

Apoptosis; Iron overload; Mitochondria; Osteoporosis; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ALKALINE PHOSPHATASE; CALCIUM; CASPASE 3; CYTOCHROME C; FERRIC ION; IRON; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BONE MINERALIZATION; CELL DEATH; CELL DIFFERENTIATION; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; IRON OVERLOAD; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OSTEOBLAST; OSTEOPOROSIS; OXIDATIVE STRESS; PHASE CONTRAST MICROSCOPY; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

EID: 84995451725     PISSN: None     EISSN: 21678359     Source Type: Journal    
DOI: 10.7717/peerj.2611     Document Type: Article

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