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Volumn 11, Issue 2, 2016, Pages

Decreased bone formation explains osteoporosis in a genetic mouse model of hemochromatosiss

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MASS; CONTROLLED STUDY; GENE MUTATION; GENETIC PREDISPOSITION; HEMOCHROMATOSIS; IN VITRO STUDY; IRON OVERLOAD; MALE; MOLECULAR MECHANICS; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; OSTEOPOROSIS; PHENOTYPE; ANIMAL; BONE; BONE DEVELOPMENT; BONE MINERALIZATION; COMPLICATION; DEFICIENCY; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; LIVER; METABOLISM; PATHOLOGY;

EID: 84959144862     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0148292     Document Type: Article
Times cited : (53)

References (43)
  • 2
    • 18944366215 scopus 로고    scopus 로고
    • Mechanisms of disease: The role of hepcidin in iron homeostasis-implications for hemochromatosis and other disorders
    • PMID: 16265043
    • Pietrangelo A & Trautwein C. Mechanisms of disease: The role of hepcidin in iron homeostasis-implications for hemochromatosis and other disorders. Nat Clin Pract Gastroenterol Hepatol 2004; 1:39-45. PMID: 16265043
    • (2004) Nat Clin Pract Gastroenterol Hepatol , vol.1 , pp. 39-45
    • Pietrangelo, A.1    Trautwein, C.2
  • 4
    • 82955174678 scopus 로고    scopus 로고
    • Miscellaneous non-inflammatory musculoskeletal conditions Haemochromatosis: The Bone and the Joint
    • PMID: 22142745
    • Guggenbuhl P, Brissot P & Loreal O. Miscellaneous non-inflammatory musculoskeletal conditions. Haemochromatosis: the bone and the joint. Best Pract Res Clin Rheumatol 2011; 25:649-64. doi: 10. 1016/j.berh.2011.10.014 PMID: 22142745
    • (2011) Best Pract Res Clin Rheumatol , vol.25 , pp. 649-664
    • Guggenbuhl, P.1    Brissot, P.2    Loreal, O.3
  • 5
    • 0027222768 scopus 로고
    • Consensus development conference: Diagnosis, prophylaxis, and treatment of osteoporosis
    • PMID: 8506892
    • Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 1993; 94:646-50. PMID: 8506892
    • (1993) Am J Med , vol.94 , pp. 646-650
  • 6
    • 33847106358 scopus 로고    scopus 로고
    • Bone texture analysis on direct digital radiographic images: Precision study and relationship with bone mineral density at the os calcis
    • PMID: 17308991
    • Lespessailles E, Gadois C, Lemineur G, Do-Huu JP & Benhamou L. Bone texture analysis on direct digital radiographic images: precision study and relationship with bone mineral density at the os calcis. Calcif Tissue Int 2007; 80: 97-102. PMID: 17308991
    • (2007) Calcif Tissue Int , vol.80 , pp. 97-102
    • Lespessailles, E.1    Gadois, C.2    Lemineur, G.3    Do-Huu, J.P.4    Benhamou, L.5
  • 7
    • 42649103291 scopus 로고    scopus 로고
    • Law's masks descriptors applied to bone texture analysis: An innovative and discriminant tool in osteoporosis
    • PMID: 18327577
    • Rachidi M, Marchadier A, Gadois C, Lespessailles E, Chappard C & Benhamou CL. Law's masks descriptors applied to bone texture analysis: an innovative and discriminant tool in osteoporosis. Skeletal Radiol 2008; 37:541-48. doi: 10.1007/s00256-008-0463-2 PMID: 18327577
    • (2008) Skeletal Radiol , vol.37 , pp. 541-548
    • Rachidi, M.1    Marchadier, A.2    Gadois, C.3    Lespessailles, E.4    Chappard, C.5    Benhamou, C.L.6
  • 8
    • 0030824218 scopus 로고    scopus 로고
    • Bone and joint involvement in genetic hemochromatosis: Role of cirrhosis and iron overload
    • PMID: 9292808
    • Sinigaglia L, Fargion S, Fracanzani AL, Binelli L, Battafarano N, Varenna M et al. Bone and joint involvement in genetic hemochromatosis: role of cirrhosis and iron overload. J Rheumatol 1997; 24:1809-13. PMID: 9292808
    • (1997) J Rheumatol , vol.24 , pp. 1809-1813
    • Sinigaglia, L.1    Fargion, S.2    Fracanzani, A.L.3    Binelli, L.4    Battafarano, N.5    Varenna, M.6
  • 9
    • 71249150782 scopus 로고    scopus 로고
    • Osteoporosis in males and females: Is there really a difference?
    • PMID: 19926512
    • Guggenbuhl P. Osteoporosis in males and females: Is there really a difference? Joint Bone Spine 2009; 76:595-601. doi: 10.1016/j.jbspin.2009.10.001 PMID: 19926512
    • (2009) Joint Bone Spine , vol.76 , pp. 595-601
    • Guggenbuhl, P.1
  • 10
    • 62149108646 scopus 로고    scopus 로고
    • Association between iron overload and osteoporosis in patients with hereditary hemochromatosis
    • PMID: 18661088
    • Valenti L, Varenna M, Fracanzani AL, Rossi V, Fargion S & Sinigaglia L. Association between iron overload and osteoporosis in patients with hereditary hemochromatosis. Osteoporos Int 2009; 20:549-55. doi: 10.1007/s00198-008-0701-4 PMID: 18661088
    • (2009) Osteoporos Int , vol.20 , pp. 549-555
    • Valenti, L.1    Varenna, M.2    Fracanzani, A.L.3    Rossi, V.4    Fargion, S.5    Sinigaglia, L.6
  • 12
    • 0037335049 scopus 로고    scopus 로고
    • Bone mineral density, biochemical and hormonal profiles in suboptimally treated children and adolescents with beta-thalassaemia disease
    • Mahachoklertwattana P, Chuansumrit A, Sirisriro R, Choubtum L, Sriphrapradang A & Rajatanavin R. Bone mineral density, biochemical and hormonal profiles in suboptimally treated children and adolescents with beta-thalassaemia disease. Clin Endocrinol 2003; 58:273-79.
    • (2003) Clin Endocrinol , vol.58 , pp. 273-279
    • Mahachoklertwattana, P.1    Chuansumrit, A.2    Sirisriro, R.3    Choubtum, L.4    Sriphrapradang, A.5    Rajatanavin, R.6
  • 15
    • 70449129929 scopus 로고    scopus 로고
    • Iron and menopause: Does increased iron affect the health of postmenopausal women?
    • PMID: 19527179
    • Jian J, Pelle E & Huang X. Iron and menopause: does increased iron affect the health of postmenopausal women? Antioxid Redox Signal 2009; 11:2939-43. doi: 10.1089/ARS.2009.2576 PMID: 19527179
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2939-2943
    • Jian, J.1    Pelle, E.2    Huang, X.3
  • 18
    • 70349282987 scopus 로고    scopus 로고
    • Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures
    • PMID: 19643212
    • Messer JG, Kilbarger AK, Erikson KM & Kipp DE. Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures. Bone 2009; 45:972-979. doi: 10.1016/j.bone.2009.07.073 PMID: 19643212
    • (2009) Bone , vol.45 , pp. 972-979
    • Messer, J.G.1    Kilbarger, A.K.2    Erikson, K.M.3    Kipp, D.E.4
  • 19
    • 70449529421 scopus 로고    scopus 로고
    • Excess iron inhibits osteoblast metabolism
    • PMID: 19735707
    • Yamasaki K & Hagiwara H. Excess iron inhibits osteoblast metabolism. Toxicol Lett 2009; 191:211-5. doi: 10.1016/j.toxlet.2009.08.023 PMID: 19735707
    • (2009) Toxicol Lett , vol.191 , pp. 211-215
    • Yamasaki, K.1    Hagiwara, H.2
  • 20
    • 79958807411 scopus 로고    scopus 로고
    • Inhibitory effects of iron on bone morphogenetic protein-2-induced osteoblastogenesis
    • PMID: 21308772
    • Yang Q, Jian J, Abramson SB & Huang X. Inhibitory effects of iron on bone morphogenetic protein-2-induced osteoblastogenesis. J Bone Miner Res 2011; 26:1188-96. doi: 10.1002/jbmr.337 PMID: 21308772
    • (2011) J Bone Miner Res , vol.26 , pp. 1188-1196
    • Yang, Q.1    Jian, J.2    Abramson, S.B.3    Huang, X.4
  • 21
    • 84867337570 scopus 로고    scopus 로고
    • Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells
    • PMID: 22237814
    • Doyard M, Fatih N, Monnier A, Island ML, Aubry M, Leroyer P et al. Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells. Osteoporos Int 2012; 23:2435-45. doi: 10.1007/s00198-011-1871-z PMID: 22237814
    • (2012) Osteoporos Int , vol.23 , pp. 2435-2445
    • Doyard, M.1    Fatih, N.2    Monnier, A.3    Island, M.L.4    Aubry, M.5    Leroyer, P.6
  • 22
    • 44949213071 scopus 로고    scopus 로고
    • Iron inhibits hydroxyapatite crystal growth in vitro
    • PMID: 18555830
    • Guggenbuhl P, Filmon R, Mabilleau G, Basle MF & Chappard D. Iron inhibits hydroxyapatite crystal growth in vitro. Metabolism 2008; 57:903-10. doi: 10.1016/j.metabol.2008.02.004 PMID: 18555830
    • (2008) Metabolism , vol.57 , pp. 903-910
    • Guggenbuhl, P.1    Filmon, R.2    Mabilleau, G.3    Basle, M.F.4    Chappard, D.5
  • 24
    • 0035671613 scopus 로고    scopus 로고
    • Iron lactate-induced osteopenia in male Sprague-Dawley rats
    • PMID: 11794378
    • Matsushima S, Hoshimoto M, Torii M, Ozaki K & Narama I. Iron lactate-induced osteopenia in male Sprague-Dawley rats. Toxicol Pathol 2001; 29:623-9. PMID: 11794378
    • (2001) Toxicol Pathol , vol.29 , pp. 623-629
    • Matsushima, S.1    Hoshimoto, M.2    Torii, M.3    Ozaki, K.4    Narama, I.5
  • 25
    • 40649097947 scopus 로고    scopus 로고
    • Effects of colloidal iron overload on renal and hepatic siderosis and the femur in male rats
    • PMID: 18289763
    • Kudo H, Suzuki S, Watanabe A, Kikuchi H, Sassa S, Sakamoto S et al. Effects of colloidal iron overload on renal and hepatic siderosis and the femur in male rats. Toxicology 2008; 246:143-7. doi: 10.1016/j. tox.2008.01.004 PMID: 18289763
    • (2008) Toxicology , vol.246 , pp. 143-147
    • Kudo, H.1    Suzuki, S.2    Watanabe, A.3    Kikuchi, H.4    Sassa, S.5    Sakamoto, S.6
  • 26
  • 27
    • 17844410928 scopus 로고    scopus 로고
    • Hypogonadism in hereditary hemochromatosis
    • PMID: 15657376
    • McDermott JH & Walsh CH. Hypogonadism in hereditary hemochromatosis. J Clin Endocrinol Metab 2005; 90:2451-5. PMID: 15657376
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2451-2455
    • McDermott, J.H.1    Walsh, C.H.2
  • 28
    • 0015228412 scopus 로고
    • Measurement of liver-iron concentration in needle-biopsy specimens
    • PMID: 4099600
    • Barry M & Sherlock S. Measurement of liver-iron concentration in needle-biopsy specimens. Lancet 1971; 1:100-3. PMID: 4099600
    • (1971) Lancet , vol.1 , pp. 100-103
    • Barry, M.1    Sherlock, S.2
  • 29
    • 0033563048 scopus 로고    scopus 로고
    • Comparison of eight histomorphometric methods for measuring trabecular bone architecture by image analysis on histological sections
    • PMID: 10383123
    • Chappard D, Legrand E, Pascaretti C, Basle MF & Audran M. Comparison of eight histomorphometric methods for measuring trabecular bone architecture by image analysis on histological sections. Microsc Res Tech 1999; 45:303-12. PMID: 10383123
    • (1999) Microsc Res Tech , vol.45 , pp. 303-312
    • Chappard, D.1    Legrand, E.2    Pascaretti, C.3    Basle, M.F.4    Audran, M.5
  • 30
    • 0033580269 scopus 로고    scopus 로고
    • Vertebrate Hedgehog signalling modulated by induction of a Hedgehogbinding protein
    • PMID: 10050855
    • Chuang PT & McMahon AP. Vertebrate Hedgehog signalling modulated by induction of a Hedgehogbinding protein. Nature 1999; 397:617-621. PMID: 10050855
    • (1999) Nature , vol.397 , pp. 617-621
    • Chuang, P.T.1    McMahon, A.P.2
  • 31
    • 65249135916 scopus 로고    scopus 로고
    • Activation of hedgehog signaling inhibits osteoblast differentiation of human mesenchymal stem cells
    • PMID: 19096040
    • Plaisant M, Fontaine C, Cousin W, Rochet N, Dani C & Peraldi P. Activation of hedgehog signaling inhibits osteoblast differentiation of human mesenchymal stem cells. Stem Cells 2009; 27:703-13. doi: 10.1634/stemcells.2008-0888 PMID: 19096040
    • (2009) Stem Cells , vol.27 , pp. 703-713
    • Plaisant, M.1    Fontaine, C.2    Cousin, W.3    Rochet, N.4    Dani, C.5    Peraldi, P.6
  • 32
    • 84055177068 scopus 로고    scopus 로고
    • Hedgehog signaling and osteoblast gene expression are regulated by purmorphamine in human mesenchymal stem cells
    • PMID: 21898541
    • Oliveira F, Bellesini L, Defino H, da Silva Herrero C, Beloti M & Rosa A. Hedgehog signaling and osteoblast gene expression are regulated by purmorphamine in human mesenchymal stem cells. J Cell Biochem 2012; 113:204-8. doi: 10.1002/jcb.23345 PMID: 21898541
    • (2012) J Cell Biochem , vol.113 , pp. 204-208
    • Oliveira, F.1    Bellesini, L.2    Defino, H.3    Da Silva Herrero, C.4    Beloti, M.5    Rosa, A.6
  • 34
    • 0031851068 scopus 로고    scopus 로고
    • The morbidity of bone disease in thalassemia
    • PMID: 9668556
    • Vichinsky EP. The morbidity of bone disease in thalassemia. Ann N Y Acad Sci 1998; 850: 344-8. PMID: 9668556
    • (1998) Ann N Y Acad Sci , vol.850 , pp. 344-348
    • Vichinsky, E.P.1
  • 37
    • 33644988157 scopus 로고    scopus 로고
    • Prevalence of fractures among the Thalassemia syndromes in North America
    • PMID: 16298178
    • Vogiatzi MG, Macklin EA, Fung EB, Vichinsky E, Olivieri N, Kwiatkowski J et al. Prevalence of fractures among the Thalassemia syndromes in North America. Bone 2006; 38:571-5. PMID: 16298178
    • (2006) Bone , vol.38 , pp. 571-575
    • Vogiatzi, M.G.1    Macklin, E.A.2    Fung, E.B.3    Vichinsky, E.4    Olivieri, N.5    Kwiatkowski, J.6
  • 39
    • 58149479413 scopus 로고    scopus 로고
    • Hormonal dysregulation and bones in thalassaemiaan overview
    • Rev
    • Skordis N, Efstathiou E, Kyriakou A & Toumba M. Hormonal dysregulation and bones in thalassaemiaan overview. Pediatr Endocrinol 2008; Rev 6 Suppl 1:107-15.
    • (2008) Pediatr Endocrinol , vol.6 , pp. 107-115
    • Skordis, N.1    Efstathiou, E.2    Kyriakou, A.3    Toumba, M.4
  • 40
    • 77957747011 scopus 로고    scopus 로고
    • Bone loss caused by iron overload in a murine model: Importance of oxidative stress
    • PMID: 20554970
    • Tsay J, Yang Z, Ross FP, Cunningham-Rundles S, Lin H, Coleman R et al. Bone loss caused by iron overload in a murine model: importance of oxidative stress. Blood 2010; 116:2582-9. doi: 10.1182/ blood-2009-12-260083 PMID: 20554970
    • (2010) Blood , vol.116 , pp. 2582-2589
    • Tsay, J.1    Yang, Z.2    Ross, F.P.3    Cunningham-Rundles, S.4    Lin, H.5    Coleman, R.6
  • 41
    • 3242795997 scopus 로고    scopus 로고
    • Osteoprotegerin and RANKL in the pathogenesis of thalassemia-induced osteoporosis: New pieces of the puzzle
    • PMID: 15068494
    • Morabito N, Gaudio A, Lasco A, Atteritano M, Pizzoleo MA, Cincotta M et al; Osteoprotegerin and RANKL in the pathogenesis of thalassemia-induced osteoporosis: new pieces of the puzzle. J Bone Miner Res 2004; 19:722-7. PMID: 15068494
    • (2004) J Bone Miner Res , vol.19 , pp. 722-727
    • Morabito, N.1    Gaudio, A.2    Lasco, A.3    Atteritano, M.4    Pizzoleo, M.A.5    Cincotta, M.6
  • 42
    • 16244369752 scopus 로고    scopus 로고
    • Osteoprotegerin to soluble receptor activator of nuclear factor kappa-B ligand ratio is reduced in patients with thalassaemia-related osteoporosis who receive vitamin D3
    • PMID: 15777350
    • Voskaridou E & Terpos E. Osteoprotegerin to soluble receptor activator of nuclear factor kappa-B ligand ratio is reduced in patients with thalassaemia-related osteoporosis who receive vitamin D3. Eur J Haematol 2005; 74:359-61. PMID: 15777350
    • (2005) Eur J Haematol , vol.74 , pp. 359-361
    • Voskaridou, E.1    Terpos, E.2
  • 43
    • 33845798015 scopus 로고    scopus 로고
    • Circulating osteoprotegerin and receptor activator of NF-kappaB ligand system in patients with beta-thalassemia major
    • PMID: 17187195
    • Angelopoulos NG, Goula A, Katounda E, Rombopoulos G, Kaltzidou V, Kaltsas D et al. Circulating osteoprotegerin and receptor activator of NF-kappaB ligand system in patients with beta-thalassemia major. J Bone Miner Metab 2007; 25:60-7. PMID: 17187195
    • (2007) J Bone Miner Metab , vol.25 , pp. 60-67
    • Angelopoulos, N.G.1    Goula, A.2    Katounda, E.3    Rombopoulos, G.4    Kaltzidou, V.5    Kaltsas, D.6


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