Ropivacaine- and bupivacaine-induced death of rabbit annulus fibrosus cells in vitro: Involvement of the mitochondrial apoptotic pathway

Osteoarthritis and Cartilage

Volumn 23, Issue 10, 2015, Pages 1763-1775

  Cai, X Y ^a   Xia, Y ^a   Yang, S H ^a   Liu, X Z ^a   Shao, Z W ^a   Liu, Y L ^a   Yang, W ^a   Xiong, L M ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Bupivacaine; Intervertebral disc; Mitochondria; Ropivacaine

Indexed keywords

ACETYLCYSTEINE; BUPIVACAINE; CASPASE 3; CASPASE 9; DICHLORODIHYDROFLUORESCEIN DIACETATE; HOE 33342; LIPOCORTIN 5; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; ROPIVACAINE; SODIUM CHLORIDE; AMIDE; LOCAL ANESTHETIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANNULUS FIBROSUS; APOPTOSIS; ARTICLE; CELL ASSAY; CELL COUNTING KIT 8 ASSAY; CELL DEATH; CELL NUCLEUS; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; IN VITRO STUDY; INTRACELLULAR SIGNALING; JAPANESE WHITE (RABBIT); MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STAINING; UPREGULATION; WESTERN BLOTTING; ANIMAL; CARTILAGE CELL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; INTERVERTEBRAL DISK; METABOLISM; MITOCHONDRION; RABBIT;

AMIDES; ANESTHETICS, LOCAL; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BUPIVACAINE; CASPASE 3; CASPASE 9; CELL DEATH; CELLS, CULTURED; CHONDROCYTES; DOWN-REGULATION; IN VITRO TECHNIQUES; INTERVERTEBRAL DISC; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; RABBITS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84942550268     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.05.013     Document Type: Article

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