메뉴 건너뛰기




Volumn 9, Issue 11, 2014, Pages

Iron overload and apoptosis of HL-1 cardiomyocytes: Effects of calcium channel blockade

Author keywords

[No Author keywords available]

Indexed keywords

CALCEIN; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; CASPASE 3; IRON; LIPOCORTIN 5; CALCIUM; FERRIC ION;

EID: 84911442423     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112915     Document Type: Article
Times cited : (37)

References (63)
  • 2
    • 0141705304 scopus 로고    scopus 로고
    • Labile plasma iron in iron overload: Redox activity and susceptibility to chelation
    • Esposito BP, Breuer W, Sirankapracha P, Pootrakul P, Hershko C, et al. (2003) Labile plasma iron in iron overload: redox activity and susceptibility to chelation. Blood 102: 2670-2677.
    • (2003) Blood , vol.102 , pp. 2670-2677
    • Esposito, B.P.1    Breuer, W.2    Sirankapracha, P.3    Pootrakul, P.4    Hershko, C.5
  • 4
    • 1942534543 scopus 로고    scopus 로고
    • Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model
    • Oudit GY, Trivieri MG, Khaper N, Husain T, Wilson GJ, et al. (2004) Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model. Circulation 109: 1877-1885.
    • (2004) Circulation , vol.109 , pp. 1877-1885
    • Oudit, G.Y.1    Trivieri, M.G.2    Khaper, N.3    Husain, T.4    Wilson, G.J.5
  • 5
    • 77956629759 scopus 로고    scopus 로고
    • Iron overload cardiomyopathy: Better understanding of an increasing disorder
    • Gujja P, Rosing DR, Tripodi DJ, Shizukuda Y (2010) Iron overload cardiomyopathy: better understanding of an increasing disorder. J Am Coll Cardiol 56: 1001-1012.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1001-1012
    • Gujja, P.1    Rosing, D.R.2    Tripodi, D.J.3    Shizukuda, Y.4
  • 7
    • 0032732695 scopus 로고    scopus 로고
    • Association of heart failure in homozygous beta-thalassemia with the major histocompatibility complex
    • Kremastinos DT, Flevari P, Spyropoulou M, Vrettou H, Tsiapras D, et al. (1999) Association of heart failure in homozygous beta-thalassemia with the major histocompatibility complex. Circulation 100: 2074-2078.
    • (1999) Circulation , vol.100 , pp. 2074-2078
    • Kremastinos, D.T.1    Flevari, P.2    Spyropoulou, M.3    Vrettou, H.4    Tsiapras, D.5
  • 9
    • 78149284772 scopus 로고    scopus 로고
    • Iron-overload cardiomyopathy: Pathophysiology, diagnosis, and treatment
    • Murphy CJ, Oudit GY (2010) Iron-overload cardiomyopathy: pathophysiology, diagnosis, and treatment. J Card Fail 16: 888-900.
    • (2010) J Card Fail , vol.16 , pp. 888-900
    • Murphy, C.J.1    Oudit, G.Y.2
  • 11
    • 0033067885 scopus 로고    scopus 로고
    • Iron-mediated cardiovascular injury
    • Horwitz LD, Rosenthal EA (1999) Iron-mediated cardiovascular injury. Vasc Med 4: 93-99.
    • (1999) Vasc Med , vol.4 , pp. 93-99
    • Horwitz, L.D.1    Rosenthal, E.A.2
  • 14
    • 0034625535 scopus 로고    scopus 로고
    • Apoptosis and heart failure: A critical review of the literature
    • Kang PM, Izumo S (2000) Apoptosis and heart failure: A critical review of the literature. Circ Res 86: 1107-1113.
    • (2000) Circ Res , vol.86 , pp. 1107-1113
    • Kang, P.M.1    Izumo, S.2
  • 15
    • 85047694494 scopus 로고    scopus 로고
    • A mechanistic role for cardiac myocyte apoptosis in heart failure
    • Wencker D, Chandra M, Nguyen K, Miao W, Garantziotis S, et al. (2003) A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest 111: 1497-1504.
    • (2003) J Clin Invest , vol.111 , pp. 1497-1504
    • Wencker, D.1    Chandra, M.2    Nguyen, K.3    Miao, W.4    Garantziotis, S.5
  • 16
    • 14644413468 scopus 로고    scopus 로고
    • Death begets failure in the heart
    • Foo RS, Mani K, Kitsis RN (2005) Death begets failure in the heart. J Clin Invest 115: 565-571.
    • (2005) J Clin Invest , vol.115 , pp. 565-571
    • Foo, R.S.1    Mani, K.2    Kitsis, R.N.3
  • 17
    • 62449157200 scopus 로고    scopus 로고
    • Role of apoptosis in cardiovascular disease
    • Lee Y, Gustafsson AB (2009) Role of apoptosis in cardiovascular disease. Apoptosis 14: 536-548.
    • (2009) Apoptosis , vol.14 , pp. 536-548
    • Lee, Y.1    Gustafsson, A.B.2
  • 18
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: Molecular control of mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Andrews NC (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell 117: 285-297.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 20
    • 0141461407 scopus 로고    scopus 로고
    • L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in ironoverload cardiomyopathy
    • Oudit GY, Sun H, Trivieri MG, Koch SE, Dawood F, et al. (2003) L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in ironoverload cardiomyopathy. Nat Med 9: 1187-1194.
    • (2003) Nat Med , vol.9 , pp. 1187-1194
    • Oudit, G.Y.1    Sun, H.2    Trivieri, M.G.3    Koch, S.E.4    Dawood, F.5
  • 21
    • 33646351076 scopus 로고    scopus 로고
    • Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy
    • Oudit GY, Trivieri MG, Khaper N, Liu PP, Backx PH (2006) Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy. J Mol Med (Berl) 84: 349-364.
    • (2006) J Mol Med (berl) , vol.84 , pp. 349-364
    • Oudit, G.Y.1    Trivieri, M.G.2    Khaper, N.3    Liu, P.P.4    Backx, P.H.5
  • 22
    • 0033546223 scopus 로고    scopus 로고
    • Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: Possible implications in iron overload
    • Tsushima RG, Wickenden AD, Bouchard RA, Oudit GY, Liu PP, et al. (1999) Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload. Circ Res 84: 1302-1309.
    • (1999) Circ Res , vol.84 , pp. 1302-1309
    • Tsushima, R.G.1    Wickenden, A.D.2    Bouchard, R.A.3    Oudit, G.Y.4    Liu, P.P.5
  • 23
    • 84861187773 scopus 로고    scopus 로고
    • Ttype calcium channel blockade improves survival and cardiovascular function in thalassemic mice
    • Kumfu S, Chattipakorn S, Chinda K, Fucharoen S, Chattipakorn N (2012) Ttype calcium channel blockade improves survival and cardiovascular function in thalassemic mice. Eur J Haematol 88: 535-548.
    • (2012) Eur J Haematol , vol.88 , pp. 535-548
    • Kumfu, S.1    Chattipakorn, S.2    Chinda, K.3    Fucharoen, S.4    Chattipakorn, N.5
  • 24
    • 78651447796 scopus 로고    scopus 로고
    • T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice
    • Kumfu S, Chattipakorn S, Srichairatanakool S, Settakorn J, Fucharoen S, et al. (2011) T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice. Eur J Haematol 86: 156-166.
    • (2011) Eur J Haematol , vol.86 , pp. 156-166
    • Kumfu, S.1    Chattipakorn, S.2    Srichairatanakool, S.3    Settakorn, J.4    Fucharoen, S.5
  • 25
    • 0032539911 scopus 로고    scopus 로고
    • HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte
    • Claycomb WC, Lanson NA Jr, Stallworth BS, Egeland DB, Delcarpio JB, et al. (1998) HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci U S A 95: 2979-2984.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 2979-2984
    • Claycomb, W.C.1    Lanson, N.A.2    Stallworth, B.S.3    Egeland, D.B.4    Delcarpio, J.B.5
  • 26
    • 1342346691 scopus 로고    scopus 로고
    • Cardiac physiology at the cellular level: Use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function
    • White SM, Constantin PE, Claycomb WC (2004) Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function. Am J Physiol Heart Circ Physiol 286: H823-829.
    • (2004) Am J Physiol Heart Circ Physiol , vol.286 , pp. H823-H829
    • White, S.M.1    Constantin, P.E.2    Claycomb, W.C.3
  • 28
    • 0031588646 scopus 로고    scopus 로고
    • Characterization of Fe2+ and Fe3 + transport by iron-loaded cardiac myocytes
    • Parkes JG, Olivieri NF, Templeton DM (1997) Characterization of Fe2+ and Fe3 + transport by iron-loaded cardiac myocytes. Toxicology 117: 141-151.
    • (1997) Toxicology , vol.117 , pp. 141-151
    • Parkes, J.G.1    Olivieri, N.F.2    Templeton, D.M.3
  • 29
    • 0028244452 scopus 로고
    • Uptake of non-transferrin- bound iron by both reductive and nonreductive processes is modulated by intracellular iron
    • Randell EW, Parkes JG, Olivieri NF, Templeton DM (1994) Uptake of non-transferrin- bound iron by both reductive and nonreductive processes is modulated by intracellular iron. J Biol Chem 269: 16046-16053.
    • (1994) J Biol Chem , vol.269 , pp. 16046-16053
    • Randell, E.W.1    Parkes, J.G.2    Olivieri, N.F.3    Templeton, D.M.4
  • 30
    • 27644539382 scopus 로고    scopus 로고
    • Intracellular labile iron pools as direct targets of iron chelators: A fluorescence study of chelator action in living cells
    • Glickstein H, El RB, Shvartsman M, Cabantchik ZI (2005) Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells. Blood 106: 3242-3250.
    • (2005) Blood , vol.106 , pp. 3242-3250
    • Glickstein, H.1    El, R.B.2    Shvartsman, M.3    Cabantchik, Z.I.4
  • 31
    • 52049101539 scopus 로고    scopus 로고
    • Analysis of apoptotic pathways by multiparametric flow cytometry: Application to HIV infection
    • Lecoeur H, Melki MT, Saidi H, Gougeon ML (2008) Analysis of apoptotic pathways by multiparametric flow cytometry: application to HIV infection. Methods Enzymol 442: 51-82.
    • (2008) Methods Enzymol , vol.442 , pp. 51-82
    • Lecoeur, H.1    Melki, M.T.2    Saidi, H.3    Gougeon, M.L.4
  • 33
    • 33745564177 scopus 로고    scopus 로고
    • Iron mobilization from transferrin and non-transferrin- bound-iron by deferiprone. Implications in the treatment of thalassemia, anemia of chronic disease, cancer and other conditions
    • Kontoghiorghes GJ (2006) Iron mobilization from transferrin and non-transferrin- bound-iron by deferiprone. Implications in the treatment of thalassemia, anemia of chronic disease, cancer and other conditions. Hemoglobin 30: 183-200.
    • (2006) Hemoglobin , vol.30 , pp. 183-200
    • Kontoghiorghes, G.J.1
  • 34
    • 84869079243 scopus 로고    scopus 로고
    • In vitro neurotoxic Fe(III) and Fe(III)-chelator activities in rat hippocampal cultures. From neurotoxicity to neuroprotection prospects
    • Nday CM, Malollari G, Petanidis S, Salifoglou A (2012) In vitro neurotoxic Fe(III) and Fe(III)-chelator activities in rat hippocampal cultures. From neurotoxicity to neuroprotection prospects. J Inorg Biochem 117: 342-350.
    • (2012) J Inorg Biochem , vol.117 , pp. 342-350
    • Nday, C.M.1    Malollari, G.2    Petanidis, S.3    Salifoglou, A.4
  • 35
    • 78650776631 scopus 로고    scopus 로고
    • Iron-induced cardiac damage: Role of apoptosis and deferasirox intervention
    • Wang Y, Wu M, Al-Rousan R, Liu H, Fannin J, et al. (2011) Iron-induced cardiac damage: role of apoptosis and deferasirox intervention. J Pharmacol Exp Ther 336: 56-63.
    • (2011) J Pharmacol Exp Ther , vol.336 , pp. 56-63
    • Wang, Y.1    Wu, M.2    Al-Rousan, R.3    Liu, H.4    Fannin, J.5
  • 36
    • 74149084445 scopus 로고    scopus 로고
    • Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide
    • Munoz JP, Chiong M, Garcia L, Troncoso R, Toro B, et al. (2010) Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide. Free Radic Biol Med 48: 526-534.
    • (2010) Free Radic Biol Med , vol.48 , pp. 526-534
    • Munoz, J.P.1    Chiong, M.2    Garcia, L.3    Troncoso, R.4    Toro, B.5
  • 37
    • 77951901715 scopus 로고    scopus 로고
    • Cell death in the pathogenesis of heart disease: Mechanisms and significance
    • Whelan RS, Kaplinskiy V, Kitsis RN (2010) Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu Rev Physiol 72: 19-44.
    • (2010) Annu Rev Physiol , vol.72 , pp. 19-44
    • Whelan, R.S.1    Kaplinskiy, V.2    Kitsis, R.N.3
  • 38
    • 35048833703 scopus 로고    scopus 로고
    • Non-transferrinbound iron reaches mitochondria by a chelator-inaccessible mechanism: Biological and clinical implications
    • Shvartsman M, Kikkeri R, Shanzer A, Cabantchik ZI (2007) Non-transferrinbound iron reaches mitochondria by a chelator-inaccessible mechanism: biological and clinical implications. Am J Physiol Cell Physiol 293: C1383-1394.
    • (2007) Am J Physiol Cell Physiol , vol.293 , pp. C1383-C1394
    • Shvartsman, M.1    Kikkeri, R.2    Shanzer, A.3    Cabantchik, Z.I.4
  • 39
    • 0026611249 scopus 로고
    • Receptor sites for Ca2 + channel antagonists
    • Catterall WA, Striessnig J (1992) Receptor sites for Ca2 + channel antagonists. Trends Pharmacol Sci 13: 256-262.
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 256-262
    • Catterall, W.A.1    Striessnig, J.2
  • 40
    • 0025965044 scopus 로고
    • Block of current through single calcium channels by Fe, Co, and Ni. Location of the transition metal binding site in the pore
    • Winegar BD, Kelly R, Lansman JB (1991) Block of current through single calcium channels by Fe, Co, and Ni. Location of the transition metal binding site in the pore. J Gen Physiol 97: 351-367.
    • (1991) J Gen Physiol , vol.97 , pp. 351-367
    • Winegar, B.D.1    Kelly, R.2    Lansman, J.B.3
  • 41
    • 0028860021 scopus 로고
    • Excitationtranscription coupling mediated by zinc influx through voltage-dependent calcium channels
    • Atar D, Backx PH, Appel MM, Gao WD, Marban E (1995) Excitationtranscription coupling mediated by zinc influx through voltage-dependent calcium channels. J Biol Chem 270: 2473-2477.
    • (1995) J Biol Chem , vol.270 , pp. 2473-2477
    • Atar, D.1    Backx, P.H.2    Appel, M.M.3    Gao, W.D.4    Marban, E.5
  • 43
    • 0025259795 scopus 로고
    • Comparative antioxidant activities of propranolol, nifedipine, verapamil, and diltiazem against sarcolemmal membrane lipid peroxidation
    • Mak IT, Weglicki WB (1990) Comparative antioxidant activities of propranolol, nifedipine, verapamil, and diltiazem against sarcolemmal membrane lipid peroxidation. Circ Res 66: 1449-1452.
    • (1990) Circ Res , vol.66 , pp. 1449-1452
    • Mak, I.T.1    Weglicki, W.B.2
  • 44
    • 0022470774 scopus 로고
    • Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore
    • Lansman JB, Hess P, Tsien RW (1986) Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+ . Voltage and concentration dependence of calcium entry into the pore. J Gen Physiol 88: 321-347.
    • (1986) J Gen Physiol , vol.88 , pp. 321-347
    • Lansman, J.B.1    Hess, P.2    Tsien, R.W.3
  • 46
    • 84860579118 scopus 로고    scopus 로고
    • The role of endocytic pathways in cellular uptake of plasma non-transferrin iron
    • Sohn YS, Ghoti H, Breuer W, Rachmilewitz E, Attar S, et al. (2012) The role of endocytic pathways in cellular uptake of plasma non-transferrin iron. Haematologica 97: 670-678.
    • (2012) Haematologica , vol.97 , pp. 670-678
    • Sohn, Y.S.1    Ghoti, H.2    Breuer, W.3    Rachmilewitz, E.4    Attar, S.5
  • 47
    • 28044446958 scopus 로고    scopus 로고
    • Pathophysiological significance of T-type Ca2+ channels: Expression of T-type Ca2+ channels in fetal and diseased heart
    • Yasui K, Niwa N, Takemura H, Opthof T, Muto T, et al. (2005) Pathophysiological significance of T-type Ca2+ channels: expression of T-type Ca2+ channels in fetal and diseased heart. J Pharmacol Sci 99: 205-210.
    • (2005) J Pharmacol Sci , vol.99 , pp. 205-210
    • Yasui, K.1    Niwa, N.2    Takemura, H.3    Opthof, T.4    Muto, T.5
  • 48
    • 0038517877 scopus 로고    scopus 로고
    • Expression of T-type Ca(2+) channels in ventricular cells from hypertrophied rat hearts
    • Martinez ML, Heredia MP, Delgado C (1999) Expression of T-type Ca(2+) channels in ventricular cells from hypertrophied rat hearts. J Mol Cell Cardiol 31: 1617-1625.
    • (1999) J Mol Cell Cardiol , vol.31 , pp. 1617-1625
    • Martinez, M.L.1    Heredia, M.P.2    Delgado, C.3
  • 49
    • 0034028205 scopus 로고    scopus 로고
    • Reexpression of T-type Ca2+ channel gene and current in post-infarction remodeled rat left ventricle
    • Huang B, Qin D, Deng L, Boutjdir M, Nabil ES (2000) Reexpression of T-type Ca2+ channel gene and current in post-infarction remodeled rat left ventricle. Cardiovasc Res 46: 442-449.
    • (2000) Cardiovasc Res , vol.46 , pp. 442-449
    • Huang, B.1    Qin, D.2    Deng, L.3    Boutjdir, M.4    Nabil, E.S.5
  • 50
    • 40849098727 scopus 로고    scopus 로고
    • Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major
    • Li W, Coates T, Wood JC (2008) Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major. Haematologica 93: 311-312.
    • (2008) Haematologica , vol.93 , pp. 311-312
    • Li, W.1    Coates, T.2    Wood, J.C.3
  • 51
    • 79957497558 scopus 로고    scopus 로고
    • Efficacy, compliance and toxicity factors are affecting the rate of normalization of body iron stores in thalassemia patients using the deferiprone and deferoxamine combination therapy
    • Kolnagou A, Kleanthous M, Kontoghiorghes GJ (2011) Efficacy, compliance and toxicity factors are affecting the rate of normalization of body iron stores in thalassemia patients using the deferiprone and deferoxamine combination therapy. Hemoglobin 35: 186-198.
    • (2011) Hemoglobin , vol.35 , pp. 186-198
    • Kolnagou, A.1    Kleanthous, M.2    Kontoghiorghes, G.J.3
  • 52
    • 80055004672 scopus 로고    scopus 로고
    • Human atrial action potential and Ca2+ model: Sinus rhythm and chronic atrial fibrillation
    • Grandi E, Pandit SV, Voigt N, Workman AJ, Dobrev D, et al. (2011) Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res 109: 1055-1066.
    • (2011) Circ Res , vol.109 , pp. 1055-1066
    • Grandi, E.1    Pandit, S.V.2    Voigt, N.3    Workman, A.J.4    Dobrev, D.5
  • 53
    • 77954474798 scopus 로고    scopus 로고
    • Transferrin-iron routing to the cytosol and mitochondria as studied by live and real-time fluorescence
    • Shvartsman M, Fibach E, Cabantchik ZI (2010) Transferrin-iron routing to the cytosol and mitochondria as studied by live and real-time fluorescence. Biochem J 429: 185-193.
    • (2010) Biochem J , vol.429 , pp. 185-193
    • Shvartsman, M.1    Fibach, E.2    Cabantchik, Z.I.3
  • 54
    • 84864923748 scopus 로고    scopus 로고
    • Intracellular iron trafficking: Role of cytosolic ligands
    • Shvartsman M, Ioav Cabantchik Z (2012) Intracellular iron trafficking: role of cytosolic ligands. Biometals 25: 711-723.
    • (2012) Biometals , vol.25 , pp. 711-723
    • Shvartsman, M.1    Ioav Cabantchik, Z.2
  • 56
    • 84878376886 scopus 로고    scopus 로고
    • A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell growth and beating
    • Wang T, Hu N, Cao J, Wu J, Su K, et al. (2013) A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell growth and beating. Biosens Bioelectron 49: 9-13.
    • (2013) Biosens Bioelectron , vol.49 , pp. 9-13
    • Wang, T.1    Hu, N.2    Cao, J.3    Wu, J.4    Su, K.5
  • 57
    • 83055173972 scopus 로고    scopus 로고
    • Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes
    • Jonsson MK, Wang QD, Becker B (2011) Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes. Assay Drug Dev Technol 9: 589-599.
    • (2011) Assay Drug Dev Technol , vol.9 , pp. 589-599
    • Jonsson, M.K.1    Wang, Q.D.2    Becker, B.3
  • 58
    • 84872170837 scopus 로고    scopus 로고
    • Mechanism of macrophage migration inhibitory factor-induced decrease of T-type Ca(2+) channel current in atrium-derived cells
    • Rao F, Deng CY, Wu SL, Xiao DZ, Huang W, et al. (2013) Mechanism of macrophage migration inhibitory factor-induced decrease of T-type Ca(2+) channel current in atrium-derived cells. Exp Physiol 98: 172-182.
    • (2013) Exp Physiol , vol.98 , pp. 172-182
    • Rao, F.1    Deng, C.Y.2    Wu, S.L.3    Xiao, D.Z.4    Huang, W.5
  • 59
    • 84876310211 scopus 로고    scopus 로고
    • Reactive oxygen species mediate the injury and deficient hematopoietic supportive capacity of umbilical cord derived mesenchymal stem cells induced by iron overload
    • Lu WY, Zhao MF, Chai X, Meng JX, Zhao N, et al. (2013) [Reactive oxygen species mediate the injury and deficient hematopoietic supportive capacity of umbilical cord derived mesenchymal stem cells induced by iron overload]. Zhonghua Yi Xue Za Zhi 93: 930-934.
    • (2013) Zhonghua Yi Xue Za Zhi , vol.93 , pp. 930-934
    • Lu, W.Y.1    Zhao, M.F.2    Chai, X.3    Meng, J.X.4    Zhao, N.5
  • 60
    • 84875968310 scopus 로고    scopus 로고
    • Effect and mechanism of iron-catalyzed oxidative stress on mesenchymal stem cells
    • Lu WY, Zhao MF, Sajin R, Zhao N, Xie F, et al. (2013) [Effect and mechanism of iron-catalyzed oxidative stress on mesenchymal stem cells]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 35: 6-12.
    • (2013) Zhongguo Yi Xue Ke Xue Yuan Xue Bao , vol.35 , pp. 6-12
    • Lu, W.Y.1    Zhao, M.F.2    Sajin, R.3    Zhao, N.4    Xie, F.5
  • 61
    • 4444283611 scopus 로고    scopus 로고
    • Iron-induced interleukin-6 gene expression: Possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways
    • Dai J, Huang C, Wu J, Yang C, Frenkel K, et al. (2004) Iron-induced interleukin-6 gene expression: possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. Toxicology 203: 199-209.
    • (2004) Toxicology , vol.203 , pp. 199-209
    • Dai, J.1    Huang, C.2    Wu, J.3    Yang, C.4    Frenkel, K.5
  • 62
    • 78951471098 scopus 로고    scopus 로고
    • Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells
    • Salvador GA, Oteiza PI (2011) Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells. Neurotoxicology 32: 75-82.
    • (2011) Neurotoxicology , vol.32 , pp. 75-82
    • Salvador, G.A.1    Oteiza, P.I.2
  • 63
    • 69549105608 scopus 로고    scopus 로고
    • Deferasirox removes cardiac iron and attenuates oxidative stress in the ironoverloaded gerbil
    • Al-Rousan RM, Paturi S, Laurino JP, Kakarla SK, Gutta AK, et al. (2009) Deferasirox removes cardiac iron and attenuates oxidative stress in the ironoverloaded gerbil. Am J Hematol 84: 565-570.
    • (2009) Am J Hematol , vol.84 , pp. 565-570
    • Al-Rousan, R.M.1    Paturi, S.2    Laurino, J.P.3    Kakarla, S.K.4    Gutta, A.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.