Understanding the structural basis of adhesion GPCR functions

Handbook of Experimental Pharmacology

Volumn 234, Issue , 2016, Pages 67-82

  Araç, Demet ^a   Sträter, Norbert ^b   Seiradake, Elena ^c  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

FLRT; GAIN; Horm; Latrophilin; Lectin; Olfactomedin; Stachel; Super complex; Tethered agonist; Unc5

Indexed keywords

G PROTEIN COUPLED RECEPTOR; HORMONE RECEPTOR; LATROPHILIN; LECTIN; OLFACTOMEDIN; PEPTIDE; STACHEL PEPTIDE; UNCLASSIFIED DRUG; LIGAND; PROTEIN BINDING;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; AUTOPROTEOLYSIS; CRYSTAL STRUCTURE; HORMONE BINDING; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; ANIMAL; BINDING SITE; CELL ADHESION; CELL MEMBRANE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR MODEL; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CELL ADHESION; CELL MEMBRANE; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84995422294     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-319-41523-9_4     Document Type: Chapter

References (39)

1. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC et al (2012) A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J 31:1364-1378. doi:10.1038/emboj.2012.26
2. Liebscher I, Schön J, Petersen SC, Fischer L, Auerbach N, Demberg LM et al (2014) A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR 133. Cell Rep 9:2018-2026. doi:10.1016/j.celrep.2014.11.036
3. Stoveken HM, Hajduczok AG, Xu L, Tall GG (2015) Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist. Proc Natl Acad Sci U S A 112:6194-6199. doi:10.1073/pnas.1421785112
4. Demberg LM, Rothemund S, Schöneberg T, Liebscher I (2015) Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG 2. Biochem Biophys Res Commun 464:743-747. doi:10.1016/j.bbrc.2015.07.020
5. Wilde C, Fischer L, Lede V, Kirchberger J, Rothemund S, Schöneberg T et al (2016) The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist. FASEB J 30:666-673. doi:10.1096/fj.15-276220
6. Vakonakis I, Langenhan T, Prömel S, Russ A, Campbell ID (2008) Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain. Structure 16:944-953. doi:10.1016/j.str.2008.02.020
7. Jackson VA, del Toro D, Carrasquero M, Roversi P, Harlos K, Klein R et al (2015) Structural basis of latrophilin-FLRT interaction. Structure 23:774-781. doi:10.1016/j.str.2015.01.013
8. Ranaivoson FM, Liu Q, Martini F, Bergami F, von Daake S, Li S et al (2015) Structural and mechanistic insights into the latrophilin3-FLRT3 complex that mediates glutamatergic synapse development. Structure 23:1665-1677. doi:10.1016/j.str.2015.06.022
9. Lu YC, Nazarko OV, Sando R, Salzman GS, Südhof TC, Araç D (2015) Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion. Structure 23:1678-1691. doi:10.1016/j.str.2015.06.024
10. Jackson VA, Mehmood S, Chavent M, Roversi P, Carrasquero M, del Toro D et al (2016) Super-complexes of adhesion GPCRs and neural guidance receptors. Nat Commun 7:11184
11. Krasnoperov VG, Bittner MA, Beavis R, Kuang Y, Salnikow KV, Chepurny OG et al (1997) alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Neuron 18:925-937
12. Lin H-H, Chang G-W, Davies JQ, Stacey M, Harris J, Gordon S (2004) Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif. J Biol Chem 279:31823-31832. doi:10.1074/jbc.M402974200
13. Krishnan A, Nijmeijer S, de Graaf C, Schiöth HB (2016) Classification, nomenclature and structural aspects of adhesion GPCRs. In: Langenhan T, Schöneberg T (eds) Adhesion G protein-coupled receptors: molecular, physiological and pharmacological principles in health and disease. Springer, Heidelberg
14. Gray JX, Haino M, Roth MJ, Maguire JE, Jensen PN, Yarme A et al (1996) CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. J Immunol 157:5438-5447
15. Shashidhar S, Lorente G, Nagavarapu U, Nelson A, Kuo J, Cummins J et al (2005) GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion. Oncogene 24:1673-1682. doi:10.1038/sj.onc.1208395
16. Stacey M, Chang G-W, Sanos SL, Chittenden LR, Stubbs L, Gordon S et al (2002) EMR4, a novel epidermal growth factor (EGF)-TM7 molecule up-regulated in activated mouse macrophages, binds to a putative cellular ligand on B lymphoma cell line A 20. J Biol Chem 277:29283-29293. doi:10.1074/jbc.M204306200
17. Liebscher I, Schöneberg T (2016) Tethered agonism: a common activation mechanism of adhesion GPCRs. In: Langenhan T, Schöneberg T (eds) Adhesion G protein-coupled receptors: molecular, physiological and pharmacological principles in health and disease. Springer, Heidelberg
18. Kishore A, Hall RA (2016) Versatile signaling activity of adhesion GPCRs. In: Langenhan T, Schöneberg T (eds) Adhesion G protein-coupled receptors: molecular, physiological and pharmacological principles in health and disease. Springer, Heidelberg
19. Nieberler M, Kittel RJ, Petrenko AG, Lin H-H, Langenhan T (2016) Control of adhesion GPCR function through proteolytic processing. In: Langenhan T, Schöneberg T (eds) Adhesion G protein-coupled receptors: molecular, physiological and pharmacological principles in health and disease. Springer, Heidelberg
20. Sigoillot SM, Monk KR, Piao X, Selimi F, Harty BL (2016) Adhesion G protein-coupled receptors in the nervous system: from synapse and dendrite morphogenesis to myelination. In: Langenhan T, Schöneberg T (eds) Adhesion G protein-coupled receptors: molecular, physiological and pharmacological principles in health and disease. Springer, Heidelberg
21. Kan Z, Jaiswal BS, Stinson J, Janakiraman V, Bhatt D, Stern HM et al (2010) Diverse somatic mutation patterns and pathway alterations in human cancers. Nature 466:869-873. doi:10.1038/nature09208
22. Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D et al (2010) A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry 15:1053-1066. doi:10.1038/mp.2010.6
23. Paavola KJ, Stephenson JR, Ritter SL, Alter SP, Hall RA (2011) The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity. J Biol Chem 286:28914-28921. doi:10.1074/jbc.M111.247973
24. Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A et al (2011) GPR56 regulates VEGF production and angiogenesis during melanoma progression. Cancer Res 71:5558-5568. doi:10.1158/0008-5472.CAN-10-4543
25. Grace CRR, Perrin MH, Gulyas J, Digruccio MR, Cantle JP, Rivier JE et al (2007) Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand. Proc Natl Acad Sci U S A 104:4858-4863. doi:10.1073/pnas.0700682104
26. Hoare SRJ (2005) Mechanisms of peptide and nonpeptide ligand binding to Class B G-proteincoupled receptors. Drug Discov Today 10:417-427. doi:10.1016/S1359-6446(05)03370-2
27. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 84:23-33. doi:10.1016/j.ygeno.2003.12.004
28. Davletov BA, Shamotienko OG, Lelianova VG, Grishin EV, Ushkaryov YA (1996) Isolation and biochemical characterization of a Ca2+-independent alpha-latrotoxin-binding protein. J Biol Chem 271:23239-23245
29. Silva J-P, Lelianova VG, Ermolyuk YS, Vysokov N, Hitchen PG, Berninghausen O et al (2011) Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities. Proc Natl Acad Sci U S A 108:12113-12118. doi:10.1073/pnas.1019434108
30. Boucard AA, Ko J, Südhof TC (2012) High affinity neurexin binding to cell adhesion Gprotein- coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex. J Biol Chem 287:9399-9413. doi:10.1074/jbc.M111.318659
31. O’Sullivan ML, de Wit J, Savas JN, Comoletti D, Otto-Hitt S, Yates JR et al (2012) FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. Neuron 73:903-910. doi:10.1016/j.neuron.2012.01.018
32. Seiradake E, del Toro D, Nagel D, Cop F, Härtl R, Ruff T et al (2014) FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development. Neuron 84:370-385. doi:10.1016/j.neuron.2014.10.008
33. Yamagishi S, Hampel F, Hata K, Del Toro D, Schwark M, Kvachnina E et al (2011) FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. EMBO J 30:2920-2933. doi:10.1038/emboj.2011.189
34. Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJE (2015) The Phyre2 web portal for protein modeling, prediction and analysis. Nat Protoc 10:845-858. doi:10.1038/nprot.2015.053
35. Wouters MA, Rigoutsos I, Chu CK, Feng LL, Sparrow DB, Dunwoodie SL (2005) Evolution of distinct EGF domains with specific functions. Protein Sci 14:1091-1103. doi:10.1110/ps.041207005
36. Handford P, Downing AK, Rao Z, Hewett DR, Sykes BC, Kielty CM (1995) The calcium binding properties and molecular organization of epidermal growth factor-like domains in human fibrillin-1. J Biol Chem 270:6751-6756
37. Scholz N, Gehring J, Guan C, Ljaschenko D, Fischer R, Lakshmanan V et al (2015) The adhesion GPCR latrophilin/CIRL shapes mechanosensation. Cell Rep 11:866-874. doi:10.1016/j.celrep.2015.04.008
38. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R et al (2015) International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev 67:338-367. doi:10.1124/pr.114.009647
39. Zhang D, Zhao Q, Wu B (2015) Structural studies of G protein-coupled receptors. Mol Cells 38:836-842, doi:10.14348/molcells.2015.0263