Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2

Biochemical and Biophysical Research Communications

Volumn 464, Issue 3, 2015, Pages 743-747

  Demberg, Lilian M ^a   Rothemund, Sven ^a   Schöneberg, Torsten ^a   Liebscher, Ines ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

G protein; GPCR; GPR64; Molecular pharmacology; Peptide agonist; Signal transduction

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GPR64 PROTEIN; MUTANT PROTEIN; PURINERGIC P2Y12 RECEPTOR; SIGNAL PEPTIDE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; GPR64 PROTEIN, MOUSE; HYBRID PROTEIN; OLIGOPEPTIDE; PEPTIDE;

AGONIST; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DNA LIBRARY; HOMOLOGOUS RECOMBINATION; HUMAN; INTRACELLULAR SIGNALING; MALE; MALE FERTILITY; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE LIBRARY; PEPTIDE SYNTHESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECOND MESSENGER; SIGNAL TRANSDUCTION; TESTIS; AGONISTS; AMINO ACID SEQUENCE; ANIMAL; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; EPIDIDYMIS; FERTILITY; GENETICS; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; EPIDIDYMIS; FERTILITY; MALE; MICE; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDES; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 84938751168     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.07.020     Document Type: Article

References (40)

1. T.K. Bjarnadottir, R. Fredriksson, and H.B. Schioth The adhesion GPCRs: a unique family of G protein-coupled receptors with important roles in both central and peripheral tissues Cell Mol. Life Sci. 64 2007 2104 2119
2. J. Hamann, G. Aust, D. Araç, F.B. Engel, C. Formstone, R. Fredriksson, R.A. Hall, B.L. Harty, C. Kirchhoff, B. Knapp, A. Krishnan, I. Liebscher, H.-H. Lin, D.C. Martinelli, K.R. Monk, M.C. Peeters, X. Piao, S. Prömel, T. Schöneberg, T.W. Schwartz, K. Singer, M. Stacey, Y.A. Ushkaryov, M. Vallon, U. Wolfrum, M.W. Wright, L. Xu, T. Langenhan, and H.B. Schiöth International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors Pharmacol. Rev. 67 2015 338 367
3. T. Langenhan, S. Prömel, L. Mestek, B. Esmaeili, H. Waller-Evans, C. Hennig, Y. Kohara, L. Avery, I. Vakonakis, R. Schnabel, and A.P. Russ Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo Dev. Cell 17 2009 494 504
4. H. Waller-Evans, S. Prömel, T. Langenhan, J. Dixon, D. Zahn, W.H. Colledge, J. Doran, Mark B.L. Carlton, B. Davies, Samuel A.J.R. Aparicio, J. Grosse, and A.P. Russ The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse PLoS One 5 2010 e14047
5. K.R. Monk, S.G. Naylor, T.D. Glenn, S. Mercurio, J.R. Perlin, C. Dominguez, C.B. Moens, and W.S. Talbot A G protein-coupled receptor is essential for Schwann cells to initiate myelination Sci. (New York, N.Y.) 325 2009 1402 1405
6. X. Piao, R.S. Hill, A. Bodell, B.S. Chang, L. Basel-Vanagaite, R. Straussberg, W.B. Dobyns, B. Qasrawi, R.M. Winter, A.M. Innes, T. Voit, M.E. Ross, J.L. Michaud, J.-C. Descarie, A.J. Barkovich, and C.A. Walsh G protein-coupled receptor-dependent development of human frontal cortex Science 303 2004 2033 2036
7. M.D. Weston, Mirjam W.J. Luijendijk, K.D. Humphrey, C. Moller, and W.J. Kimberling Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of usher syndrome type II Am. J. Hum. Genet. 74 2004 357 366
8. F. Marroni, A. Pfeufer, Y.S. Aulchenko, C.S. Franklin, A. Isaacs, I. Pichler, S.H. Wild, B.A. Oostra, A.F. Wright, H. Campbell, J.C. Witteman, S. Kaab, A.A. Hicks, U. Gyllensten, I. Rudan, T. Meitinger, C. Pattaro, Cornelia M. van Duijn, J.F. Wilson, and P.P. Pramstaller A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project Circ. Cardiovasc Genet. 2 2009 322 328
9. A. Tonjes, M. Koriath, D. Schleinitz, K. Dietrich, Y. Bottcher, N.W. Rayner, P. Almgren, B. Enigk, O. Richter, S. Rohm, A. Fischer-Rosinsky, A. Pfeiffer, K. Hoffmann, K. Krohn, G. Aust, J. Spranger, L. Groop, M. Bluher, P. Kovacs, and M. Stumvoll Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs Hum. Mol. Genet. 18 2009 4662 4668
10. R.C. Harvey, C.G. Mullighan, X. Wang, K.K. Dobbin, G.S. Davidson, E.J. Bedrick, I.-M. Chen, S.R. Atlas, H. Kang, K. Ar, C.S. Wilson, W. Wharton, M. Murphy, M. Devidas, A.J. Carroll, M.J. Borowitz, W.P. Bowman, J.R. Downing, M. Relling, J. Yang, D. Bhojwani, W.L. Carroll, B. Camitta, G.H. Reaman, M. Smith, S.P. Hunger, and C.L. Willman Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome Blood 116 2010 4874 4884
11. T. Langenhan, G. Aust, and J. Hamann Sticky signaling-adhesion class G protein-coupled receptors take the stage Sci. Signal. 6 2013 re3
12. I. Liebscher, T. Schöneberg, and S. Prömel Progress in demystification of adhesion G protein-coupled receptors Biol. Chem. 394 2013 937 950
13. J. Bohnekamp, and T. Schöneberg Cell adhesion receptor GPR133 couples to Gs protein J. Biol. Chem. 286 2011 41912 41916
14. J. Gupte, G. Swaminath, J. Danao, H. Tian, Y. Li, and X. Wu Signaling property study of adhesion G-protein-coupled receptors FEBS Lett. 586 2012 1214 1219
15. A. Mogha, A.E. Benesh, C. Patra, F.B. Engel, T. Schöneberg, I. Liebscher, and K.R. Monk Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation J. Neurosci. Official J. Soc. Neurosci. 33 2013 17976 17985
16. D. Okajima, G. Kudo, and H. Yokota Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing J. Recept. Signal Transduct. Res. 30 2010 143 153
17. K.J. Paavola, J.R. Stephenson, S.L. Ritter, S.P. Alter, and R.A. Hall The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity J. Biol. Chem. 286 2011 28914 28921
18. L. Yang, G. Chen, S. Mohanty, G. Scott, F. Fazal, A. Rahman, S. Begum, R.O. Hynes, and L. Xu GPR56 regulates VEGF production and angiogenesis during melanoma progression Cancer Res. 71 2011 5558 5568
19. I. Liebscher, J. Schön, S.C. Petersen, L. Fischer, N. Auerbach, L.M. Demberg, A. Mogha, M. Cöster, K.-U. Simon, S. Rothemund, K.R. Monk, and T. Schöneberg A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR133 Cell Rep. 9 2014 2018 2026
20. H.M. Stoveken, A.G. Hajduczok, L. Xu, and G.G. Tall Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist Proc. Natl. Acad. Sci. U. S. A. 112 2015 6194 6199
21. C. Osterhoff, R. Ivell, and C. Kirchhoff Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily DNA Cell Biol. 16 1997 379 389
22. C. Kirchhoff, H. Obermann, M. Behnen, and B. Davies Role of epididymal receptor HE6 in the regulation of sperm microenvironment Mol. Cell Endocrinol. 250 2006 43 48
23. B. Davies, C. Baumann, C. Kirchhoff, R. Ivell, R. Nubbemeyer, U.-F. Habenicht, F. Theuring, and U. Gottwald Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility Mol. Cell Biol. 24 2004 8642 8648
24. P. Sipilä, J. Jalkanen, I.T. Huhtaniemi, and M. Poutanen Novel epididymal proteins as targets for the development of post-testicular male contraception Reprod. Camb. Engl. 137 2009 379 389
25. U. Gottwald, B. Davies, M. Fritsch, and U.F. Habenicht New approaches for male fertility control: HE6 as an example of a putative target Mol. Cell Endocrinol. 250 2006 49 57
26. Günther H.S. Richter, A. Fasan, K. Hauer, Thomas G.P. Grunewald, C. Berns, S. Rössler, I. Naumann, M.S. Staege, S. Fulda, I. Esposito, and S. Burdach G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1 J. Pathol. 230 2013 70 81
27. K.L. Whittier, E.A. Boese, K.N. Gibson-Corley, P.A. Kirby, B.W. Darbro, Q. Qian, W.J. Ingram, T. Robertson, M. Remke, M.D. Taylor, and M.S. O'Dorisio G-protein coupled receptor expression patterns delineate medulloblastoma subgroups Acta Neuropathol. Commun. 1 2013 66
28. H. Okayama, and P. Berg A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells Mol. Cell Biol. 3 1983 280 289
29. D. Thor, D. Le Duc, R. Strotmann, and T. Schoneberg Luciferase activity under direct ligand-dependent control of a muscarinic acetylcholine receptor BMC Biotechnol. 9 2009 46
30. M.J. Berridge Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol Biochem. J. 212 1983 849 858
31. T. Schoneberg, A. Schulz, H. Biebermann, A. Gruters, T. Grimm, K. Hubschmann, G. Filler, T. Gudermann, and G. Schultz V2 vasopressin receptor dysfunction in nephrogenic diabetes insipidus caused by different molecular mechanisms Hum. Mutat. 12 1998 196 205
32. H. Rompler, H.-T. Yu, A. Arnold, A. Orth, and T. Schoneberg Functional consequences of naturally occurring DRY motif variants in the mammalian chemoattractant receptor GPR33 Genomics 87 2006 724 732
33. R.J. Lefkowitz, S. Cotecchia, P. Samama, and T. Costa Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins Trends Pharmacol. Sci. 14 1993 303 307
34. I. Boselt, H. Rompler, T. Hermsdorf, D. Thor, W. Busch, A. Schulz, and T. Schoneberg Involvement of the V2 vasopressin receptor in adaptation to limited water supply PLoS One 4 2009 e5573
35. D. Eggerickx, J.F. Denef, O. Labbe, Y. Hayashi, S. Refetoff, G. Vassart, M. Parmentier, and F. Libert Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase Biochem. J. 309 Pt 3 1995 837 843
36. B.R. Conklin, Z. Farfel, K.D. Lustig, D. Julius, and H.R. Bourne Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha Nature 363 1993 274 276
37. T. Gudermann, T. Schoneberg, and G. Schultz Functional and structural complexity of signal transduction via G-protein-coupled receptors Annu. Rev. Neurosci. 20 1997 399 427
38. J. Wess, K. Nakajima, and S. Jain Novel designer receptors to probe GPCR signaling and physiology Trends Pharmacol. Sci. 34 2013 385 392
39. K.J. Paavola, H. Sidik, J.B. Zuchero, M. Eckart, and W.S. Talbot Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126 Sci. Signal. 7 2014 ra76
40. S.C. Petersen, R. Luo, I. Liebscher, S. Giera, S.-J. Jeong, A. Mogha, M. Ghidinelli, M.L. Feltri, T. Schoneberg, X. Piao, and K.R. Monk The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211 Neuron 85 2015 755 769