Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif

Journal of Biological Chemistry

Volumn 279, Issue 30, 2004, Pages 31823-31832

  Lin, Hsi Hsien ^a   Chang, Gin Wen ^a   Davies, John Q ^a   Stacey, Martin ^a   Harris, James ^a   Gordon, Siamon ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYSIS; CELLS; CHEMICAL ACTIVATION; DIMERS; HYDROLYSIS; MUTAGENESIS;

AUTOCATALYTIC CLEAVAGE; CELL SURFACE RECEPTORS; INTRAMOLECULAR REACTION; PROTEOLYSIS;

PROTEINS;

CELL SURFACE PROTEIN; CYSTEINE; EPIDERMAL GROWTH FACTOR MODULE CONTAINING MUCIN LIKE RECEPTOR 2; G PROTEIN COUPLED RECEPTOR; HISTIDINE; HYDROLASE; LEUCINE; POLYCYSTIN 1; PROTEIN; SERINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; HYDROLYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN MOTIF; RAT; SITE DIRECTED MUTAGENESIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CONSERVED SEQUENCE; EPIDERMAL GROWTH FACTOR; HUMANS; KINETICS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN SUBUNITS; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 3843101589     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M402974200     Document Type: Article

References (61)

1. Krem, M. M., and Cera, E. D. (2002) Trends Biochem. Sci. 27, 67-74
2. Selkoe, D., and Kopan, R. (2003) Annu. Rev. Neurosci. 26, 565-597
3. Coughlin, S. R. (2000) Nature 407, 258-264
4. Hooper, J. D., Clements, J. A., Quigley, J. P., and Antalis, T. M. (2001) J. Biol. Chem. 276, 857-860
5. Stamenkovic, I. (2003) J. Pathol. 200, 448-464
6. Salvesen, G. S., and Dixit, V. M. (1997) Cell 91, 443-446
7. Anderson, E. D., Molloy, S. S., Jean, F., Fei, H., Shimamura, S., and Thomas, G. (2002) J. Biol. Chem. 277, 12879-12890
8. Anderson, E. D., VanSlyke, J. K., Thulin, C. D., Jean, F., and Thomas, G. (1997) EMBO J. 16, 1508-1518
9. Creemers, J. W., Vey, M., Schafer, W., Ayoubi, T. A., Roebroek, A. J., Klenk, H. D., Garten, W., and Van de Ven, W. J. (1995) J. Biol. Chem. 270, 2695-2702
10. Elagoz, A., Benjannet, S., Mammarbassi, A., Wickham, L., and Seidah, N. G. (2002) J. Biol. Chem. 277, 11265-11275
11. Brannigan, J. A., Dodson, G., Duggleby, H. J., Moody, P. C., Smith, J. L., Tomchick, D. R., and Murzin, A. G. (1995) Nature 378, 416-419
12. Perler, F. B., Xu, M. Q., and Paulus, H. (1997) Curr. Opin. Chem. Biol. 1, 292-299
13. Perler, F. B. (1998) Nat. Struct. Biol. 5, 249-252
14. Oinonen, C., Tikkanen, R., Rouvinen, J., and Peltonen, L. (1995) Nat. Struct. Biol. 2, 1102-1108
15. Saarela, J., Laine, M., Tikkanen, R., Oinonen, C., Jalanko, A., Rouvinen, J., and Peltonen, L. (1998) J. Biol. Chem. 273, 25320-25328
16. Tikkanen, R., Riikonen, A., Oinonen, C., Rouvinen, R., and Peltonen, L. (1996) EMBO J. 15, 2954-2960
17. Xu, Q., Buckley, D., Guan, C., and Guo, H. C. (1999) Cell 98, 651-661
18. Isupov, M. N., Obmolova, G., Butterworth, S., Badet-Denisot, M. A., Badet, B., Polikarpov, I., Littlechild, J. A., and Teplyakov, A. (1996) Structure 4, 801-810
19. Larsen, T. M., Boehlein, S. K., Schuster, S. M., Richards, N. G., Thoden, J. B., Holden, H. M., and Rayment, I. (1999) Biochemistry 38, 16146-16157
20. Choi, K. S., Kim, J. A., and Kang, H. S. (1992) J. Bacteriol. 174, 6270-6276
21. Duggleby, H. J., Tolley, S. P., Hill, C. P., Dodson, E. J., Dodson, G., and Moody, P. C. (1995) Nature 373, 264-268
22. Guan, C., Cui, T., Rao, V., Liao, W., Benner, J., Lin, C. L., and Comb, D. (1996) J. Biol. Chem. 271, 1732-1737
23. Kisselev, A. F., Songyang, Z., and Goldberg, A. L. (2000) J. Biol. Chem. 275, 14831-14837
24. Suzuki, H., and Kumagai, H. (2002) J. Biol. Chem. 277, 43536-43543
25. Hsieh, J. J., Cheng, E. H., and Korsmeyer, S. J. (2003) Cell 115, 293-303
26. Lee, J. J., Ekker, S. C., von Kessler, D. P., Porter, J. A., Sun, B. I., and Beachy, P. A. (1994) Science 266, 1528-1537
27. Porter, J. A., von Kessler, D. P., Ekker, S. C., Young, K. E., Lee, J. J., Moses, K., and Beachy, P. A. (1995) Nature 374, 363-366
28. Perler, F. B. (1998) Cell 92, 1-4
29. Teixeira, M. T., Fabre, E., and Dujon, B. (1999) J. Biol. Chem. 274, 32439-32444
30. Rosenblum, J. S., and Blobel, G. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11370-11375
31. Krasnoperov, V. G., Bittner, M. A., Beavis, R., Kuang, Y., Salnikow, K. V., Chepurny, O. G., Little, A. R., Plotnikov, A. N., Wu, D., Holz, R. W., and Petrenko, A. G. (1997) Neuron 18, 925-937
32. Harmar, A. J. (2001) Genome Biol. 2, 3013
33. Stacey, M., Lin, H. H., Gordon, S., and McKnight, A. J. (2000) Trends Biochem. Sci. 25, 284-289
34. Usui, T., Shima, Y., Shimada, Y., Hirano, S., Burgess, R. W., Schwarz, T. L., Takeichi, M., and Uemura, T. (1999) Cell 98, 585-595
35. Sugita, S., Ichtchenko, K., Khvotchev, M., and Sudhof, T. C. (1998) J. Biol. Chem. 273, 32715-32724
36. Abe, J., Fukuzawa, T., and Hirose, S. (2002) J. Biol. Chem. 277, 23391-23398
37. Obermann, H., Samalecos, A., Osterhoff, C., Schroder, B., Heller, R., and Kirchhoff, C. (2003) Mol. Reprod. Dev. 64, 13-26
38. McKnight, A. J., and Gordon, S. (1998) J. Leukocyte Biol. 63, 271-280
39. Moy, G. W., Mendoza, L. M., Schulz, J. R., Swanson, W. J., Glabe, C. G., and Vacquier, V. D. (1996) J. Cell Biol. 133, 809-817
40. Mengerink, K. J., Moy, G. W., and Vacquier, V. D. (2002) J. Biol. Chem. 277, 943-948
41. Qian, F., Boletta, A., Bhunia, A. K., Xu, H., Liu, L., Ahrabi, A. K., Watnick, T. J., Zhou, F., and Germino, G. G. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 16981-16986
42. Ponting, C. P., Hofmann, K., and Bork, P. (1999) Curr. Biol. 9, 585-588
43. Stacey, M., Chang, G. W., Sanos, S. L., Chittenden, L. R., Stubbs, L., Gordon, S., and Lin, H. H. (2002) J. Biol. Chem. 277, 29283-29293
44. Stacey, M., Chang, G. W., Davies, J. Q., Kwakkenbos, M. J., Sanderson, R. D., Hamann, J., Gordon, S., and Lin, H. H. (2003) Blood 102, 2916-2924
45. Lin, H. H., Stacey, M., Hamann, J., Gordon, S., and McKnight, A. J. (2000) Genomics 67, 188-200
46. Kwakkenbos, M. J., Chang, G. W., Lin, H. H., Pouwels, W., de Jong, E. C., van Lier, R. A., Gordon, S., and Hamann, J. (2002) J. Leukocyte Biol. 71, 854-862
47. Chang, G. W., Stacey, M., Kwakkenbos, M. J., Hamann, J., Gordon, S., and Lin, H. H. (2003) FEBS Lett. 547, 145-150
48. Lin, H. H., Stacey, M., Saxby, C., Knott, V., Chaudhry, Y., Evans, D., Gordon, S., McKnight, A. J., Handford, P., and Lea, S. (2001) J. Biol. Chem. 276, 24160-24169
49. Krasnoperov, V., Lu, Y., Buryanovsky, L., Neubert, T. A., Ichtchenko, K., and Petrenko, A. G. (2002) J. Biol. Chem. 277, 46518-46526
50. Gray, J. X., Haino, M., Roth, M. J., Maguire, J. E., Jensen, P. N., Yarme, A., Stetler-Stevenson, M. A., Siebenlist, U., and Kelly, K. (1996) J. Immunol. 157, 5438-5447
51. Nechiporuk, T., Urness, L. D., and Keating, M. T. (2001) J. Biol. Chem. 276, 4150-4157
52. Hauri, H. P., Kappeler, F., Andersson, H., and Appenzeller, C. (2000) J. Cell Sci. 113, 587-596
53. Boker, C., von Figura, K., and Hille-Rehfeld, A. (1997) J. Cell Sci. 110, 1023-1032
54. Shao, Y., and Kent, S. B. (1997) Chem. Biol. 4, 187-194
55. Guan, C., Liu, Y., Shao, Y., Cui, T., Liao, W., Ewel, A., Whitaker, R., and Paulus, H. (1998) J. Biol. Chem. 273, 9695-9702
56. Hanaoka, K., Qian, F., Boletta, A., Bhunia, A. K., Piontek, K., Tsiokas, L., Sukhatme, V. P., Guggino, W. B., and Germino, G. G. (2000) Nature 408, 990-994
57. Krasnoperov, V., Bittner, M. A., Holz, R. W., Chepurny, O., and Petrenko, A. G. (1999) J. Biol. Chem. 274, 3590-3596
58. Trimmer, J. S., Schackmann, R. W., and Vacquier, V. D. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 9055-9059
59. Aronson, N. N., Jr. (1999) Biochim. Biophys. Acta 1455, 139-154
60. Riikonen, A., Rouvinen, J., Tikkanen, R., Julkunen, I., Peltonen, L., and Jalanko, A. (1996) J. Biol. Chem. 271, 21340-21344
61. Wang, Y., and Guo, H. C. (2003) J. Biol. Chem. 278, 3210-3219